JP6572497B2 - 修飾された治療剤、ステープル留めされたペプチド脂質複合体、及びそれらの組成物 - Google Patents

修飾された治療剤、ステープル留めされたペプチド脂質複合体、及びそれらの組成物 Download PDF

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JP6572497B2
JP6572497B2 JP2016541096A JP2016541096A JP6572497B2 JP 6572497 B2 JP6572497 B2 JP 6572497B2 JP 2016541096 A JP2016541096 A JP 2016541096A JP 2016541096 A JP2016541096 A JP 2016541096A JP 6572497 B2 JP6572497 B2 JP 6572497B2
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peptide
residues
amino acid
disease
lipids
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JP2017502024A5 (OSRAM
JP2017502024A (ja
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シェン，ウェイジュン
ヤン，ポンユ
ゾウ，フアフェイ
シュルツ，ピーター，ジー．
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Scripps Research Institute
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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JP2016541096A 2013-12-18 2014-12-17 修飾された治療剤、ステープル留めされたペプチド脂質複合体、及びそれらの組成物 Active JP6572497B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361917816P 2013-12-18 2013-12-18
US61/917,816 2013-12-18
PCT/US2014/070977 WO2015095406A1 (en) 2013-12-18 2014-12-17 Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof

Publications (3)

Publication Number Publication Date
JP2017502024A JP2017502024A (ja) 2017-01-19
JP2017502024A5 JP2017502024A5 (OSRAM) 2017-11-30
JP6572497B2 true JP6572497B2 (ja) 2019-09-11

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JP2016541096A Active JP6572497B2 (ja) 2013-12-18 2014-12-17 修飾された治療剤、ステープル留めされたペプチド脂質複合体、及びそれらの組成物

Country Status (8)

Country Link
US (5) US10039809B2 (OSRAM)
EP (2) EP3082797A4 (OSRAM)
JP (1) JP6572497B2 (OSRAM)
KR (1) KR102455171B1 (OSRAM)
CN (1) CN106456589B (OSRAM)
AU (1) AU2014364589B2 (OSRAM)
CA (1) CA2933701C (OSRAM)
WO (1) WO2015095406A1 (OSRAM)

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JP6822839B2 (ja) 2013-09-13 2021-01-27 ザ・スクリップス・リサーチ・インスティテュート 修飾された治療剤、及びその組成物
CN106456589B (zh) 2013-12-18 2020-07-07 斯克利普斯研究所 修饰的治疗剂、订合的肽脂质缀合物及其组合物
US20160151511A1 (en) 2014-12-02 2016-06-02 Antriabio, Inc. Proteins and protein conjugates with increased hydrophobicity
RU2730848C2 (ru) 2015-06-04 2020-08-26 Резолют, Инк. Способы пэгилирования по аминогруппе для получения сайт-специфичных конъюгатов белков
CN107921098A (zh) * 2015-06-17 2018-04-17 加州生物医学研究所 修饰的治疗剂及其组合物
EP3322437B1 (en) 2015-06-30 2024-01-17 Hanmi Pharm. Co., Ltd. Glucagon derivative and a composition comprising a long acting conjugate of the same
WO2017075583A2 (en) * 2015-10-30 2017-05-04 The Research Foundation For The State University Of New York Oxyntomodulin analogs and methods of making and using same
KR102508651B1 (ko) 2015-12-23 2023-03-13 더 존스 홉킨스 유니버시티 신경계 및 신경변성 상태의 요법으로서 장기간 작용하는 glf-1r 작용제
CN116059389A (zh) 2015-12-31 2023-05-05 韩美药品株式会社 胰高血糖素/glp-1/gip受体三重激动剂的长效缀合物
CN106046145B (zh) 2016-04-22 2022-11-04 深圳市图微安创科技开发有限公司 Glp-1r/gcgr双靶点激动剂多肽治疗脂肪肝病、高脂血症和动脉硬化
BR112018077457A2 (pt) 2016-06-29 2019-04-02 Hanmi Pharm. Co., Ltd. composição farmacêutica para evitar ou tratar hiperinsulinismo congênito e seu método, hipoglicemia e seu método, síndrome metabólica e seu método e peptídeo isolado
US10864279B2 (en) 2016-12-16 2020-12-15 Industrial Technology Research Institute Linker-drug and antibody-drug conjugate (ADC) employing the same
KR102670432B1 (ko) 2017-02-08 2024-05-28 브리스톨-마이어스 스큅 컴퍼니 약동학적 인핸서를 포함하는 변형된 렐락신 폴리펩티드 및 그의 용도
KR20190123351A (ko) * 2017-03-22 2019-10-31 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 개질된 올리고뉴클레오티드 및 이의 치료 용도
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JP7691421B2 (ja) * 2019-12-04 2025-06-11 ザ スクリプス リサーチ インスティテュート Ｇｌｐ２受容体アゴニストおよびその使用方法
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TW202241491A (zh) * 2020-12-16 2022-11-01 丹麥商西蘭製藥公司 Ｇｌｐ－１／ｇｌｐ－２雙重促效劑之醫藥組合物
WO2022156189A1 (zh) * 2021-01-22 2022-07-28 深圳市图微安创科技开发有限公司 多肽化合物在预防或治疗炎症性肠病及其相关的肠纤维化中的应用
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