JP6659703B2 - ピリダジノン誘導体および癌の処置におけるそれらの使用 - Google Patents

ピリダジノン誘導体および癌の処置におけるそれらの使用 Download PDF

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JP6659703B2
JP6659703B2 JP2017536301A JP2017536301A JP6659703B2 JP 6659703 B2 JP6659703 B2 JP 6659703B2 JP 2017536301 A JP2017536301 A JP 2017536301A JP 2017536301 A JP2017536301 A JP 2017536301A JP 6659703 B2 JP6659703 B2 JP 6659703B2
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heterocyclyl
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JP2018501287A (ja
JP2018501287A5 (enExample
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ブライアン ケー． アルブレヒト，
ブライアン ケー． アルブレヒト，
ダニエル ジェイ． バーディック，
ダニエル ジェイ． バーディック，
アレクサンドル コート，
アレクサンドル コート，
マーティン デュプレシス，
マーティン デュプレシス，
クリストファー ジー． ナスヴェスチャック，
クリストファー ジー． ナスヴェスチャック，
アレクサンダー エム． テイラー，
アレクサンダー エム． テイラー，
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Constellation Pharmaceuticals Inc
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Constellation Pharmaceuticals Inc
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system

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  • Orthopedic Medicine & Surgery (AREA)
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JP2017536301A 2015-01-09 2016-01-08 ピリダジノン誘導体および癌の処置におけるそれらの使用 Expired - Fee Related JP6659703B2 (ja)

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US201562101953P 2015-01-09 2015-01-09
US62/101,953 2015-01-09
PCT/US2016/012659 WO2016112298A1 (en) 2015-01-09 2016-01-08 Pyridazinone derivatives and their use in the treatment of cancer

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JP2018501287A JP2018501287A (ja) 2018-01-18
JP2018501287A5 JP2018501287A5 (enExample) 2019-01-31
JP6659703B2 true JP6659703B2 (ja) 2020-03-04

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US (1) US10239861B2 (enExample)
EP (1) EP3242874B1 (enExample)
JP (1) JP6659703B2 (enExample)
CN (1) CN107406429B (enExample)
WO (1) WO2016112298A1 (enExample)

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EP3189049B1 (en) 2014-09-05 2024-03-20 Genentech, Inc. Phthalazine derivatives of formula (i) as pcaf and gcn5 inhibitors for use in the treatment of cancer
CN107074823B (zh) 2014-09-05 2021-05-04 基因泰克公司 治疗性化合物及其用途
KR102194536B1 (ko) * 2019-06-10 2020-12-23 연세대학교 산학협력단 타목시펜의 반응성 예측용 조성물
CN112824381B (zh) * 2019-11-21 2024-04-26 广东东阳光药业股份有限公司 一种哌啶胺的制备方法
CN116057045B (zh) 2020-06-05 2026-06-09 金耐特生物制药公司 成纤维细胞生长因子受体激酶抑制剂
WO2022076735A1 (en) * 2020-10-09 2022-04-14 Regents Of The University Of Minnesota Inhibitors of the bromodomain phd finger transcription factor (bptf) as anti-cancer agents
KR102766287B1 (ko) * 2021-10-15 2025-02-12 고려대학교 산학협력단 피리다벤을 포함하는 자궁내막 세포, 영양막 세포 또는 고환 세포의 비정상적 증식 관련 질환의 예방 또는 치료용 약학적 조성물
AU2023333181A1 (en) 2022-09-02 2025-03-13 Auron Therapeutics, Inc. Pyridazinon derivatives as kat2 degraders for the treatment of proliferative disorders

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US10239861B2 (en) 2019-03-26
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