AU2014232714B2 - Metabolites of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide - Google Patents

Metabolites of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide Download PDF

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AU2014232714B2
AU2014232714B2 AU2014232714A AU2014232714A AU2014232714B2 AU 2014232714 B2 AU2014232714 B2 AU 2014232714B2 AU 2014232714 A AU2014232714 A AU 2014232714A AU 2014232714 A AU2014232714 A AU 2014232714A AU 2014232714 B2 AU2014232714 B2 AU 2014232714B2
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metabolite
cabozantinib
pharmaceutically acceptable
jun2018
acceptable salt
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AU2014232714A1 (en
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Dana T. Aftab
Steven LACY
Sriram Naganathan
Linh Nguyen
Wei Xu
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Exelixis Inc
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Exelixis Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/22—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings
    • C07C305/24—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to carbon atoms of six-membered aromatic rings of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pain & Pain Management (AREA)
AU2014232714A 2013-03-15 2014-03-17 Metabolites of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide Active AU2014232714B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018204666A AU2018204666A1 (en) 2013-03-15 2018-06-27 Metabolites of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361792413P 2013-03-15 2013-03-15
US61/792,413 2013-03-15
PCT/US2014/030524 WO2014145715A1 (en) 2013-03-15 2014-03-17 Metabolites of n-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide

Related Child Applications (1)

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AU2018204666A Division AU2018204666A1 (en) 2013-03-15 2018-06-27 Metabolites of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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AU2014232714A1 AU2014232714A1 (en) 2015-10-08
AU2014232714B2 true AU2014232714B2 (en) 2018-07-19

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AU2014232714A Active AU2014232714B2 (en) 2013-03-15 2014-03-17 Metabolites of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide
AU2018204666A Abandoned AU2018204666A1 (en) 2013-03-15 2018-06-27 Metabolites of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

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US (4) US10273211B2 (enExample)
EP (1) EP2970126B1 (enExample)
JP (1) JP6389238B2 (enExample)
KR (1) KR102276348B1 (enExample)
CN (1) CN105121412B (enExample)
AU (2) AU2014232714B2 (enExample)
BR (1) BR112015023109A2 (enExample)
CA (1) CA2907334C (enExample)
EA (1) EA033786B1 (enExample)
ES (1) ES2729626T3 (enExample)
GE (2) GEP20196995B (enExample)
IL (1) IL241577B (enExample)
MX (1) MX366003B (enExample)
NZ (1) NZ712330A (enExample)
UA (1) UA119321C2 (enExample)
WO (1) WO2014145715A1 (enExample)
ZA (1) ZA201506842B (enExample)

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CN107556238A (zh) * 2016-06-30 2018-01-09 深圳万乐药业有限公司 一种卡博替尼的合成方法
HRP20251184T1 (hr) 2018-01-26 2025-12-05 Exelixis, Inc. Spojevi za liječenje poremećaja ovisnih o kinazi
TWI787523B (zh) 2018-06-15 2022-12-21 漢達生技醫藥股份有限公司 達沙替尼十二烷基硫酸鹽之結晶
CN110423218A (zh) * 2019-08-09 2019-11-08 新乡双鹭药业有限公司 一种苹果酸卡博替尼合成中杂质的制备方法
CN114685368A (zh) * 2020-12-29 2022-07-01 南京佰麦生物技术有限公司 一种仑伐替尼n-氧化物杂质的制备方法
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KR20250136810A (ko) 2023-01-31 2025-09-16 한다 온콜로지, 엘엘씨 개선된 카보잔티닙 조성물 및 사용 방법

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JP2016516074A (ja) 2016-06-02
KR102276348B1 (ko) 2021-07-12
KR20150130376A (ko) 2015-11-23
WO2014145715A1 (en) 2014-09-18
MX2015012490A (es) 2016-05-24
GEP20196995B (en) 2019-07-25
IL241577B (en) 2019-11-28
US20160031818A1 (en) 2016-02-04
HK1220447A1 (en) 2017-05-05
EP2970126A1 (en) 2016-01-20
NZ712330A (en) 2020-04-24
EA201591756A1 (ru) 2016-02-29
US20210002228A1 (en) 2021-01-07
CA2907334C (en) 2021-12-07
ZA201506842B (en) 2017-08-30
AU2018204666A1 (en) 2018-07-19
CN105121412B (zh) 2019-07-12
US10273211B2 (en) 2019-04-30
UA119321C2 (uk) 2019-06-10
AU2014232714A1 (en) 2015-10-08
US20190218182A1 (en) 2019-07-18
CN105121412A (zh) 2015-12-02
US20240287002A1 (en) 2024-08-29
CA2907334A1 (en) 2014-09-18
BR112015023109A2 (en) 2018-05-15
ES2729626T3 (es) 2019-11-05
GEAP201913960A (en) 2019-04-10
MX366003B (es) 2019-06-24
JP6389238B2 (ja) 2018-09-12
EA033786B1 (ru) 2019-11-26
EP2970126B1 (en) 2019-03-06

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