JP7467445B2 - 一過性バイオフィルムを処置するための組成物および方法 - Google Patents
一過性バイオフィルムを処置するための組成物および方法 Download PDFInfo
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Description
本出願は、2018年11月2日に出願された米国仮特許出願第62/755,113号(この内容は、その全体が参照により本明細書に組み込まれる)の優先権および利益を主張する。
本発明は、一般に、天然微生物叢を維持しながら一過性バイオフィルムを処置するための酢酸および次亜塩素酸の組成物に関する。本発明は、口腔バイオフィルムの処置のための酢酸および次亜塩素酸の組成物に関する。
抗菌石鹸および水による洗浄よりも低研磨性かつ容易であるので、医療専門家は、これまでかなりの期間にわたって手洗いの代替または補足として手指殺菌剤の使用に依拠していた。そして、食品医薬品局が消費者による特定の抗菌石鹸の購入および使用を禁止する記事を発表すると、より幅広い人口の間で手指殺菌剤の使用の増加が広がった。手指殺菌剤または手指除菌剤は、一般に、微生物を殺傷するための有効成分を含むゲル、発泡体または液体溶液である。ほとんどの手指殺菌剤は、エタノールまたはイソプロパノールの形態のアルコールを含む。
従来技術の殺菌剤組成物は、様々な欠点を有する。いくつかは、一過性細菌を処置する一方で天然微生物叢を根絶する。いくつかは長い回復時間を有し、病原性細菌感染症に対して組織を無防備にする。他のものは、病原菌感染を予防することができない。
本明細書に記載される次亜塩素酸および有機酸、例えば酢酸を含む抗菌組成物は、天然微生物叢を害さずに一過性微生物を処置するために有用である。例えば、次亜塩素酸および酢酸を含む組成物は、天然皮膚微生物叢の恒常性を維持しながら、皮膚上のバイオフィルムを処置するために有用である。本発明の組成物は、皮膚上に天然に存在する細菌の保護的性質に悪影響を与えずに皮膚を殺菌するために有用である。したがって、本発明の組成物は、手の殺菌に有効である。次亜塩素酸および酢酸の組成物はまた、鼻腔、膣および口腔に見られる病原性一過性微生物の処置に有効である。本発明の組成物は、皮膚上に天然に存在する微生物叢の恒常性を維持しながら、病原性細菌を減少させるかまたは排除する。相乗効果を達成するためにHOC1およびHAcの濃度のバランスを取り、各成分自体の抗菌特性に基づいて予想されるよりも高い抗菌能力の組成物をもたらす。特にpHを恒常性レベルにする傾向がある環境では、酢酸は、次亜塩素酸の最適性能を可能にする重要な緩衝能力を提供する。例えば、口腔内では、天然pHは約7.4であり、酢酸はその環境で緩衝能力を提供して、HOClの最適活性を可能にする。加えて、次亜塩素酸は酢酸の毒性をモジュレートし、鎮痛効果を提供して、有害な副作用、患者の不快感または天然微生物叢の根絶を伴わずに、皮膚または他の組織へのより強力な組成物の付与を可能にする。最後に、酢酸は、Pseudomonaなどの嫌気性菌に対して特に有効である。酢酸に加えて、他の有機酸、例えばアスコルビン酸、乳酸、ギ酸、リンゴ酸、クエン酸、尿酸および他のカルボン酸またはスルホン酸。
細菌感染症およびバイオフィルムの処置は、有機酸、例えば酢酸および次亜塩素酸を含む相乗的組成物を使用して達成される。酢酸成分は、組織に浸透するために特に有効であり、次亜塩素酸は、組織の外面上のバイオフィルムを処置するために特に有効である。酢酸は、創傷の表面下に最大2mmまたはそれを超えて浸透して、他の方法では到達困難なバイオフィルムを処置し得る。
次亜塩素酸組成物の生産
HCl(水溶液)+NaOCl(水溶液)⇔HOCl(水溶液)+NaCl(水溶液).
または
HAc(水溶液)+NaOCl(水溶液)⇔HOCl(水溶液)+NaA(水溶液).
創傷ケア
他の組織上のバイオフィルムの処置
非組織表面上のバイオフィルムの処置
歯の処置
乳腺炎の処置
創傷および外科的使用
他の医療用途
ナノ粒子カプセル化による制御放出
バイオフィルム処置のための酢酸および次亜塩素酸の組成物
天然微生物叢を維持しながら一過性細菌を処置するための次亜塩素酸および酢酸の組成物
参照による援用
均等物
可視範囲もカバーするように分光光度法を拡張する場合、色を検出することが可能である。HOClの生産中に一般に生産される気体はClO2、Cl2OおよびCl2であり、これらはすべて、黄色または黄赤色として可視範囲で検出可能である。Tzanavarasら、(Central European J.of Chemistry,2007,5(1)1-12)。図9のデータは、本発明の方法により生産されたHOClが、着色物質の欠如により示されているように、着色気体からの吸収を示さないことを示す。HOClは、292nmでピークを生じさせることが公知である(Fengら、2007,J.Environ.Eng.Sci.6,277-284)。
実施例2:
実施例3:塩酸と比較した酢酸
実施例4:手指殺菌剤
本発明は、例えば、以下の項目を提供する。
(項目1)
組織の天然バイオフィルムを害さずに病原性細菌バイオフィルムを処置するために十分な有機酸および次亜塩素酸を含む、組成物。
(項目2)
前記有機酸が、約0.1%~約5.0%の濃度の酢酸である、項目1に記載の組成物。
(項目3)
前記次亜塩素酸濃度が10ppm~2500ppmである、項目1に記載の組成物。
(項目4)
前記次亜塩素酸濃度がおよそ150ppmである、項目1に記載の組成物。
(項目5)
前記酢酸が、前記組織に浸透するために十分な濃度で存在する、項目2に記載の組成物。
(項目6)
前記組織が皮膚組織である、項目1に記載の組成物。
(項目7)
前記皮膚組織が表皮組織である、項目6に記載の組成物。
(項目8)
前記皮膚組織が膣組織である、項目6に記載の組成物。
(項目9)
スプレー、ゲル、クリーム、軟膏または油で製剤化される、項目1に記載の組成物。
(項目10)
前記酢酸がナノ粒子中にカプセル化される、項目2に記載の組成物。
(項目11)
組織中の細菌感染症を処置するための方法であって、酢酸と、前記組織の天然微生物叢を害さずに前記酢酸の毒性特性をモジュレートするために有効な量の次亜塩素酸とを含む組成物を前記組織に提供することを含む、方法。
(項目12)
前記酢酸が、前記組織に浸透するために十分な濃度である、項目11に記載の方法。
(項目13)
前記酢酸が約0.1%~約5.0%の量で存在し、前記次亜塩素酸が約10ppm~約2500ppmの濃度で存在する、項目11に記載の方法。
(項目14)
前記組織が皮膚組織であり、前記次亜塩素酸濃度が約150ppmであり、前記酢酸濃度が約0.1~約1.0%である、項目13に記載の方法。
(項目15)
口腔関連細菌バイオフィルムを処置するために十分な酢酸および次亜塩素酸を含む、組成物。
(項目16)
前記酢酸濃度が0.1%~1.0%である、項目15に記載の組成物。
(項目17)
前記次亜塩素酸濃度が5ppm~250ppmである、項目15に記載の組成物。
(項目18)
天然バイオフィルムを害さない、項目15に記載の組成物。
(項目19)
前記酢酸が、口腔粘膜に浸透するために十分な濃度で存在する、項目15に記載の組成物。
(項目20)
口腔関連細菌バイオフィルムを予防するために十分な酢酸および次亜塩素酸を含む、組成物。
(項目21)
前記酢酸濃度が0.1%~1.0%であり、前記次亜塩素酸が5ppm~250ppmである、項目20に記載の組成物。
(項目22)
天然微生物叢を害さない、項目20に記載の組成物。
(項目23)
口腔表面の口腔関連バイオフィルムを処置する方法であって、口腔関連バイオフィルムに感染していると疑われる口腔表面を処置するために有効な量の酢酸および次亜塩素酸を含む組成物を前記口腔表面に提供することを含む、方法。
(項目24)
前記酢酸が約0.1%~約5.0%の量で存在し、前記次亜塩素酸が約5ppm~約2500ppmの濃度で存在する、項目23に記載の方法。
(項目25)
前記口腔表面が歯および口腔粘膜を含む、項目24に記載の方法。
(項目26)
口腔関連バイオフィルムを予防する方法であって、予防有効量の酢酸および次亜塩素酸を含む組成物を口腔表面に提供することを含む、方法。
Claims (8)
- 組織の天然バイオフィルムを害さずに病原性細菌バイオフィルムを処置するために使用するための抗菌組成物であって、
4%~5%の酢酸(HAc)濃度の水溶液中の酢酸(HAc);
5ppm~2500ppmの次亜塩素酸(HOCl)濃度の前記水溶液中の次亜塩素酸(HOCl);および
前記水溶液中に懸濁された複数のナノ粒子であって、前記HAcの一部が前記ナノ粒子中にカプセル化されている、ナノ粒子
を含む、組成物。 - 前記水溶液中の前記HAc濃度が、4%である、請求項1に記載の組成物。
- 前記水溶液中の前記HOCl濃度が200ppm~250ppmである、請求項1に記載の組成物。
- 前記水溶液中の前記HOCl濃度が200ppm~500ppmである、請求項1に記載の組成物。
- スプレー、ゲル、クリーム、軟膏または油で製剤化される、請求項1に記載の組成物。
- 前記ナノ粒子がポリマーを含む、請求項2に記載の組成物。
- 前記ポリマーが、セルロース、ポリアクリルアミド、ポリ(D,L-ラクチド-co-グリコリド酸)、ポリ(乳酸)、ポリ(キシリトールアジペートサリシレート)、ポリ無水物、ポリ(エチレンオキシド)、ポリ(エチレンイミン)、脂肪酸のポリグリセロールエステル、多糖、ポリビニルアルコール、ポビドンからなる群から選択される、請求項6に記載の組成物。
- 前記ナノ粒子が脂溶性である、請求項1に記載の組成物。
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