CN107406429B - 哒嗪酮衍生物及其在治疗癌症中的用途 - Google Patents

哒嗪酮衍生物及其在治疗癌症中的用途 Download PDF

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CN107406429B
CN107406429B CN201680014128.0A CN201680014128A CN107406429B CN 107406429 B CN107406429 B CN 107406429B CN 201680014128 A CN201680014128 A CN 201680014128A CN 107406429 B CN107406429 B CN 107406429B
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cancer
alkyl
independently selected
carbocyclyl
heterocyclyl
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CN107406429A (zh
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B·K·阿尔布雷希特
D·J·伯迪克
A·科特
M·杜普莱西斯
C·G·纳斯维斯查克
A·M·泰勒
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Genentech Inc
Constellation Pharmaceuticals Inc
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Constellation Pharmaceuticals Inc
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
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  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
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  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
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CN201680014128.0A 2015-01-09 2016-01-08 哒嗪酮衍生物及其在治疗癌症中的用途 Active CN107406429B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562101953P 2015-01-09 2015-01-09
US62/101,953 2015-01-09
PCT/US2016/012659 WO2016112298A1 (en) 2015-01-09 2016-01-08 Pyridazinone derivatives and their use in the treatment of cancer

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CN107406429A CN107406429A (zh) 2017-11-28
CN107406429B true CN107406429B (zh) 2021-07-06

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US (1) US10239861B2 (enExample)
EP (1) EP3242874B1 (enExample)
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WO (1) WO2016112298A1 (enExample)

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JP6814730B2 (ja) 2014-09-05 2021-01-20 ジェネンテック， インコーポレイテッド 治療用化合物およびその使用
CN107074824B (zh) 2014-09-05 2021-01-08 基因泰克公司 作为用于治疗癌症的pcaf和gcn5抑制剂的式(i)的酞嗪衍生物
KR102194536B1 (ko) * 2019-06-10 2020-12-23 연세대학교 산학협력단 타목시펜의 반응성 예측용 조성물
CN112824381B (zh) * 2019-11-21 2024-04-26 广东东阳光药业股份有限公司 一种哌啶胺的制备方法
CN116057045A (zh) 2020-06-05 2023-05-02 金耐特生物制药公司 成纤维细胞生长因子受体激酶抑制剂
WO2022076735A1 (en) * 2020-10-09 2022-04-14 Regents Of The University Of Minnesota Inhibitors of the bromodomain phd finger transcription factor (bptf) as anti-cancer agents
KR102766287B1 (ko) * 2021-10-15 2025-02-12 고려대학교 산학협력단 피리다벤을 포함하는 자궁내막 세포, 영양막 세포 또는 고환 세포의 비정상적 증식 관련 질환의 예방 또는 치료용 약학적 조성물
JP2025530801A (ja) 2022-09-02 2025-09-17 オーロン セラピューティクス，インコーポレーテッド 増殖性障害を処置するためのｋａｔ２分解誘導薬としてのピリダジノン誘導体

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