JP6508544B2 - 腫瘍を治療するための薬用組成物 - Google Patents
腫瘍を治療するための薬用組成物 Download PDFInfo
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- JP6508544B2 JP6508544B2 JP2016571283A JP2016571283A JP6508544B2 JP 6508544 B2 JP6508544 B2 JP 6508544B2 JP 2016571283 A JP2016571283 A JP 2016571283A JP 2016571283 A JP2016571283 A JP 2016571283A JP 6508544 B2 JP6508544 B2 JP 6508544B2
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
- A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410250113.7A CN105311030B (zh) | 2014-06-06 | 2014-06-06 | 用于抗肿瘤的螺取代化合物 |
| CN201410250113.7 | 2014-06-06 | ||
| PCT/CN2015/080863 WO2015185012A1 (fr) | 2014-06-06 | 2015-06-05 | Méthode de traitement antitumoral, composition pharmaceutique et kit associés |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017527524A JP2017527524A (ja) | 2017-09-21 |
| JP6508544B2 true JP6508544B2 (ja) | 2019-05-08 |
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| JP2016571283A Active JP6508544B2 (ja) | 2014-06-06 | 2015-06-05 | 腫瘍を治療するための薬用組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10251876B2 (fr) |
| EP (1) | EP3153169B1 (fr) |
| JP (1) | JP6508544B2 (fr) |
| CN (3) | CN105311030B (fr) |
| DK (1) | DK3153169T3 (fr) |
| ES (1) | ES2828177T3 (fr) |
| HK (1) | HK1231377A1 (fr) |
| HR (1) | HRP20201737T1 (fr) |
| HU (1) | HUE051707T2 (fr) |
| PL (1) | PL3153169T3 (fr) |
| RS (1) | RS60990B1 (fr) |
| SI (1) | SI3153169T1 (fr) |
| WO (2) | WO2015185013A1 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311030B (zh) | 2014-06-06 | 2020-03-24 | 正大天晴药业集团股份有限公司 | 用于抗肿瘤的螺取代化合物 |
| CN105311029A (zh) | 2014-06-06 | 2016-02-10 | 正大天晴药业集团股份有限公司 | 抗肿瘤活性的喹啉衍生物 |
| AU2015290007B2 (en) | 2014-07-14 | 2019-11-21 | Advenchen Pharmaceuticals, Nanjing Ltd. | Fused quinoline compunds as pi3k, mTor inhibitors |
| ES2793286T3 (es) | 2014-12-09 | 2020-11-13 | Chai Tai Tianqing Pharmaceutical Group Co Ltd | Derivado de quinolina contra carcinoma de pulmón no microcítico |
| US9751859B2 (en) * | 2015-05-04 | 2017-09-05 | Advenchen Pharmaceuticals, LLC | Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine, its crystalline form and its salts |
| CN110078730B (zh) | 2015-07-11 | 2021-09-07 | 南京爱德程医药科技有限公司 | 作为pi3k/mtor抑制剂的喹啉取代的稠合喹啉化合物 |
| CN107296811B (zh) | 2016-04-15 | 2022-12-30 | 正大天晴药业集团股份有限公司 | 一种用于治疗胃癌的喹啉衍生物 |
| WO2018214925A1 (fr) * | 2017-05-26 | 2018-11-29 | 正大天晴药业集团股份有限公司 | Dérivé de quinoléine pour le traitement du cancer colorectal |
| WO2019052520A1 (fr) * | 2017-09-15 | 2019-03-21 | 正大天晴药业集团股份有限公司 | Dérivé de quinoléine pour le traitement de tumeurs neuroendocrines |
| CN107970241B (zh) * | 2018-01-22 | 2020-05-22 | 正大天晴药业集团股份有限公司 | 一种新型酪氨酸激酶抑制剂安罗替尼在制备抑制骨肉瘤的药物中的应用 |
| WO2019166012A1 (fr) | 2018-03-02 | 2019-09-06 | 正大天晴药业集团股份有限公司 | Cristal d'un composé à utiliser en tant qu'inhibiteur de kinase c-met, son procédé de préparation et son utilisation |
| AU2019236578B2 (en) * | 2018-03-14 | 2024-04-04 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Quinoline derivative for treatment of nasopharyngeal carcinoma |
| WO2019174590A1 (fr) * | 2018-03-14 | 2019-09-19 | 正大天晴药业集团股份有限公司 | Dérivé de quinoléine pour le traitement du cancer du sein triple-négatif |
| US11419862B2 (en) | 2018-03-14 | 2022-08-23 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Quinoline derivative for treatment of nasopharyngeal carcinoma |
| CA3112946A1 (fr) * | 2018-09-18 | 2020-03-26 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Derive de quinoleine utilise pour le traitement du cancer du poumon a petites cellules |
| CN111110681A (zh) * | 2018-10-31 | 2020-05-08 | 正大天晴药业集团股份有限公司 | 喹啉衍生物联合卡培他滨在治疗肝癌的用途 |
| CN109748904A (zh) * | 2019-01-31 | 2019-05-14 | 正大天晴药业集团股份有限公司 | 喹啉衍生物的结晶 |
| WO2020211860A1 (fr) * | 2019-04-19 | 2020-10-22 | 正大天晴药业集团股份有限公司 | Composé de quinoléine ou sel pharmaceutiquement acceptable de celui-ci pour le traitement du sarcome d'ewing |
| JP2022532189A (ja) * | 2019-05-10 | 2022-07-13 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | 軟部肉腫の併用療法用キノリン誘導体 |
| EP3973964A4 (fr) * | 2019-05-20 | 2023-05-03 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Dérivé de quinoléine utilisé pour le traitement combiné du cancer du poumon à petites cellules |
| CN112043831A (zh) * | 2019-06-05 | 2020-12-08 | 正大天晴药业集团股份有限公司 | 用于联合治疗乳腺癌的喹啉类化合物 |
| WO2022237889A1 (fr) * | 2021-05-14 | 2022-11-17 | 南京创特医药科技有限公司 | Composition pharmaceutique |
| WO2024002147A1 (fr) * | 2022-06-29 | 2024-01-04 | 正大天晴药业集团股份有限公司 | Complexe d'inclusion de cyclodextrine et d'un dérivé de quinoléine ou d'un sel de celui-ci |
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| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| BRPI0807893A2 (pt) | 2007-02-20 | 2014-06-17 | Novartis Ag | Imidazoquinolinas como inibidores duais de lipídio quinase e mtor. |
| US8163923B2 (en) | 2007-03-14 | 2012-04-24 | Advenchen Laboratories, Llc | Spiro substituted compounds as angiogenesis inhibitors |
| US8148532B2 (en) | 2007-03-14 | 2012-04-03 | Guoqing Paul Chen | Spiro substituted compounds as angiogenesis inhibitors |
| US20080229184A1 (en) * | 2007-03-15 | 2008-09-18 | Microsoft Corporation | Private sheets in shared spreadsheets |
| EP2303890A4 (fr) | 2008-06-19 | 2012-04-11 | Progenics Pharm Inc | Inhibiteurs de phosphatidylinositol 3 kinase |
| IT1393351B1 (it) | 2009-03-16 | 2012-04-20 | Eos Ethical Oncology Science Spa In Forma Abbreviata Eos Spa | Procedimento per la preparazione della 6-(7-((1-amminociclopropil)metossi)-6-metossichinolin-4-ilossi)-n-metil-1-naftammide e suoi intermedi di sintesi |
| AU2010258355B2 (en) * | 2009-06-12 | 2016-04-28 | Generex Pharmaceuticals, Inc. | Compositions and methods for prevention and treatment of coronary heart diseases |
| CN103664892B (zh) * | 2010-08-01 | 2015-09-02 | 正大天晴药业集团股份有限公司 | 喹啉衍生物的结晶 |
| CN103974954B (zh) | 2011-11-14 | 2016-08-24 | 北京赛林泰医药技术有限公司 | 调节激酶的化合物、含有它们的组合物及其用途 |
| MA38274A1 (fr) | 2013-01-18 | 2017-02-28 | Advenchen Pharmaceuticals Llc | Procédé pour l'élaboration d'un agent antitumoral, la 6-(7-((1-amino-cyclo-propyl)-méthoxy)-6- méthoxyquinolin-4-yloxy)-n-méthyl-1-naphthamide, et de sa forme cristalline |
| CN103127024B (zh) * | 2013-03-12 | 2014-10-15 | 成都天台山制药有限公司 | 稳定的三磷酸腺苷二钠片剂 |
| CN104513229A (zh) | 2013-09-28 | 2015-04-15 | 正大天晴药业集团股份有限公司 | 喹唑啉衍生物及其制备方法 |
| CN105311029A (zh) | 2014-06-06 | 2016-02-10 | 正大天晴药业集团股份有限公司 | 抗肿瘤活性的喹啉衍生物 |
| CN105311030B (zh) | 2014-06-06 | 2020-03-24 | 正大天晴药业集团股份有限公司 | 用于抗肿瘤的螺取代化合物 |
| AU2015290007B2 (en) | 2014-07-14 | 2019-11-21 | Advenchen Pharmaceuticals, Nanjing Ltd. | Fused quinoline compunds as pi3k, mTor inhibitors |
| ES2793286T3 (es) * | 2014-12-09 | 2020-11-13 | Chai Tai Tianqing Pharmaceutical Group Co Ltd | Derivado de quinolina contra carcinoma de pulmón no microcítico |
| US9751859B2 (en) | 2015-05-04 | 2017-09-05 | Advenchen Pharmaceuticals, LLC | Process for preparing an anti-cancer agent, 1-((4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinolin-7-yloxy)methyl)cyclopropanamine, its crystalline form and its salts |
-
2014
- 2014-06-06 CN CN201410250113.7A patent/CN105311030B/zh active Active
-
2015
- 2015-06-05 CN CN202010913233.6A patent/CN112076192A/zh active Pending
- 2015-06-05 SI SI201531400T patent/SI3153169T1/sl unknown
- 2015-06-05 DK DK15803424.9T patent/DK3153169T3/da active
- 2015-06-05 JP JP2016571283A patent/JP6508544B2/ja active Active
- 2015-06-05 HU HUE15803424A patent/HUE051707T2/hu unknown
- 2015-06-05 EP EP15803424.9A patent/EP3153169B1/fr active Active
- 2015-06-05 ES ES15803424T patent/ES2828177T3/es active Active
- 2015-06-05 WO PCT/CN2015/080868 patent/WO2015185013A1/fr active Application Filing
- 2015-06-05 CN CN201580026809.4A patent/CN106456625A/zh active Pending
- 2015-06-05 PL PL15803424T patent/PL3153169T3/pl unknown
- 2015-06-05 RS RS20201292A patent/RS60990B1/sr unknown
- 2015-06-05 US US15/315,655 patent/US10251876B2/en active Active
- 2015-06-05 WO PCT/CN2015/080863 patent/WO2015185012A1/fr active Application Filing
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2017
- 2017-05-18 HK HK17104983.2A patent/HK1231377A1/zh unknown
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2019
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2020
- 2020-10-28 HR HRP20201737TT patent/HRP20201737T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK3153169T3 (da) | 2020-11-02 |
| EP3153169A4 (fr) | 2018-01-10 |
| CN106456625A (zh) | 2017-02-22 |
| PL3153169T3 (pl) | 2021-04-06 |
| ES2828177T3 (es) | 2021-05-25 |
| CN112076192A (zh) | 2020-12-15 |
| EP3153169A1 (fr) | 2017-04-12 |
| EP3153169B1 (fr) | 2020-08-05 |
| JP2017527524A (ja) | 2017-09-21 |
| RS60990B1 (sr) | 2020-11-30 |
| US20190269671A1 (en) | 2019-09-05 |
| US20170182027A1 (en) | 2017-06-29 |
| WO2015185012A1 (fr) | 2015-12-10 |
| CN105311030A (zh) | 2016-02-10 |
| CN105311030B (zh) | 2020-03-24 |
| HUE051707T2 (hu) | 2021-03-29 |
| SI3153169T1 (sl) | 2021-01-29 |
| US10251876B2 (en) | 2019-04-09 |
| HRP20201737T1 (hr) | 2021-03-19 |
| WO2015185013A1 (fr) | 2015-12-10 |
| HK1231377A1 (zh) | 2017-12-22 |
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