JP6479505B2 - 皮膚治療用組成物 - Google Patents
皮膚治療用組成物 Download PDFInfo
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- JP6479505B2 JP6479505B2 JP2015042351A JP2015042351A JP6479505B2 JP 6479505 B2 JP6479505 B2 JP 6479505B2 JP 2015042351 A JP2015042351 A JP 2015042351A JP 2015042351 A JP2015042351 A JP 2015042351A JP 6479505 B2 JP6479505 B2 JP 6479505B2
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- Prior art keywords
- arbutin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- Epidemiology (AREA)
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Description
純水を窒素ガス下で予混合タンクに加えた。以下の水相成分(メチルパラベン、エデト酸二ナトリウム、グリセリン、ラウリル硫酸ナトリウム、サポニン、乳酸88%、アスコルビン酸、メタ重亜硫酸ナトリウム、アルブチン)を穏やかに加熱しながら表1に示した量で加え、約70〜75℃で混合して均一分散させた。以下の油相成分(セチルアルコール、ステアリルアルコール、プロピルパラベン、ブチルパラベン、酢酸トコフェロール、およびBHT)を約70〜75℃でタンクに表1に示した量で混合した。次いで、全内容物を窒素ガス下でジャケットタンクに移し、油相と水相とを混合し、冷却し、乳剤を生成した。使用前に全溶媒を窒素で脱ガスし、全ての調合物および中間調合物を脱ガスした。アルブチン含有調合物を、容器に充填する前後に窒素でパージした貯蔵容器に移した。
混合実施形態
18歳〜60歳の10人のボランティアが試験に参加した。本試験に含まれるボランティアは、フィッツパトリックフォトタイプIII以上の家系のアジア人または白人であった。参加した対象は、医学研究者の意見において、試験の遂行、結果の解釈を妨げ得る、あるいは、有害反応のリスクを増加させ得るアレルギーもしくは他の内科疾患の公知の履歴を含む、あらゆる全身性疾患または皮膚疾患がなかった。さらに、ボランティアは、病歴に基づいて、研究者によって判断した際に試験参加に影響を及ぼし得る臨床的に著しく異常な所見は見られなかった。選ばれた女性ボランティアは、妊娠しておらず(試験開始時およびその後4週間ごとに尿妊娠試験で評価)、試験期間中には適当な避妊法を用いることに同意した。ボランティア全員は、試験期間中に、あらゆる薬剤、保湿剤、日焼け止め剤、芳香剤、または新規のパーソナルケア製品/洗濯洗剤の背中への使用を控えることを快諾し、なおかつ、試験期間中に、背中への日光暴露(即ち、日光浴)をできる限り避け、日焼け室の使用も控えることを快諾した。さらに、対象は、試験期間中に水泳を避けることに同意した。
実施例1 7%アルブチン 10mg/cm2
実施例2 7%アルブチン 10mg/cm2または5mg/cm2**
実施例1A 4%アルブチン 10mg/cm2
実施例2A 4%アルブチン 10mg/cm2
漂白兼補正クリーム*
4%ヒドロキノン 10mg/cm2
ブレンダー* 4%ヒドロキノン 10mg/cm2または5mg/cm2**
トナー* 10μL/cm2
カチオントナー*** 10μL/cm2
0.025%トレチノイン 5mg/cm2
*OMP,Inc.,Long Beach,CAから市販
**0.025%トレチノインと併用した場合
***公開米国特許出願第2007/0269534A1号の実施例1を参照されたい(その内容全体を引用により本明細書に組み込む)
Claims (8)
- 皮膚の美白、つや、又は明るさの促進に使用するためのアルブチン含有組成物であって、前記組成物は、水相及び油相を含み、
前記水相は、水と、美白剤と、防腐剤と、キレート剤と、湿潤剤と、乳化剤と、pH調整剤と及び還元剤と、を含み、
前記美白剤は、全組成物の5〜10重量%のアルブチンであり、
前記防腐剤は、全組成物の0.01〜5重量%の防腐剤であり、
前記キレート剤は、全組成物の0.01〜5重量%の量のキレート剤であり、
前記湿潤剤は、全組成物の1〜20重量%の量であり、
前記乳化剤は、全組成物の2〜5重量%の量であり、
前記pH調整剤は、全組成物の0.01〜5重量%の量であり、且つ
前記還元剤は、全組成物の0.1〜10重量%の量である、ことを特徴とし、
前記油相は、皮膚軟化剤と、酸化防止剤と、を含み、
前記皮膚軟化剤は、全組成物の2〜25重量%の量であり、且つ
前記酸化防止剤は、全組成物の0.1〜2重量%の量である、ことを特徴とし、且つ
前記組成物は、カチオントナ―及びトレチノインと組合せて使用され、前記トレチノインは、0.025重量%であり、前記カチオントナ―は、前記アルブチン含有組成物を適用する前に使用されることを特徴とする、
アルブチン含有組成物。 - 前記水相において、
前記防腐剤とは、メチルパラベン、プロピルパラベン、ブチルパラベン、又はそれらの組合せであり、
前記キレート剤とは、エデト酸二ナトリウムであり、
前記湿潤剤とは、グリセリンであり、
前記乳化剤とは、ラウリル硫酸ナトリウム、サポニン、トリエタノールアミンサリチレート、又はそれらの組合せであり、
前記pH調整剤とは、乳酸であり、且つ
前記還元剤とは、メタ重亜硫酸ナトリウム、アスコルビン酸、又はそれらの組合せである、
請求項1に記載のアルブチン含有組成物。 - 前記油相において、
前記皮膚軟化剤とは、セチルアルコール、ステアリルアルコール、又はそれらの組合せであり、
前記酸化防止剤とは、酢酸トコフェロール、ブチル化ヒドロキシトルエン(BHT)、又はそれらの組合せである、
請求項1に記載のアルブチン含有組成物。 - 2,500〜35,000cpsの粘度を有する請求項1に記載のアルブチン含有組成物。
- 0.90〜1.05の比重を有する請求項1に記載のアルブチン含有組成物。
- 前記全組成物の7重量%の量のアルブチンを含む、請求項1〜5のいずれか1項に記載のアルブチン含有組成物。
- 前記組成物が実質的に白色及び/又は準粘性を有する、請求項1〜6のいずれか1項に記載のアルブチン含有組成物。
- 前記組成物を1日1回、少なくとも8週間にわたって肌に塗布する、請求項1〜7のいずれか1項に記載のアルブチン含有組成物。
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EP (1) | EP2209458B1 (ja) |
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CA (1) | CA2705573C (ja) |
ES (1) | ES2687406T3 (ja) |
MX (1) | MX2010005285A (ja) |
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JP6071166B2 (ja) | 2017-02-01 |
EP2209458A1 (en) | 2010-07-28 |
CA2705573A1 (en) | 2009-05-22 |
JP2015129174A (ja) | 2015-07-16 |
BRPI0820252B1 (pt) | 2020-09-24 |
US9168398B2 (en) | 2015-10-27 |
CN101938974A (zh) | 2011-01-05 |
BRPI0820252A2 (pt) | 2018-06-12 |
US20100303747A1 (en) | 2010-12-02 |
US20160067165A1 (en) | 2016-03-10 |
US9883998B2 (en) | 2018-02-06 |
MX2010005285A (es) | 2010-06-02 |
PL2209458T3 (pl) | 2019-01-31 |
CA2705573C (en) | 2015-06-16 |
KR101295789B1 (ko) | 2013-08-12 |
EP2209458B1 (en) | 2018-06-20 |
KR20100074308A (ko) | 2010-07-01 |
ES2687406T3 (es) | 2018-10-25 |
EP2209458A4 (en) | 2014-08-13 |
WO2009065008A1 (en) | 2009-05-22 |
JP2011503205A (ja) | 2011-01-27 |
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