JP6355648B2 - Wntシグナル伝達経路の3−(ベンゾイミダゾール−2−イル)−インダゾール阻害剤およびそれらの治療的使用 - Google Patents
Wntシグナル伝達経路の3−(ベンゾイミダゾール−2−イル)−インダゾール阻害剤およびそれらの治療的使用 Download PDFInfo
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- JP6355648B2 JP6355648B2 JP2015551853A JP2015551853A JP6355648B2 JP 6355648 B2 JP6355648 B2 JP 6355648B2 JP 2015551853 A JP2015551853 A JP 2015551853A JP 2015551853 A JP2015551853 A JP 2015551853A JP 6355648 B2 JP6355648 B2 JP 6355648B2
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- alkyl
- cancer
- disease
- pyridin
- syndrome
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- 0 *c1cccc(-c2c[s]cc2)c1N Chemical compound *c1cccc(-c2c[s]cc2)c1N 0.000 description 2
- BCUALCDSQFXRGN-UHFFFAOYSA-N Bc1cncc(CN2CCCC2)c1 Chemical compound Bc1cncc(CN2CCCC2)c1 BCUALCDSQFXRGN-UHFFFAOYSA-N 0.000 description 1
- LCSVAHIPMYKDKJ-UHFFFAOYSA-N Bc1cncc(NC(C(CC)CC)=O)c1 Chemical compound Bc1cncc(NC(C(CC)CC)=O)c1 LCSVAHIPMYKDKJ-UHFFFAOYSA-N 0.000 description 1
- DNJVSCHWUBIRFU-QFMYHPSQSA-N C/C=C(/C)\C(\c(cc1)cc2c1[nH]nc2-c1nc(c(-c(cc2)ccc2F)ccc2)c2[nH]1)=C/N=C Chemical compound C/C=C(/C)\C(\c(cc1)cc2c1[nH]nc2-c1nc(c(-c(cc2)ccc2F)ccc2)c2[nH]1)=C/N=C DNJVSCHWUBIRFU-QFMYHPSQSA-N 0.000 description 1
- QUFYXRYFSATNBX-XILPRMTJSA-N CC(C(C1=C2)NN=C1c1nc(cccc3)c3[nH]1)C=C2/C(/C=C(\C)/NC(CC(C)(C)C)=O)=C/N=C Chemical compound CC(C(C1=C2)NN=C1c1nc(cccc3)c3[nH]1)C=C2/C(/C=C(\C)/NC(CC(C)(C)C)=O)=C/N=C QUFYXRYFSATNBX-XILPRMTJSA-N 0.000 description 1
- APLXZANZLFGRSE-UHFFFAOYSA-N CC(C)(C)C[IH](Nc1cc(-c(cc23)ccc2[nH]nc3-c2nc(c(-c3cccc(F)c3)ccc3)c3[nH]2)cnc1)=O Chemical compound CC(C)(C)C[IH](Nc1cc(-c(cc23)ccc2[nH]nc3-c2nc(c(-c3cccc(F)c3)ccc3)c3[nH]2)cnc1)=O APLXZANZLFGRSE-UHFFFAOYSA-N 0.000 description 1
- OOGWQLZAIFYMND-UHFFFAOYSA-N CC(C)C(Nc1cncc(-c(cc2)cc3c2[nH]nc3-c([nH]c2ccc3)nc2c3-c(cc2)ccc2F)c1)=O Chemical compound CC(C)C(Nc1cncc(-c(cc2)cc3c2[nH]nc3-c([nH]c2ccc3)nc2c3-c(cc2)ccc2F)c1)=O OOGWQLZAIFYMND-UHFFFAOYSA-N 0.000 description 1
- JMALIHBPDDYPJF-WSDLNYQXSA-N CCCC(N/C(/C=C(C)C)=C/Cc(cc1)cc2c1[nH]nc2-c1nc(c(N2CCN(C)CC2)ccc2)c2[nH]1)=O Chemical compound CCCC(N/C(/C=C(C)C)=C/Cc(cc1)cc2c1[nH]nc2-c1nc(c(N2CCN(C)CC2)ccc2)c2[nH]1)=O JMALIHBPDDYPJF-WSDLNYQXSA-N 0.000 description 1
- ZOFIECLEPFCGPS-UHFFFAOYSA-N CCCC(Nc1cc(-c(cc23)ccc2[nH]nc3-c2nc(c(-c(cc3)ccc3F)ccc3)c3[nH]2)cnc1)=O Chemical compound CCCC(Nc1cc(-c(cc23)ccc2[nH]nc3-c2nc(c(-c(cc3)ccc3F)ccc3)c3[nH]2)cnc1)=O ZOFIECLEPFCGPS-UHFFFAOYSA-N 0.000 description 1
- CIBXHKMACXAHKO-UHFFFAOYSA-N CCCCC(Nc1cc(-c(cc2)cc3c2[nH]nc3-c2nc3ccccc3[nH]2)cnc1)=O Chemical compound CCCCC(Nc1cc(-c(cc2)cc3c2[nH]nc3-c2nc3ccccc3[nH]2)cnc1)=O CIBXHKMACXAHKO-UHFFFAOYSA-N 0.000 description 1
- UYDYXBDAPGBFNR-UHFFFAOYSA-N CCCCC(Nc1cc(Br)cnc1)=O Chemical compound CCCCC(Nc1cc(Br)cnc1)=O UYDYXBDAPGBFNR-UHFFFAOYSA-N 0.000 description 1
- UHFLNMAGEOIGDM-UHFFFAOYSA-N CCNCc1cc(-c(cc23)ccc2[nH]nc3-c([nH]c2ccc3)nc2c3-c(cccc2)c2F)cnc1 Chemical compound CCNCc1cc(-c(cc23)ccc2[nH]nc3-c([nH]c2ccc3)nc2c3-c(cccc2)c2F)cnc1 UHFLNMAGEOIGDM-UHFFFAOYSA-N 0.000 description 1
- CWSKKDGBMSJFAJ-UHFFFAOYSA-N Cc(nc1)c[n]1-c1cccc2c1nc(-c(c1c3)n[nH]c1ccc3-c1cncc(NC(C3CCCC3)=O)c1)[nH]2 Chemical compound Cc(nc1)c[n]1-c1cccc2c1nc(-c(c1c3)n[nH]c1ccc3-c1cncc(NC(C3CCCC3)=O)c1)[nH]2 CWSKKDGBMSJFAJ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361750221P | 2013-01-08 | 2013-01-08 | |
| US61/750,221 | 2013-01-08 | ||
| PCT/US2014/010607 WO2014110086A2 (en) | 2013-01-08 | 2014-01-08 | 3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016504387A JP2016504387A (ja) | 2016-02-12 |
| JP2016504387A5 JP2016504387A5 (enExample) | 2017-02-16 |
| JP6355648B2 true JP6355648B2 (ja) | 2018-07-11 |
Family
ID=51061428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551853A Active JP6355648B2 (ja) | 2013-01-08 | 2014-01-08 | Wntシグナル伝達経路の3−(ベンゾイミダゾール−2−イル)−インダゾール阻害剤およびそれらの治療的使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9908867B2 (enExample) |
| EP (1) | EP2943198B1 (enExample) |
| JP (1) | JP6355648B2 (enExample) |
| CN (1) | CN105120862A (enExample) |
| CA (1) | CA2897400A1 (enExample) |
| MX (1) | MX370487B (enExample) |
| WO (1) | WO2014110086A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2987487T3 (da) | 2009-08-10 | 2020-12-07 | Samumed Llc | Indazolinhibitorer af wnt-signalvejen og terapeutiske anvendelser deraf |
| NO3001903T3 (enExample) | 2009-12-21 | 2018-03-24 | ||
| PT2755483T (pt) | 2011-09-14 | 2019-02-18 | Samumed Llc | Indazol-3-carboxamidas e sua utilização como inibidores da via de sinalização de wnt/β-catenina |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| PT2770994T (pt) | 2012-05-04 | 2019-11-04 | Samumed Llc | 1h-pirazolo[3,4-b]piridinas e utilizações terapêuticas destas |
| MX370487B (es) | 2013-01-08 | 2019-12-16 | Samumed Llc | Inhibidores de 3-(benzo-imidazol-2-il)-indazol de la senda de señalización de wnt y usos terapéuticos de los mismos. |
| WO2016040185A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
| WO2016040193A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| WO2016040188A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040182A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof |
| WO2016040180A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040184A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040190A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| ES2928084T3 (es) | 2015-02-20 | 2022-11-15 | Rigel Pharmaceuticals Inc | Inhibidores de GDF-8 |
| WO2017024003A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10350199B2 (en) | 2015-08-03 | 2019-07-16 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
| US10206909B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| WO2017023987A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| WO2017023993A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-indol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10329309B2 (en) | 2015-08-03 | 2019-06-25 | Samumed, Llc | 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| WO2017023989A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| WO2017023975A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| WO2017024025A1 (en) | 2015-08-03 | 2017-02-09 | Sunil Kumar Kc | 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10285983B2 (en) | 2015-08-03 | 2019-05-14 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof |
| WO2017024026A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| WO2017023980A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| WO2017023984A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| US10195185B2 (en) | 2015-08-03 | 2019-02-05 | Samumed, Llc | 3-(1H-imidazo[4,5-C]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| US10188634B2 (en) | 2015-08-03 | 2019-01-29 | Samumed, Llc | 3-(3H-imidazo[4,5-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
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| WO2016040185A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
| WO2016040182A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof |
| US10350199B2 (en) | 2015-08-03 | 2019-07-16 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
| NZ742200A (en) | 2015-11-06 | 2023-01-27 | Samumed Llc | Treatment of osteoarthritis |
| AU2017274350B2 (en) | 2016-06-01 | 2022-03-03 | Samumed, Llc | Process for preparing N-(5-(3-(7-(3-fluorophenyl)-3H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide |
| CA3041291A1 (en) | 2016-10-21 | 2018-04-26 | Samumed, Llc | Methods of using indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors |
| WO2018085865A1 (en) | 2016-11-07 | 2018-05-11 | Samumed, Llc | Single-dose, ready-to-use injectable formulations |
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2014
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- 2014-01-08 EP EP14737972.1A patent/EP2943198B1/en active Active
- 2014-01-08 WO PCT/US2014/010607 patent/WO2014110086A2/en not_active Ceased
- 2014-01-08 CA CA2897400A patent/CA2897400A1/en not_active Abandoned
- 2014-01-08 US US14/149,948 patent/US9908867B2/en active Active
- 2014-01-08 CN CN201480013031.9A patent/CN105120862A/zh active Pending
- 2014-01-08 JP JP2015551853A patent/JP6355648B2/ja active Active
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2018
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Also Published As
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|---|---|
| CA2897400A1 (en) | 2014-07-17 |
| US20190352279A1 (en) | 2019-11-21 |
| WO2014110086A3 (en) | 2014-10-09 |
| WO2014110086A2 (en) | 2014-07-17 |
| JP2016504387A (ja) | 2016-02-12 |
| US20140194441A1 (en) | 2014-07-10 |
| EP2943198A2 (en) | 2015-11-18 |
| US10654832B2 (en) | 2020-05-19 |
| US10183929B2 (en) | 2019-01-22 |
| EP2943198B1 (en) | 2019-07-17 |
| MX370487B (es) | 2019-12-16 |
| US9908867B2 (en) | 2018-03-06 |
| EP2943198A4 (en) | 2016-08-03 |
| US20180162840A1 (en) | 2018-06-14 |
| CN105120862A (zh) | 2015-12-02 |
| MX2015008860A (es) | 2016-04-04 |
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