JP6669744B2 - ブロモドメインのインヒビターとしての置換ピロロピリジン - Google Patents

ブロモドメインのインヒビターとしての置換ピロロピリジン Download PDF

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Publication number
JP6669744B2
JP6669744B2 JP2017525075A JP2017525075A JP6669744B2 JP 6669744 B2 JP6669744 B2 JP 6669744B2 JP 2017525075 A JP2017525075 A JP 2017525075A JP 2017525075 A JP2017525075 A JP 2017525075A JP 6669744 B2 JP6669744 B2 JP 6669744B2
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Prior art keywords
pyrrolo
pyridin
oxo
enyl
alkyl
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Expired - Fee Related
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Japanese (ja)
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JP2017533248A (ja
JP2017533248A5 (OSRAM
Inventor
ブライアン ケー． アルブレヒト，
ブライアン ケー． アルブレヒト，
スティーブン エフ． ベロン，
スティーブン エフ． ベロン，
ダニエル ジェイ． バーディック，
ダニエル ジェイ． バーディック，
アレクサンドル コート，
アレクサンドル コート，
テリー クローフォード，
テリー クローフォード，
レス エー． デイキン，
レス エー． デイキン，
マイケル チャールズ ヒューイット，
マイケル チャールズ ヒューイット，
ツイ， ビッキー シャオ−ウェイ
ツイ， ビッキー シャオ−ウェイ
イブ レブラン，
イブ レブラン，
スティーブン アール． マグヌソン，
スティーブン アール． マグヌソン，
クリストファー ジー． ナスヴェスチャック，
クリストファー ジー． ナスヴェスチャック，
エフ． アントニー ロメロ，
エフ． アントニー ロメロ，
ヨン タン，
ヨン タン，
アレクサンダー エム． テイラー，
アレクサンダー エム． テイラー，
シューメイ ワン，
シューメイ ワン，
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Constellation Pharmaceuticals Inc
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Constellation Pharmaceuticals Inc
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Obesity (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017525075A 2014-11-10 2015-11-10 ブロモドメインのインヒビターとしての置換ピロロピリジン Expired - Fee Related JP6669744B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462077703P 2014-11-10 2014-11-10
US62/077,703 2014-11-10
PCT/US2015/060003 WO2016077378A1 (en) 2014-11-10 2015-11-10 Substituted pyrrolopyrdines as inhibitors of bromodomain

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JP2017533248A JP2017533248A (ja) 2017-11-09
JP2017533248A5 JP2017533248A5 (OSRAM) 2018-12-20
JP6669744B2 true JP6669744B2 (ja) 2020-03-18

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Country Link
US (1) US10183009B2 (OSRAM)
EP (1) EP3218375B1 (OSRAM)
JP (1) JP6669744B2 (OSRAM)
CN (3) CN116003409A (OSRAM)
MA (1) MA40943A (OSRAM)
WO (1) WO2016077378A1 (OSRAM)

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WO2016077378A1 (en) 2016-05-19
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