JP6678319B2 - 撮像可能なポリマー - Google Patents
撮像可能なポリマー Download PDFInfo
- Publication number
- JP6678319B2 JP6678319B2 JP2016539623A JP2016539623A JP6678319B2 JP 6678319 B2 JP6678319 B2 JP 6678319B2 JP 2016539623 A JP2016539623 A JP 2016539623A JP 2016539623 A JP2016539623 A JP 2016539623A JP 6678319 B2 JP6678319 B2 JP 6678319B2
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- Prior art keywords
- beads
- radiopaque
- microspheres
- polymer
- hydrogel
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F116/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
- C08F116/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
- C08F116/04—Acyclic compounds
- C08F116/06—Polyvinyl alcohol ; Vinyl alcohol
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
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- C08F8/18—Introducing halogen atoms or halogen-containing groups
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
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- A—HUMAN NECESSITIES
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- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
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- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
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- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Optics & Photonics (AREA)
- Vascular Medicine (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020031653A JP7483406B2 (ja) | 2013-09-06 | 2020-02-27 | ヒドロゲルポリマーのマイクロスフェア、それを含んだ組成物、および、ポリマーのマイクロスフェア |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1315936.3A GB2519738A (en) | 2013-09-06 | 2013-09-06 | Radiopaque polymers |
| GB1315936.3 | 2013-09-06 | ||
| PCT/GB2014/000351 WO2015033092A1 (en) | 2013-09-06 | 2014-09-05 | Imageable polymers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020031653A Division JP7483406B2 (ja) | 2013-09-06 | 2020-02-27 | ヒドロゲルポリマーのマイクロスフェア、それを含んだ組成物、および、ポリマーのマイクロスフェア |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016529055A JP2016529055A (ja) | 2016-09-23 |
| JP2016529055A5 JP2016529055A5 (https=) | 2017-10-12 |
| JP6678319B2 true JP6678319B2 (ja) | 2020-04-08 |
Family
ID=49486871
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016539623A Active JP6678319B2 (ja) | 2013-09-06 | 2014-09-05 | 撮像可能なポリマー |
| JP2020031653A Active JP7483406B2 (ja) | 2013-09-06 | 2020-02-27 | ヒドロゲルポリマーのマイクロスフェア、それを含んだ組成物、および、ポリマーのマイクロスフェア |
| JP2022146757A Active JP7705834B2 (ja) | 2013-09-06 | 2022-09-15 | ヒドロゲルおよびヒドロゲルを含む組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020031653A Active JP7483406B2 (ja) | 2013-09-06 | 2020-02-27 | ヒドロゲルポリマーのマイクロスフェア、それを含んだ組成物、および、ポリマーのマイクロスフェア |
| JP2022146757A Active JP7705834B2 (ja) | 2013-09-06 | 2022-09-15 | ヒドロゲルおよびヒドロゲルを含む組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US9895452B2 (https=) |
| EP (2) | EP4000639A1 (https=) |
| JP (3) | JP6678319B2 (https=) |
| CN (2) | CN111518285B (https=) |
| CA (1) | CA2922961C (https=) |
| GB (2) | GB2519738A (https=) |
| WO (1) | WO2015033092A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2519738A (en) * | 2013-09-06 | 2015-05-06 | Biocompatibles Uk Ltd | Radiopaque polymers |
| GB2521997A (en) | 2013-09-06 | 2015-07-15 | Biocompatibles Uk Ltd | Radiopaque polymers |
| US9594070B2 (en) * | 2013-11-05 | 2017-03-14 | Spectrum Tracer Services, Llc | Method using halogenated benzoic acid esters and aldehydes for hydraulic fracturing and for tracing petroleum production |
| US10265423B2 (en) | 2015-01-12 | 2019-04-23 | Biosphere Medical, Inc. | Radiopaque monomers, polymers, microspheres, and methods related thereto |
| US20190070332A1 (en) * | 2016-03-14 | 2019-03-07 | Biocompatibles Uk Limited | Oily compositions |
| US10017684B2 (en) | 2016-04-20 | 2018-07-10 | Spectrum Tracer Services, Llc | Method and compositions for hydraulic fracturing and for tracing formation water |
| EP3541368B1 (en) | 2016-11-16 | 2023-07-12 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Imageable particles, methods of making and methods of use thereof |
| CN106822983B (zh) * | 2016-12-29 | 2020-09-15 | 苏州恒瑞迦俐生生物医药科技有限公司 | 一种用于微创介入疗法治疗肿瘤疾病的可显影栓塞微球及其制备方法 |
| CN107050501B (zh) * | 2016-12-29 | 2020-09-15 | 苏州恒瑞迦俐生生物医药科技有限公司 | 一种可视化多羟基聚合体栓塞微球及其制备方法 |
| CN107854720B (zh) * | 2017-12-28 | 2020-12-08 | 苏州恒瑞迦俐生生物医药科技有限公司 | 具有造影功能的可载药多羟基聚合物栓塞微球及其制备方法 |
| EP3765096A1 (en) * | 2018-03-12 | 2021-01-20 | Boston Scientific Scimed Inc. | Scavenging methods, and scavenging system for radiocontrast agents |
| GB201810788D0 (en) | 2018-06-29 | 2018-08-15 | Biocompatibles Uk Ltd | Biodegradable polymer |
| GB201810784D0 (en) * | 2018-06-29 | 2018-08-15 | Biocompatibles Uk Ltd | Radiopaque polymers |
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