JP6586016B2 - 組織因子系凝固インヒビター上の２つのエピトープに特異的に結合することが可能な抗体 - Google Patents
組織因子系凝固インヒビター上の２つのエピトープに特異的に結合することが可能な抗体 Download PDFInfo
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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| PCT/EP2014/055055 WO2014140240A1 (en) | 2013-03-15 | 2014-03-14 | Antibodies capable of specifically binding two epitopes on tissue factor pathway inhibitor |
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| US9150663B2 (en) * | 2010-04-20 | 2015-10-06 | Genmab A/S | Heterodimeric antibody Fc-containing proteins and methods for production thereof |
| EP3022228B1 (en) * | 2013-07-19 | 2019-02-27 | Novo Nordisk A/S | Antibodies recognizing the n-terminal part of tissue factor pathway inhibitor capable of eliciting pro-coagulant activity |
| PL3081576T3 (pl) * | 2013-12-12 | 2020-03-31 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Przeciwciało anty pd-1, jego fragment wiążący antygen i ich zastosowanie medyczne |
| IL283006B2 (en) | 2015-04-01 | 2023-10-01 | Anaptysbio Inc | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
| AU2016307967C9 (en) | 2015-08-19 | 2025-02-20 | Pfizer Inc. | Tissue factor pathway inhibitor antibodies and uses thereof |
| CN106554420A (zh) * | 2015-09-30 | 2017-04-05 | 上海众合医药科技股份有限公司 | Pcsk9抗体、其抗原结合片段及其医药用途 |
| WO2017130528A1 (ja) * | 2016-01-29 | 2017-08-03 | ソニー株式会社 | 血液凝固系解析装置、血液凝固系解析システム、血液凝固系解析方法及び血液凝固系解析装置用パラメーターの決定方法 |
| EP3689419A1 (en) | 2016-11-01 | 2020-08-05 | AnaptysBio, Inc. | Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3) |
| SG10201913083SA (en) | 2017-01-09 | 2020-03-30 | Tesaro Inc | Methods of treating cancer with anti-tim-3 antibodies |
| KR20240135884A (ko) | 2018-10-11 | 2024-09-12 | 화이자 인코포레이티드 | Tfpi 길항제의 투여량 섭생법 |
| KR20210089175A (ko) * | 2018-11-07 | 2021-07-15 | 바우닥스 바이오, 인코포레이티드 | Iv 멜록시캄으로 혈소판 기능 장애가 있는 피험자를 치료하는 방법 |
| TWI874341B (zh) | 2018-12-18 | 2025-03-01 | 美商健生生物科技公司 | 產生異二聚體抗體之方法 |
| CN112390884B (zh) * | 2019-04-09 | 2022-07-08 | 苏州大学 | Semaphorin7A单克隆抗体及其在制备用于治疗炎症疾病药物方面的应用 |
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| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| EP0539975A1 (en) | 1991-10-31 | 1993-05-05 | Teijin Limited | Method for immunological assay of free lipoprotein-associated coagulation inhibitor (LACI) and kit therefor |
| EP0617706B1 (en) | 1991-11-25 | 2001-10-17 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
| US5629384A (en) | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
| US5932462A (en) | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
| WO1998049198A1 (en) | 1997-04-30 | 1998-11-05 | Enzon, Inc. | Single-chain antigen-binding proteins capable of glycosylation, production and uses thereof |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| ES2411007T3 (es) | 2001-10-10 | 2013-07-04 | Novo Nordisk A/S | Remodelación y glicoconjugación de péptidos |
| CA2522345A1 (en) | 2003-04-09 | 2004-11-18 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| WO2005040219A1 (en) | 2003-10-28 | 2005-05-06 | Novo Nordisk A/S | Laminin-5 gamma2-binding peptides, related compositions, and use thereof |
| MX2007015676A (es) | 2005-06-15 | 2008-02-20 | Novo Nordisk Healthcare Ag | Conjugacion de la hormona de crecimiento mediada por transglutaminasa. |
| CN102300876A (zh) | 2008-12-22 | 2011-12-28 | 诺沃—诺迪斯克有限公司 | 针对组织因子途径抑制剂(tfpi)的抗体 |
| MX2011006501A (es) | 2008-12-22 | 2011-07-12 | Novo Nordisk As | Anticuerpos contra inhibidor de la via de factor de tejido. |
| CN103080135B (zh) | 2010-06-30 | 2017-06-13 | 诺沃—诺迪斯克有限公司 | 能够特异性结合组织因子途径抑制剂的抗体 |
| PT2694544T (pt) | 2011-04-01 | 2019-04-02 | Bayer Healthcare Llc | Anticorpos monoclonais contra inibidor da via do fator tecidual (tfpi) |
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| CN105209497A (zh) | 2015-12-30 |
| US9896513B2 (en) | 2018-02-20 |
| JP2016512214A (ja) | 2016-04-25 |
| WO2014140240A1 (en) | 2014-09-18 |
| US20180208675A1 (en) | 2018-07-26 |
| ES2926773T3 (es) | 2022-10-28 |
| CN105209497B (zh) | 2021-09-07 |
| US10717784B2 (en) | 2020-07-21 |
| EP2970499A1 (en) | 2016-01-20 |
| US20160032012A1 (en) | 2016-02-04 |
| EP2970499B1 (en) | 2022-08-10 |
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