JP6586104B2 - ５−置換インダゾール−３−カルボキサミドならびにその調製および使用の方法 - Google Patents

５−置換インダゾール−３−カルボキサミドならびにその調製および使用の方法 Download PDF

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JP6586104B2
JP6586104B2 JP2016558073A JP2016558073A JP6586104B2 JP 6586104 B2 JP6586104 B2 JP 6586104B2 JP 2016558073 A JP2016558073 A JP 2016558073A JP 2016558073 A JP2016558073 A JP 2016558073A JP 6586104 B2 JP6586104 B2 JP 6586104B2
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pyridin
carboxamide
indazole
alkyl
ylmethyl
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JP2017508763A (ja
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ジョン フード
ジョン フード
スニル クマー ケーシー
スニル クマー ケーシー
デービッド マーク ウォーレンス
デービッド マーク ウォーレンス
ゴピ クマー ミッタパリ
ゴピ クマー ミッタパリ
ブライアン ジョゼフ ホフィレナ
ブライアン ジョゼフ ホフィレナ
チ チン マック
チ チン マック
ベンカタイア ボル
ベンカタイア ボル
ブライアン イーストマン
ブライアン イーストマン
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サミュメッド リミテッド ライアビリティ カンパニー
サミュメッド リミテッド ライアビリティ カンパニー
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    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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JP2016558073A 2014-03-20 2015-03-20 ５−置換インダゾール−３−カルボキサミドならびにその調製および使用の方法 Active JP6586104B2 (ja)

Applications Claiming Priority (3)

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US201461968350P 2014-03-20 2014-03-20
US61/968,350 2014-03-20
PCT/US2015/021847 WO2015143380A1 (en) 2014-03-20 2015-03-20 5-substituted indazole-3-carboxamides and preparation and use thereof

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JP2017508763A JP2017508763A (ja) 2017-03-30
JP2017508763A5 JP2017508763A5 (cg-RX-API-DMAC7.html) 2018-05-10
JP6586104B2 true JP6586104B2 (ja) 2019-10-02

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US (2) US9745271B2 (cg-RX-API-DMAC7.html)
EP (1) EP3119393A4 (cg-RX-API-DMAC7.html)
JP (1) JP6586104B2 (cg-RX-API-DMAC7.html)
KR (1) KR20160135283A (cg-RX-API-DMAC7.html)
CN (1) CN106535890A (cg-RX-API-DMAC7.html)
BR (1) BR112016021626A2 (cg-RX-API-DMAC7.html)
CA (1) CA2942687A1 (cg-RX-API-DMAC7.html)
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SG10201914121YA (en) 2011-09-14 2020-03-30 Samumed Llc Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
CN105120862A (zh) 2013-01-08 2015-12-02 萨穆梅德有限公司 Wnt信号途径的3-(苯并咪唑-2-基)-吲唑抑制剂及其治疗应用
US9745271B2 (en) 2014-03-20 2017-08-29 Samumed, Llc 5-substituted indazole-3-carboxamides and preparation and use thereof
WO2016040185A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040190A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040180A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040184A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040181A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
US10463651B2 (en) 2015-08-03 2019-11-05 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof
US10206909B2 (en) 2015-08-03 2019-02-19 Samumed, Llc 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
US10166218B2 (en) 2015-08-03 2019-01-01 Samumed, Llc 3-(1H-indol-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
WO2017023988A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10392383B2 (en) 2015-08-03 2019-08-27 Samumed, Llc 3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
WO2017023980A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
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