JP6665154B2 - 置換尿素誘導体及びその薬学的使用 - Google Patents

置換尿素誘導体及びその薬学的使用 Download PDF

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JP6665154B2
JP6665154B2 JP2017502247A JP2017502247A JP6665154B2 JP 6665154 B2 JP6665154 B2 JP 6665154B2 JP 2017502247 A JP2017502247 A JP 2017502247A JP 2017502247 A JP2017502247 A JP 2017502247A JP 6665154 B2 JP6665154 B2 JP 6665154B2
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cancer
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JP2017520607A5 (enExample
JP2017520607A (ja
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チェン、チャンチュン
ツァン、インジュン
リュウ、ビン
ロン、ボハ
チェン、ユ
チェン、ツィシン
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ノース・アンド・サウス・ブラザー・ファーマシー・インベストメント・カンパニー・リミテッド
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    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
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PCT/CN2015/084253 WO2016008433A1 (en) 2014-07-17 2015-07-16 Substituted urea derivatives and pharmaceutical uses thereof

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US11065230B2 (en) 2016-09-16 2021-07-20 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of systemic mastocytosis
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
JOP20190077A1 (ar) 2016-10-10 2019-04-09 Array Biopharma Inc مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret
CN106883235B (zh) * 2016-12-29 2019-04-30 天津国际生物医药联合研究院 恶二唑类化合物的制备和应用
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