JP6527132B2 - 肝臓がんの診断及び治療のための組成物及び方法 - Google Patents

肝臓がんの診断及び治療のための組成物及び方法 Download PDF

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JP6527132B2
JP6527132B2 JP2016502189A JP2016502189A JP6527132B2 JP 6527132 B2 JP6527132 B2 JP 6527132B2 JP 2016502189 A JP2016502189 A JP 2016502189A JP 2016502189 A JP2016502189 A JP 2016502189A JP 6527132 B2 JP6527132 B2 JP 6527132B2
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antibody
amino acid
seq
acid sequence
notch2
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JP2016520520A (ja
JP2016520520A5 (https=
Inventor
ドロシー フレンチ，
ドロシー フレンチ，
エーリク ハントジッカー，
エーリク ハントジッカー，
クリスチャン ダブリュ． シーベル，
クリスチャン ダブリュ． シーベル，
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Genentech Inc
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Genentech Inc
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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JP2016502189A 2013-03-15 2014-03-13 肝臓がんの診断及び治療のための組成物及び方法 Expired - Fee Related JP6527132B2 (ja)

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US201361789475P 2013-03-15 2013-03-15
US61/789,475 2013-03-15
PCT/US2014/026588 WO2014151866A1 (en) 2013-03-15 2014-03-13 Compositions and methods for diagnosis and treatment of hepatic cancers

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JP2016520520A JP2016520520A (ja) 2016-07-14
JP2016520520A5 JP2016520520A5 (https=) 2017-03-23
JP6527132B2 true JP6527132B2 (ja) 2019-06-05

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US (3) US9550829B2 (https=)
EP (1) EP2970476A1 (https=)
JP (1) JP6527132B2 (https=)
KR (1) KR20150128707A (https=)
CN (1) CN105143264A (https=)
AU (1) AU2014236815B2 (https=)
BR (1) BR112015020290A2 (https=)
CA (1) CA2902765A1 (https=)
CL (1) CL2015002571A1 (https=)
CR (1) CR20150483A (https=)
EA (1) EA201591705A1 (https=)
HK (1) HK1211963A1 (https=)
IL (1) IL240116A0 (https=)
MA (1) MA38495A1 (https=)
MX (1) MX2015011444A (https=)
PE (1) PE20151750A1 (https=)
PH (1) PH12015501997A1 (https=)
SG (2) SG11201507427QA (https=)
TW (1) TW201511770A (https=)
WO (1) WO2014151866A1 (https=)

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