JP6668241B2 - 予測可能で、一貫性のある、且つ再現可能な糖型特性を示すＦｃ含有分子 - Google Patents

予測可能で、一貫性のある、且つ再現可能な糖型特性を示すＦｃ含有分子 Download PDF

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JP6668241B2
JP6668241B2 JP2016540433A JP2016540433A JP6668241B2 JP 6668241 B2 JP6668241 B2 JP 6668241B2 JP 2016540433 A JP2016540433 A JP 2016540433A JP 2016540433 A JP2016540433 A JP 2016540433A JP 6668241 B2 JP6668241 B2 JP 6668241B2
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containing molecule
antibody
polypeptide
host cell
protein
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JP2016531581A5 (https=
JP2016531581A (ja
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ドゥ，ジーメイ
レディー，プラニーサ
バス，ランドル・ビー
ホー，フオン
ファンスロー，ウィリアム・シー・ザ・サード
ジャン，ユイリン
レン，ダー
ケッチェム，ランドル・アール
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アムジエン・インコーポレーテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
JP2016540433A 2013-09-05 2014-09-05 予測可能で、一貫性のある、且つ再現可能な糖型特性を示すＦｃ含有分子 Active JP6668241B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361874222P 2013-09-05 2013-09-05
US61/874,222 2013-09-05
PCT/US2014/054359 WO2015035215A1 (en) 2013-09-05 2014-09-05 Fc-containing molecules exhibiting predictable, consistent, and reproducible glycoform profiles

Publications (3)

Publication Number Publication Date
JP2016531581A JP2016531581A (ja) 2016-10-13
JP2016531581A5 JP2016531581A5 (https=) 2017-10-12
JP6668241B2 true JP6668241B2 (ja) 2020-03-18

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JP2016540433A Active JP6668241B2 (ja) 2013-09-05 2014-09-05 予測可能で、一貫性のある、且つ再現可能な糖型特性を示すＦｃ含有分子

Country Status (7)

Country Link
US (2) US11427627B2 (https=)
EP (2) EP3041863A4 (https=)
JP (1) JP6668241B2 (https=)
AU (1) AU2014318017B2 (https=)
CA (2) CA3278705A1 (https=)
MX (1) MX2016002870A (https=)
WO (1) WO2015035215A1 (https=)

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CN113603780B (zh) * 2017-03-28 2022-07-01 礼进生物医药科技（上海）有限公司 用于增强肿瘤微环境中免疫应答的治疗剂和方法
IL307155B2 (en) * 2018-05-01 2025-11-01 Amgen Inc Antibodies with modulated glycan profiles
WO2020168554A1 (zh) * 2019-02-22 2020-08-27 武汉友芝友生物制药有限公司 改造的Fc片段，包含其的抗体及其应用
US12286475B2 (en) 2023-07-31 2025-04-29 Sanofi Anti-GPRC5D antibodies and compositions

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US20230235024A1 (en) 2023-07-27
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