JP6342393B2 - 置換型ピラゾロン化合物及び使用方法 - Google Patents
置換型ピラゾロン化合物及び使用方法 Download PDFInfo
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- JP6342393B2 JP6342393B2 JP2015524334A JP2015524334A JP6342393B2 JP 6342393 B2 JP6342393 B2 JP 6342393B2 JP 2015524334 A JP2015524334 A JP 2015524334A JP 2015524334 A JP2015524334 A JP 2015524334A JP 6342393 B2 JP6342393 B2 JP 6342393B2
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- Prior art keywords
- alkylene
- heterocyclyl
- cycloalkyl
- alkyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 title description 57
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 34
- 239000008194 pharmaceutical composition Substances 0.000 claims description 33
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 32
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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| CN106467541B (zh) * | 2015-08-18 | 2019-04-05 | 暨南大学 | 取代喹诺酮类衍生物或其药学上可接受的盐或立体异构体及其药用组合物和应用 |
| CN105153026B (zh) * | 2015-08-21 | 2018-02-02 | 江西科技师范大学 | 含联芳基酰胺结构的索拉非尼衍生物及其制备方法和应用 |
| CN105237523B (zh) * | 2015-10-08 | 2018-06-01 | 深圳市博圣康生物科技有限公司 | 嘧啶衍生物及其制备方法、用途 |
| RU2018134336A (ru) | 2016-03-02 | 2020-04-02 | Медивир Актиеболаг | Комбинированная терапия сорафенибом или регорафенибом и фосфорамидатным пролекарством троксацитабина |
| AR108107A1 (es) * | 2016-04-29 | 2018-07-18 | Syngenta Participations Ag | Proceso para preparar compuestos herbicidas |
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| WO2018134254A1 (en) | 2017-01-17 | 2018-07-26 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| CN111484442B (zh) | 2018-06-01 | 2021-11-09 | 杭州阿诺生物医药科技有限公司 | 一种具有抗肿瘤活性的csf1r抑制剂中间体的制备方法 |
| CN109096250A (zh) * | 2018-09-25 | 2018-12-28 | 辽宁大学 | 含哒嗪酮的4-苯氧基吡啶类化合物及其应用 |
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| US20220235029A1 (en) * | 2019-05-24 | 2022-07-28 | Medshine Discovery Inc. | Crystal form of c-met/axl inhibitor |
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| CA3178450A1 (en) | 2020-03-30 | 2021-10-07 | Hutchison Medipharma Limited | Amide compounds and uses thereof |
| JP7556604B2 (ja) * | 2020-07-10 | 2024-09-26 | 範恩柯爾生物科技（中山）有限公司 | トリアジン系化合物およびその組成物と用途 |
| WO2022270881A1 (ko) * | 2021-06-22 | 2022-12-29 | 주식회사 엘지화학 | 단백질 키나아제 억제제로서의 신규한 화합물 |
| TW202315628A (zh) * | 2021-06-24 | 2023-04-16 | 南韓商Ｌｇ化學股份有限公司 | 作為ｒｏｎ抑制劑之新穎吡啶衍生物化合物 |
| CN114213404B (zh) * | 2021-12-27 | 2024-08-06 | 武汉九州钰民医药科技有限公司 | Vegfr抑制剂替沃扎尼的合成工艺 |
| CN114796227B (zh) * | 2022-05-30 | 2023-12-01 | 中山大学 | Ponatinib在制备预防或治疗血管退行性疾病药物中的应用及该药物 |
| CN114903996B (zh) * | 2022-06-22 | 2023-10-20 | 武汉大学中南医院 | Hedgehog通路的特异性抑制剂在制备用于治疗宫腔粘连的药物中的应用 |
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| KR20140097402A (ko) | 2011-11-22 | 2014-08-06 | 데시페라 파마슈티칼스, 엘엘씨. | 항암 및 항증식 활성을 나타내는 피리돈 아미드 및 유사체 |
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| AU2013296897A1 (en) | 2014-12-18 |
| WO2014022117A1 (en) | 2014-02-06 |
| ES2634414T3 (es) | 2017-09-27 |
| EP2879676B1 (en) | 2017-06-14 |
| EP2879677B1 (en) | 2017-06-14 |
| AU2013296897B2 (en) | 2015-09-17 |
| EP2879676A1 (en) | 2015-06-10 |
| JP2015523390A (ja) | 2015-08-13 |
| US20150050239A1 (en) | 2015-02-19 |
| WO2014022116A8 (en) | 2015-04-02 |
| WO2014022116A3 (en) | 2015-07-16 |
| WO2014022116A2 (en) | 2014-02-06 |
| EP2879676A4 (en) | 2015-12-09 |
| US8969388B1 (en) | 2015-03-03 |
| EP2879677A2 (en) | 2015-06-10 |
| BR112015001528B1 (pt) | 2020-12-22 |
| CA2876246C (en) | 2019-05-07 |
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