JP6672175B2 - Glp−1及び抗il−21を使用した1型糖尿病の治療 - Google Patents

Glp−1及び抗il−21を使用した1型糖尿病の治療 Download PDF

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Publication number
JP6672175B2
JP6672175B2 JP2016566689A JP2016566689A JP6672175B2 JP 6672175 B2 JP6672175 B2 JP 6672175B2 JP 2016566689 A JP2016566689 A JP 2016566689A JP 2016566689 A JP2016566689 A JP 2016566689A JP 6672175 B2 JP6672175 B2 JP 6672175B2
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glp
inhibitor
function
agonist
peptide
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Japanese (ja)
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JP2017514860A (ja
JP2017514860A5 (enExample
Inventor
ケン・コピエテルス
マティアス・ヴォン・ヘラート
テイマー・ボーサリアン
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Novo Nordisk AS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016566689A 2014-05-07 2015-05-05 Glp−1及び抗il−21を使用した1型糖尿病の治療 Active JP6672175B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461989841P 2014-05-07 2014-05-07
US61/989,841 2014-05-07
EP14169596 2014-05-23
EP14169596.5 2014-05-23
EP14189732 2014-10-21
EP14189732.2 2014-10-21
PCT/EP2015/059811 WO2015169789A1 (en) 2014-05-07 2015-05-05 Treatment of diabetes type 1 using glp-1 and anti-il-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019229235A Division JP6824373B2 (ja) 2014-05-07 2019-12-19 Glp−1及び抗il−21を使用した1型糖尿病の治療

Publications (3)

Publication Number Publication Date
JP2017514860A JP2017514860A (ja) 2017-06-08
JP2017514860A5 JP2017514860A5 (enExample) 2018-05-31
JP6672175B2 true JP6672175B2 (ja) 2020-03-25

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JP2016566689A Active JP6672175B2 (ja) 2014-05-07 2015-05-05 Glp−1及び抗il−21を使用した1型糖尿病の治療

Country Status (9)

Country Link
US (1) US10105442B2 (enExample)
EP (1) EP3139948B1 (enExample)
JP (1) JP6672175B2 (enExample)
CN (1) CN106999553B (enExample)
PL (1) PL3139948T3 (enExample)
RS (1) RS60316B1 (enExample)
SI (1) SI3139948T1 (enExample)
TW (1) TWI668010B (enExample)
WO (1) WO2015169789A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190070266A1 (en) * 2016-03-04 2019-03-07 Novo Nordisk A/S Liraglutide in Diabetic Foot Ulcer
US12012441B2 (en) 2020-10-26 2024-06-18 Neptune Biosciences Llc Engineered human IL-21 cytokines and methods for using the same
WO2025257327A1 (en) 2024-06-13 2025-12-18 Almirall, S.A. Therapeutic approaches for the management of hidradenitis suppurativa

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL128332A0 (en) 1996-08-30 2000-01-31 Novo Nordisk As GLP-1 derivatives
US7186683B2 (en) 2000-09-18 2007-03-06 Sanos Bioscience A/S Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders
JP5562510B2 (ja) * 2001-06-28 2014-07-30 ノヴォ ノルディスク アー/エス 修飾glp−1の安定な処方剤
JP2005508915A (ja) * 2001-10-04 2005-04-07 ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー インターロイキン21受容体活性を調節する方法および組成物
EP1515749B1 (en) 2002-06-14 2012-08-15 Novo Nordisk A/S Combined use of a modulator of cd3 and a glp-1 compound
WO2005023291A2 (en) 2003-09-11 2005-03-17 Novo Nordisk A/S Use of glp1-agonists in the treatment of patients with type i diabetes
CN100444898C (zh) * 2003-09-19 2008-12-24 诺沃挪第克公司 治疗肽的清蛋白结合型衍生物
DE602004031455D1 (de) * 2003-12-09 2011-03-31 Novo Nordisk As Regulierung der nahrungspräferenz mit glp-1-agonisten
US7393827B2 (en) 2004-12-30 2008-07-01 Diakine Therapeutics, Inc. Pharmaceutical compositions and methods for restoring β-cell mass and function
TWI362392B (en) 2005-03-18 2012-04-21 Novo Nordisk As Acylated glp-1 compounds
EA013821B1 (ru) 2005-05-25 2010-08-30 Кьюрдм, Инк. Проостровковые пептиды человека, их производные и аналоги и способы их применения
WO2007005738A2 (en) * 2005-06-30 2007-01-11 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Glp-1 pharmaceutical compositions
EP1924293A4 (en) 2005-08-06 2008-12-24 Qinghua Wang COMPOSITION AND METHOD FOR THE PREVENTION AND TREATMENT OF DIABETES TYPE I
DK3524261T5 (da) * 2005-08-19 2024-09-02 Amylin Pharmaceuticals Llc Exendin til anvendelse til behandling af diabetes og reduktion af kropsvægt
CN101291685A (zh) * 2005-08-19 2008-10-22 安米林药品公司 治疗糖尿病和降低体重的毒蜥外泌肽
US8084022B2 (en) * 2006-06-23 2011-12-27 Aegis Therapeutics, Llc Stabilizing alkylglycoside compositions and methods thereof
NZ574710A (en) * 2006-09-07 2012-02-24 Nycomed Gmbh Combination treatment comprising the PDE4 inhibitor Compound A ((2R,4aR, 10bR)6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1 ,2,3,4,4a,10b-hexahydrophenanthridin-2-ol) for diabetes mellitus
EP2170951A2 (en) * 2007-05-31 2010-04-07 Genmab A/S Recombinant non glycosylated monovalent half-antibodies obtained by molecular engineering
EA201000399A1 (ru) * 2007-08-30 2011-02-28 Кьюрдм, Инк. Композиции и способы использования проостровковых пептидов и их аналогов
WO2009030738A1 (en) * 2007-09-05 2009-03-12 Novo Nordisk A/S Glucagon-like peptide-1 derivatives and their pharmaceutical use
EP2426146B1 (en) * 2007-12-07 2016-02-17 ZymoGenetics, Inc. Anti-human IL-21 monoclonal antibodies
MX2010012201A (es) * 2008-05-07 2011-05-30 Merrion Res Iii Ltd Composiciones de péptidos y procedimientos de preparación de las mismas.
CN105727261A (zh) * 2008-06-27 2016-07-06 杜克大学 包含弹性蛋白样肽的治疗剂
CA3011480C (en) * 2009-11-13 2021-11-09 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a glp-1 agonist, an insulin and methionine
EP2359843A1 (en) * 2010-01-21 2011-08-24 Sanofi Pharmaceutical composition for treating a metabolic syndrome
JP2013520208A (ja) 2010-02-24 2013-06-06 ザ・ボード・オブ・トラスティーズ・オブ・ザ・レランド・スタンフォード・ジュニア・ユニバーシティ 自己免疫疾患の診断、予後判定、及び処置法
JP2014506259A (ja) 2011-01-17 2014-03-13 ノヴォ ノルディスク アー/エス Il−21リガンド
CN104011072B (zh) * 2011-05-05 2018-10-12 阿尔布梅迪克斯医疗有限公司 白蛋白变体
JP2014518198A (ja) * 2011-05-31 2014-07-28 ノヴォ ノルディスク アー/エス Il−21のエピトープおよびil−21リガンド
EP2746293A1 (en) 2012-12-21 2014-06-25 Novo Nordisk A/S Anti-IL21 antibodies for use in the treatment of cardiovascular diseases
US20140178395A1 (en) 2012-12-21 2014-06-26 Novo Nordisk A/S Treatment of nephropathy

Also Published As

Publication number Publication date
US10105442B2 (en) 2018-10-23
RS60316B1 (sr) 2020-07-31
US20170043014A1 (en) 2017-02-16
PL3139948T3 (pl) 2020-08-10
EP3139948A1 (en) 2017-03-15
JP2017514860A (ja) 2017-06-08
CN106999553B (zh) 2021-11-26
EP3139948B1 (en) 2020-03-04
SI3139948T1 (sl) 2020-07-31
TWI668010B (zh) 2019-08-11
WO2015169789A1 (en) 2015-11-12
CN106999553A (zh) 2017-08-01
TW201625289A (zh) 2016-07-16

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