JP6696908B2 - 肺腺癌の治療方法 - Google Patents

肺腺癌の治療方法 Download PDF

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JP6696908B2
JP6696908B2 JP2016564236A JP2016564236A JP6696908B2 JP 6696908 B2 JP6696908 B2 JP 6696908B2 JP 2016564236 A JP2016564236 A JP 2016564236A JP 2016564236 A JP2016564236 A JP 2016564236A JP 6696908 B2 JP6696908 B2 JP 6696908B2
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ros1
compound
composition
slc34a2
fusion
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JP2017513908A (ja
JP2017513908A5 (cg-RX-API-DMAC7.html
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ダナ ティー. アフタブ,
ダナ ティー. アフタブ,
ペイウェン ユー,
ペイウェン ユー,
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エグゼリクシス, インコーポレイテッド
エグゼリクシス, インコーポレイテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
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    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00Medicinal preparations containing organic active ingredients
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    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
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    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016564236A 2014-04-25 2015-04-27 肺腺癌の治療方法 Active JP6696908B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461984599P 2014-04-25 2014-04-25
US61/984,599 2014-04-25
PCT/US2015/027800 WO2015164869A1 (en) 2014-04-25 2015-04-27 Method of treating lung adenocarcinoma

Related Child Applications (1)

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JP2019126230A Division JP2019189646A (ja) 2014-04-25 2019-07-05 肺腺癌の治療方法

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JP2017513908A JP2017513908A (ja) 2017-06-01
JP2017513908A5 JP2017513908A5 (cg-RX-API-DMAC7.html) 2018-06-14
JP6696908B2 true JP6696908B2 (ja) 2020-05-20

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JP2019126230A Pending JP2019189646A (ja) 2014-04-25 2019-07-05 肺腺癌の治療方法

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US (1) US20170042880A1 (cg-RX-API-DMAC7.html)
EP (2) EP3134084B1 (cg-RX-API-DMAC7.html)
JP (2) JP6696908B2 (cg-RX-API-DMAC7.html)
KR (1) KR102474701B1 (cg-RX-API-DMAC7.html)
CN (1) CN106488768A (cg-RX-API-DMAC7.html)
AR (1) AR100191A1 (cg-RX-API-DMAC7.html)
AU (1) AU2015249232B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016024672A2 (cg-RX-API-DMAC7.html)
CA (1) CA2946416C (cg-RX-API-DMAC7.html)
DK (1) DK3134084T3 (cg-RX-API-DMAC7.html)
EA (1) EA035223B1 (cg-RX-API-DMAC7.html)
ES (1) ES2874875T3 (cg-RX-API-DMAC7.html)
HU (1) HUE054557T2 (cg-RX-API-DMAC7.html)
IL (1) IL248408B (cg-RX-API-DMAC7.html)
MX (1) MX375716B (cg-RX-API-DMAC7.html)
PL (1) PL3134084T3 (cg-RX-API-DMAC7.html)
PT (1) PT3134084T (cg-RX-API-DMAC7.html)
SG (1) SG11201608657QA (cg-RX-API-DMAC7.html)
TW (1) TWI724988B (cg-RX-API-DMAC7.html)
UA (1) UA121655C2 (cg-RX-API-DMAC7.html)
WO (1) WO2015164869A1 (cg-RX-API-DMAC7.html)

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KR20140025496A (ko) 2011-05-02 2014-03-04 엑셀리시스, 인코포레이티드 암 및 뼈 암 통증의 치료방법
JP6666849B2 (ja) 2014-03-17 2020-03-18 エグゼリクシス, インコーポレイテッド カボザンチニブ製剤の投与
WO2016019285A1 (en) 2014-07-31 2016-02-04 Exelixis, Inc. Method of preparing fluorine-18 labeled cabozantinib and its analogs
KR102634247B1 (ko) 2014-08-05 2024-02-05 엑셀리시스, 인코포레이티드 다발성 골수종을 치료하기 위한 약물 병용물
CA3020749A1 (en) 2016-04-15 2017-10-19 Exelixis, Inc. Method of treating renal cell carcinoma using n-(4-(6,7-dimethoxyquinolin-4-yloxy) phenyl)-n'-(4-fluoropheny)cyclopropane-1,1-dicarboxamide, (2s)-hydroxybutanedioate
CN107353246A (zh) * 2016-12-27 2017-11-17 辅仁药业集团熙德隆肿瘤药品有限公司 一种制备抗肿瘤药物卡博替尼的方法
CA3059119C (en) * 2017-05-31 2024-01-23 F. Hoffman-La Roche Ag Multiplex pcr detection of alk, ret, and ros fusions
MX2019014298A (es) 2017-06-09 2020-02-03 Exelixis Inc Formas de dosificacion liquida para tratar el cancer.
CN107541550A (zh) * 2017-08-21 2018-01-05 上海派森诺生物科技股份有限公司 人ros1融合基因检测方法
JP7279026B2 (ja) * 2017-09-20 2023-05-22 メルサナ セラピューティクス インコーポレイテッド Napi2b標的化療法に対する応答を予測するための組成物および方法
SG11202006921PA (en) 2018-01-26 2020-08-28 Exelixis Inc Compounds for the treatment of kinase-dependent disorders
EP3743417A1 (en) 2018-01-26 2020-12-02 Exelixis, Inc. Compounds for the treatment of kinase-dependent disorders
WO2019148036A1 (en) 2018-01-26 2019-08-01 Exelixis, Inc. Compounds for the treatment of kinase-dependent disorders
AR119069A1 (es) * 2019-06-04 2021-11-24 Exelixis Inc Compuestos para el tratamiento de trastornos dependientes de quinasas
DE102020005002A1 (de) * 2020-08-17 2022-02-17 Epo Experimentelle Pharmakologie & Onkologie Berlin-Buch Gmbh Mittel zur Therapie von Tumorerkrankungen

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Also Published As

Publication number Publication date
EA035223B1 (ru) 2020-05-18
NZ725576A (en) 2021-03-26
AR100191A1 (es) 2016-09-14
HUE054557T2 (hu) 2021-09-28
IL248408A0 (en) 2016-11-30
WO2015164869A1 (en) 2015-10-29
EP3134084A1 (en) 2017-03-01
CA2946416A1 (en) 2015-10-29
KR20160147934A (ko) 2016-12-23
US20170042880A1 (en) 2017-02-16
CA2946416C (en) 2022-07-19
CN106488768A (zh) 2017-03-08
PT3134084T (pt) 2021-05-11
TWI724988B (zh) 2021-04-21
AU2015249232B2 (en) 2020-06-25
DK3134084T3 (da) 2021-05-03
PL3134084T3 (pl) 2021-09-27
AU2015249232A1 (en) 2016-11-10
EA201692150A1 (ru) 2017-02-28
SG11201608657QA (en) 2016-11-29
UA121655C2 (uk) 2020-07-10
MX2016013600A (es) 2017-04-27
TW201622723A (zh) 2016-07-01
IL248408B (en) 2022-06-01
BR112016024672A2 (pt) 2021-02-02
ES2874875T3 (es) 2021-11-05
JP2017513908A (ja) 2017-06-01
EP3906921A1 (en) 2021-11-10
MX375716B (es) 2025-03-06
JP2019189646A (ja) 2019-10-31
EP3134084B1 (en) 2021-03-17
KR102474701B1 (ko) 2022-12-05

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