JP6570593B2 - 抗微生物性組成物とその使用方法 - Google Patents
抗微生物性組成物とその使用方法 Download PDFInfo
- Publication number
- JP6570593B2 JP6570593B2 JP2017194262A JP2017194262A JP6570593B2 JP 6570593 B2 JP6570593 B2 JP 6570593B2 JP 2017194262 A JP2017194262 A JP 2017194262A JP 2017194262 A JP2017194262 A JP 2017194262A JP 6570593 B2 JP6570593 B2 JP 6570593B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- bacteria
- biofilm
- wound
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
- A01N41/04—Sulfonic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/26—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/02—Ammonia; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Materials Engineering (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Description
この出願は出願日2011年10月8日の米国特許出願番号61/545,108、および出願日2012年6月15日の米国特許出願番号61/660,649の利益を請求する。その開示は本明細書中に参考として援用する。
背景
微生物が同伴されることのできるHAIs、および/またはバイオフィルムを防ぐか、または治すことができる方法および組成物;
移植可能なまたは移植された装置と物品でのバイオフィルムの成長を防ぐか、またはバイオフィルムを除去できる方法および組成物;
殺菌または他の方法で複数回使用される医療機器を処理することについて持たれている。
本発明はバクテリアを含むがこれに限定されない微生物の処理または排除に使用される組成物と物品に関し、それらがプランクトン、胞子、またはバイオフィルムの形態であるか否かにかかわらない。
「細菌」は、すべてのタイプの微生物を意味し、たとえばバクテリア、ウイルス、菌類、ウイルス様体、プリオン、および同様のものを包含するが、これらに限定されない。
「抗菌剤」は1以上の細菌の数を90%(1ログ(1 log))より多く低減する能力を有する物質を意味する。
「活性抗菌剤」は例えば細菌の細胞分裂のようなライフサイクルの活性の間のみ、またはその期間に主として有効な抗菌剤を意味する。
「バイオフィルム」は、細菌のコミュニティーを意味し、特にはバクテリアと菌類のコミュニティーを意味し、自己発生高分子マトリックス中にあるかまたはそれにより守られているコミュニティーメンバーにより表面に付着している。
「滞留時間」は、抗菌剤の細菌性バイオフィルムとの接触が許容されている時間を意味する。
「生物学的に適合している」は、哺乳類種の体表面または哺乳類種の体内における顕著な長期の有害な効果を示さないことを意味する。
「生物分解」は、酵素によるか、または化学的もしくは物理的な生体内のプロセスによる、より小さい化学種への変化を意味する。
「抗出血性物質」は、抑制性フィブリン溶解の防止、凝固の促進、血小板凝集の促進、または血管収縮を引き起こすことの1つまたはそれ以上により出血を抑制する化合物または物質を意味する。
「病院内感染」は、インキュベーションに関する証拠がないかまたは存在していない限局性または全身性感染を意味し、患者が入院が許可された時、大部分は入院の48時間以内に臨床的に明白になる。
「高分子電解質」は、水中で解離ができる電解質基を含む複数のモノマーからのポリマーを意味する。
「強高分子電解質」は電解質基が、3≦pH≦9で水中で完全に解離する高分子電解質をいう。
「弱高分子電解質」は、約2から約10までの解離定数を有する高分子電解質をいい、強高分子電解質の基が完全に解離される範囲内のpHで部分的に解離する。
「高分子両性電解質」は、いくらかのモノマーが陽イオン性電解質基を含み、他のモノマーが陰イオン性電解質基を含む高分子電解質である。
有用な塩基性(苛性の)液組成物は、少なくとも中程度に高い浸透圧モル濃度、すなわち多量の浸透圧的に活性の溶質と比較的高いか(7.5≦pH<9)、または非常に高いpH(9≦pH<11)を示す。多量の溶質が存在している界面活性剤と共に働いて、バクテリアの膜漏れを引き起こし、細胞分解に導く。
水、少なくとも1つの塩基の解離生成物、および少なくとも1つの界面活性剤。それのそれぞれが一般的に生物学的に適合していると考えられている。1種以上の塩類の解離生成物も含まれることができる。
クエン酸、2−メチルプロパン−1,2,3−トリカルボン酸、ベンゼントリカルボン酸、ニトリロトリ酢酸、および同様のもののようなトリプロトン酸;プレニト酸、ピロメリット酸、および同様のもののようなテトラプロトン酸;より多官能の酸類(例えば、ペンタ、ヘキサ、ヘプタプロトン酸など)も使用できる。ここで、トリ−、テトラ−、およびより多官能の酸が使用される場合、カルボキシルプロトンの1以上がカチオン性の原子または基(例えば、アルカリ金属イオン)で置き換えることができ、これらは同じであるか、または異なったものであってよい。
効力とは微生物に対する致死性、および/またはある特定の細菌コロニーがあるEPS/ECPSを崩壊するかまたは取り除く事ができる能力をいい、低い効力はバクテリア(特に強固なバイオフィルム中のバクテリア)の低減が<2ログ、またはさらには<1ログのものをいい、高い効力は>2ログ、>3ログ、>4ログ、>5ログ、および>6ログの低下を示す。効力は、pHが中性から遠ざかるにつれて、界面活性剤の量が増えるにつれて、毒性が大きくなるにつれて大きくなる。界面活性剤の構造(例えば、より高い電荷の可能性、荷電された部位の近くのより小さい基、より小さい親水性の部位など)、またはタイプ(すなわち、カチオン性>両性イオン性>アニオン性>非イオン性)により最適化される。
多くの病原バクテリアが創傷と創傷の周りにしばしば存在している。グラム陽性菌はエンテロコッカス−フェカーリス(Enterococcus faecalis)、表皮ブドウ球菌(Staphylococcus epidermidis)、および黄色ブドウ球菌(Staphylococcus aureus)を包含する。
グラム陰性菌はクレブシェラ肺炎杆菌(Klebsiella pneumonia)、アシネトバクター バウワニー(Acinetobacter baumanii)、ヘモフィールスインフルエンザ(Haemophilus influenza)、バルクホルデリアセノセパシア(Burkholderia cenocepacia)、および緑膿菌(Pseudomonas aeruginosa)を包含する。また、種々の菌類は火傷にも存在している。
次に、組織トロンボプラスチンは凝固経路を活性化し、フィブリン形成に導き、血小板と赤血球が捕らえられるプラグを形成し、その結果凝塊を形成する。
代わりに、別々に変数の多くについて議論するだろう。そして、当業者は特定の形態を提供するためにこれらの個々の説明を結合できる。これらは創傷または治癒過程の特定のステージの特定のタイプの創傷に使用できる。
慢性と急性の創傷の両者は、表皮と真皮だけに影響するか、または筋膜組織に影響する。
基本的な創傷部のケアプロトコールは、洗浄(すなわち、破片の取り出しと壊死組織の軟化)、可能なデブリードマン、余分な滲出液の吸収、肉芽と上皮形成の促進、および感染治療を含む。この段階で使用される清浄化薬剤は、汚れとバクテリアの物理的除去を目的とする界面活性剤に基づき、バクテリアの殺害能力はあっても非常に小さい。
例えば、一般用医薬品(OTC薬)と処方箋薬品(Rx)またはプログレード薬品は、以下の表1に示されたような組成と特性を持っている:
表1:
例示の創傷ケア組成物
中間的な性質を持っているグレードも企図される。
軍事および緊急医療機関で使用される一般的な抗出血性薬剤の例としては、フィブリン、コラーゲン酸化でんぷん、カルボキシメチルセルロース、トロンビンおよびキトサンがあげられる。消毒組成物または材料の様々な実施態様が、抗出血性薬剤または物品に加えられることができ、たとえば止血性包帯(HemCon Medical Technologies;ポートランド、オレゴン)、Tisseel(登録商標)フィブリンシーラント(バクスター・インターナショナル社;ディアフィールド、イリノイ州)、Thrombi−Gel(登録商標)ゼラチン発泡止血薬(ファイザー社;ニューヨーク、ニューヨーク)、GelFoam(登録商標)−ゼラチンスポンジ(ファイザー)、GelFoam(登録商標)プラス止血キット(バクスター)などがあげられる。別法として、抗出血性物質の液体消毒組成物、固体の消毒物質または物品への添加も有用である。例として、少なくとも約5%、しばしば少なくとも約10%、一般には少なくとも約20%の消毒性組成物または物質が、固体または半固形の抗出血性物質(例えば、ゲル−フォームとキトサン包帯)中に存在する。逆に、消毒組成物または物質中に、約1から約80%、一般には約3から約70%(重量基準)、典型的には約5から約60%の抗出血性物質が加えられることができる。量は例えば、トロンビン、キトサン、酸化セルロース、またはカルボキシメチルセルロースである抗出血性物質の種類と効力に基づいて異なる。
ホストの食物における、炭水化物の増加する濃度により、口腔環境は初期的に変化する。これらの炭水化物の発酵により、プラークバイオフィルム中の嫌気性細菌は酸を生成し、その結果バイオフィルムのpHを減少させる。組成物におけるこのシフトの原因となるいくつかの、より一般的なバクテリアは、ミュータンス菌(S.mutans)、ミュータンス群レンサ菌(S.sorbrinus)、およびカゼイ菌(Lactobacillus casei)である。そのすべてがpHレベル最小3.0で生き残る。pHが低下するのに従って、ミクロフローラは酸性耐性バクテリアに向かってシフトする。不耐性のバクテリアが形成された酸性条件下で生き残ることができないからである。
消毒または殺菌の前に、すべての再利用できる医療用品を徹底的に清浄化しなければならない。この工程はすべての表面、内部および外部に要求され、いわゆるバイオバーデン、すなわち、組織および流体の残渣、バクテリア、菌類、ウイルス、蛋白質類、および炭水化物を完全に除かなければならない。人手によるかまたは機械による表面処理の後に、すべてのバイオバーデン残渣と洗浄薬を取り除くために装置を徹底的にすすがなければならない。現状技術では、装置が清潔でないなら、消毒を達成できない。
清浄化の後に2,3の生菌が残っていても、時間がたつにつれてバイオフィルムの中に蓄積する。一般的に使用される酵素の洗浄剤は生存可能な細菌数を減少させることも、細菌性のEPSを取り除くこともできないことが見い出された。高酵素活性を有するクリーナーは、ある種のバイオフィルムを取り除くが、2ログを(すなわち、99%)以上にバクテリア数を減らすことはできず、いくつかの酵素の溶液は実際にバイオフィルムの形成に貢献する。従って、適切な消毒が下方制御された微生物を殺し、バイオフィルムの形成を防ぐのに必要である。
感染症の基本的なルートは接触(直接的および間接的)、液滴、空気、一般的なビヒクル(食物、水、薬物、器具および装置などの汚染物質)、および保菌生物(カ、ハエ、齧歯動物など)を通した伝播を伴う。最も頻繁なモードは直接接触である。
最終的には殺菌されるが、インプランテーションの間の、およびその前の医療用品インプラントは、環境または医療労働者からのバクテリアにより、またはより一般的には患者自身の皮膚に存在しているバクテリアからコロニー形成されることがある。挿入の後に、インプラント表面が宿主免疫によって保護されないので、インプラントは全身性バクテリアからコロニー形成されるようになり、表面にバイオフィルムを形成する。
Claims (5)
- 創傷部を治療するための組成物であって、該組成物は2から4のpHと、1.8から2.8 Osm/Lの総溶質濃度を有し、本質的に以下からなる組成物:
(1) 水、
(2) 1以上の有機酸と少なくとも1つの1以上の有機酸の塩を含む緩衝系、および
(3) 0.9から1.7g/Lの少なくとも1つのカチオン性界面活性剤。 - 該1以上の有機酸が、少なくとも1つのポリ酸を含む、請求項1記載の組成物。
- 該少なくとも1つの1以上の有機酸の塩が、ポリ酸の塩を含む、請求項1記載の組成物。
- 該少なくとも1つのカチオン性界面活性剤が、ベンザルコニウムクロリドを含む、請求項1記載の組成物。
- 該少なくとも1つのカチオン性界面活性剤が、ベンザルコニウムクロリドである、請求項1記載の組成物。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2019098430A JP6956143B2 (ja) | 2011-10-08 | 2019-05-27 | 抗微生物性組成物とその使用方法 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161545108P | 2011-10-08 | 2011-10-08 | |
US61/545,108 | 2011-10-08 | ||
US201261660649P | 2012-06-15 | 2012-06-15 | |
US61/660,649 | 2012-06-15 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014534822A Division JP6236390B2 (ja) | 2011-10-08 | 2012-10-08 | 抗微生物性組成物とその使用方法 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019098430A Division JP6956143B2 (ja) | 2011-10-08 | 2019-05-27 | 抗微生物性組成物とその使用方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017226704A JP2017226704A (ja) | 2017-12-28 |
JP6570593B2 true JP6570593B2 (ja) | 2019-09-04 |
Family
ID=48044439
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014534822A Active JP6236390B2 (ja) | 2011-10-08 | 2012-10-08 | 抗微生物性組成物とその使用方法 |
JP2017194262A Active JP6570593B2 (ja) | 2011-10-08 | 2017-10-04 | 抗微生物性組成物とその使用方法 |
JP2019098430A Active JP6956143B2 (ja) | 2011-10-08 | 2019-05-27 | 抗微生物性組成物とその使用方法 |
JP2021078217A Active JP7147002B2 (ja) | 2011-10-08 | 2021-05-03 | 抗微生物性組成物とその使用方法 |
JP2022149755A Active JP7486557B2 (ja) | 2011-10-08 | 2022-09-21 | バクテリア混入を防止するための半固体組成物 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014534822A Active JP6236390B2 (ja) | 2011-10-08 | 2012-10-08 | 抗微生物性組成物とその使用方法 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019098430A Active JP6956143B2 (ja) | 2011-10-08 | 2019-05-27 | 抗微生物性組成物とその使用方法 |
JP2021078217A Active JP7147002B2 (ja) | 2011-10-08 | 2021-05-03 | 抗微生物性組成物とその使用方法 |
JP2022149755A Active JP7486557B2 (ja) | 2011-10-08 | 2022-09-21 | バクテリア混入を防止するための半固体組成物 |
Country Status (11)
Country | Link |
---|---|
US (12) | US9872843B2 (ja) |
EP (2) | EP2763665B1 (ja) |
JP (5) | JP6236390B2 (ja) |
AU (1) | AU2012318331B2 (ja) |
BR (2) | BR112014008255B1 (ja) |
CA (2) | CA3115561A1 (ja) |
DK (1) | DK2763665T3 (ja) |
ES (1) | ES2756848T3 (ja) |
HU (1) | HUE047099T2 (ja) |
PL (1) | PL2763665T3 (ja) |
WO (1) | WO2013052958A2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11219208B2 (en) | 2013-05-02 | 2022-01-11 | Next Science IP Holdings Pty Ltd | High osmolarity antimicrobial composition containing one or more organic solvents |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11006629B2 (en) | 2008-11-20 | 2021-05-18 | Armis Biopharma, Inc. | Antimicrobial, disinfecting, and wound healing compositions and methods for producing and using the same |
CA2835211C (en) | 2011-05-10 | 2019-09-24 | Next Science, Llc | Antimicrobial solid and methods of making and using same |
ES2756848T3 (es) | 2011-10-08 | 2020-04-27 | Next Science IP Holdings Pty Ltd | Composiciones antimicrobianas y métodos que las emplean |
SE536581C2 (sv) * | 2012-07-24 | 2014-03-11 | Rls Global Ab | Ett kit för behandling av sår eller liknande och ett preparat och metoder därav |
US10272098B2 (en) | 2013-03-14 | 2019-04-30 | Drexel University | Chelated drug delivery systems |
PL3043769T3 (pl) * | 2013-09-11 | 2023-10-23 | Aim Targeted Therapies, Inc. | Hipertoniczne, terapeutyczne kompozycje przeciwdrobnoustrojowe |
US9839718B1 (en) * | 2014-01-10 | 2017-12-12 | University Of South Florida | Intracorporal ultra high purity calcium sulfate cast mixed with antimicrobials for the treatment of penile implant infections |
US10869479B2 (en) * | 2014-04-28 | 2020-12-22 | American Sterilizer Company | Wipe for killing spores |
BR112016030580B1 (pt) * | 2014-06-26 | 2023-12-19 | The Rockefeller University | Polipeptídeo de lisina e fragmento de polipeptídeo com atividade para matar bactérias gram-negativas |
JP2018521134A (ja) | 2015-07-17 | 2018-08-02 | ネクスト サイエンス アイピー ホールディングス ピーティワイ エルティーディ | 内生胞子に対する効能を有する抗菌性組成物 |
CA2994696A1 (en) | 2015-08-07 | 2017-02-16 | Next Science IP Holdings Pty Ltd | Antimicrobial composition having efficacy against endospores |
CN109310087A (zh) | 2016-06-30 | 2019-02-05 | 贴近科学Ip控股私人有限公司 | 抗微生物的组合物和应用该组合物的方法 |
US10266793B2 (en) * | 2016-09-30 | 2019-04-23 | Novaflux, Inc. | Compositions for cleaning and decontamination |
US10308897B2 (en) | 2017-04-24 | 2019-06-04 | Gpcp Ip Holdings Llc | Alkaline sanitizing soap preparations containing quaternary ammonium chloride agents |
US20210077438A1 (en) | 2017-07-07 | 2021-03-18 | Armis Biopharma, Inc. | Compositions and methods for remediating chemical warfare agent exposure and surface decontamination |
US11076969B2 (en) | 2017-08-23 | 2021-08-03 | Little Latchers, LLC | Simulated breast feeding system |
WO2019099932A1 (en) | 2017-11-19 | 2019-05-23 | Next Science IP Holdings Pty Ltd | Compositions and methods for treating intervertebral discs |
EP3498261A1 (en) * | 2017-12-14 | 2019-06-19 | Infection Elimination Services LLC | Improved method for removing bacterial biofilms and treating tissue |
JP2021520442A (ja) | 2018-04-03 | 2021-08-19 | ノバフラックス インコーポレイテッド | 高吸収性ポリマーを備える洗浄組成物 |
GB2572642B (en) * | 2018-04-06 | 2021-03-31 | Pellis Care Ltd | Treatment of diabetic foot ulcers |
US20210267731A1 (en) * | 2018-08-17 | 2021-09-02 | Nibec Co., Ltd. | Composition for treating and preventing gingivoperiodontitis or peri-implantitis, and interdental brush coated with same |
US20200246511A1 (en) * | 2019-02-04 | 2020-08-06 | Armis Biopharma, Inc. | Methods and devices to reduce the risk of infection |
US11918677B2 (en) | 2019-10-03 | 2024-03-05 | Protegera, Inc. | Oral cavity cleaning composition method and apparatus |
WO2021195245A1 (en) * | 2020-03-27 | 2021-09-30 | Yaso Therapeutics Inc. | Antimicrobial compositions containing polyphenylene carboxymethylene |
US20220015363A1 (en) * | 2020-07-14 | 2022-01-20 | The Trustees Of Princeton University | Small molecule pathogen dispersal agent |
WO2022081737A1 (en) * | 2020-10-14 | 2022-04-21 | Next Science IP Holdings Pty Ltd | Methods and compositions useful for reducing bioburden in wounds |
US11672773B2 (en) | 2020-12-13 | 2023-06-13 | Next Science IP Holdings Pty Ltd | Methods for treating ciliated cavities |
EP4301141A1 (en) * | 2021-03-01 | 2024-01-10 | Carlo Ratti | Combination therapy for treatment of conditions associated with aging |
CN115634210A (zh) * | 2022-09-30 | 2023-01-24 | 成都世联康健生物科技有限公司 | 一种模拟酶微球和牙周炎用组合物、制法及其牙周炎注射用制剂 |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1052273A (en) | 1975-12-18 | 1979-04-10 | Edwin B. Michaels | Antimicrobial compositions |
CA1090706A (en) * | 1976-06-30 | 1980-12-02 | Jordan B. Barth | Stable mouthwash containing sodium bicarbonate |
US4206282A (en) * | 1977-08-29 | 1980-06-03 | Pfizer Inc. | Hypertonic culture media |
JPS5945643B2 (ja) | 1982-01-13 | 1984-11-07 | 日本新薬株式会社 | 防腐用組成物 |
US4590064A (en) * | 1985-03-11 | 1986-05-20 | Colgate-Palmolive Company | Anticalculus oral composition |
US4973466A (en) * | 1988-06-21 | 1990-11-27 | Chiron Ophthalmics, Inc. | Wound-healing dressings and methods |
CA2009118C (en) * | 1989-02-21 | 1996-02-27 | Mary F. Mowrey-Mckee | Method and composition for cleaning and disinfecting contact lenses |
US5043183A (en) * | 1989-09-13 | 1991-08-27 | Cambridge Research Laboratories, Inc. | Oral rinse and method for plaque removal |
AU2254192A (en) * | 1991-06-24 | 1993-01-25 | Carrington Laboratories, Inc. | Wound cleanser |
AU682489B2 (en) * | 1993-01-27 | 1997-10-09 | Warner-Lambert Company | Reduced alcohol mouthwash antiseptic and antiseptic preparations |
US5661170A (en) * | 1994-03-21 | 1997-08-26 | Woodward Laboratories, Inc. | Antimicrobial compositions and methods for using the same |
GB9419668D0 (en) | 1994-09-28 | 1994-11-16 | Diversey Corp | Disinfectant compositions |
DE69619675T2 (de) * | 1995-06-27 | 2002-11-07 | Procter & Gamble | Verfahren zur reinigung und entkeimung von leblosen nicht-nahrungsmitteloberflächen |
GB9611364D0 (en) * | 1996-05-31 | 1996-08-07 | Smithkline Beecham Plc | Composition |
US5891422A (en) * | 1996-10-10 | 1999-04-06 | Warner-Lambert Company | Antimicrobial composition containing a C3 -C6 alcohol |
US6180640B1 (en) * | 1998-06-25 | 2001-01-30 | Sepracor, Inc. | Di- and tetra-hydroquinoline-indole antimicrobial agents, uses and compositions related thereto |
US6149822A (en) | 1999-03-01 | 2000-11-21 | Polymer Ventures, Inc. | Bio-film control |
US6790816B2 (en) * | 1999-09-24 | 2004-09-14 | Bausch & Lomb Incorporated | High osmolyte cleaning and disinfection method and solution for contact lenses |
US20040037891A1 (en) * | 1999-10-04 | 2004-02-26 | Karagoezian Hampar L. | Synergistic antimicrobial ophthalmic and dermatologic preparations containing chlorite and hydrogen peroxide |
JP2001181189A (ja) * | 1999-12-28 | 2001-07-03 | Kyoto Dobutsu Kensa Center:Kk | 癒傷促進性基剤 |
US6953772B2 (en) | 2000-07-18 | 2005-10-11 | Lopes John A | Concentrated sanitizing compositions for cleaning food and food contact surfaces |
US6610314B2 (en) | 2001-03-12 | 2003-08-26 | Kimberly-Clark Worldwide, Inc. | Antimicrobial formulations |
US6701940B2 (en) | 2001-10-11 | 2004-03-09 | S. C. Johnson & Son, Inc. | Hard surface cleaners containing ethylene oxide/propylene oxide block copolymer surfactants |
JP3940332B2 (ja) * | 2001-12-27 | 2007-07-04 | アース製薬株式会社 | 液状咽喉用組成物 |
EP1515607A2 (en) * | 2002-06-21 | 2005-03-23 | The Procter & Gamble Company | Antimicrobial compositions, products and methods employing same |
US7045492B2 (en) | 2002-07-30 | 2006-05-16 | Earl Jenevein | Cleaning composition comprising cationic surfactants, chelant, and an alcohol solvent mixture |
JP2004238375A (ja) * | 2003-02-10 | 2004-08-26 | Earth Chem Corp Ltd | 殺菌性口腔用組成物 |
GB0303677D0 (en) | 2003-02-18 | 2003-03-19 | Quest Int | Flavoured products |
US7090882B2 (en) | 2003-06-12 | 2006-08-15 | Cargill, Incorporated | Antimicrobial salt solutions for food safety applications |
US20080020025A1 (en) * | 2003-08-28 | 2008-01-24 | Pharmaionx, Inc. | Composition for wound care and method of using same |
US9241885B2 (en) * | 2004-01-29 | 2016-01-26 | The Procter & Gamble Company | Oral care compositions comprising increased bioavailable levels of quaternary ammonium antimicrobials |
US7578996B2 (en) * | 2004-04-07 | 2009-08-25 | Advanced Medical Optics, Inc. | Cetylpyridinium chloride as an antimicrobial agent in ophthalmic compositions |
EP1809264B1 (en) * | 2004-09-20 | 2016-04-13 | Avent, Inc. | Antimicrobial amorphous compositions |
JP4452601B2 (ja) * | 2004-10-20 | 2010-04-21 | 花王株式会社 | 液体口腔用組成物 |
CA2588786A1 (en) | 2004-12-09 | 2006-06-15 | The Dial Corporation | Compositions having a high antiviral and antibacterial efficacy |
BRPI0519737A2 (pt) * | 2004-12-21 | 2009-01-27 | Musc Found For Res Dev | composiÇÕes e mÉtodos para promover a cura de feridas e a regeneraÇço de tecidos |
US20060134020A1 (en) * | 2004-12-21 | 2006-06-22 | Robinson Richard S | Anti-caries oral care composition with a chelating agent |
US20070166242A1 (en) | 2005-12-19 | 2007-07-19 | Kross Robert D | Oral care product and method for the reduction of dental caries through inclusion of mannan and galactomannan polysaccharides in dentifrice formulations |
WO2007076125A2 (en) * | 2005-12-22 | 2007-07-05 | Swiss-American Products, Inc. | Zinc compositions and their use in anti-microbial applications |
EP1847248A1 (de) * | 2006-04-21 | 2007-10-24 | Schrader, Andreas, Dr. | Kosmetische Mittel zum Schutz oder zur Regenerierung des Haares oder der Haut |
US7959943B2 (en) | 2006-05-10 | 2011-06-14 | Medtronics Xomed, Inc. | Solvating system and sealant for medical use in the middle or inner ear |
US20070264296A1 (en) | 2006-05-10 | 2007-11-15 | Myntti Matthew F | Biofilm extracellular polysachharide solvating system |
US7993675B2 (en) | 2006-05-10 | 2011-08-09 | Medtronic Xomed, Inc. | Solvating system and sealant for medical use in the sinuses and nasal passages |
US7976873B2 (en) | 2006-05-10 | 2011-07-12 | Medtronic Xomed, Inc. | Extracellular polysaccharide solvating system for treatment of bacterial ear conditions |
US8389022B2 (en) * | 2006-10-12 | 2013-03-05 | Nm Tech Nanomaterials Microdevice Technology Ltd. | Material, item and products comprising a composition having anti-microbial properties |
KR20080098157A (ko) * | 2007-05-04 | 2008-11-07 | 한국화학연구원 | 살균 소독용 과초산 조성물 |
CN101675153B (zh) | 2007-05-04 | 2014-09-24 | 埃科莱布有限公司 | 含水溶性镁化合物的清洁组合物及其使用方法 |
CN101148451A (zh) | 2007-05-16 | 2008-03-26 | 好维股份有限公司 | 一种口腔药物及口腔护理用品 |
US20100330000A1 (en) | 2007-11-06 | 2010-12-30 | Kristian Hellgren | Enzymes for treatment of gingivitis |
US20090123570A1 (en) * | 2007-11-09 | 2009-05-14 | Warner W Randolph | Composition and method for treating sore throat |
AU2009257390B2 (en) * | 2008-06-12 | 2014-09-04 | Medtronic Xomed, Inc. | Method for treating chronic wounds with an extracellular polymeric substance solvating system |
WO2010042427A2 (en) | 2008-10-06 | 2010-04-15 | Microbial Defense Systems, Llc | Antimicrobial composition and methods of making and using same |
KR20100092843A (ko) * | 2009-02-13 | 2010-08-23 | (주)비젼사이언스 | 콘택트렌즈 보존제 |
US20100256576A1 (en) * | 2009-04-07 | 2010-10-07 | Tyco Healthcare Group Lp | Disinfectant Compositions, Methods and Systems |
ES2958410T3 (es) * | 2009-08-21 | 2024-02-08 | Novan Inc | Geles tópicos |
US20110104279A1 (en) * | 2009-11-04 | 2011-05-05 | Marraccini Philip A | Healing powder and method of use thereof |
NL2004260C2 (en) * | 2010-02-18 | 2011-08-22 | Univ Amsterdam | Disinfectant composition and its use in dental treatment. |
CN103153290B (zh) * | 2010-10-11 | 2018-01-16 | 普渡研究基金会 | 有助于伤口愈合的抗微生物制剂 |
CA2835211C (en) | 2011-05-10 | 2019-09-24 | Next Science, Llc | Antimicrobial solid and methods of making and using same |
ES2756848T3 (es) | 2011-10-08 | 2020-04-27 | Next Science IP Holdings Pty Ltd | Composiciones antimicrobianas y métodos que las emplean |
EP2991483A4 (en) | 2013-05-02 | 2016-11-30 | Next Science Llc | ANTIMICROBIAL COMPOSITION WITH HIGH OSMOLARITY WITH ONE OR MORE ORGANIC SOLVENTS |
CN109310087A (zh) | 2016-06-30 | 2019-02-05 | 贴近科学Ip控股私人有限公司 | 抗微生物的组合物和应用该组合物的方法 |
-
2012
- 2012-10-08 ES ES12838205T patent/ES2756848T3/es active Active
- 2012-10-08 CA CA3115561A patent/CA3115561A1/en active Pending
- 2012-10-08 WO PCT/US2012/059263 patent/WO2013052958A2/en active Application Filing
- 2012-10-08 US US14/350,322 patent/US9872843B2/en active Active
- 2012-10-08 AU AU2012318331A patent/AU2012318331B2/en active Active
- 2012-10-08 EP EP12838205.8A patent/EP2763665B1/en active Active
- 2012-10-08 BR BR112014008255-3A patent/BR112014008255B1/pt active IP Right Grant
- 2012-10-08 CA CA2851146A patent/CA2851146C/en active Active
- 2012-10-08 EP EP18209422.7A patent/EP3524229A1/en active Pending
- 2012-10-08 DK DK12838205T patent/DK2763665T3/da active
- 2012-10-08 JP JP2014534822A patent/JP6236390B2/ja active Active
- 2012-10-08 BR BR122020015748-8A patent/BR122020015748B1/pt active IP Right Grant
- 2012-10-08 HU HUE12838205A patent/HUE047099T2/hu unknown
- 2012-10-08 PL PL12838205T patent/PL2763665T3/pl unknown
- 2012-11-23 US US13/684,456 patent/US9314017B2/en active Active
-
2016
- 2016-03-19 US US15/075,147 patent/US9427417B2/en active Active
- 2016-07-25 US US15/218,756 patent/US9486420B1/en active Active
- 2016-10-31 US US15/339,298 patent/US9730903B2/en active Active
-
2017
- 2017-08-13 US US15/675,758 patent/US20170340590A1/en not_active Abandoned
- 2017-10-04 JP JP2017194262A patent/JP6570593B2/ja active Active
-
2018
- 2018-01-21 US US15/876,181 patent/US10166208B2/en active Active
- 2018-09-02 US US16/120,272 patent/US11752083B2/en active Active
- 2018-11-15 US US16/192,100 patent/US20190201310A1/en not_active Abandoned
-
2019
- 2019-01-01 US US16/237,709 patent/US10780037B2/en active Active
- 2019-05-27 JP JP2019098430A patent/JP6956143B2/ja active Active
-
2020
- 2020-08-23 US US17/000,348 patent/US20200390675A1/en not_active Abandoned
-
2021
- 2021-05-03 JP JP2021078217A patent/JP7147002B2/ja active Active
-
2022
- 2022-09-21 JP JP2022149755A patent/JP7486557B2/ja active Active
-
2023
- 2023-07-02 US US18/217,568 patent/US20230338260A1/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11219208B2 (en) | 2013-05-02 | 2022-01-11 | Next Science IP Holdings Pty Ltd | High osmolarity antimicrobial composition containing one or more organic solvents |
US11234435B2 (en) | 2013-05-02 | 2022-02-01 | Next Science IP Holdings Pty Ltd | High osmolarity antimicrobial composition containing one or more organic solvents |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7147002B2 (ja) | 抗微生物性組成物とその使用方法 | |
CA2606734C (en) | Method of using oxidative reductive potential water solution in dental applications | |
KR101569134B1 (ko) | 일산화 이염소 함유 항균 용액, 그의 제조 방법 및 사용 방법 | |
JP7467445B2 (ja) | 一過性バイオフィルムを処置するための組成物および方法 | |
JP2022506394A (ja) | 薬剤耐性を誘導せずにバイオフィルムを処置するための組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20171004 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20180412 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180803 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180815 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190107 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20190322 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20190729 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20190806 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6570593 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |