JP6673939B2 - Ｇｐｒ５２に関連する障害の治療または予防に有用なｇｐｒ５２のモジュレーターとしての１−ヘテロアリール−インドリン−４−カルボキサミド - Google Patents
Ｇｐｒ５２に関連する障害の治療または予防に有用なｇｐｒ５２のモジュレーターとしての１−ヘテロアリール−インドリン−４−カルボキサミド Download PDFInfo
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- JP6673939B2 JP6673939B2 JP2017556818A JP2017556818A JP6673939B2 JP 6673939 B2 JP6673939 B2 JP 6673939B2 JP 2017556818 A JP2017556818 A JP 2017556818A JP 2017556818 A JP2017556818 A JP 2017556818A JP 6673939 B2 JP6673939 B2 JP 6673939B2
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- Prior art keywords
- pyridin
- indoline
- carboxamide
- fluoro
- ethyl
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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| PCT/US2016/030105 WO2016176571A1 (en) | 2015-04-29 | 2016-04-29 | 1-heteroaryl-indoline-4-carboxamides as modulators of gpr52 useful for the treatment or prevention of disorders related thereto |
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| CN111792990A (zh) * | 2019-04-09 | 2020-10-20 | 中国科学院上海药物研究所 | 一种不饱和酮类化合物、其制备方法和用途 |
| BR112022008685A2 (pt) | 2019-11-08 | 2022-07-26 | Heptares Therapeutics Ltd | Compostos moduladores de gpr52 |
| GB202003668D0 (en) | 2020-03-13 | 2020-04-29 | Heptares Therapeutics Ltd | GPR52 Modulator compounds |
| PE20221918A1 (es) * | 2020-03-30 | 2022-12-29 | Boehringer Ingelheim Int | 3-fenoxiazetidin-1-il-pirazinas sustituidas que tienen actividad agonista de gpr52 |
| US12421193B2 (en) | 2020-04-22 | 2025-09-23 | Neurocrine Biosciences, Inc. | GPR52 modulators and methods of use |
| GB202013558D0 (en) * | 2020-08-28 | 2020-10-14 | Heptares Therapeutics Ltd | GRP52 Modularor compounds |
| EP4330232A1 (en) | 2021-04-26 | 2024-03-06 | Neurocrine Biosciences, Inc. | Gpr52 modulators and methods of use |
| CN117940420A (zh) | 2021-09-14 | 2024-04-26 | 勃林格殷格翰国际有限公司 | 3-苯氧基氮杂环丁烷-1-基-杂芳基吡咯烷衍生物及其作为药物的用途 |
| GB202113186D0 (en) | 2021-09-15 | 2021-10-27 | Heptares Therapeutics Ltd | GPR52 Modulator compounds |
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| TW202425979A (zh) * | 2022-10-26 | 2024-07-01 | 美商紐羅克里生物科學有限公司 | 作為gpr52調節劑之化合物及組合物 |
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| JP2012082175A (ja) * | 2010-10-14 | 2012-04-26 | Daiichi Sankyo Co Ltd | インドリン化合物を含有する医薬組成物 |
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| MX373876B (es) | 2020-03-26 |
| BR112017022987A2 (pt) | 2018-07-24 |
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