JP6352029B2 - 抗疲労剤 - Google Patents
抗疲労剤 Download PDFInfo
- Publication number
- JP6352029B2 JP6352029B2 JP2014077817A JP2014077817A JP6352029B2 JP 6352029 B2 JP6352029 B2 JP 6352029B2 JP 2014077817 A JP2014077817 A JP 2014077817A JP 2014077817 A JP2014077817 A JP 2014077817A JP 6352029 B2 JP6352029 B2 JP 6352029B2
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- Prior art keywords
- vinegar
- ganoderma
- fatigue
- extract
- hot water
- Prior art date
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- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
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Description
赤霊芝の乾燥物20gに400mLの精製水を加え、95〜100℃で2時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥して赤霊芝熱水抽出物を1.4g得た。
黒霊芝の乾燥物20gに400mLの精製水を加え、95〜100℃で2時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥して黒霊芝熱水抽出物を1.3g得た。
赤霊芝の乾燥物100gに900mLのエタノールを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固して、赤霊芝エタノール抽出物を1.6g得た。
黒霊芝の乾燥物100gに900mLのエタノールを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固して、黒霊芝エタノール抽出物を1.5g得た。
りんご酢100gを凍結乾燥してりんご酢凍結乾燥物を4.5g得た。
<処方> 配合量(%)
1.赤霊芝熱水抽出物(製造例1) 0.03
2.黒霊芝熱水抽出物(製造例2) 0.03
3.りんご酢(酢酸10%含有) 30.0
4.寒天オリゴ糖 0.01
5.はちみつ 60.0
6.精製水で全量を100とする
<製造方法>
成分6に成分1〜5を加え、攪拌溶解して濾過し、加熱殺菌して720mLガラス瓶に充填する。
<用法>
1日当り20mLを水で6倍に希釈して摂取する。
<処方> 配合量(%)
1.赤霊芝熱水抽出物(製造例1) 0.03
2.黒霊芝熱水抽出物(製造例2) 0.03
3.寒天オリゴ糖 0.01
4.はちみつ 60.0
5.精製水で全量を100とする
<製造方法>
成分5に成分1〜4を加え、攪拌溶解して濾過し、加熱殺菌して720mLガラス瓶に充填する。
<用法>
1日当り20mLを水で6倍に希釈して摂取する。
<処方> 配合量(%)
1.赤霊芝熱水抽出物(製造例1) 0.02
2.りんご酢(酢酸10%含有) 5.0
3.はちみつ 60.0
4.精製水で全量を100とする
<製造方法>
成分4に成分1〜3を加え、攪拌溶解して濾過し、加熱殺菌して720mLガラス瓶に充填する。
<用法>
1日当り20mLを水で6倍に希釈して摂取する。
<処方> 配合量(%)
1.赤霊芝熱水抽出物(製造例1) 0.1
2.ぶどう酢(酢酸10%含有) 4.0
3.ぶどう果汁 30.0
4.精製水で全量を100とする。
<製造方法>
成分4に成分1〜3を加え、攪拌溶解して濾過し、加熱殺菌して125mL紙容器に充填する。<用法>
本飲料を1日1本摂取する。
<処方> 配合量(%)
1.赤霊芝エタノール抽出物(製造例3) 0.2
2.粉末米酢(酢酸10%含有) 30.0
3.乳糖 64.8
4.セルロース 5.0
<製造方法>
成分1〜4を乾式法により造粒し、顆粒剤を得る。
<用法>
1日当り3g摂取する。
<処方>
成分 配合量(%)
1.黒霊芝エタノール抽出物(製造例4) 0.5
2.粉末りんご酢(酢酸20%含有) 25.0
3.米胚芽油 54.5
4.ミツロウ 10.0
5.ビタミンE 10.0
<製造方法>
成分1〜5を混合し、ゼラチン、グリセリン、カラメル色素で構成される被膜に、250mg充填し、乾燥後、軟カプセル剤を得る。
<用法>
1日当り4粒摂取する。
<処方>
成分 配合量(%)
1.赤霊芝熱水抽出物(製造例1) 0.1
2.粉末酢(酢酸20%含有) 30.0
3.乳糖 36.9
4.還元麦芽糖水飴 30.0
5.ショ糖脂肪酸エステル 3.0
<製造方法>
成分1〜5を混合して打錠成型し、0.5gの錠剤を得る。
<用法>
1日当り2粒摂取する。
<処方> 配合量(%)
1.赤霊芝熱水抽出物(製造例1) 0.1
2.カラギーナン 1.0
3.ゼラチン 0.5
4.砂糖 20.0
5.精製水 68.4
6.ブルーベリー酢(酢酸10%含有) 10.0
<製造方法>
成分1〜5を混合し、加熱しながら煮詰める。冷却しながら、成分6を加え、ゼリーの型10個に流し込み、冷却する。
<用法>
1日当り1個(100g)を摂取する。
<処方> 配合量(%)
1.黒霊芝熱水抽出物(製造例2) 0.01
2.りんご酢(酢酸10%含有) 20.0
3.穀物酢(酢酸10%含有) 14.0
4.オリーブオイル 17.99
5.濃口醤油 34.0
6.砂糖 14.0
<製造方法>
成分1〜6を混合し、攪拌溶解して濾過し、加熱殺菌して150mLガラス瓶に充填する。
<用法>
1日当り大さじ1杯(15mL)を摂取する。
実施例1の飲料において、赤霊芝熱水抽出物、黒霊芝熱水抽出物およびりんご酢を水に置き換えたものを従来の飲料とした。
実施例1の飲料において、赤霊芝熱水抽出物および黒霊芝熱水抽出物を水に置き換えたものを食酢のみを含有する飲料とした。
筋芽細胞であるC2C12(理研バイオリソースセンター)を、10%FBSを含むDMEM培地にて37℃、5%CO2条件下で培養し、実験に用いた。12ウェルプレートに1ウェルあたり1.2×104個播種して4日間培養してサブコンフルエントの状態にした。製造例1で調製した赤霊芝熱水抽出物を0.15mg/mL、製造例5で調製したりんご酢凍結乾燥物を1.9mg/mLとなるように溶解させたDMEM培地に置換してから24時間培養し、遺伝子発現解析を行った。遺伝子発現解析は、筋芽細胞におけるエネルギー産生に関連する遺伝子であるCPT1、MCAD、PPARαの遺伝子発現変動をリアルタイムPCR法で評価した。赤霊芝熱水抽出物、りんご酢凍結乾燥物を添加していないものを1とした遺伝子発現量比を算出した。
日頃から疲労を自覚している男女40人(28〜55歳)を10名ずつ試験群1、試験群2、試験群3、試験群4に分け、試験群1には実施例1の霊芝抽出物と食酢とを含有する飲料、試験群2には実施例2の霊芝抽出物のみ含有する飲料、試験群3には比較例2の食酢のみ含有する飲料、試験群4には比較例1の従来の飲料を用いて、1日20mLを水で6倍に希釈して1日1回3ヶ月間摂取させ、試験開始時から終了時にかけての疲労感の変化をアンケートにより評価した。なお、アンケートでは試験開始時から終了時にかけて疲労感が「改善した」、「やや改善した」、「変化なし」、「悪化した」の4段階の回答を設けた。「改善した」を2点、「やや改善した」を1点、「変化なし」を0点、「悪化した」を−1点として、合計点数での比較を行った。
Claims (2)
- 霊芝熱水抽出物及び食酢とを含有することを特徴とする肉体疲労改善剤。
- 食酢が、果実酢である請求項1記載の肉体疲労改善剤。
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CN105725192A (zh) * | 2016-02-01 | 2016-07-06 | 郝振荣 | 中华蕈芝胶囊 |
JP2018070468A (ja) * | 2016-10-26 | 2018-05-10 | 育宏 南 | 免疫賦活剤 |
JP2018104397A (ja) * | 2016-12-28 | 2018-07-05 | 国立大学法人九州大学 | 抗精神疲労剤、該抗精神疲労剤を用いた食品(健康補助食品)、苦味料、並びにそれらの製造方法 |
JP2018166415A (ja) * | 2017-03-29 | 2018-11-01 | 株式会社ノエビア | 飲料組成物及びその製造方法 |
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JP2020018215A (ja) * | 2018-07-31 | 2020-02-06 | 株式会社 伊藤園 | 疲労感軽減剤および疲労感軽減用飲食品組成物 |
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JP2983981B1 (ja) * | 1998-12-09 | 1999-11-29 | 三島食品株式会社 | 蜂蜜と酢とによる霊芝抽出物及びその利用 |
JP2003063981A (ja) * | 2001-08-29 | 2003-03-05 | Nonogawa Shoji Kk | 滋養強壮剤 |
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