JP6347793B2 - Bcl−2/Bcl−xL阻害薬およびそれを使用した治療方法 - Google Patents

Bcl−2/Bcl−xL阻害薬およびそれを使用した治療方法 Download PDF

Info

Publication number
JP6347793B2
JP6347793B2 JP2015553788A JP2015553788A JP6347793B2 JP 6347793 B2 JP6347793 B2 JP 6347793B2 JP 2015553788 A JP2015553788 A JP 2015553788A JP 2015553788 A JP2015553788 A JP 2015553788A JP 6347793 B2 JP6347793 B2 JP 6347793B2
Authority
JP
Japan
Prior art keywords
bcl
compound
alkyl
cancer
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015553788A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016506916A (ja
JP2016506916A5 (enExample
Inventor
ワン,シャオメン
チェン,ジエンファン
マッカカーン,ドナ
バイ,ロンチュアン
リュー,リュー
サン,ドキシン
リー,シャオチン
アギラール,アンジェロ
Original Assignee
ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン
ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン, ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン filed Critical ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン
Publication of JP2016506916A publication Critical patent/JP2016506916A/ja
Publication of JP2016506916A5 publication Critical patent/JP2016506916A5/ja
Application granted granted Critical
Publication of JP6347793B2 publication Critical patent/JP6347793B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/30Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015553788A 2013-01-16 2014-01-15 Bcl−2/Bcl−xL阻害薬およびそれを使用した治療方法 Active JP6347793B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361753066P 2013-01-16 2013-01-16
US61/753,066 2013-01-16
PCT/US2014/011571 WO2014113413A1 (en) 2013-01-16 2014-01-15 Bcl-2bcl-xl inhibitors and therapeutic methods using the same

Publications (3)

Publication Number Publication Date
JP2016506916A JP2016506916A (ja) 2016-03-07
JP2016506916A5 JP2016506916A5 (enExample) 2017-01-26
JP6347793B2 true JP6347793B2 (ja) 2018-06-27

Family

ID=51165292

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015553788A Active JP6347793B2 (ja) 2013-01-16 2014-01-15 Bcl−2/Bcl−xL阻害薬およびそれを使用した治療方法

Country Status (13)

Country Link
US (2) US9096625B2 (enExample)
EP (2) EP2945940B1 (enExample)
JP (1) JP6347793B2 (enExample)
KR (2) KR102318204B1 (enExample)
CN (3) CN110302205B (enExample)
AU (1) AU2014207716B2 (enExample)
CA (1) CA2897055C (enExample)
ES (1) ES2819232T3 (enExample)
HK (1) HK1219734A1 (enExample)
NZ (1) NZ709635A (enExample)
SG (1) SG11201505525UA (enExample)
WO (1) WO2014113413A1 (enExample)
ZA (1) ZA201504902B (enExample)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102318204B1 (ko) * 2013-01-16 2021-10-26 더 리젠츠 오브 더 유니버시티 오브 미시간 Bcl-2bcl-xl 억제제 및 그를 사용하는 치료 방법
EP3099380B1 (en) 2014-01-28 2021-08-11 Buck Institute for Research on Aging Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
EP3139942B1 (en) 2014-05-05 2019-12-18 Bioventures, Llc COMPOSITIONS AND METHODS FOR INHIBITING ANTIAPOPTOTIC Bcl-2 PROTEINS AS ANTI-AGING AGENTS
JP2017522388A (ja) 2014-07-22 2017-08-10 バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーBioVentures, LLC 老化細胞を選択的に枯渇させるための組成物及び方法
AU2016215035A1 (en) * 2015-02-06 2017-09-28 Buck Institute For Research On Aging Compounds and uses in treatment of senescence-associated conditions
US20180000816A1 (en) * 2015-02-06 2018-01-04 Unity Biotechnology, Inc. Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions
WO2017101851A1 (en) * 2015-12-18 2017-06-22 Unity Biotechnology, Inc. Acylsulfonamide derivatives for treating senescence-associated diseases and disorders
WO2017172826A1 (en) 2016-03-28 2017-10-05 Presage Biosciences, Inc. Pharmaceutical combinations for the treatment of cancer
JP6936498B2 (ja) * 2016-04-21 2021-09-15 バイオベンチャーズ・リミテッド・ライアビリティ・カンパニーBioVentures, LLC 抗アポトーシス性Bcl−2ファミリータンパク質の分解を誘導する化合物及びその使用
CN106177955B (zh) * 2016-08-18 2018-03-16 广州威溶特医药科技有限公司 Bcl‑xL抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用
WO2018098534A1 (en) * 2016-12-02 2018-06-07 Garvan Institute Of Medical Research Methods of treating cancer and reagents thereof
US20200354336A9 (en) * 2017-08-11 2020-11-12 Unity Biotechnology, Inc. Treatment of Lung Diseases Using Pharmaceutical Agents that Eliminate Senescent Cells
WO2019033122A1 (en) * 2017-08-11 2019-02-14 Unity Biotechnology, Inc. TREATMENT OF PULMONARY DISEASES USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS
WO2019033119A1 (en) * 2017-08-11 2019-02-14 Unity Biotechnology, Inc. TREATMENT OF OPHTHALMIC CONDITIONS SUCH AS MACULAR DEGENERATION, GLAUCOMA AND DIABETIC RETINOPATHY USING PHARMACEUTICAL AGENTS THAT ELIMINATE SENESCENT CELLS
US10588916B2 (en) 2017-10-31 2020-03-17 Unity Biotechnology, Inc. Technology to inhibit vascular changes that lead to vision loss in the eye
EP3548504B1 (en) 2017-12-30 2021-07-21 Unity Biotechnology, Inc. Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer
CA3087262A1 (en) 2018-01-10 2019-07-18 Recurium Ip Holdings, Llc Benzamide compounds
ES3041854T3 (en) * 2018-01-22 2025-11-17 Bioventures Llc Bcl-2 proteins degraders for cancer treatment
MX2020011495A (es) 2018-04-29 2021-01-15 Beigene Ltd Inhibidores de bcl-2.
US10738042B2 (en) 2018-04-30 2020-08-11 Unity Biotechnology, Inc. Phosphonamidates that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
CA3056878C (en) 2018-04-30 2021-03-30 Unity Biotechnology Phospholidines that are bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
WO2019213160A1 (en) 2018-04-30 2019-11-07 Unity Biotechnology Acyl phosphonamidates and acyl benzylamines that are bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
WO2019221755A1 (en) 2018-05-18 2019-11-21 Bioventures, Llc Piperlongumine analogues and uses thereof
US10717722B2 (en) 2018-06-13 2020-07-21 Unity Biotechnology, Inc. Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer
EP3672595B1 (en) 2018-07-31 2021-07-21 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases
AU2019315550B2 (en) * 2018-07-31 2021-07-01 Ascentage Pharma (Suzhou) Co., Ltd. Combination of Bcl-2/Bcl-xL inhibitors and chemotherapeutic agent and use thereof
US11491168B2 (en) 2018-07-31 2022-11-08 Ascentage Pharma (Suzhou) Co., Ltd. Combination of Bcl-2/Bcl-xL inhibitors and chemotherapeutic agent and use thereof
EP3672594B1 (en) 2018-07-31 2021-09-29 Ascentage Pharma (Suzhou) Co., Ltd. Combination product of bcl-2 inhibitor and mdm2 inhibitor and use thereof in the prevention and/or treatment of diseases
CN110772640B (zh) 2018-07-31 2023-02-03 苏州亚盛药业有限公司 Bcl-2抑制剂与利妥昔单抗和/或苯达莫司汀或与CHOP联合的协同抗肿瘤作用
CN114522167A (zh) 2018-07-31 2022-05-24 苏州亚盛药业有限公司 Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途
WO2020041405A1 (en) 2018-08-22 2020-02-27 Newave Pharmaceutical Inc. Bcl-2 inhibitors
US11872237B2 (en) * 2018-12-28 2024-01-16 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical composition and preparation method thereof
TWI731540B (zh) * 2019-01-04 2021-06-21 大陸商蘇州亞盛藥業有限公司 製備磺胺類藥物的方法
WO2020140956A1 (en) * 2019-01-04 2020-07-09 Ascentage Pharma (Suzhou) Co., Ltd. Process for preparing sulfonamide compounds
TWI770503B (zh) * 2019-05-13 2022-07-11 大陸商蘇州亞盛藥業有限公司 用於預測bcl-2/bcl-xl抑制劑對癌症的功效的方法和組合物
CN112168830B (zh) * 2019-07-02 2022-01-25 苏州亚盛药业有限公司 一种含有mTOR抑制剂的药物组合及其应用
CN112294966B (zh) * 2019-07-31 2021-12-17 苏州亚盛药业有限公司 Bcl-2/Bcl-xL抑制剂与化疗药的组合产品及其在预防和/或治疗疾病中的用途
US20220372042A1 (en) 2019-10-03 2022-11-24 Newave Pharmaceutical Inc. Condensed heterocycles as bcl-2 inhibitors
CN112707900B (zh) * 2019-10-24 2022-06-10 上海科技大学 蛋白降解剂及其在疾病治疗中的应用
WO2021083135A1 (en) 2019-10-28 2021-05-06 Beigene, Ltd. Bcl-2 INHIBITORS
CN112852959B (zh) * 2019-11-27 2026-02-06 苏州亚盛药业有限公司 用于预测靶向细胞凋亡途径的化合物的抗癌功效的方法和组合物
US12514863B2 (en) 2019-12-04 2026-01-06 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical combination and use thereof
WO2021119439A1 (en) * 2019-12-11 2021-06-17 The Regents Of The University Of Michigan Compositions and methods for systemic delivery of bcl-2 and bcl-xl antagonists
CN113350281B (zh) * 2020-03-02 2023-08-15 苏州亚盛药业有限公司 载药聚合物胶束及其制剂和制备方法
WO2021204060A1 (en) * 2020-04-10 2021-10-14 Ascentage Pharma (Suzhou) Co., Ltd. Combinations of bcl-2/bcl-xl inhibitors and related uses
KR20230002419A (ko) 2020-04-15 2023-01-05 베이진 엘티디 Bcl-2 억제제
WO2021233948A1 (en) 2020-05-19 2021-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to treat a pathogen lung infection
EP4175644A1 (en) 2020-07-06 2023-05-10 Inserm (Institut National De La Sante Et De La Recherche Medicale) Combination of antineoplastic antibiotics and bcl-2 inhibitors for the treatment of npm-1-driven acute myeloid leukemia (aml)
US12528832B2 (en) 2020-07-13 2026-01-20 Ascentage Pharma (Suzhou) Co., Ltd. Crystalline or amorphous form of Bcl-2/Bcl-xL inhibitor compound or its salts
WO2022022706A1 (en) * 2020-07-31 2022-02-03 Ascentage Pharma (Suzhou) Co., Ltd. Compositions and methods for treating lung diseases
CN117062808A (zh) * 2020-11-10 2023-11-14 联合生物科技公司 Bcl的结晶固体葡甲胺盐抑制剂及其制备和使用方法
WO2022111647A1 (en) * 2020-11-27 2022-06-02 Ascentage Pharma (Suzhou) Co., Ltd. Formulation combination containing freeze-dried formulation and reconstituted solvent, preparation method and application thereof
US12454674B2 (en) 2020-12-04 2025-10-28 University Of Notre Dame Du Lac Method of encapsulating single cells utilizing an alternating current electrospray
WO2023011488A1 (zh) 2021-08-02 2023-02-09 苏州亚盛药业有限公司 一种药物组合及其用途
TW202415653A (zh) * 2022-08-02 2024-04-16 大陸商北京星奇原生物科技有限公司 Bcl-xl降解化合物
TW202415647A (zh) * 2022-09-06 2024-04-16 大陸商西藏海思科製藥有限公司 抑制Bcl-2或Bcl-xL的化合物及其在醫藥上的應用
WO2024245312A1 (en) * 2023-05-30 2024-12-05 Ascentage Pharma (Suzhou) Co., Ltd. Bcl-2/bcl-xl protein degrader and use thereof
WO2025087879A2 (en) 2023-10-23 2025-05-01 Institut National de la Santé et de la Recherche Médicale Suppressing the pi3kgamma/akt signalling pathway for the treatment of acute myeloid leukemia

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432304B2 (en) 2001-05-30 2008-10-07 The Regents Of The University Of Michigan Small molecule antagonists of Bcl-2 family proteins
US7973161B2 (en) * 2003-11-13 2011-07-05 Abbott Laboratories Apoptosis promoters
CA2577752A1 (en) 2004-08-20 2006-03-02 The Regents Of The University Of Michigan Small molecule inhibitors of anti-apoptotic bcl-2 family members and the uses thereof
PT1888550E (pt) 2005-05-12 2014-09-03 Abbvie Bahamas Ltd Promotores de apoptose
WO2007061923A2 (en) 2005-11-18 2007-05-31 Takeda San Diego, Inc. Glucokinase activators
EP2061560A2 (en) * 2006-09-05 2009-05-27 Abbott Laboratories Bcl inhibitors for treating platelet excess
AU2009273197B2 (en) 2008-07-24 2014-01-16 Nerviano Medical Sciences S.R.L. 3,4-diarylpyrazoles as protein kinase inhibitors
US20100278921A1 (en) 2009-04-30 2010-11-04 Fischer Cristina M Solid oral formulation of abt-263
TWI535712B (zh) 2010-08-06 2016-06-01 阿斯特捷利康公司 化合物
US8691184B2 (en) * 2011-01-25 2014-04-08 The Regents Of The University Of Michigan Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same
KR102318204B1 (ko) * 2013-01-16 2021-10-26 더 리젠츠 오브 더 유니버시티 오브 미시간 Bcl-2bcl-xl 억제제 및 그를 사용하는 치료 방법

Also Published As

Publication number Publication date
SG11201505525UA (en) 2015-08-28
JP2016506916A (ja) 2016-03-07
US9403856B2 (en) 2016-08-02
CA2897055A1 (en) 2014-07-24
US9096625B2 (en) 2015-08-04
EP2945940A4 (en) 2016-07-06
US20140199234A1 (en) 2014-07-17
US20150336994A1 (en) 2015-11-26
WO2014113413A1 (en) 2014-07-24
KR20150104631A (ko) 2015-09-15
EP2945940B1 (en) 2020-07-15
CN110305162A (zh) 2019-10-08
KR102210316B1 (ko) 2021-01-29
CA2897055C (en) 2021-04-20
KR20210002126A (ko) 2021-01-06
AU2014207716B2 (en) 2017-07-27
CN110302205B (zh) 2020-06-09
ES2819232T3 (es) 2021-04-15
CN110302205A (zh) 2019-10-08
EP3689886A1 (en) 2020-08-05
HK1219734A1 (zh) 2017-04-13
CN105246882A (zh) 2016-01-13
KR102318204B1 (ko) 2021-10-26
EP2945940A1 (en) 2015-11-25
NZ709635A (en) 2019-10-25
ZA201504902B (en) 2016-07-27
AU2014207716A1 (en) 2015-07-23

Similar Documents

Publication Publication Date Title
JP6347793B2 (ja) Bcl−2/Bcl−xL阻害薬およびそれを使用した治療方法
JP5998152B2 (ja) Bcl−2/bcl−xl阻害剤およびそれを使用する治療方法
JP6247298B2 (ja) Iapタンパク質の二価阻害薬およびそれを用いた治療方法
AU2012209295A1 (en) Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same
HK40025523A (en) Bcl-2/bcl-xl inhibitors and their use in the treatment of cancer
HK40008278A (en) Bcl-2/bcl-xl inhibitors and therapeutic methods using the same
HK40008279A (en) Medical use of bcl-2/bcl-xl inhibitors and pharmaceutical compositions thereof
HK40008279B (en) Medical use of bcl-2/bcl-xl inhibitors and pharmaceutical compositions thereof
NZ613504B2 (en) Bcl-2/bcl-xl inhibitors and therapeutic methods using the same

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151113

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161209

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20161209

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20171026

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20171031

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180131

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180220

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180507

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20180522

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180529

R150 Certificate of patent or registration of utility model

Ref document number: 6347793

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250