JP6444882B2 - 心不全治療用の合成鎖状アペリン模倣物 - Google Patents
心不全治療用の合成鎖状アペリン模倣物 Download PDFInfo
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- JP6444882B2 JP6444882B2 JP2015543111A JP2015543111A JP6444882B2 JP 6444882 B2 JP6444882 B2 JP 6444882B2 JP 2015543111 A JP2015543111 A JP 2015543111A JP 2015543111 A JP2015543111 A JP 2015543111A JP 6444882 B2 JP6444882 B2 JP 6444882B2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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| US61/781,397 | 2013-03-14 | ||
| US201361858251P | 2013-07-25 | 2013-07-25 | |
| US61/858,251 | 2013-07-25 | ||
| PCT/US2013/070742 WO2014081702A2 (en) | 2012-11-20 | 2013-11-19 | Synthetic linear apelin mimetics for the treatment of heart failure |
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| WO2015013165A1 (en) | 2013-07-25 | 2015-01-29 | Novartis Ag | Cyclic apelin derivatives for the treatment of heart failure |
| CN105612174A (zh) | 2013-07-25 | 2016-05-25 | 诺华股份有限公司 | 用于治疗心力衰竭的二硫化物环状多肽 |
| SG11201609706VA (en) | 2014-06-23 | 2017-01-27 | Novartis Ag | Site specific protein modifications |
| US10588980B2 (en) | 2014-06-23 | 2020-03-17 | Novartis Ag | Fatty acids and their use in conjugation to biomolecules |
| WO2016102648A1 (en) * | 2014-12-23 | 2016-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Metabolically stable apelin analogs in the treatment of disease mediated by the apelin receptor |
| ES2930077T3 (es) | 2016-02-15 | 2022-12-07 | Inst Nat Sante Rech Med | Apelina para su uso en el tratamiento de la disfunción cognitiva posoperatoria |
| JOP20190245A1 (ar) | 2017-04-20 | 2019-10-15 | Novartis Ag | أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط |
| US10640545B2 (en) | 2017-07-03 | 2020-05-05 | The Governors Of The Univ Of Alberta Tec Edmonton | Apelin peptides and uses thereof |
| CN109771634A (zh) * | 2017-07-11 | 2019-05-21 | 南华大学 | 含有apelin 12环肽的药物组合物及用途 |
| US10905738B2 (en) * | 2018-07-05 | 2021-02-02 | Biozeus Desenvolvimento De Produtos Biofarmacêuticos | Synthetic peptides, prodrugs, pharmaceutical compositions and uses |
| TW202120524A (zh) * | 2019-08-15 | 2021-06-01 | 美商寇峇有限公司 | 治療性肽 |
| CN114099642A (zh) * | 2021-11-12 | 2022-03-01 | 南通大学 | 基因Apln在制备治疗与细胞成血管有关疾病药物中的应用 |
| WO2026007692A1 (zh) * | 2024-07-05 | 2026-01-08 | 浙江大学 | Apelin-13多肽突变体 |
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| JP2018172410A (ja) | 2018-11-08 |
| WO2014081702A3 (en) | 2014-07-17 |
| AR093559A1 (es) | 2015-06-10 |
| US10005829B2 (en) | 2018-06-26 |
| EP2922559A2 (en) | 2015-09-30 |
| EP2922559B1 (en) | 2018-10-10 |
| CN105007928B (zh) | 2018-03-20 |
| UY35144A (es) | 2014-06-30 |
| CN105007928A (zh) | 2015-10-28 |
| JP2016501851A (ja) | 2016-01-21 |
| ES2705323T3 (es) | 2019-03-22 |
| WO2014081702A4 (en) | 2014-09-04 |
| TW201425339A (zh) | 2014-07-01 |
| WO2014081702A2 (en) | 2014-05-30 |
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