GB2519738A - Radiopaque polymers - Google Patents

Radiopaque polymers Download PDF

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Publication number
GB2519738A
GB2519738A GB1315936.3A GB201315936A GB2519738A GB 2519738 A GB2519738 A GB 2519738A GB 201315936 A GB201315936 A GB 201315936A GB 2519738 A GB2519738 A GB 2519738A
Authority
GB
United Kingdom
Prior art keywords
hydrogel
radiopaque
pva
polymer
iodinated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1315936.3A
Other languages
English (en)
Other versions
GB201315936D0 (en
Inventor
St Phane Hohn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocompatibles UK Ltd
Original Assignee
Biocompatibles UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocompatibles UK Ltd filed Critical Biocompatibles UK Ltd
Priority to GB1315936.3A priority Critical patent/GB2519738A/en
Publication of GB201315936D0 publication Critical patent/GB201315936D0/en
Priority to CN201480049219.9A priority patent/CN105517582B/zh
Priority to US14/916,472 priority patent/US10098972B2/en
Priority to CA2922961A priority patent/CA2922961C/en
Priority to JP2016539623A priority patent/JP6678319B2/ja
Priority to EP21203058.9A priority patent/EP4000639A1/en
Priority to CN202010385369.4A priority patent/CN111518285B/zh
Priority to EP14783895.7A priority patent/EP3041516B1/en
Priority to GB1415730.9A priority patent/GB2523863B8/en
Priority to PCT/GB2014/000351 priority patent/WO2015033092A1/en
Priority to US14/478,213 priority patent/US9895452B2/en
Publication of GB2519738A publication Critical patent/GB2519738A/en
Priority to HK16102311.0A priority patent/HK1214286B/xx
Priority to US16/122,317 priority patent/US10556022B2/en
Priority to US16/733,405 priority patent/US10925979B2/en
Priority to JP2020031653A priority patent/JP7483406B2/ja
Priority to US17/150,310 priority patent/US20210236660A1/en
Priority to JP2022146757A priority patent/JP7705834B2/ja
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00Processes of treating or compounding macromolecular substances
    • C08J3/02Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075Macromolecular gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K49/0409Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414Particles, beads, capsules or spheres
    • A61K49/0419Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
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    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476Particles, beads, capsules, spheres
    • A61K49/048Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1213Semi-solid forms, gels, hydrogels, ointments, fats and waxes that are solid at room temperature
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0015Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0031Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F116/00Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical
    • C08F116/02Homopolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical by an alcohol radical
    • C08F116/04Acyclic compounds
    • C08F116/06Polyvinyl alcohol ; Vinyl alcohol
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    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment
    • C08F8/18Introducing halogen atoms or halogen-containing groups
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12Chemical modification
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476Particles, beads, capsules, spheres
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • AHUMAN NECESSITIES
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62Encapsulated active agents, e.g. emulsified droplets
    • A61L2300/622Microcapsules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/06Flowable or injectable implant compositions
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/36Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Optics & Photonics (AREA)
  • Vascular Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
GB1315936.3A 2013-09-06 2013-09-06 Radiopaque polymers Withdrawn GB2519738A (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
GB1315936.3A GB2519738A (en) 2013-09-06 2013-09-06 Radiopaque polymers
US14/916,472 US10098972B2 (en) 2013-09-06 2014-09-05 Imageable polymers
GB1415730.9A GB2523863B8 (en) 2013-09-06 2014-09-05 Imageable polymers
US14/478,213 US9895452B2 (en) 2013-09-06 2014-09-05 Imageable polymers
CA2922961A CA2922961C (en) 2013-09-06 2014-09-05 Imageable polymers
JP2016539623A JP6678319B2 (ja) 2013-09-06 2014-09-05 撮像可能なポリマー
EP21203058.9A EP4000639A1 (en) 2013-09-06 2014-09-05 Imageable polymers
CN202010385369.4A CN111518285B (zh) 2013-09-06 2014-09-05 可成像聚合物
EP14783895.7A EP3041516B1 (en) 2013-09-06 2014-09-05 Imageable polymers
CN201480049219.9A CN105517582B (zh) 2013-09-06 2014-09-05 可成像聚合物
PCT/GB2014/000351 WO2015033092A1 (en) 2013-09-06 2014-09-05 Imageable polymers
HK16102311.0A HK1214286B (en) 2013-09-06 2016-02-29 Imageable polymers
US16/122,317 US10556022B2 (en) 2013-09-06 2018-09-05 Imageable polymers
US16/733,405 US10925979B2 (en) 2013-09-06 2020-01-03 Imageable polymers
JP2020031653A JP7483406B2 (ja) 2013-09-06 2020-02-27 ヒドロゲルポリマーのマイクロスフェア、それを含んだ組成物、および、ポリマーのマイクロスフェア
US17/150,310 US20210236660A1 (en) 2013-09-06 2021-01-15 Imageable polymers
JP2022146757A JP7705834B2 (ja) 2013-09-06 2022-09-15 ヒドロゲルおよびヒドロゲルを含む組成物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1315936.3A GB2519738A (en) 2013-09-06 2013-09-06 Radiopaque polymers

Publications (2)

Publication Number Publication Date
GB201315936D0 GB201315936D0 (en) 2013-10-23
GB2519738A true GB2519738A (en) 2015-05-06

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Family Applications (2)

Application Number Title Priority Date Filing Date
GB1315936.3A Withdrawn GB2519738A (en) 2013-09-06 2013-09-06 Radiopaque polymers
GB1415730.9A Active GB2523863B8 (en) 2013-09-06 2014-09-05 Imageable polymers

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1415730.9A Active GB2523863B8 (en) 2013-09-06 2014-09-05 Imageable polymers

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US (5) US9895452B2 (https=)
EP (2) EP4000639A1 (https=)
JP (3) JP6678319B2 (https=)
CN (2) CN111518285B (https=)
CA (1) CA2922961C (https=)
GB (2) GB2519738A (https=)
WO (1) WO2015033092A1 (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
GB2521997A (en) 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
US9594070B2 (en) * 2013-11-05 2017-03-14 Spectrum Tracer Services, Llc Method using halogenated benzoic acid esters and aldehydes for hydraulic fracturing and for tracing petroleum production
US10265423B2 (en) 2015-01-12 2019-04-23 Biosphere Medical, Inc. Radiopaque monomers, polymers, microspheres, and methods related thereto
US20190070332A1 (en) * 2016-03-14 2019-03-07 Biocompatibles Uk Limited Oily compositions
US10017684B2 (en) 2016-04-20 2018-07-10 Spectrum Tracer Services, Llc Method and compositions for hydraulic fracturing and for tracing formation water
EP3541368B1 (en) 2016-11-16 2023-07-12 The United States of America, as represented by the Secretary, Department of Health and Human Services Imageable particles, methods of making and methods of use thereof
CN106822983B (zh) * 2016-12-29 2020-09-15 苏州恒瑞迦俐生生物医药科技有限公司 一种用于微创介入疗法治疗肿瘤疾病的可显影栓塞微球及其制备方法
CN107050501B (zh) * 2016-12-29 2020-09-15 苏州恒瑞迦俐生生物医药科技有限公司 一种可视化多羟基聚合体栓塞微球及其制备方法
CN107854720B (zh) * 2017-12-28 2020-12-08 苏州恒瑞迦俐生生物医药科技有限公司 具有造影功能的可载药多羟基聚合物栓塞微球及其制备方法
EP3765096A1 (en) * 2018-03-12 2021-01-20 Boston Scientific Scimed Inc. Scavenging methods, and scavenging system for radiocontrast agents
GB201810788D0 (en) 2018-06-29 2018-08-15 Biocompatibles Uk Ltd Biodegradable polymer
GB201810784D0 (en) * 2018-06-29 2018-08-15 Biocompatibles Uk Ltd Radiopaque polymers
JP7322073B2 (ja) 2018-06-29 2023-08-07 バイオコンパティブルズ ユーケー リミテッド 放射線不透過性ポリマー
WO2020061207A1 (en) * 2018-09-20 2020-03-26 Reva Medical, Inc. Porous bioresorbable radiopaque embolic microspheres for drug delivery
WO2020185897A1 (en) 2019-03-11 2020-09-17 Biocompatibles Uk Limited Radioactive microshperes for the treatment of cns tumours
AU2020244771B2 (en) 2019-03-22 2022-10-27 Biocompatibles Uk Limited Embolic microspheres and methods
CN111821503B (zh) * 2019-04-17 2022-07-12 苏州恒瑞宏远医疗科技有限公司 一种不透射线的高效载药栓塞微球及其制备和应用
WO2020247151A1 (en) 2019-06-05 2020-12-10 Boston Scientific Scimed, Inc. Click chemistry capturable platinum-based antineoplastic agents
GB201910286D0 (en) 2019-07-18 2019-09-04 Biocompatibles Uk Ltd Radiopaque polymers
KR20220079600A (ko) 2019-10-07 2022-06-13 게르브 비분해성 방사선 불투과성 색전술 미소구체
CN115279427A (zh) * 2020-03-17 2022-11-01 微仙美国有限公司 液体栓子
CN114099442B (zh) * 2020-08-25 2024-01-30 复旦大学 用于肿瘤放化疗栓塞治疗和影像的多功能微球制剂及其制备方法
US20220242817A1 (en) 2021-01-12 2022-08-04 Boston Scientific Scimed Inc. Iodinated compounds having radiocontrast properties
CN113350298A (zh) * 2021-06-11 2021-09-07 复旦大学附属中山医院 一种载药微球的配制方法
US20230201122A1 (en) * 2021-12-23 2023-06-29 Boston Scientific Medical Device Limited Chemoembolic compositions and methods of treatment using them
CN114262279B (zh) * 2021-12-30 2022-12-16 上海汇禾医疗科技有限公司 一种x射线可显影分子、栓塞微球及其制备方法
CN114146190B (zh) * 2021-12-30 2024-01-26 科睿驰(深圳)医疗科技发展有限公司 一种高悬浮性显影微球及其制备方法
US20230346535A1 (en) * 2022-05-02 2023-11-02 EmStop, Inc. Method of Evaluating an Embolic Filter
EP4563569A1 (en) 2022-08-25 2025-06-04 Cardiolink Science (Shenzhen) Medical Technology Development Co., Ltd. Amide compound containing iodo aryl or iodo heteroaryl, and preparation method therefor and use thereof
CN116256442A (zh) * 2022-09-26 2023-06-13 科睿驰(深圳)医疗科技发展有限公司 一种聚乙烯醇栓塞微球中含碘化合物的检测方法
KR102891713B1 (ko) * 2023-11-15 2025-11-26 건국대학교 산학협력단 팽윤율이 증가된 하이드로젤

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0391741A2 (en) * 1989-04-06 1990-10-10 Merocel Corporation Polymeric broad-spectrum antimicrobial materials
US20010051670A1 (en) * 2000-03-13 2001-12-13 Goupil Dennis W. Tissue bulking and coating compositions

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2860986A (en) 1956-08-31 1958-11-18 Eastman Kodak Co Partially acetalized polyvinyl alcohol containing active halogen
US3631225A (en) 1970-04-28 1971-12-28 Union Carbide Corp Preparation of polyvinyl acetals
US3840482A (en) 1971-09-13 1974-10-08 Ici Australia Ltd Process for curing poly(vinyl alcohol)matrix beads
US4406878A (en) 1978-08-02 1983-09-27 Eastman Kodak Company Iodinated contrast agent for radiography
US4306031A (en) 1979-08-14 1981-12-15 Mitsubishi Chemical Industries Limited Weakly acidic cation exchange resin and process for producing same
US5082909A (en) 1990-10-12 1992-01-21 Hercules Incorporated Pure tungsten oxyphenolate complexes as DCPD polymerization catalysts
DK0586524T3 (https=) 1991-06-03 1997-05-20 Nycomed Imaging As
JPH0656676A (ja) 1992-08-05 1994-03-01 Hori Shinichi 血管塞栓用懸濁液
US5330739A (en) 1992-12-04 1994-07-19 Sterling Winthrop Inc. Iodinated benzoyl acetals and ketals for x-ray imaging
TW272976B (https=) * 1993-08-06 1996-03-21 Ciba Geigy Ag
AU4438696A (en) * 1995-02-03 1996-08-21 Novartis Ag Crosslinked polymers
AU6378096A (en) * 1995-06-07 1996-12-30 Brown University Research Foundation Spray dried polymeric microparticles containing imaging agen ts
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6255033B1 (en) 1999-07-30 2001-07-03 Creo, Ltd. Positive acting photoresist compositions and imageable element
AU4566001A (en) * 2000-03-13 2001-09-24 Biocure Inc Embolic compositions
EP1263801B1 (en) * 2000-03-13 2006-05-24 BioCure, Inc. Tissue bulking and coating compositions
US6911219B2 (en) * 2001-09-27 2005-06-28 Surgica Corporation Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
EP1490120B1 (en) 2002-03-29 2009-11-11 Boston Scientific Limited Embolization
CN103393605B (zh) 2003-02-12 2018-05-29 生物相容英国有限公司 用于实体瘤的化学栓塞治疗的组合物
US20040161466A1 (en) 2003-02-14 2004-08-19 Biocompatibles Uk Limited Chemoembolisation
US7201918B2 (en) 2004-11-16 2007-04-10 Microvention, Inc. Compositions, systems and methods for treatment of defects in blood vessels
KR101429774B1 (ko) 2005-05-09 2014-10-02 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및방법
EP1810698A1 (en) * 2006-01-24 2007-07-25 Biocompatibles UK Limited Process for producing radiopaque embolic microspheres
CA2648243C (en) 2006-04-11 2015-12-22 Shaker A. Mousa Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof
US9107833B2 (en) 2006-06-22 2015-08-18 Biocompatibles Uk Limited Rehydratable pharmaceutical product
WO2008039827A2 (en) * 2006-09-26 2008-04-03 Aeris Therapeutics, Inc. Polymer systems for lung volume reduction therapy
JP2010526914A (ja) 2007-05-11 2010-08-05 エアリス セラピューティクス エルエルシー 架橋した非天然ポリマーを用いる肺容量減少療法
EP1992371A1 (de) 2007-05-15 2008-11-19 Occlutech GmbH Bioresorbierbare röntgenopake Polymermaterialien und daraus hergestellte Occlussionsinstrumente
JP2010534563A (ja) 2007-07-24 2010-11-11 ネクスバイオ,インク. マイクロ粒子の作製のための技術
WO2009018280A2 (en) * 2007-07-30 2009-02-05 Auspex Pharamaceuticals, Inc. Substituted indoles
EP2090592A1 (en) 2007-07-31 2009-08-19 OctoPlus Sciences B.V. Biodegradable hydrogels based on click chemistry
CN101125225A (zh) * 2007-08-10 2008-02-20 苏州迦俐生生物医药科技有限公司 微球型栓塞剂及其制备工艺
CN101810587B (zh) * 2007-08-10 2012-05-23 苏州迦俐生生物医药科技有限公司 微球型栓塞剂的制备工艺
WO2009086098A1 (en) 2007-12-28 2009-07-09 Boston Scientific Scimed, Inc. Porous microparticles for injection and processes for forming the same
US20090269390A1 (en) 2008-04-25 2009-10-29 Medtronic, Inc. Medical devices, polymers, compositions, and methods for delivering a haloacetate
WO2009134344A1 (en) 2008-04-28 2009-11-05 Surmodics, Inc. POLY-α(1→4)GLUCOPYRANOSE-BASED MATRICES WITH HYDRAZIDE CROSSLINKING
EP2365009A1 (en) * 2010-03-10 2011-09-14 Universite Claude Bernard Lyon 1 (UCBL) Radiopaque, non-biodegradable, water-insoluble iodinated benzyl ethers of poly(vinyl alcohol), preparation method thereof, injectable embolizing compositions containing thereof and use thereof
ES2368307B1 (es) 2010-04-28 2012-10-17 Universidade De Santiago De Compostela Hidrogeles elaborados a base de polímeros aniónicos de origen natural.
US9724421B2 (en) * 2010-11-29 2017-08-08 Centre Hospitalier Universitaire Vaudois Chemoembolization composition comprising anti-angiogenic agents
CN103249436B (zh) 2010-12-09 2015-09-30 东丽株式会社 生物降解性颗粒、血管栓塞材料及生物降解性颗粒的制造方法
GB201101429D0 (en) 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
HK1220119A1 (zh) * 2013-03-15 2017-04-28 Matthew R. Dreher 可成像栓塞微球
US9910037B2 (en) 2013-03-15 2018-03-06 Iris International, Inc. Conjugation of multiple vancomycin molecules on a polyvinyl alcohol backbone for the capture of microorganisms
GB2521997A (en) * 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
GB2519738A (en) 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0391741A2 (en) * 1989-04-06 1990-10-10 Merocel Corporation Polymeric broad-spectrum antimicrobial materials
US20010051670A1 (en) * 2000-03-13 2001-12-13 Goupil Dennis W. Tissue bulking and coating compositions

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