JP6506313B2 - 癌及び増殖性疾患の治療のための抗有糸分裂性アミド - Google Patents
癌及び増殖性疾患の治療のための抗有糸分裂性アミド Download PDFInfo
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- JP6506313B2 JP6506313B2 JP2016570919A JP2016570919A JP6506313B2 JP 6506313 B2 JP6506313 B2 JP 6506313B2 JP 2016570919 A JP2016570919 A JP 2016570919A JP 2016570919 A JP2016570919 A JP 2016570919A JP 6506313 B2 JP6506313 B2 JP 6506313B2
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- Prior art keywords
- unsubstituted
- substituted
- cancer
- compound
- cyclopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 *c(nc1)ncc1C(Nc(nc1)ccc1-c1cccc(S(C2CC2)(=O)=O)c1)=O Chemical compound *c(nc1)ncc1C(Nc(nc1)ccc1-c1cccc(S(C2CC2)(=O)=O)c1)=O 0.000 description 6
- NPJBPJIQMCHZLJ-UHFFFAOYSA-N Nc1ccc(B(O)O)cn1 Chemical compound Nc1ccc(B(O)O)cn1 NPJBPJIQMCHZLJ-UHFFFAOYSA-N 0.000 description 2
- CKXAMCSVTNPSCZ-UHFFFAOYSA-N CC(C)(C)OC(Nc(nc1)ccc1Br)=O Chemical compound CC(C)(C)OC(Nc(nc1)ccc1Br)=O CKXAMCSVTNPSCZ-UHFFFAOYSA-N 0.000 description 1
- YAJSCINLTAMULK-UHFFFAOYSA-N CCc(nc1)ncc1C(Nc(cc1)ncc1-c1cc(N2CCN(C[IH]C)CC2)cc(O)c1)=O Chemical compound CCc(nc1)ncc1C(Nc(cc1)ncc1-c1cc(N2CCN(C[IH]C)CC2)cc(O)c1)=O YAJSCINLTAMULK-UHFFFAOYSA-N 0.000 description 1
- YZLCHCLPWMGKFD-UHFFFAOYSA-N CN(CC1)CCN1c1cc(-c(cc2)cnc2N)ccc1 Chemical compound CN(CC1)CCN1c1cc(-c(cc2)cnc2N)ccc1 YZLCHCLPWMGKFD-UHFFFAOYSA-N 0.000 description 1
- AIFUXAUBWCIRRG-UHFFFAOYSA-N Cc(nc1)ncc1C(Nc(nc1)ccc1-c1cc(N2CCN(C)CC2)cc(C2CC2)c1)=O Chemical compound Cc(nc1)ncc1C(Nc(nc1)ccc1-c1cc(N2CCN(C)CC2)cc(C2CC2)c1)=O AIFUXAUBWCIRRG-UHFFFAOYSA-N 0.000 description 1
- OACMAACLKLQFMP-UHFFFAOYSA-N Cc1nc(NC(c2cnc(C)nc2)=O)ccc1-c1cc(N2CCN(C)CC2)cc(Cl)c1 Chemical compound Cc1nc(NC(c2cnc(C)nc2)=O)ccc1-c1cc(N2CCN(C)CC2)cc(Cl)c1 OACMAACLKLQFMP-UHFFFAOYSA-N 0.000 description 1
- SLPBFCYPZUMPBY-UHFFFAOYSA-N N=CCc(cc1)ncc1-c1cccc(C2CC2)c1 Chemical compound N=CCc(cc1)ncc1-c1cccc(C2CC2)c1 SLPBFCYPZUMPBY-UHFFFAOYSA-N 0.000 description 1
- ALYNCZNDIQEVRV-UHFFFAOYSA-N Nc(cc1)ccc1C(O)=O Chemical compound Nc(cc1)ccc1C(O)=O ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 1
- NTRIUHGYRCTKTL-UHFFFAOYSA-N Nc(nc1)ccc1-c1cccc(-c2ccccc2)c1 Chemical compound Nc(nc1)ccc1-c1cccc(-c2ccccc2)c1 NTRIUHGYRCTKTL-UHFFFAOYSA-N 0.000 description 1
- WGOLHUGPTDEKCF-UHFFFAOYSA-N Nc(nc1)ccc1Br Chemical compound Nc(nc1)ccc1Br WGOLHUGPTDEKCF-UHFFFAOYSA-N 0.000 description 1
- QUDMCKMIBUQRBI-UHFFFAOYSA-N O=C(Cc(cc1)ncc1-c1cc(C2COC2)ccc1)c1ccccc1 Chemical compound O=C(Cc(cc1)ncc1-c1cc(C2COC2)ccc1)c1ccccc1 QUDMCKMIBUQRBI-UHFFFAOYSA-N 0.000 description 1
- CWHGXRQPQNGBME-UHFFFAOYSA-N O=S(C1CC1)(c1cccc(Br)c1)=O Chemical compound O=S(C1CC1)(c1cccc(Br)c1)=O CWHGXRQPQNGBME-UHFFFAOYSA-N 0.000 description 1
- UUEMVXPDQPRWIY-UHFFFAOYSA-N [CH2+]N(CC1)CCN1c1cc(Br)ccc1 Chemical compound [CH2+]N(CC1)CCN1c1cc(Br)ccc1 UUEMVXPDQPRWIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461942956P | 2014-02-21 | 2014-02-21 | |
| US61/942,956 | 2014-02-21 | ||
| PCT/US2015/016928 WO2015127284A2 (en) | 2014-02-21 | 2015-02-20 | Antimitotic amides for the treatment of cancer and proliferative disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017506267A JP2017506267A (ja) | 2017-03-02 |
| JP2017506267A5 JP2017506267A5 (cg-RX-API-DMAC7.html) | 2018-04-05 |
| JP6506313B2 true JP6506313B2 (ja) | 2019-04-24 |
Family
ID=52684675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016570919A Active JP6506313B2 (ja) | 2014-02-21 | 2015-02-20 | 癌及び増殖性疾患の治療のための抗有糸分裂性アミド |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US10016398B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3107909B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6506313B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102420508B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN114634483B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2015218775C1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016019161B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2940237C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2893374T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL247293B (cg-RX-API-DMAC7.html) |
| MX (1) | MX390530B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2713179C2 (cg-RX-API-DMAC7.html) |
| SG (2) | SG11201606869TA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015127284A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201606471B (cg-RX-API-DMAC7.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6420622B1 (en) | 1997-08-01 | 2002-07-16 | 3M Innovative Properties Company | Medical article having fluid control film |
| CN114634483B (zh) | 2014-02-21 | 2024-08-13 | 弗洛斯特生物科技有限公司 | 用于治疗癌症和增殖性疾病的抗有丝分裂酰胺 |
| CN106727583A (zh) * | 2016-12-12 | 2017-05-31 | 范旭升 | 一种治疗舒张性心衰的药物组合物 |
| US11377436B2 (en) * | 2017-07-12 | 2022-07-05 | The Brigham And Women's Hospital, Inc. | EAAT2 enhancing molecules |
| US11760701B2 (en) | 2018-02-27 | 2023-09-19 | The Research Foundation For The State University Of New Yrok | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same |
| KR20250173438A (ko) * | 2024-05-30 | 2025-12-10 | 삼진제약주식회사 | Nr2f6 억제제 및 이의 용도 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0001930D0 (en) | 2000-01-27 | 2000-03-22 | Novartis Ag | Organic compounds |
| CN1433413A (zh) * | 2000-06-05 | 2003-07-30 | 东亚制药株式会社 | 新的噁唑烷酮衍生物及其制备方法 |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| GB0209715D0 (en) * | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| AU2005259488B2 (en) * | 2004-06-30 | 2009-10-01 | Novartis Ag | Method for increasing the susceptibility of peptide deformylase inhibitors by using efflux pump inhibitors |
| EP1921066A4 (en) * | 2005-08-11 | 2010-07-07 | Takeda Pharmaceutical | Pyridylphenol compound and its use |
| CA2640049A1 (en) * | 2006-01-31 | 2007-08-09 | Synta Pharmaceuticals Corp. | Pyridylphenyl compounds for inflammation and immune-related uses |
| EP2086966B1 (en) | 2006-11-17 | 2011-09-14 | GlaxoSmithKline LLC | 2-carboxy thiophene derivatives as anti viral agents |
| WO2008125839A2 (en) * | 2007-04-12 | 2008-10-23 | Piramed Limited | Pyrimidine derivatives as inhibitors of phosphatidylinositol-3-kinase |
| JP2012504603A (ja) * | 2008-10-01 | 2012-02-23 | シンタ ファーマシューティカルズ コーポレーション | 炎症および免疫関連の使用のための化合物 |
| WO2010100475A1 (en) * | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
| ES2528485T3 (es) * | 2009-09-11 | 2015-02-10 | Amgen, Inc | N-(4-((3-(2-amino-4-pirimidinil)-2-piridinil)oxi)fenil)-4-(4-metil-2-tienil)-1-ftalazinamina para su uso en el tratamiento del cáncer resistente a agentes antimitóticos |
| WO2011139489A2 (en) * | 2010-04-27 | 2011-11-10 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
| WO2011142151A1 (ja) * | 2010-05-14 | 2011-11-17 | シャープ株式会社 | 携帯型情報端末およびその制御方法 |
| TWI541243B (zh) * | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
| CN103380117A (zh) * | 2011-01-21 | 2013-10-30 | Abbvie公司 | 激酶的吡啶酰胺抑制剂 |
| CN103402985A (zh) * | 2011-02-10 | 2013-11-20 | 先正达参股股份有限公司 | 杀微生物的吡唑衍生物 |
| US9604978B2 (en) * | 2011-05-03 | 2017-03-28 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| CA2853485A1 (en) * | 2011-10-28 | 2013-05-02 | Synta Pharmaceuticals Corp. | Compounds for inflammation and immune-related uses |
| CN114634483B (zh) * | 2014-02-21 | 2024-08-13 | 弗洛斯特生物科技有限公司 | 用于治疗癌症和增殖性疾病的抗有丝分裂酰胺 |
-
2015
- 2015-02-20 CN CN202210190090.XA patent/CN114634483B/zh active Active
- 2015-02-20 JP JP2016570919A patent/JP6506313B2/ja active Active
- 2015-02-20 CA CA2940237A patent/CA2940237C/en active Active
- 2015-02-20 CN CN201580009889.2A patent/CN106068263A/zh active Pending
- 2015-02-20 US US15/120,470 patent/US10016398B2/en active Active
- 2015-02-20 BR BR112016019161-7A patent/BR112016019161B1/pt active IP Right Grant
- 2015-02-20 AU AU2015218775A patent/AU2015218775C1/en active Active
- 2015-02-20 ES ES15710328T patent/ES2893374T3/es active Active
- 2015-02-20 EP EP15710328.4A patent/EP3107909B1/en active Active
- 2015-02-20 SG SG11201606869TA patent/SG11201606869TA/en unknown
- 2015-02-20 WO PCT/US2015/016928 patent/WO2015127284A2/en not_active Ceased
- 2015-02-20 KR KR1020167026016A patent/KR102420508B1/ko active Active
- 2015-02-20 RU RU2016135555A patent/RU2713179C2/ru active
- 2015-02-20 MX MX2016010877A patent/MX390530B/es unknown
- 2015-02-20 SG SG10202000590SA patent/SG10202000590SA/en unknown
-
2016
- 2016-08-16 IL IL247293A patent/IL247293B/en active IP Right Grant
- 2016-09-20 ZA ZA2016/06471A patent/ZA201606471B/en unknown
-
2018
- 2018-06-29 US US16/024,407 patent/US10772872B2/en active Active
-
2020
- 2020-09-03 US US17/011,589 patent/US11129813B2/en active Active
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2021
- 2021-09-13 US US17/473,364 patent/US12383533B2/en active Active
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