JP6491213B2 - 疼痛および他の障害の治療のためのガンマ−アミノ酪酸（ｇａｂａ）類似体 - Google Patents

疼痛および他の障害の治療のためのガンマ−アミノ酪酸（ｇａｂａ）類似体 Download PDF

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JP6491213B2
JP6491213B2 JP2016540644A JP2016540644A JP6491213B2 JP 6491213 B2 JP6491213 B2 JP 6491213B2 JP 2016540644 A JP2016540644 A JP 2016540644A JP 2016540644 A JP2016540644 A JP 2016540644A JP 6491213 B2 JP6491213 B2 JP 6491213B2
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JP2017502020A5 (https=
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メグハニ，プレムジ
クリセク，フランツ
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ノヴァッセイ エスエー
ノヴァッセイ エスエー
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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JP2016540644A 2013-12-18 2014-12-16 疼痛および他の障害の治療のためのガンマ−アミノ酪酸（ｇａｂａ）類似体 Expired - Fee Related JP6491213B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361917623P 2013-12-18 2013-12-18
US61/917,623 2013-12-18
PCT/EP2014/077937 WO2015091463A1 (en) 2013-12-18 2014-12-16 Gamma-aminobutyric acid (gaba) analogues for the treatment of pain and other disorders

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JP2017502020A JP2017502020A (ja) 2017-01-19
JP2017502020A5 JP2017502020A5 (https=) 2018-02-01
JP6491213B2 true JP6491213B2 (ja) 2019-03-27

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US (2) US9663479B2 (https=)
EP (1) EP3083572B1 (https=)
JP (1) JP6491213B2 (https=)
KR (1) KR102031334B1 (https=)
CN (2) CN105899495B (https=)
AU (1) AU2014364693B2 (https=)
CA (1) CA2932050C (https=)
RU (1) RU2679407C1 (https=)
WO (1) WO2015091463A1 (https=)

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JP6491213B2 (ja) * 2013-12-18 2019-03-27 ノヴァッセイ エスエー 疼痛および他の障害の治療のためのガンマ−アミノ酪酸（ｇａｂａ）類似体
CN107667097B (zh) * 2015-05-27 2021-02-12 诺瓦色生物公司 3-乙基双环[3.2.0]庚-3-烯-6-酮的对映体的分离
CN110818582B (zh) * 2019-11-20 2023-06-09 合肥拓锐生物科技有限公司 一种gaba类似物及其盐，及其合成方法、应用、药物

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
HUT74380A (en) * 1993-04-01 1996-12-30 Univ Virginia 7-azabicyclo-[2.2.1]-heptane and -heptene derivatives pharmaceutical compositions containing them, and process for producing former compounds
DE19508459A1 (de) * 1995-03-09 1996-09-12 Wacker Chemie Gmbh Verfahren zur Herstellung von Alkylsilanen mit sperrigen Alkylresten
CN1131855C (zh) * 1997-12-16 2003-12-24 沃尼尔·朗伯公司 1－取代－1－氨基甲基－环烷衍生物(=加巴喷丁类似物)、其制备及其在治疗神经病方面的用途
US6620829B2 (en) * 2000-10-17 2003-09-16 Warner-Lambert Company Method of treating noninflammatory cartilage damage
NZ545494A (en) * 2003-09-12 2009-10-30 Pfizer Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
BRPI0818193B8 (pt) * 2007-09-28 2021-05-25 Daiichi Sankyo Co Ltd composto, composição farmacêutica, e, uso de um composto
WO2010079668A1 (ja) 2009-01-08 2010-07-15 第一三共株式会社 オレフィン化合物
JP5557292B2 (ja) 2009-03-26 2014-07-23 第一三共株式会社 二環性γ−アミノ酸誘導体の製造方法
CN104755465A (zh) * 2012-08-24 2015-07-01 武田药品工业株式会社 杂环化合物
TWI635071B (zh) * 2013-07-08 2018-09-11 第一三共股份有限公司 光學活性二環γ－胺基酸衍生物及其製造方法
JP6491213B2 (ja) * 2013-12-18 2019-03-27 ノヴァッセイ エスエー 疼痛および他の障害の治療のためのガンマ−アミノ酪酸（ｇａｂａ）類似体

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CA2932050A1 (en) 2015-06-25
CA2932050C (en) 2023-09-26
CN105899495B (zh) 2019-02-19
WO2015091463A1 (en) 2015-06-25
EP3083572B1 (en) 2019-02-13
KR102031334B1 (ko) 2019-10-11
US9750720B2 (en) 2017-09-05
US9663479B2 (en) 2017-05-30
JP2017502020A (ja) 2017-01-19
KR20160095166A (ko) 2016-08-10
EP3083572A1 (en) 2016-10-26
US20160318885A1 (en) 2016-11-03
US20170071909A1 (en) 2017-03-16
CN109721562A (zh) 2019-05-07
AU2014364693A1 (en) 2016-07-28
AU2014364693B2 (en) 2018-12-06
CN105899495A (zh) 2016-08-24
RU2679407C1 (ru) 2019-02-08

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