JP6355648B2 - Wntシグナル伝達経路の3−(ベンゾイミダゾール−2−イル)−インダゾール阻害剤およびそれらの治療的使用 - Google Patents
Wntシグナル伝達経路の3−(ベンゾイミダゾール−2−イル)−インダゾール阻害剤およびそれらの治療的使用 Download PDFInfo
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- JP6355648B2 JP6355648B2 JP2015551853A JP2015551853A JP6355648B2 JP 6355648 B2 JP6355648 B2 JP 6355648B2 JP 2015551853 A JP2015551853 A JP 2015551853A JP 2015551853 A JP2015551853 A JP 2015551853A JP 6355648 B2 JP6355648 B2 JP 6355648B2
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- alkyl
- cancer
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- pyridin
- syndrome
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- 0 *c1cccc(-c2c[s]cc2)c1N Chemical compound *c1cccc(-c2c[s]cc2)c1N 0.000 description 2
- BCUALCDSQFXRGN-UHFFFAOYSA-N Bc1cncc(CN2CCCC2)c1 Chemical compound Bc1cncc(CN2CCCC2)c1 BCUALCDSQFXRGN-UHFFFAOYSA-N 0.000 description 1
- LCSVAHIPMYKDKJ-UHFFFAOYSA-N Bc1cncc(NC(C(CC)CC)=O)c1 Chemical compound Bc1cncc(NC(C(CC)CC)=O)c1 LCSVAHIPMYKDKJ-UHFFFAOYSA-N 0.000 description 1
- DNJVSCHWUBIRFU-QFMYHPSQSA-N C/C=C(/C)\C(\c(cc1)cc2c1[nH]nc2-c1nc(c(-c(cc2)ccc2F)ccc2)c2[nH]1)=C/N=C Chemical compound C/C=C(/C)\C(\c(cc1)cc2c1[nH]nc2-c1nc(c(-c(cc2)ccc2F)ccc2)c2[nH]1)=C/N=C DNJVSCHWUBIRFU-QFMYHPSQSA-N 0.000 description 1
- QUFYXRYFSATNBX-XILPRMTJSA-N CC(C(C1=C2)NN=C1c1nc(cccc3)c3[nH]1)C=C2/C(/C=C(\C)/NC(CC(C)(C)C)=O)=C/N=C Chemical compound CC(C(C1=C2)NN=C1c1nc(cccc3)c3[nH]1)C=C2/C(/C=C(\C)/NC(CC(C)(C)C)=O)=C/N=C QUFYXRYFSATNBX-XILPRMTJSA-N 0.000 description 1
- APLXZANZLFGRSE-UHFFFAOYSA-N CC(C)(C)C[IH](Nc1cc(-c(cc23)ccc2[nH]nc3-c2nc(c(-c3cccc(F)c3)ccc3)c3[nH]2)cnc1)=O Chemical compound CC(C)(C)C[IH](Nc1cc(-c(cc23)ccc2[nH]nc3-c2nc(c(-c3cccc(F)c3)ccc3)c3[nH]2)cnc1)=O APLXZANZLFGRSE-UHFFFAOYSA-N 0.000 description 1
- OOGWQLZAIFYMND-UHFFFAOYSA-N CC(C)C(Nc1cncc(-c(cc2)cc3c2[nH]nc3-c([nH]c2ccc3)nc2c3-c(cc2)ccc2F)c1)=O Chemical compound CC(C)C(Nc1cncc(-c(cc2)cc3c2[nH]nc3-c([nH]c2ccc3)nc2c3-c(cc2)ccc2F)c1)=O OOGWQLZAIFYMND-UHFFFAOYSA-N 0.000 description 1
- JMALIHBPDDYPJF-WSDLNYQXSA-N CCCC(N/C(/C=C(C)C)=C/Cc(cc1)cc2c1[nH]nc2-c1nc(c(N2CCN(C)CC2)ccc2)c2[nH]1)=O Chemical compound CCCC(N/C(/C=C(C)C)=C/Cc(cc1)cc2c1[nH]nc2-c1nc(c(N2CCN(C)CC2)ccc2)c2[nH]1)=O JMALIHBPDDYPJF-WSDLNYQXSA-N 0.000 description 1
- ZOFIECLEPFCGPS-UHFFFAOYSA-N CCCC(Nc1cc(-c(cc23)ccc2[nH]nc3-c2nc(c(-c(cc3)ccc3F)ccc3)c3[nH]2)cnc1)=O Chemical compound CCCC(Nc1cc(-c(cc23)ccc2[nH]nc3-c2nc(c(-c(cc3)ccc3F)ccc3)c3[nH]2)cnc1)=O ZOFIECLEPFCGPS-UHFFFAOYSA-N 0.000 description 1
- CIBXHKMACXAHKO-UHFFFAOYSA-N CCCCC(Nc1cc(-c(cc2)cc3c2[nH]nc3-c2nc3ccccc3[nH]2)cnc1)=O Chemical compound CCCCC(Nc1cc(-c(cc2)cc3c2[nH]nc3-c2nc3ccccc3[nH]2)cnc1)=O CIBXHKMACXAHKO-UHFFFAOYSA-N 0.000 description 1
- UYDYXBDAPGBFNR-UHFFFAOYSA-N CCCCC(Nc1cc(Br)cnc1)=O Chemical compound CCCCC(Nc1cc(Br)cnc1)=O UYDYXBDAPGBFNR-UHFFFAOYSA-N 0.000 description 1
- UHFLNMAGEOIGDM-UHFFFAOYSA-N CCNCc1cc(-c(cc23)ccc2[nH]nc3-c([nH]c2ccc3)nc2c3-c(cccc2)c2F)cnc1 Chemical compound CCNCc1cc(-c(cc23)ccc2[nH]nc3-c([nH]c2ccc3)nc2c3-c(cccc2)c2F)cnc1 UHFLNMAGEOIGDM-UHFFFAOYSA-N 0.000 description 1
- CWSKKDGBMSJFAJ-UHFFFAOYSA-N Cc(nc1)c[n]1-c1cccc2c1nc(-c(c1c3)n[nH]c1ccc3-c1cncc(NC(C3CCCC3)=O)c1)[nH]2 Chemical compound Cc(nc1)c[n]1-c1cccc2c1nc(-c(c1c3)n[nH]c1ccc3-c1cncc(NC(C3CCCC3)=O)c1)[nH]2 CWSKKDGBMSJFAJ-UHFFFAOYSA-N 0.000 description 1
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- Health & Medical Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361750221P | 2013-01-08 | 2013-01-08 | |
| US61/750,221 | 2013-01-08 | ||
| PCT/US2014/010607 WO2014110086A2 (en) | 2013-01-08 | 2014-01-08 | 3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016504387A JP2016504387A (ja) | 2016-02-12 |
| JP2016504387A5 JP2016504387A5 (enExample) | 2017-02-16 |
| JP6355648B2 true JP6355648B2 (ja) | 2018-07-11 |
Family
ID=51061428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015551853A Expired - Fee Related JP6355648B2 (ja) | 2013-01-08 | 2014-01-08 | Wntシグナル伝達経路の3−(ベンゾイミダゾール−2−イル)−インダゾール阻害剤およびそれらの治療的使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9908867B2 (enExample) |
| EP (1) | EP2943198B1 (enExample) |
| JP (1) | JP6355648B2 (enExample) |
| CN (1) | CN105120862A (enExample) |
| CA (1) | CA2897400A1 (enExample) |
| MX (1) | MX370487B (enExample) |
| WO (1) | WO2014110086A2 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2464232T3 (pl) | 2009-08-10 | 2016-04-29 | Samumed Llc | Indazolowe inhibitory szlaku sygnałowego Wnt i ich zastosowania terapeutyczne |
| US8450340B2 (en) | 2009-12-21 | 2013-05-28 | Samumed, Llc | 1H-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| EP3473099A1 (en) | 2011-09-14 | 2019-04-24 | Samumed, LLC | Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors |
| PH12017500997A1 (en) | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| CN107417707A (zh) | 2012-05-04 | 2017-12-01 | 萨穆梅德有限公司 | 1H‑吡唑并[3,4‑b]吡啶及其治疗应用 |
| WO2014110086A2 (en) | 2013-01-08 | 2014-07-17 | Samumed, Llc | 3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof |
| WO2016040190A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| WO2016040185A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof |
| WO2016040188A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040184A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040182A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof |
| WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040180A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2016040193A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof |
| CN107531666A (zh) | 2015-02-20 | 2018-01-02 | 里格尔药品股份有限公司 | Gdf‑8抑制剂 |
| WO2017023975A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| WO2017023988A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| WO2017024010A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
| US10604512B2 (en) | 2015-08-03 | 2020-03-31 | Samumed, Llc | 3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof |
| US10519169B2 (en) | 2015-08-03 | 2019-12-31 | Samumed, Llc | 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| WO2017024021A1 (en) * | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
| WO2017023989A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| WO2017023980A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| US10206909B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof |
| WO2017023996A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| WO2017024026A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof |
| WO2017023987A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc. | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof |
| WO2017024003A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof |
| US10206908B2 (en) | 2015-08-03 | 2019-02-19 | Samumed, Llc | 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof |
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| WO2016040181A1 (en) | 2014-09-08 | 2016-03-17 | Samumed, Llc | 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof |
| WO2017024021A1 (en) | 2015-08-03 | 2017-02-09 | Samumed, Llc | 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof |
| NZ742200A (en) | 2015-11-06 | 2023-01-27 | Samumed Llc | Treatment of osteoarthritis |
| SI3464285T1 (sl) | 2016-06-01 | 2023-02-28 | Biosplice Therapeutics, Inc. | Postopek za pripravo N-(5-(3-(7-(3-fluorofenil)-3H-imidazo(4,5-C)piridin-2-il)-1H-indazol-5- il)piridin-3-il)-3-metilbutanamida |
| EP3528808B1 (en) | 2016-10-21 | 2021-10-06 | BioSplice Therapeutics, Inc. | Methods of using indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors |
| KR102558716B1 (ko) | 2016-11-07 | 2023-07-21 | 사뮤메드, 엘엘씨 | 단일-투여량, 즉시-사용가능한 주사용 제제 |
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2014
- 2014-01-08 WO PCT/US2014/010607 patent/WO2014110086A2/en not_active Ceased
- 2014-01-08 JP JP2015551853A patent/JP6355648B2/ja not_active Expired - Fee Related
- 2014-01-08 MX MX2015008860A patent/MX370487B/es active IP Right Grant
- 2014-01-08 EP EP14737972.1A patent/EP2943198B1/en active Active
- 2014-01-08 US US14/149,948 patent/US9908867B2/en active Active
- 2014-01-08 CN CN201480013031.9A patent/CN105120862A/zh active Pending
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2018
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Also Published As
| Publication number | Publication date |
|---|---|
| CN105120862A (zh) | 2015-12-02 |
| EP2943198B1 (en) | 2019-07-17 |
| US20140194441A1 (en) | 2014-07-10 |
| MX370487B (es) | 2019-12-16 |
| US20190352279A1 (en) | 2019-11-21 |
| CA2897400A1 (en) | 2014-07-17 |
| JP2016504387A (ja) | 2016-02-12 |
| US20180162840A1 (en) | 2018-06-14 |
| US10654832B2 (en) | 2020-05-19 |
| EP2943198A2 (en) | 2015-11-18 |
| US10183929B2 (en) | 2019-01-22 |
| US9908867B2 (en) | 2018-03-06 |
| EP2943198A4 (en) | 2016-08-03 |
| MX2015008860A (es) | 2016-04-04 |
| WO2014110086A2 (en) | 2014-07-17 |
| WO2014110086A3 (en) | 2014-10-09 |
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