JP6581774B2 - 非天然アミノ酸結合ドラスタチン誘導体を含有する化合物またはその化合物の溶媒和物、およびドラスタチンアナログを誘導体化するための方法 - Google Patents
非天然アミノ酸結合ドラスタチン誘導体を含有する化合物またはその化合物の溶媒和物、およびドラスタチンアナログを誘導体化するための方法 Download PDFInfo
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- JP6581774B2 JP6581774B2 JP2014512124A JP2014512124A JP6581774B2 JP 6581774 B2 JP6581774 B2 JP 6581774B2 JP 2014512124 A JP2014512124 A JP 2014512124A JP 2014512124 A JP2014512124 A JP 2014512124A JP 6581774 B2 JP6581774 B2 JP 6581774B2
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- 0 CC1C(CCC2)C2(C)C1* Chemical compound CC1C(CCC2)C2(C)C1* 0.000 description 28
- KKBOTCLIASJIFL-OALUTQOASA-N CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(Nc1ccc(COC(C)=O)cc1)=O)=O)NC(C)=O Chemical compound CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(Nc1ccc(COC(C)=O)cc1)=O)=O)NC(C)=O KKBOTCLIASJIFL-OALUTQOASA-N 0.000 description 1
- MGLNEKXMOCILEL-UHFFFAOYSA-N CC(NC(CCC(O)=O)C(NC)=O)=O Chemical compound CC(NC(CCC(O)=O)C(NC)=O)=O MGLNEKXMOCILEL-UHFFFAOYSA-N 0.000 description 1
- GUYYIYQTQTYUES-UHFFFAOYSA-N CNC1OC1[O]=C Chemical compound CNC1OC1[O]=C GUYYIYQTQTYUES-UHFFFAOYSA-N 0.000 description 1
- AZGOFWCZAWGSOJ-UHFFFAOYSA-N O=CCOCCOCCON(C(c1c2cccc1)=O)C2=O Chemical compound O=CCOCCOCCON(C(c1c2cccc1)=O)C2=O AZGOFWCZAWGSOJ-UHFFFAOYSA-N 0.000 description 1
- NUSHTCRMYZMNBE-UHFFFAOYSA-N OCCOCCOCCON(C(c1c2cccc1)=O)C2=O Chemical compound OCCOCCOCCON(C(c1c2cccc1)=O)C2=O NUSHTCRMYZMNBE-UHFFFAOYSA-N 0.000 description 1
- CFMZSMGAMPBRBE-UHFFFAOYSA-N ON(C(c1c2cccc1)=O)C2=O Chemical compound ON(C(c1c2cccc1)=O)C2=O CFMZSMGAMPBRBE-UHFFFAOYSA-N 0.000 description 1
- IVURTNNWJAPOML-UHFFFAOYSA-N c(cc1)cc2c1Nc1ccccc1N2 Chemical compound c(cc1)cc2c1Nc1ccccc1N2 IVURTNNWJAPOML-UHFFFAOYSA-N 0.000 description 1
- OOVVBDPQJDURKE-UHFFFAOYSA-N c(cc1)cc2c1cc1Nc3ccccc3Nc1c2 Chemical compound c(cc1)cc2c1cc1Nc3ccccc3Nc1c2 OOVVBDPQJDURKE-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161491146P | 2011-05-27 | 2011-05-27 | |
| US61/491,146 | 2011-05-27 | ||
| PCT/US2012/039472 WO2012166560A1 (en) | 2011-05-27 | 2012-05-24 | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018026159A Division JP6781721B2 (ja) | 2011-05-27 | 2018-02-16 | 非天然アミノ酸結合ドラスタチン誘導体を含有する組成物、それを用いた方法、およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014516050A JP2014516050A (ja) | 2014-07-07 |
| JP6581774B2 true JP6581774B2 (ja) | 2019-09-25 |
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Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512124A Active JP6581774B2 (ja) | 2011-05-27 | 2012-05-24 | 非天然アミノ酸結合ドラスタチン誘導体を含有する化合物またはその化合物の溶媒和物、およびドラスタチンアナログを誘導体化するための方法 |
| JP2018026159A Active JP6781721B2 (ja) | 2011-05-27 | 2018-02-16 | 非天然アミノ酸結合ドラスタチン誘導体を含有する組成物、それを用いた方法、およびその使用 |
| JP2020097905A Pending JP2020147587A (ja) | 2011-05-27 | 2020-06-04 | 非天然アミノ酸結合ドラスタチン誘導体を含有する組成物、それを用いた方法、およびその使用 |
| JP2022166871A Active JP7638942B2 (ja) | 2011-05-27 | 2022-10-18 | 非天然アミノ酸結合ドラスタチン誘導体を含有する組成物、それを用いた方法、およびその使用 |
| JP2024154766A Pending JP2024170587A (ja) | 2011-05-27 | 2024-09-09 | 非天然アミノ酸結合ドラスタチン誘導体を含有する組成物、それを用いた方法、およびその使用 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018026159A Active JP6781721B2 (ja) | 2011-05-27 | 2018-02-16 | 非天然アミノ酸結合ドラスタチン誘導体を含有する組成物、それを用いた方法、およびその使用 |
| JP2020097905A Pending JP2020147587A (ja) | 2011-05-27 | 2020-06-04 | 非天然アミノ酸結合ドラスタチン誘導体を含有する組成物、それを用いた方法、およびその使用 |
| JP2022166871A Active JP7638942B2 (ja) | 2011-05-27 | 2022-10-18 | 非天然アミノ酸結合ドラスタチン誘導体を含有する組成物、それを用いた方法、およびその使用 |
| JP2024154766A Pending JP2024170587A (ja) | 2011-05-27 | 2024-09-09 | 非天然アミノ酸結合ドラスタチン誘導体を含有する組成物、それを用いた方法、およびその使用 |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US9796754B2 (https=) |
| EP (2) | EP2714684B1 (https=) |
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Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA030886B1 (ru) | 2010-08-17 | 2018-10-31 | Амбркс, Инк. | Модифицированные полипептиды релаксина, содержащие некодируемую в природе аминокислоту, связанную с полимером, и их применение |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| KR102356286B1 (ko) | 2011-05-27 | 2022-02-08 | 암브룩스, 인코포레이티드 | 비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도 |
| CN110078789A (zh) * | 2011-05-27 | 2019-08-02 | Ambrx 公司 | 含有非天然氨基酸连接的海兔毒素衍生物的组合物、涉及该海兔毒素衍生物的方法及其用途 |
| US20130190248A1 (en) * | 2011-07-26 | 2013-07-25 | Agensys, Inc. | Substituted peptide analogs |
| CN104640572B (zh) | 2012-05-15 | 2018-04-27 | 索伦托医疗有限公司 | 药物偶联物,偶联方法,及其用途 |
| CN108727466B (zh) * | 2012-06-07 | 2023-04-28 | Ambrx公司 | 前列腺特异性膜抗原抗体药物结合物 |
| KR102190832B1 (ko) | 2012-06-19 | 2020-12-15 | 암브룩스, 인코포레이티드 | 항cd70 항체 약물 컨쥬게이트 |
| WO2014093379A1 (en) | 2012-12-10 | 2014-06-19 | Mersana Therapeutics, Inc. | Auristatin compounds and conjugates thereof |
| CN105283201B (zh) | 2013-03-14 | 2019-08-02 | 斯克利普斯研究所 | 靶向剂抗体偶联物及其用途 |
| EP2968591A1 (en) * | 2013-03-15 | 2016-01-20 | Novartis AG | Cell proliferation inhibitors and conjugates thereof |
| HK1220626A1 (zh) | 2013-03-15 | 2017-05-12 | The Centre For Drug Research And Development | 具细胞毒性和抗有丝分裂的化合物以及其使用方法 |
| FR3005051A1 (fr) * | 2013-04-25 | 2014-10-31 | Pf Medicament | Derives de la dolastatine 10 et d'auristatines |
| PL2991683T3 (pl) | 2013-05-02 | 2020-03-31 | Glykos Finland Oy | Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem |
| NZ758049A (en) | 2013-10-15 | 2024-03-22 | Seagen Inc | Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics |
| AU2014337317A1 (en) | 2013-10-15 | 2016-09-15 | Sorrento Therapeutics Inc. | Drug-conjugates with a targeting molecule and two different drugs |
| CN105829349B (zh) | 2013-10-15 | 2023-02-03 | 斯克利普斯研究所 | 肽嵌合抗原受体t细胞开关和其用途 |
| CN103665104B (zh) * | 2013-12-09 | 2015-05-20 | 天津市康信医药科技有限公司 | 一种mmaf中间体五肽的合成方法 |
| JP6636925B2 (ja) | 2013-12-17 | 2020-01-29 | ノバルティス アーゲー | 細胞障害性ペプチドおよびその抱合体 |
| WO2015095953A1 (en) | 2013-12-27 | 2015-07-02 | The Centre For Drug Research And Development | Sulfonamide-containing linkage systems for drug conjugates |
| HRP20190888T8 (hr) | 2014-04-25 | 2019-10-04 | Pierre Fabre Médicament | Konjugat antitijela za igf-1r i lijeka i njegova upotreba u liječenju karcinoma |
| HUE047952T2 (hu) | 2014-04-25 | 2020-05-28 | Pf Medicament | Ellenanyag-drog konjugátum és alkalmazása rák kezelésében történõ alkalmazásra |
| CA2951368A1 (en) | 2014-06-13 | 2015-12-17 | Novartis Ag | Auristatin derivatives and conjugates thereof |
| EP3160513B1 (en) | 2014-06-30 | 2020-02-12 | Glykos Finland Oy | Saccharide derivative of a toxic payload and antibody conjugates thereof |
| ES2905569T3 (es) | 2014-09-17 | 2022-04-11 | Zymeworks Inc | Compuestos citotóxicos y antimitóticos y métodos para utilizarlos |
| AU2015358532C1 (en) * | 2014-12-03 | 2020-10-29 | Genentech, Inc. | Quaternary amine compounds and antibody-drug conjugates thereof |
| EP3250238B1 (en) | 2015-01-28 | 2022-06-01 | Sorrento Therapeutics, Inc. | Antibody drug conjugates |
| EP3268038B1 (en) | 2015-03-09 | 2021-05-05 | Agensys, Inc. | Antibody drug conjugates (adc) that bind to flt3 proteins |
| US10800828B2 (en) | 2015-03-26 | 2020-10-13 | The Scripps Research Institute | Switchable non-scFv chimeric receptors, switches, and methods of use thereof to treat cancer |
| US11091546B2 (en) | 2015-04-15 | 2021-08-17 | The Scripps Research Institute | Optimized PNE-based chimeric receptor T cell switches and uses thereof |
| CN105949277B (zh) * | 2015-05-05 | 2019-03-01 | 成都永泰诺科技有限公司 | 一种抗肿瘤化合物及其用途 |
| CN107029242A (zh) | 2015-11-03 | 2017-08-11 | 财团法人工业技术研究院 | 抗体药物复合物及其制造方法 |
| KR102891788B1 (ko) | 2016-02-04 | 2025-11-26 | 더 스크립스 리서치 인스티튜트 | 인간화 항-cd3 항체, 접합체 및 이의 용도 |
| PE20231050A1 (es) | 2016-03-02 | 2023-07-11 | Eisai Randd Man Co Ltd | Conjugados de anticuerpo y farmaco basados en eribulina y metodos para su uso |
| CN109843919A (zh) | 2016-03-25 | 2019-06-04 | 西雅图基因公司 | 用于制备聚乙二醇化的药物-接头及其中间体的方法 |
| EP3529268B1 (en) | 2016-10-19 | 2025-02-26 | The Scripps Research Institute | Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof |
| PE20191716A1 (es) | 2017-02-08 | 2019-12-05 | Bristol Myers Squibb Co | Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos |
| KR102648564B1 (ko) | 2017-03-24 | 2024-03-19 | 씨젠 인크. | 글루쿠로니드 약물-링커의 제조 공정 및 그 중간물 |
| MX2020004691A (es) | 2017-11-07 | 2020-08-20 | Regeneron Pharma | Enlazadores hidrofilicos para conjugados anticuerpo-farmaco. |
| KR102762352B1 (ko) * | 2017-11-30 | 2025-02-05 | 씨젠 인크. | 약물 링커 화합물의 제조방법 |
| MX2020010104A (es) | 2018-03-29 | 2020-11-06 | Ambrx Inc | Conjugados de farmaco-anticuerpo anti-antigeno de membrana especifico de prostata (psma) humanizado. |
| EP3807644A4 (en) | 2018-06-12 | 2022-07-06 | Angiex, Inc. | ANTIBODY-OLIGONUCLEOTIDE CONJUGATES |
| CN109232712B (zh) * | 2018-08-21 | 2021-08-03 | 联宁(苏州)生物制药有限公司 | 一种用于抗体药物偶联物的中间体的制备方法 |
| CN119264211A (zh) | 2018-08-27 | 2025-01-07 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| MX2021002301A (es) | 2018-08-28 | 2021-04-28 | Ambrx Inc | Bioconjugados de anticuerpo-foliato anti-cd3 y sus usos. |
| CA3128081A1 (en) | 2019-02-12 | 2020-08-20 | Ambrx, Inc. | Compositions containing, methods and uses of antibody-tlr agonist conjugates |
| MX2021010254A (es) | 2019-02-27 | 2021-09-21 | Angiex Inc | Conjugados de anticuerpo-farmaco que comprenden anticuerpos anti-tm4sf1 y metodos de uso de los mismos. |
| BR112022001054A2 (pt) * | 2019-08-21 | 2022-03-15 | Kalvista Pharmaceuticals Ltd | Inibidores enzimáticos |
| EP4017542A1 (en) | 2019-10-04 | 2022-06-29 | Tae Life Sciences | Antibody compositions comprising fc mutations and site-specific conjugation properties |
| WO2021173889A1 (en) | 2020-02-26 | 2021-09-02 | Ambrx, Inc. | Uses of anti-cd3 antibody folate bioconjugates |
| US20230022596A1 (en) * | 2021-06-18 | 2023-01-26 | Clarence Hurt | Neoantigen-eliciting antibody drug conjugates for the immunotherapy of cancer |
| WO2023000171A1 (zh) * | 2021-07-20 | 2023-01-26 | 浙江新码生物医药有限公司 | 一种含有抗her2-药物偶联物的冻干组合物、冻干制剂及其制备方法和用途 |
| CN118119409A (zh) | 2021-09-03 | 2024-05-31 | 东丽株式会社 | 癌的治疗和/或预防用药物组合物 |
| WO2024077277A1 (en) | 2022-10-07 | 2024-04-11 | Ambrx, Inc. | Drug linkers and antibody conjugates thereof |
| JP2026504093A (ja) | 2023-01-16 | 2026-02-03 | アンブレツクス・インコーポレイテツド | 抗cd70抗体薬物コンジュゲート |
| WO2024178310A1 (en) | 2023-02-23 | 2024-08-29 | Ambrx, Inc. | Trop2-directed antibody-drug conjugates and uses thereof |
| WO2024241086A1 (en) | 2023-05-24 | 2024-11-28 | Ambrx, Inc. | Pegylated bovine interferon lambda and methods of use thereof |
| AU2024304180A1 (en) | 2023-06-13 | 2026-01-08 | Adcentrx Therapeutics, Inc. | Methods and compositions related to antibodies and antibody drug conjugates (adcs) that bind nectin-4 proteins |
| AU2024329469A1 (en) | 2023-08-22 | 2026-04-09 | Ambrx, Inc. | Anti-psma adc conjugate compositions and methods of use thereof |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
| CN118754934B (zh) * | 2024-06-05 | 2025-02-07 | 浙江新码生物医药有限公司 | 一种用于制备药物偶联物的毒素衍生物 |
| WO2025264533A1 (en) | 2024-06-17 | 2025-12-26 | Adcentrx Therapeutics Inc. | Methods and compositions related to antibody drug conjugates (adcs) that bind steap-1 proteins |
| WO2025262641A1 (en) | 2024-06-19 | 2025-12-26 | Pheon Therapeutics Ltd | Antibody drug conjugates that bind cdcp1 and uses thereof |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2504010B1 (fr) | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
| US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
| US4659839A (en) | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
| ATE66469T1 (de) | 1985-01-14 | 1991-09-15 | Neorx Corp | Metall-radionuklid markiertes protein fuer diagnose und therapie. |
| US4680338A (en) | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
| US4699784A (en) | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
| US4816444A (en) * | 1987-07-10 | 1989-03-28 | Arizona Board Of Regents, Arizona State University | Cell growth inhibitory substance |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| US5831002A (en) | 1992-05-20 | 1998-11-03 | Basf Aktiengesellschaft | Antitumor peptides |
| US6034065A (en) * | 1992-12-03 | 2000-03-07 | Arizona Board Of Regents | Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10 |
| US5635483A (en) * | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
| US5599902A (en) * | 1994-11-10 | 1997-02-04 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Cancer inhibitory peptides |
| WO1999045026A1 (en) | 1998-03-05 | 1999-09-10 | Chiron Corporation | Method for increasing the serum half-life of a biologically active molecule |
| CN1762990A (zh) * | 1999-06-08 | 2006-04-26 | 拉卓拉药物公司 | 包含氨基氧基的化合价平台分子 |
| US6323315B1 (en) * | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
| AU7476101A (en) * | 2000-06-16 | 2001-12-24 | Department Of Radiation Oncolo | Biotin derivatives |
| WO2002085923A2 (en) | 2001-04-19 | 2002-10-31 | The Scripps Research Institute | In vivo incorporation of unnatural amino acids |
| US6649402B2 (en) | 2001-06-22 | 2003-11-18 | Wisconsin Alumni Research Foundation | Microfabricated microbial growth assay method and apparatus |
| US6737409B2 (en) | 2001-07-19 | 2004-05-18 | Hoffmann-La Roche Inc. | Dolastatin 10 derivatives |
| CA2467242A1 (en) * | 2001-11-20 | 2003-05-30 | Seattle Genetics, Inc. | Treatment of immunological disorders using anti-cd30 antibodies |
| DK1545613T3 (da) * | 2002-07-31 | 2011-11-14 | Seattle Genetics Inc | Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom |
| CA2508939A1 (en) | 2002-12-22 | 2004-07-15 | The Scripps Research Institute | Protein arrays |
| JP5356648B2 (ja) * | 2003-02-20 | 2013-12-04 | シアトル ジェネティックス, インコーポレイテッド | 抗cd70抗体−医薬結合体、ならびに癌および免疫障害の処置のためのそれらの使用 |
| EP2478912B1 (en) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy |
| MXPA06013998A (es) * | 2004-06-02 | 2007-02-08 | Hoffmann La Roche | Sintesis de ester de alquilo de acido amino-alcoxi-heptanoico. |
| US7807619B2 (en) | 2004-11-01 | 2010-10-05 | The Regents Of The University Of California | Compositions and methods for modification of biomolecules |
| DK1912677T3 (da) * | 2005-06-20 | 2014-01-13 | Psma Dev Company L L C | PSMA-antistof-lægemiddel-konjugater |
| CN101400646A (zh) | 2005-11-08 | 2009-04-01 | Ambrx公司 | 用于修饰非天然氨基酸和非天然氨基酸多肽的促进剂 |
| US7750116B1 (en) * | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| DK2265283T3 (da) * | 2008-03-18 | 2014-10-20 | Seattle Genetics Inc | Auristatin-lægemiddel-linker-konjugater |
| US8309093B2 (en) * | 2009-03-06 | 2012-11-13 | Agensys, Inc. | Antibody drug conjugates (ADC) that bind to 24P4C12 proteins |
| RU2583270C2 (ru) * | 2009-04-01 | 2016-05-10 | Дженентек, Инк. | АНТИТЕЛА К FcRH5, ИХ ИММУНОКОНЪЮГАТЫ И СПОСОБЫ ИХ ПРИМЕНЕНИЯ |
| US8521087B2 (en) | 2009-07-15 | 2013-08-27 | Lg Electronics Inc. | System and method for cognitive radio transmission |
| JP2013505944A (ja) * | 2009-09-24 | 2013-02-21 | シアトル ジェネティックス, インコーポレイテッド | Dr5リガンド薬物結合体 |
| EP2501711B1 (en) * | 2009-11-16 | 2014-01-08 | Centre National De La Recherche Scientifique CNRS | Compounds and methods for purifying peptides produced by solid phase peptide synthesis |
| MX393973B (es) | 2011-05-08 | 2025-03-24 | Legochem Biosciences Inc | Conjugados de proteína-agente activo y método para su preparación. |
| CN110078789A (zh) * | 2011-05-27 | 2019-08-02 | Ambrx 公司 | 含有非天然氨基酸连接的海兔毒素衍生物的组合物、涉及该海兔毒素衍生物的方法及其用途 |
| KR102356286B1 (ko) * | 2011-05-27 | 2022-02-08 | 암브룩스, 인코포레이티드 | 비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도 |
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