JP6700203B2 - ボロン酸誘導体およびその治療的使用 - Google Patents
ボロン酸誘導体およびその治療的使用 Download PDFInfo
- Publication number
- JP6700203B2 JP6700203B2 JP2016575893A JP2016575893A JP6700203B2 JP 6700203 B2 JP6700203 B2 JP 6700203B2 JP 2016575893 A JP2016575893 A JP 2016575893A JP 2016575893 A JP2016575893 A JP 2016575893A JP 6700203 B2 JP6700203 B2 JP 6700203B2
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- Prior art keywords
- optionally substituted
- alkyl
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- compound
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *CCC1CCCC1 Chemical compound *CCC1CCCC1 0.000 description 8
- ARZUMMLUZDAIAU-ZDUSSCGKSA-N COc1ccc(C[C@@H](B(O)O2)Sc3nnc(SCCN4CCNCC4)[s]3)c2c1C(O)=O Chemical compound COc1ccc(C[C@@H](B(O)O2)Sc3nnc(SCCN4CCNCC4)[s]3)c2c1C(O)=O ARZUMMLUZDAIAU-ZDUSSCGKSA-N 0.000 description 2
- REBMDVNAJPVARL-LURJTMIESA-N OB1Oc2c(C(O)=O)c(F)ccc2C[C@@H]1Sc1nnc(C(F)(F)F)[s]1 Chemical compound OB1Oc2c(C(O)=O)c(F)ccc2C[C@@H]1Sc1nnc(C(F)(F)F)[s]1 REBMDVNAJPVARL-LURJTMIESA-N 0.000 description 2
- WIILWRPJAVDLOL-UHFFFAOYSA-N CC(/S=C1/Cc2cccc(C(O)=O)c2OB1O)=N Chemical compound CC(/S=C1/Cc2cccc(C(O)=O)c2OB1O)=N WIILWRPJAVDLOL-UHFFFAOYSA-N 0.000 description 1
- WPGLRFGDZJSQGI-UHFFFAOYSA-N CC(C)(C)OC(N(C1)CC1N)=O Chemical compound CC(C)(C)OC(N(C1)CC1N)=O WPGLRFGDZJSQGI-UHFFFAOYSA-N 0.000 description 1
- YEQMQPWKRCNFRO-UHFFFAOYSA-N CC(C)(C)OC(N(C1)CC1NC(SC)=S)=O Chemical compound CC(C)(C)OC(N(C1)CC1NC(SC)=S)=O YEQMQPWKRCNFRO-UHFFFAOYSA-N 0.000 description 1
- GPEWAEMBWUBOTF-UHFFFAOYSA-N CC(C)(C)OC(N(C1)CC1Nc1nnc(S)[s]1)=O Chemical compound CC(C)(C)OC(N(C1)CC1Nc1nnc(S)[s]1)=O GPEWAEMBWUBOTF-UHFFFAOYSA-N 0.000 description 1
- OPTCHSMAUQAOEX-UHFFFAOYSA-N CCC(O1)=C(C)OC1=O Chemical compound CCC(O1)=C(C)OC1=O OPTCHSMAUQAOEX-UHFFFAOYSA-N 0.000 description 1
- XSQJSGURQRNYDW-ZETCQYMHSA-N CO[C@H](B(O)Oc1c2C(O)=O)Cc1ccc2F Chemical compound CO[C@H](B(O)Oc1c2C(O)=O)Cc1ccc2F XSQJSGURQRNYDW-ZETCQYMHSA-N 0.000 description 1
- JFXDEZBEJRDVEY-LURJTMIESA-N COc(c(C(O)=O)c(c(C[C@@H]1Sc2nnc(N)[s]2)c2)OB1O)c2F Chemical compound COc(c(C(O)=O)c(c(C[C@@H]1Sc2nnc(N)[s]2)c2)OB1O)c2F JFXDEZBEJRDVEY-LURJTMIESA-N 0.000 description 1
- ICUJWHOWEQDPCX-SQJZIBIZSA-N COc1c(C(O)=O)c(OB([C@H](C2)SC(C3)CN3C3=NC(COc4ccc(C[C@@H](B(O)O5)Sc6nnc(C(F)(F)F)[nH]6)c5c4C(O)=O)CS3)O)c2cc1 Chemical compound COc1c(C(O)=O)c(OB([C@H](C2)SC(C3)CN3C3=NC(COc4ccc(C[C@@H](B(O)O5)Sc6nnc(C(F)(F)F)[nH]6)c5c4C(O)=O)CS3)O)c2cc1 ICUJWHOWEQDPCX-SQJZIBIZSA-N 0.000 description 1
- GOWVYGOLNMMSIY-UHFFFAOYSA-N COc1ccc(CC(B(O)O2)Sc3nc(N)n[s]3)c2c1C(O)=O Chemical compound COc1ccc(CC(B(O)O2)Sc3nc(N)n[s]3)c2c1C(O)=O GOWVYGOLNMMSIY-UHFFFAOYSA-N 0.000 description 1
- GFPUGVSUXHTYFY-MRVPVSSYSA-N COc1ccc(C[C@@H](B(O)O2)CSc3cnn[s]3)c2c1C(O)=O Chemical compound COc1ccc(C[C@@H](B(O)O2)CSc3cnn[s]3)c2c1C(O)=O GFPUGVSUXHTYFY-MRVPVSSYSA-N 0.000 description 1
- IHCBBGWGXIIOTD-MRVPVSSYSA-N COc1ccc(C[C@@H](B(O)O2)CSc3nnc[s]3)c2c1C(O)=O Chemical compound COc1ccc(C[C@@H](B(O)O2)CSc3nnc[s]3)c2c1C(O)=O IHCBBGWGXIIOTD-MRVPVSSYSA-N 0.000 description 1
- SNASLOXHVKKQND-VIFPVBQESA-N COc1ccc(C[C@@H](B(O)O2)Sc3cnc[s]3)c2c1C(O)=O Chemical compound COc1ccc(C[C@@H](B(O)O2)Sc3cnc[s]3)c2c1C(O)=O SNASLOXHVKKQND-VIFPVBQESA-N 0.000 description 1
- GVQZVCLRKSVJQE-QMMMGPOBSA-N COc1ccc(C[C@@H](B(O)O2)Sc3nnc(CN)[n]3N)c2c1C(O)=O Chemical compound COc1ccc(C[C@@H](B(O)O2)Sc3nnc(CN)[n]3N)c2c1C(O)=O GVQZVCLRKSVJQE-QMMMGPOBSA-N 0.000 description 1
- FTBQGGGPAATUGP-LBPRGKRZSA-N COc1ccc(C[C@@H](B(O)O2)Sc3nnc(CN4CCNCC4)[n]3N)c2c1C(O)=O Chemical compound COc1ccc(C[C@@H](B(O)O2)Sc3nnc(CN4CCNCC4)[n]3N)c2c1C(O)=O FTBQGGGPAATUGP-LBPRGKRZSA-N 0.000 description 1
- KXVAAHBWCIRPPN-LBPRGKRZSA-N COc1ccc(C[C@@H](B(O)O2)Sc3nnc(NCCNC4CNC4)[s]3)c2c1C(O)=O Chemical compound COc1ccc(C[C@@H](B(O)O2)Sc3nnc(NCCNC4CNC4)[s]3)c2c1C(O)=O KXVAAHBWCIRPPN-LBPRGKRZSA-N 0.000 description 1
- JZYCXVYMCMHJQN-QMMMGPOBSA-N COc1ccc(C[C@@H](B(O)O2)Sc3nnc(SCC(N)=N)[s]3)c2c1C(O)=O Chemical compound COc1ccc(C[C@@H](B(O)O2)Sc3nnc(SCC(N)=N)[s]3)c2c1C(O)=O JZYCXVYMCMHJQN-QMMMGPOBSA-N 0.000 description 1
- IGHZKWFWYONCMS-ZDUSSCGKSA-N COc1ccc(C[C@@H](B(O)O2)Sc3nnc(SCCN4CCOCC4)[s]3)c2c1C(O)=O Chemical compound COc1ccc(C[C@@H](B(O)O2)Sc3nnc(SCCN4CCOCC4)[s]3)c2c1C(O)=O IGHZKWFWYONCMS-ZDUSSCGKSA-N 0.000 description 1
- IXRSTFJNAHTDPU-MRVPVSSYSA-N CSc1ccc(C[C@@H](B(O)O2)CSc3nnc[n]3N)c2c1C(O)=O Chemical compound CSc1ccc(C[C@@H](B(O)O2)CSc3nnc[n]3N)c2c1C(O)=O IXRSTFJNAHTDPU-MRVPVSSYSA-N 0.000 description 1
- ZQCVSACVVSLEBV-QMMMGPOBSA-N C[n]1c(S[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)nnc1 Chemical compound C[n]1c(S[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)nnc1 ZQCVSACVVSLEBV-QMMMGPOBSA-N 0.000 description 1
- KQIGSWPJXOPGGH-QMMMGPOBSA-N N#CCS[C@H](B(O)Oc1c2C(O)=O)Cc1ccc2F Chemical compound N#CCS[C@H](B(O)Oc1c2C(O)=O)Cc1ccc2F KQIGSWPJXOPGGH-QMMMGPOBSA-N 0.000 description 1
- RDGXHFRUQUNGAN-ZETCQYMHSA-N NC(CS[C@H](B(O)Oc1c2C(O)=O)Cc1ccc2F)=O Chemical compound NC(CS[C@H](B(O)Oc1c2C(O)=O)Cc1ccc2F)=O RDGXHFRUQUNGAN-ZETCQYMHSA-N 0.000 description 1
- AJMCDBKATZBNHS-QMMMGPOBSA-N NC(c1cnc(S[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)[s]1)=O Chemical compound NC(c1cnc(S[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)[s]1)=O AJMCDBKATZBNHS-QMMMGPOBSA-N 0.000 description 1
- UBZDLTZSIBMTQJ-VIFPVBQESA-N NCCSc1nnc(S[C@H]2Cc3cccc(C(O)=O)c3OB2O)[s]1 Chemical compound NCCSc1nnc(S[C@H]2Cc3cccc(C(O)=O)c3OB2O)[s]1 UBZDLTZSIBMTQJ-VIFPVBQESA-N 0.000 description 1
- QGAWUTJNTSYULE-VIFPVBQESA-N NCc1cnc(S[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)[s]1 Chemical compound NCc1cnc(S[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)[s]1 QGAWUTJNTSYULE-VIFPVBQESA-N 0.000 description 1
- BMVQNYKVSHHBFR-ZETCQYMHSA-N N[n]1c(S[C@H]2Cc(ccc(F)c3C(O)=O)c3OB2O)nnc1 Chemical compound N[n]1c(S[C@H]2Cc(ccc(F)c3C(O)=O)c3OB2O)nnc1 BMVQNYKVSHHBFR-ZETCQYMHSA-N 0.000 description 1
- WMSFSMPRPNIWDD-QMMMGPOBSA-N N[n]1c(S[C@H]2Cc3cccc(C(O)=O)c3OB2O)nnc1 Chemical compound N[n]1c(S[C@H]2Cc3cccc(C(O)=O)c3OB2O)nnc1 WMSFSMPRPNIWDD-QMMMGPOBSA-N 0.000 description 1
- JYNVMYRYEYYHCX-ZETCQYMHSA-N Nc1ncc(S[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)[s]1 Chemical compound Nc1ncc(S[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)[s]1 JYNVMYRYEYYHCX-ZETCQYMHSA-N 0.000 description 1
- DVCOUFYAYPANSK-UHFFFAOYSA-N Nc1nnc(CCSC(B(O)Oc2c3C(O)=O)Cc2ccc3F)[s]1 Chemical compound Nc1nnc(CCSC(B(O)Oc2c3C(O)=O)Cc2ccc3F)[s]1 DVCOUFYAYPANSK-UHFFFAOYSA-N 0.000 description 1
- DVCOUFYAYPANSK-QMMMGPOBSA-N Nc1nnc(CCS[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)[s]1 Chemical compound Nc1nnc(CCS[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)[s]1 DVCOUFYAYPANSK-QMMMGPOBSA-N 0.000 description 1
- GWSDAQZCKOLKMJ-LURJTMIESA-N Nc1nnc(S[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)[s]1 Chemical compound Nc1nnc(S[C@H](B(O)Oc2c3C(O)=O)Cc2ccc3F)[s]1 GWSDAQZCKOLKMJ-LURJTMIESA-N 0.000 description 1
- MDFYRHMTCKYBKU-MRVPVSSYSA-N OB1Oc2c(C(O)=O)c(F)ccc2C[C@@H]1CSc1ncc(NC=O)[s]1 Chemical compound OB1Oc2c(C(O)=O)c(F)ccc2C[C@@H]1CSc1ncc(NC=O)[s]1 MDFYRHMTCKYBKU-MRVPVSSYSA-N 0.000 description 1
- RBGQRSWYVGULBU-ZETCQYMHSA-N OB1Oc2c(C(O)=O)c(F)ccc2C[C@@H]1Sc1cnn[s]1 Chemical compound OB1Oc2c(C(O)=O)c(F)ccc2C[C@@H]1Sc1cnn[s]1 RBGQRSWYVGULBU-ZETCQYMHSA-N 0.000 description 1
- KJTIZQKAMZFMTQ-ZETCQYMHSA-N OB1Oc2c(C(O)=O)c(F)ccc2C[C@@H]1Sc1nnc[s]1 Chemical compound OB1Oc2c(C(O)=O)c(F)ccc2C[C@@H]1Sc1nnc[s]1 KJTIZQKAMZFMTQ-ZETCQYMHSA-N 0.000 description 1
- DVBZVPCWWAVOBE-UHFFFAOYSA-N OC(c(cccc1CC2OCc3ccccc3)c1OS2O)=O Chemical compound OC(c(cccc1CC2OCc3ccccc3)c1OS2O)=O DVBZVPCWWAVOBE-UHFFFAOYSA-N 0.000 description 1
- AZJTXDQIEKEPCH-UHFFFAOYSA-N OC(c(cccc1CC2Sc3ncc[s]3)c1OS2O)=O Chemical compound OC(c(cccc1CC2Sc3ncc[s]3)c1OS2O)=O AZJTXDQIEKEPCH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462019758P | 2014-07-01 | 2014-07-01 | |
| US62/019,758 | 2014-07-01 | ||
| PCT/US2015/038364 WO2016003929A1 (en) | 2014-07-01 | 2015-06-29 | Boronic acid derivatives and therapeutic uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017526636A JP2017526636A (ja) | 2017-09-14 |
| JP2017526636A5 JP2017526636A5 (cg-RX-API-DMAC7.html) | 2018-09-06 |
| JP6700203B2 true JP6700203B2 (ja) | 2020-05-27 |
Family
ID=55019887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575893A Active JP6700203B2 (ja) | 2014-07-01 | 2015-06-29 | ボロン酸誘導体およびその治療的使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10206937B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3164406B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6700203B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20170024087A (cg-RX-API-DMAC7.html) |
| CN (1) | CN106536529B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015284307A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2952968A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA201692301A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2016016666A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016003929A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201608682B (cg-RX-API-DMAC7.html) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE048859T2 (hu) | 2010-08-10 | 2020-08-28 | Rempex Pharmaceuticals Inc | Gyûrûs bórsavészter származékok, eljárás elõállításukra, és terápiás alkalmazásuk |
| EA201591003A1 (ru) | 2013-01-04 | 2015-12-30 | Ремпекс Фармасьютикалз, Инк. | Производные бороновой кислоты и их терапевтическое применение |
| EP2943204B1 (en) * | 2013-01-10 | 2019-03-13 | Venatorx Pharmaceuticals Inc | Beta-lactamase inhibitors |
| PT3140310T (pt) | 2014-05-05 | 2019-11-18 | Rempex Pharmaceuticals Inc | Síntese de sais de boronato e utilizações dos mesmos |
| WO2015171398A1 (en) | 2014-05-05 | 2015-11-12 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
| BR112016026291A2 (pt) | 2014-05-19 | 2017-08-15 | Rempex Pharmaceuticals Inc | Derivados do ácido borônico e usos terapêuticos dos mesmos |
| US9511142B2 (en) | 2014-06-11 | 2016-12-06 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| CA2950917C (en) | 2014-06-11 | 2022-08-23 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| US10662205B2 (en) | 2014-11-18 | 2020-05-26 | Qpex Biopharma, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| WO2016149393A1 (en) * | 2015-03-17 | 2016-09-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US10399996B2 (en) | 2015-09-11 | 2019-09-03 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| WO2017100537A1 (en) | 2015-12-10 | 2017-06-15 | VenatoRx Pharmaceuticals, Inc. | Beta-lactamase inhibitors |
| CN106008446A (zh) * | 2016-04-29 | 2016-10-12 | 广州药本君安医药科技股份有限公司 | 呫吨酮衍生物及呫吨酮和其衍生物的制备方法与用途 |
| SG11201811549UA (en) | 2016-06-30 | 2019-01-30 | Qpex Biopharma Inc | Boronic acid derivatives and therapeutic uses thereof |
| FR3053968A1 (fr) * | 2016-07-13 | 2018-01-19 | Biomerieux | Reactifs pour la protection reversible de molecules biologiques |
| WO2018027062A1 (en) | 2016-08-04 | 2018-02-08 | VenatoRx Pharmaceuticals, Inc. | Boron-containing compounds |
| GB201613946D0 (en) | 2016-08-15 | 2016-09-28 | Univ Oslo | Compounds |
| JOP20190188A1 (ar) | 2017-02-01 | 2019-08-01 | Rempex Pharmaceuticals Inc | جهاز وعملية تدفق مستمرة لإنتاج مشتق حمض بورونيك |
| TW201841642A (zh) * | 2017-04-28 | 2018-12-01 | 日商大日本住友製藥股份有限公司 | 雜環衍生物 |
| WO2018218154A1 (en) | 2017-05-26 | 2018-11-29 | VenatoRx Pharmaceuticals, Inc. | Penicillin-binding protein inhibitors |
| CN110959008A (zh) | 2017-05-26 | 2020-04-03 | 维纳拓尔斯制药公司 | 青霉素结合蛋白抑制剂 |
| WO2019009369A1 (ja) * | 2017-07-06 | 2019-01-10 | 大日本住友製薬株式会社 | イミン誘導体 |
| WO2019009370A1 (ja) * | 2017-07-06 | 2019-01-10 | 大日本住友製薬株式会社 | アミド誘導体 |
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| CN106536529A (zh) | 2017-03-22 |
| EP3164406A1 (en) | 2017-05-10 |
| AU2015284307A1 (en) | 2017-02-02 |
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