KR102031334B1 - 통증 및 기타 장애의 치료용의 감마-아미노뷰티르산(gaba) 유사체 - Google Patents

통증 및 기타 장애의 치료용의 감마-아미노뷰티르산(gaba) 유사체 Download PDF

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KR102031334B1
KR102031334B1 KR1020167019522A KR20167019522A KR102031334B1 KR 102031334 B1 KR102031334 B1 KR 102031334B1 KR 1020167019522 A KR1020167019522 A KR 1020167019522A KR 20167019522 A KR20167019522 A KR 20167019522A KR 102031334 B1 KR102031334 B1 KR 102031334B1
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KR20160095166A (ko
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프렘지 메가니
프란츠 크리첵
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노바쎄이 에스에이
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • C07C233/10—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
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    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
KR1020167019522A 2013-12-18 2014-12-16 통증 및 기타 장애의 치료용의 감마-아미노뷰티르산(gaba) 유사체 Active KR102031334B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361917623P 2013-12-18 2013-12-18
US61/917,623 2013-12-18
PCT/EP2014/077937 WO2015091463A1 (en) 2013-12-18 2014-12-16 Gamma-aminobutyric acid (gaba) analogues for the treatment of pain and other disorders

Publications (2)

Publication Number Publication Date
KR20160095166A KR20160095166A (ko) 2016-08-10
KR102031334B1 true KR102031334B1 (ko) 2019-10-11

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KR1020167019522A Active KR102031334B1 (ko) 2013-12-18 2014-12-16 통증 및 기타 장애의 치료용의 감마-아미노뷰티르산(gaba) 유사체

Country Status (9)

Country Link
US (2) US9663479B2 (https=)
EP (1) EP3083572B1 (https=)
JP (1) JP6491213B2 (https=)
KR (1) KR102031334B1 (https=)
CN (2) CN105899495B (https=)
AU (1) AU2014364693B2 (https=)
CA (1) CA2932050C (https=)
RU (1) RU2679407C1 (https=)
WO (1) WO2015091463A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6491213B2 (ja) * 2013-12-18 2019-03-27 ノヴァッセイ エスエー 疼痛および他の障害の治療のためのガンマ−アミノ酪酸（ｇａｂａ）類似体
CN107667097B (zh) * 2015-05-27 2021-02-12 诺瓦色生物公司 3-乙基双环[3.2.0]庚-3-烯-6-酮的对映体的分离
CN110818582B (zh) * 2019-11-20 2023-06-09 合肥拓锐生物科技有限公司 一种gaba类似物及其盐，及其合成方法、应用、药物

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HUT74380A (en) * 1993-04-01 1996-12-30 Univ Virginia 7-azabicyclo-[2.2.1]-heptane and -heptene derivatives pharmaceutical compositions containing them, and process for producing former compounds
DE19508459A1 (de) * 1995-03-09 1996-09-12 Wacker Chemie Gmbh Verfahren zur Herstellung von Alkylsilanen mit sperrigen Alkylresten
CN1131855C (zh) * 1997-12-16 2003-12-24 沃尼尔·朗伯公司 1－取代－1－氨基甲基－环烷衍生物(=加巴喷丁类似物)、其制备及其在治疗神经病方面的用途
US6620829B2 (en) * 2000-10-17 2003-09-16 Warner-Lambert Company Method of treating noninflammatory cartilage damage
NZ545494A (en) * 2003-09-12 2009-10-30 Pfizer Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
BRPI0818193B8 (pt) * 2007-09-28 2021-05-25 Daiichi Sankyo Co Ltd composto, composição farmacêutica, e, uso de um composto
WO2010079668A1 (ja) 2009-01-08 2010-07-15 第一三共株式会社 オレフィン化合物
JP5557292B2 (ja) 2009-03-26 2014-07-23 第一三共株式会社 二環性γ−アミノ酸誘導体の製造方法
CN104755465A (zh) * 2012-08-24 2015-07-01 武田药品工业株式会社 杂环化合物
TWI635071B (zh) * 2013-07-08 2018-09-11 第一三共股份有限公司 光學活性二環γ－胺基酸衍生物及其製造方法
JP6491213B2 (ja) * 2013-12-18 2019-03-27 ノヴァッセイ エスエー 疼痛および他の障害の治療のためのガンマ−アミノ酪酸（ｇａｂａ）類似体

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CA2932050A1 (en) 2015-06-25
CA2932050C (en) 2023-09-26
CN105899495B (zh) 2019-02-19
WO2015091463A1 (en) 2015-06-25
EP3083572B1 (en) 2019-02-13
US9750720B2 (en) 2017-09-05
US9663479B2 (en) 2017-05-30
JP2017502020A (ja) 2017-01-19
KR20160095166A (ko) 2016-08-10
EP3083572A1 (en) 2016-10-26
US20160318885A1 (en) 2016-11-03
US20170071909A1 (en) 2017-03-16
CN109721562A (zh) 2019-05-07
AU2014364693A1 (en) 2016-07-28
AU2014364693B2 (en) 2018-12-06
CN105899495A (zh) 2016-08-24
JP6491213B2 (ja) 2019-03-27
RU2679407C1 (ru) 2019-02-08

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