JP6618066B2 - 線維芽細胞を含む心臓疾患を治療するための注射用組成物、及び治療用線維芽細胞の製造方法 - Google Patents

線維芽細胞を含む心臓疾患を治療するための注射用組成物、及び治療用線維芽細胞の製造方法 Download PDF

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JP6618066B2
JP6618066B2 JP2019501845A JP2019501845A JP6618066B2 JP 6618066 B2 JP6618066 B2 JP 6618066B2 JP 2019501845 A JP2019501845 A JP 2019501845A JP 2019501845 A JP2019501845 A JP 2019501845A JP 6618066 B2 JP6618066 B2 JP 6618066B2
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fibroblasts
cells
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JPWO2018155651A1 (ja
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貴紘 岩宮
貴紘 岩宮
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METCELA INC.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/33Fibroblasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Developmental Biology & Embryology (AREA)
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  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019501845A 2017-02-24 2018-02-23 線維芽細胞を含む心臓疾患を治療するための注射用組成物、及び治療用線維芽細胞の製造方法 Active JP6618066B2 (ja)

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JP2017033624 2017-02-24
JP2017033624 2017-02-24
PCT/JP2018/006795 WO2018155651A1 (ja) 2017-02-24 2018-02-23 線維芽細胞を含む心臓疾患を治療するための注射用組成物、及び治療用線維芽細胞の製造方法

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JP2019182761A Division JP7072135B2 (ja) 2017-02-24 2019-10-03 線維芽細胞を含む心臓疾患を治療するための注射用組成物、及び治療用線維芽細胞の製造方法

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JP6618066B2 true JP6618066B2 (ja) 2019-12-11

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JP2019182761A Active JP7072135B2 (ja) 2017-02-24 2019-10-03 線維芽細胞を含む心臓疾患を治療するための注射用組成物、及び治療用線維芽細胞の製造方法

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US (2) US11096969B2 (enExample)
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CN (1) CN109890398B (enExample)
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CA (1) CA3032654A1 (enExample)
DK (1) DK3476395T3 (enExample)
ES (1) ES2885080T3 (enExample)
IL (1) IL267958B2 (enExample)
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Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
CA3110831A1 (en) 2018-08-29 2020-03-05 Metcela Inc. Method for producing fibroblast, and g-csf-positive fibroblast mass
CN109589337B (zh) 2018-12-29 2022-04-26 南京艾尔普再生医学科技有限公司 心肌细胞制剂及其制备方法和应用
IL296125A (en) 2020-03-04 2022-11-01 Metcela Inc Fibroblasts have an increased ability to produce erythropoietin
AU2022231584A1 (en) * 2021-03-04 2023-09-07 Lymphogenix Limited Lymphangiogenesis promoting factor-expressing fibroblast, and pharmaceutical composition containing same
US20240316113A1 (en) * 2021-09-08 2024-09-26 Metcela Inc. Fibroblast-containing pharmaceutical composition for treating kidney disease
EP4249585A1 (en) * 2022-03-25 2023-09-27 Technische Universität München - TUM Heart tissue models, method of producing heart tissue models and uses of heart tissue models

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
AU2003901668A0 (en) * 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
CA2487254A1 (en) * 2002-05-08 2003-11-20 The Regents Of The University Of California System and method for treating cardiac arrhythmias with fibroblast cells
AU2003239418B2 (en) * 2002-05-08 2008-01-31 The Regents Of The University Of California System and method for forming a non-ablative cardiac conduction block
US20040161412A1 (en) * 2002-08-22 2004-08-19 The Cleveland Clinic Foundation Cell-based VEGF delivery
US7470538B2 (en) * 2002-12-05 2008-12-30 Case Western Reserve University Cell-based therapies for ischemia
CN101415458A (zh) * 2003-11-10 2009-04-22 辛弗尼医药有限公司 控制心房纤维性颤动患者心室律的方法
US8513011B2 (en) * 2004-08-26 2013-08-20 Biotech Research Ventures Pte Limited Methods and compositions for culturing cardiomyocyte-like cells
ES2325715B1 (es) * 2007-08-03 2010-06-17 Genetrix, S.L. Poblacion de celulas madre adultas derivadas de tejido adiposo cardiaco y su uso en regeneracion cardiaca.
JP5378743B2 (ja) 2008-09-30 2013-12-25 テルモ株式会社 医療用細胞シートの製造方法
WO2013028968A1 (en) * 2011-08-25 2013-02-28 Wisconsin Alumni Research Foundation 3-dimensional cardiac fibroblast derived extracellular matrix
EP2826855B1 (en) 2012-03-15 2018-08-29 iHeart Japan Corporation Myocardial sheet
US20140072611A1 (en) * 2012-09-07 2014-03-13 Fibrocell Technologies, Inc. Methods and Compositions for Treating Post-Cardial Infarction Damage
GB201309057D0 (en) * 2013-05-20 2013-07-03 Cell Therapy Ltd Method
KR20150009655A (ko) * 2013-07-16 2015-01-27 학교법인 동아학숙 Gcp-2 유전자를 과발현하는 지방 간엽줄기세포를 포함하는 허혈성 질환 치료용 조성물
CA2954743C (en) * 2014-07-11 2022-03-15 Metcela Inc. Cardiac cell culture material

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EP3476395A4 (en) 2020-02-26
SG11201900810WA (en) 2019-02-27
CN109890398B (zh) 2024-01-16
CN109890398A (zh) 2019-06-14
IL267958A (en) 2019-09-26
AU2018223739A1 (en) 2019-02-14
US20210346436A1 (en) 2021-11-11
EP3476395A1 (en) 2019-05-01
CA3032654A1 (en) 2018-08-30
IL267958B2 (en) 2023-08-01
JP7072135B2 (ja) 2022-05-20
IL267958B1 (en) 2023-04-01
EP3476395B1 (en) 2021-07-21
WO2018155651A1 (ja) 2018-08-30
DK3476395T3 (da) 2021-08-16
JP2019218408A (ja) 2019-12-26
US20190224250A1 (en) 2019-07-25
KR20190117468A (ko) 2019-10-16
US11096969B2 (en) 2021-08-24
AU2018223739B2 (en) 2023-06-22
KR102407387B1 (ko) 2022-06-10
JPWO2018155651A1 (ja) 2019-11-07
ES2885080T3 (es) 2021-12-13

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