SG11201900810WA - Composition for injection which can be used for treatment of heart diseases and contains fibroblasts, and method for producing fibroblast for therapy use - Google Patents
Composition for injection which can be used for treatment of heart diseases and contains fibroblasts, and method for producing fibroblast for therapy useInfo
- Publication number
- SG11201900810WA SG11201900810WA SG11201900810WA SG11201900810WA SG11201900810WA SG 11201900810W A SG11201900810W A SG 11201900810WA SG 11201900810W A SG11201900810W A SG 11201900810WA SG 11201900810W A SG11201900810W A SG 11201900810WA SG 11201900810W A SG11201900810W A SG 11201900810WA
- Authority
- SG
- Singapore
- Prior art keywords
- composition
- fibroblasts
- treatment
- injection
- heart diseases
- Prior art date
Links
- 210000002950 fibroblast Anatomy 0.000 title abstract 6
- 208000019622 heart disease Diseases 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 238000002347 injection Methods 0.000 title 1
- 239000007924 injection Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 208000020446 Cardiac disease Diseases 0.000 abstract 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 abstract 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 abstract 1
- 210000005003 heart tissue Anatomy 0.000 abstract 1
- 239000007972 injectable composition Substances 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001338 necrotic effect Effects 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/33—Fibroblasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Hospice & Palliative Care (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
OPPCT 59 The present invention aims to provide a method which has not been established yet and which is useful for achieving long-term and fundamental cure of a necrotic cardiac tissue region to allow recovery of functionality of the heart. The present invention provides an injectable composition for treatment of a cardiac disease, the composition comprising fibroblasts, wherein the fibroblasts contain CD106-positive fibroblasts, preferably contain CD90-positive fibroblasts. Fig 2A accompanies
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2017033624 | 2017-02-24 | ||
| PCT/JP2018/006795 WO2018155651A1 (en) | 2017-02-24 | 2018-02-23 | Composition for injection which can be used for treatment of heart diseases and contains fibroblasts, and method for producing fibroblast for therapy use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201900810WA true SG11201900810WA (en) | 2019-02-27 |
Family
ID=63253929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201900810WA SG11201900810WA (en) | 2017-02-24 | 2018-02-23 | Composition for injection which can be used for treatment of heart diseases and contains fibroblasts, and method for producing fibroblast for therapy use |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11096969B2 (en) |
| EP (1) | EP3476395B1 (en) |
| JP (2) | JP6618066B2 (en) |
| KR (1) | KR102407387B1 (en) |
| CN (1) | CN109890398B (en) |
| AU (1) | AU2018223739B2 (en) |
| CA (1) | CA3032654A1 (en) |
| DK (1) | DK3476395T3 (en) |
| ES (1) | ES2885080T3 (en) |
| IL (1) | IL267958B2 (en) |
| SG (1) | SG11201900810WA (en) |
| WO (1) | WO2018155651A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3110831A1 (en) | 2018-08-29 | 2020-03-05 | Metcela Inc. | Method for producing fibroblast, and g-csf-positive fibroblast mass |
| CN109589337B (en) * | 2018-12-29 | 2022-04-26 | 南京艾尔普再生医学科技有限公司 | Myocardial cell preparation and preparation method and application thereof |
| CN115210361A (en) * | 2020-03-04 | 2022-10-18 | 玛土撤拉有限公司 | Fibroblast cells with enhanced erythropoietin producing capacity |
| EP4249585A1 (en) * | 2022-03-25 | 2023-09-27 | Technische Universität München - TUM | Heart tissue models, method of producing heart tissue models and uses of heart tissue models |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003901668A0 (en) * | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
| CA2487280A1 (en) * | 2002-05-08 | 2003-11-20 | The Regents Of The University Of California | System and method for forming a substantially non-ablative cardiac conduction block |
| CN100435882C (en) * | 2002-05-08 | 2008-11-26 | 加利福尼亚大学董事会 | System and method for treating cardiac arrhythmias with fibroblast cells |
| US20040161412A1 (en) * | 2002-08-22 | 2004-08-19 | The Cleveland Clinic Foundation | Cell-based VEGF delivery |
| US7470538B2 (en) * | 2002-12-05 | 2008-12-30 | Case Western Reserve University | Cell-based therapies for ischemia |
| CN101415458A (en) * | 2003-11-10 | 2009-04-22 | 辛弗尼医药有限公司 | Method to control ventricular rate in atrial fibrillation patients |
| US8513011B2 (en) * | 2004-08-26 | 2013-08-20 | Biotech Research Ventures Pte Limited | Methods and compositions for culturing cardiomyocyte-like cells |
| ES2325715B1 (en) * | 2007-08-03 | 2010-06-17 | Genetrix, S.L. | POPULATION OF ADULT MOTHER CELLS DERIVED FROM CARDIAC ADIPOSE TISSUE AND ITS USE IN CARDIAC REGENERATION. |
| JP5378743B2 (en) | 2008-09-30 | 2013-12-25 | テルモ株式会社 | Method for producing medical cell sheet |
| WO2013028968A1 (en) * | 2011-08-25 | 2013-02-28 | Wisconsin Alumni Research Foundation | 3-dimensional cardiac fibroblast derived extracellular matrix |
| JP5920741B2 (en) | 2012-03-15 | 2016-05-18 | ｉＨｅａｒｔ Ｊａｐａｎ株式会社 | Method for producing myocardial and vascular mixed cells from induced pluripotent stem cells |
| WO2014039995A1 (en) * | 2012-09-07 | 2014-03-13 | Fibrocell Technologies, Inc. | Fibroblast compositions for treating cardial damage after an infarct |
| GB201309057D0 (en) * | 2013-05-20 | 2013-07-03 | Cell Therapy Ltd | Method |
| KR20150009655A (en) * | 2013-07-16 | 2015-01-27 | 학교법인 동아학숙 | Compositions comprising adipose-derived mesenchymal stem cell overexpressing gcp-2 gene for treating ischemic disease |
| CN106661552B (en) * | 2014-07-11 | 2020-07-07 | 玛土撤拉有限公司 | Cardiac cell culture material |
-
2018
- 2018-02-23 SG SG11201900810WA patent/SG11201900810WA/en unknown
- 2018-02-23 ES ES18758465T patent/ES2885080T3/en active Active
- 2018-02-23 CN CN201880003050.1A patent/CN109890398B/en active Active
- 2018-02-23 JP JP2019501845A patent/JP6618066B2/en active Active
- 2018-02-23 KR KR1020197003364A patent/KR102407387B1/en active IP Right Grant
- 2018-02-23 CA CA3032654A patent/CA3032654A1/en active Pending
- 2018-02-23 WO PCT/JP2018/006795 patent/WO2018155651A1/en unknown
- 2018-02-23 AU AU2018223739A patent/AU2018223739B2/en active Active
- 2018-02-23 EP EP18758465.1A patent/EP3476395B1/en active Active
- 2018-02-23 DK DK18758465.1T patent/DK3476395T3/en active
-
2019
- 2019-01-31 US US16/263,321 patent/US11096969B2/en active Active
- 2019-07-09 IL IL267958A patent/IL267958B2/en unknown
- 2019-10-03 JP JP2019182761A patent/JP7072135B2/en active Active
-
2021
- 2021-07-19 US US17/379,671 patent/US20210346436A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK3476395T3 (en) | 2021-08-16 |
| ES2885080T3 (en) | 2021-12-13 |
| WO2018155651A1 (en) | 2018-08-30 |
| EP3476395A1 (en) | 2019-05-01 |
| EP3476395A4 (en) | 2020-02-26 |
| IL267958B2 (en) | 2023-08-01 |
| US20190224250A1 (en) | 2019-07-25 |
| CN109890398A (en) | 2019-06-14 |
| KR20190117468A (en) | 2019-10-16 |
| AU2018223739B2 (en) | 2023-06-22 |
| US11096969B2 (en) | 2021-08-24 |
| JP2019218408A (en) | 2019-12-26 |
| AU2018223739A1 (en) | 2019-02-14 |
| IL267958B1 (en) | 2023-04-01 |
| IL267958A (en) | 2019-09-26 |
| EP3476395B1 (en) | 2021-07-21 |
| JPWO2018155651A1 (en) | 2019-11-07 |
| KR102407387B1 (en) | 2022-06-10 |
| CA3032654A1 (en) | 2018-08-30 |
| CN109890398B (en) | 2024-01-16 |
| JP7072135B2 (en) | 2022-05-20 |
| JP6618066B2 (en) | 2019-12-11 |
| US20210346436A1 (en) | 2021-11-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201900810WA (en) | Composition for injection which can be used for treatment of heart diseases and contains fibroblasts, and method for producing fibroblast for therapy use | |
| MX2023012450A (en) | Esketamine for the treatment of depression. | |
| MX2023007212A (en) | Epinephrine spray formulations. | |
| BR112015026247A2 (en) | methods for cancer treatment using tor kinase inhibitor combination therapy | |
| SG11202011018PA (en) | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization | |
| SG11202011010YA (en) | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization | |
| MX2020006284A (en) | Bis-choline tetrathiomolybdate for treating wilson disease. | |
| EA202090564A1 (en) | METHODS FOR STRENGTHENING AND / OR STABILIZING THE CARDIAC FUNCTION IN PATIENTS WITH FABRIC DISEASE | |
| WO2019166412A9 (en) | Modulation of pla2-g1b in therapy | |
| TN2016000147A1 (en) | Compositions for body reconstruction and body-shaping. | |
| EA201891007A1 (en) | AIMING FOR FORMILPEPTID RECEPTOR 2 / LIPOXIN A RECEPTOR (FPR2 / ALX) FOR TREATING HEART DISEASES | |
| PH12017500392A1 (en) | Medical treatments based on anamorelin | |
| JOP20190241B1 (en) | Epinephrine spray formulations | |
| MX2023010711A (en) | Phenalkylamines and methods of making and using the same. | |
| EA202193276A1 (en) | METHODS FOR THE TREATMENT OF CHOLANGIOCARCINOMA | |
| MY193963A (en) | Composition for treating joint diseases and kit containing same | |
| MX2022001450A (en) | Method of treating cancer. | |
| EA201592058A1 (en) | APPLICATION OF LANDIOLOL HYDROCHLORIDE IN LONG-TERM TREATMENT OF TACHIHARITHMIA | |
| EA202190360A1 (en) | COMBINATION THERAPY | |
| MX2021000207A (en) | Dosing regimens for treating hypoxia-associated tissue damage. | |
| EP4241788A3 (en) | Methods of treating basal cell carcinoma and glioblastoma | |
| MX2022000349A (en) | Cardiac therapeutic. | |
| TR201721322A2 (en) | MULTIFUNCTIONAL GEL IMPLANT | |
| PH22019000676U1 (en) | Organic mulberry leaf water extract having anticlastogenic activity and method of production thereof | |
| MX2020007183A (en) | Ret9 and vegfr2 inhibitors. |