JP6389238B2 - Ｎ−（４−｛［６，７−ビス（メンチルオキシ）キノリン−４−イル］オキシ｝フェニル）−ｎ’−（４−フルオロフェニル）サイクロプロペイン−１，１−ジカルボキシアミドのメタボライト - Google Patents

Ｎ−（４−｛［６，７−ビス（メンチルオキシ）キノリン−４−イル］オキシ｝フェニル）−ｎ’−（４−フルオロフェニル）サイクロプロペイン−１，１−ジカルボキシアミドのメタボライト Download PDF

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JP6389238B2
JP6389238B2 JP2016503412A JP2016503412A JP6389238B2 JP 6389238 B2 JP6389238 B2 JP 6389238B2 JP 2016503412 A JP2016503412 A JP 2016503412A JP 2016503412 A JP2016503412 A JP 2016503412A JP 6389238 B2 JP6389238 B2 JP 6389238B2
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metabolite
pharmaceutically acceptable
acceptable salt
cabozantinib
compound
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JP2016516074A (ja
JP2016516074A5 (enExample
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ダナ ティー． アフタブ，
ダナ ティー． アフタブ，
スリラム ナガナサン，
スリラム ナガナサン，
ウェイ シュー，
ウェイ シュー，
スティーブン レイシー，
スティーブン レイシー，
リン グウェン，
リン グウェン，
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エグゼリクシス， インコーポレイテッド
エグゼリクシス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/22—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings
    • C07C305/24—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pain & Pain Management (AREA)
JP2016503412A 2013-03-15 2014-03-17 Ｎ−（４−｛［６，７−ビス（メンチルオキシ）キノリン−４−イル］オキシ｝フェニル）−ｎ’−（４−フルオロフェニル）サイクロプロペイン−１，１−ジカルボキシアミドのメタボライト Active JP6389238B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361792413P 2013-03-15 2013-03-15
US61/792,413 2013-03-15
PCT/US2014/030524 WO2014145715A1 (en) 2013-03-15 2014-03-17 Metabolites of n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide

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JP2016516074A JP2016516074A (ja) 2016-06-02
JP2016516074A5 JP2016516074A5 (enExample) 2017-04-20
JP6389238B2 true JP6389238B2 (ja) 2018-09-12

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US (4) US10273211B2 (enExample)
EP (1) EP2970126B1 (enExample)
JP (1) JP6389238B2 (enExample)
KR (1) KR102276348B1 (enExample)
CN (1) CN105121412B (enExample)
AU (2) AU2014232714B2 (enExample)
BR (1) BR112015023109A2 (enExample)
CA (1) CA2907334C (enExample)
EA (1) EA033786B1 (enExample)
ES (1) ES2729626T3 (enExample)
GE (2) GEP20196995B (enExample)
IL (1) IL241577B (enExample)
MX (1) MX366003B (enExample)
NZ (1) NZ712330A (enExample)
UA (1) UA119321C2 (enExample)
WO (1) WO2014145715A1 (enExample)
ZA (1) ZA201506842B (enExample)

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Also Published As

Publication number Publication date
JP2016516074A (ja) 2016-06-02
KR102276348B1 (ko) 2021-07-12
KR20150130376A (ko) 2015-11-23
WO2014145715A1 (en) 2014-09-18
MX2015012490A (es) 2016-05-24
GEP20196995B (en) 2019-07-25
IL241577B (en) 2019-11-28
US20160031818A1 (en) 2016-02-04
HK1220447A1 (en) 2017-05-05
EP2970126A1 (en) 2016-01-20
NZ712330A (en) 2020-04-24
EA201591756A1 (ru) 2016-02-29
US20210002228A1 (en) 2021-01-07
AU2014232714B2 (en) 2018-07-19
CA2907334C (en) 2021-12-07
ZA201506842B (en) 2017-08-30
AU2018204666A1 (en) 2018-07-19
CN105121412B (zh) 2019-07-12
US10273211B2 (en) 2019-04-30
UA119321C2 (uk) 2019-06-10
AU2014232714A1 (en) 2015-10-08
US20190218182A1 (en) 2019-07-18
CN105121412A (zh) 2015-12-02
US20240287002A1 (en) 2024-08-29
CA2907334A1 (en) 2014-09-18
BR112015023109A2 (en) 2018-05-15
ES2729626T3 (es) 2019-11-05
GEAP201913960A (en) 2019-04-10
MX366003B (es) 2019-06-24
EA033786B1 (ru) 2019-11-26
EP2970126B1 (en) 2019-03-06

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