JP6340346B2 - 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 - Google Patents
異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 Download PDFInfo
- Publication number
- JP6340346B2 JP6340346B2 JP2015145739A JP2015145739A JP6340346B2 JP 6340346 B2 JP6340346 B2 JP 6340346B2 JP 2015145739 A JP2015145739 A JP 2015145739A JP 2015145739 A JP2015145739 A JP 2015145739A JP 6340346 B2 JP6340346 B2 JP 6340346B2
- Authority
- JP
- Japan
- Prior art keywords
- particles
- density
- tissue
- sheet
- extracellular matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/26—Materials or treatment for tissue regeneration for kidney reconstruction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Description
porcine bone)、脱塩同種移植骨、または石灰化した同種移植骨などの、骨代替材料と組み合わせ可能である。別の実施形態では、骨粒子および本発明の異なる密度のECM粒子は、接着剤、結合剤、またはあらゆるその他の添加剤を用いずに混合可能である。粒子は骨代替材料に被覆および/または注入される。骨代替材料が患者の組織部位に移植されると、骨代替材料は欠損を安定化するために強固な構造をもたらし、一方で、低密度な粒子は部位における急速な組織修復を促進する。高密度な粒子が低密度な粒子よりも低速で生体吸収されるため、長期間の間、高密度な粒子は移植部位における組織修復を維持する。高密度粒子は組織部位が修復するまで、通常は完全に生体吸収されない。
ECM粒子の混合物を、50〜1000μmの大きさで約0.05g/cm3の密度を有する60mgのUBM粒子、および50〜500μmの大きさで約0.25g/cm3の密度を有する20mgのUBM粒子を、重量に基づき3:1の粒子割合で用いて作成する。混合物を慢性皮膚潰瘍に局所的に投与する。10日以内に、0.05g/cm3の粒子が吸収され、組織再生が創傷部位において観察される。30日以内に、0.25g/cm3の粒子が吸収され、創傷部位の組織が完全に再生する。
ECM粒子の混合物を、腫瘍が切除された腎臓部位へ移植するために調製する。ECM粒子の混合物を、500〜1000μmの大きさで約0.10g/cm3の密度を有する200mgのUBM粒子、および50〜500μmの大きさで約0.35g/cm3の密度を有する1000mgのUBM粒子を、重量に基づき1:5の粒子割合で用いて作成する。混合物を患者に注射器を用いて外科的に移植する。20日以内に、0.10g/cm3の粒子が吸収され、磁気共鳴画像法によって組織再生が創傷部位において観察される。60日以内に、0.35g/cm3の粒子が吸収され、磁気共鳴画像法で観察されるよう
に、創傷部位の組織は完全に再生する。
Claims (13)
- 移植片を調製する方法であって、
第1天然細胞外マトリックスの複数の生体活性細胞外マトリックス成分および第1密度を有する第1粒子と、第2天然細胞外マトリックスおよび前記第1密度よりも少なくとも150%大きい第2密度を有する第2粒子と、を圧縮することで、解剖学的部位に対応する立体物体を形成することを含む方法。 - 請求項1の方法であって、前記第1粒子の前記第1天然細胞外マトリックスおよび前記第2粒子の前記第2天然細胞外マトリックスの1つは、膀胱粘膜下層、小腸粘膜下層、および、膀胱の上皮基底膜から成る群より選択される方法。
- 請求項1の方法であって、前記第1密度の粒子は前記移植片の中心部を形成し、前記第2密度の粒子は前記移植片の外面を形成する、方法。
- 請求項1の方法であって、前記方法は、
前記第1粒子を、第1密度を有するコーティングで被覆し、
前記第2粒子を、第2密度を有するコーティングで被覆することをさらに含む方法。 - 請求項1の方法であって、前記第1粒子は、前記第2粒子の天然組織源とは異なる天然組織源に由来する細胞外マトリックス成分を含む、方法。
- 請求項5の方法であって、前記第1粒子の前記天然組織源は膀胱を含み、前記第1粒子は膀胱の上皮基底膜を含む、方法。
- 請求項1の方法であって、前記複数の第2粒子の前記第2天然細胞外マトリックスは、前記複数の第1粒子の前記第1天然細胞外マトリックスとは異なる、方法。
- 請求項1の方法であって、前記第1粒子および前記第2粒子は、非架橋細胞外マトリックスを含む、方法。
- 請求項1の方法であって、前記第1粒子の前記第1天然細胞外マトリックスおよび前記
第2粒子の前記第2天然細胞外マトリックスの1つは、膀胱の上皮基底膜を含む、方法。 - 複数の生体活性天然細胞外マトリックス成分を含む天然細胞外マトリックスを含み、かつ第1密度を有する複数の第1生体吸収性粒子と
前記複数の第1生体吸収性粒子の天然細胞外マトリックスとは異なる別の天然細胞外マトリックスを含み、かつ前記第1密度よりも少なくとも150%大きい第2密度を有する複数の第2生体吸収性粒子と、を含み、
前記第1密度よりも少なくとも150%大きい第2密度を有する前記複数の第2生体吸収性粒子は、前記複数の第1生体吸収性粒子よりも遅く吸収される、混合物。 - 請求項10の混合物であって、前記混合物は液体またはゲルの媒体を含む混合物。
- 請求項10の混合物であって、前記混合物は注入可能である混合物。
- 請求項10の混合物であって、前記混合物は患者の解剖学的部位に局所的に投与される混合物。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/507,311 US8652500B2 (en) | 2009-07-22 | 2009-07-22 | Particulate tissue graft with components of differing density and methods of making and using the same |
US12/507,311 | 2009-07-22 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012521747A Division JP6226524B2 (ja) | 2009-07-22 | 2010-07-21 | 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017188962A Division JP6640808B2 (ja) | 2009-07-22 | 2017-09-28 | 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015186653A JP2015186653A (ja) | 2015-10-29 |
JP6340346B2 true JP6340346B2 (ja) | 2018-06-06 |
Family
ID=42709107
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012521747A Active JP6226524B2 (ja) | 2009-07-22 | 2010-07-21 | 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 |
JP2015145739A Active JP6340346B2 (ja) | 2009-07-22 | 2015-07-23 | 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 |
JP2017188962A Active JP6640808B2 (ja) | 2009-07-22 | 2017-09-28 | 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 |
JP2019134133A Pending JP2019193877A (ja) | 2009-07-22 | 2019-07-19 | 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 |
JP2020007232A Pending JP2020058884A (ja) | 2009-07-22 | 2020-01-21 | 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012521747A Active JP6226524B2 (ja) | 2009-07-22 | 2010-07-21 | 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017188962A Active JP6640808B2 (ja) | 2009-07-22 | 2017-09-28 | 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 |
JP2019134133A Pending JP2019193877A (ja) | 2009-07-22 | 2019-07-19 | 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 |
JP2020007232A Pending JP2020058884A (ja) | 2009-07-22 | 2020-01-21 | 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 |
Country Status (10)
Country | Link |
---|---|
US (7) | US8652500B2 (ja) |
EP (2) | EP2456476B1 (ja) |
JP (5) | JP6226524B2 (ja) |
KR (4) | KR20120069668A (ja) |
CN (1) | CN102573939B (ja) |
AU (1) | AU2010276271B2 (ja) |
CA (2) | CA2986673C (ja) |
DK (1) | DK2456476T3 (ja) |
ES (1) | ES2749377T3 (ja) |
WO (1) | WO2011011484A2 (ja) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7393339B2 (en) | 2003-02-21 | 2008-07-01 | C. R. Bard, Inc. | Multi-lumen catheter with separate distal tips |
US20040243095A1 (en) | 2003-05-27 | 2004-12-02 | Shekhar Nimkar | Methods and apparatus for inserting multi-lumen spit-tip catheters into a blood vessel |
US8992454B2 (en) | 2004-06-09 | 2015-03-31 | Bard Access Systems, Inc. | Splitable tip catheter with bioresorbable adhesive |
EP1765981A4 (en) * | 2004-06-11 | 2007-09-12 | Victorian Tissue Engineering C | WOVEN MATERIAL AND MUSCLE MATRIX |
US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
US20150359934A1 (en) * | 2007-05-10 | 2015-12-17 | CorMartix Cardiovascular, Inc. | Articles for Tissue Regeneration with Biodegradable Polymer |
US8500939B2 (en) | 2007-10-17 | 2013-08-06 | Bard Access Systems, Inc. | Manufacture of split tip catheters |
US8066660B2 (en) | 2007-10-26 | 2011-11-29 | C. R. Bard, Inc. | Split-tip catheter including lateral distal openings |
US8292841B2 (en) | 2007-10-26 | 2012-10-23 | C. R. Bard, Inc. | Solid-body catheter including lateral distal openings |
WO2009059220A1 (en) | 2007-11-01 | 2009-05-07 | C.R. Bard, Inc. | Catheter assembly including triple lumen tip |
US9579485B2 (en) | 2007-11-01 | 2017-02-28 | C. R. Bard, Inc. | Catheter assembly including a multi-lumen configuration |
WO2009111069A1 (en) * | 2008-03-05 | 2009-09-11 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
US8652500B2 (en) | 2009-07-22 | 2014-02-18 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
CA2859657C (en) * | 2011-12-20 | 2021-03-02 | Lifecell Corporation | Acellular tissue matrix particles and flowable products comprising them |
EP2793964B1 (en) * | 2011-12-20 | 2019-03-20 | LifeCell Corporation | Sheet tissue products |
KR101750349B1 (ko) * | 2013-02-08 | 2017-06-23 | 아셀, 인크. | 세포외 기질 재료로부터의 생리활성 겔의 제조 방법 |
USD748252S1 (en) | 2013-02-08 | 2016-01-26 | C. R. Bard, Inc. | Multi-lumen catheter tip |
KR102215401B1 (ko) * | 2013-02-22 | 2021-02-10 | 알로소스 | 연골 모자이크 조성물 및 방법 |
US9878071B2 (en) | 2013-10-16 | 2018-01-30 | Purdue Research Foundation | Collagen compositions and methods of use |
EP3785742A1 (en) * | 2013-11-19 | 2021-03-03 | Cornell University | Tissue scaffold materials for tissue regeneration and methods of making |
US20150283308A1 (en) * | 2014-04-03 | 2015-10-08 | Cook Biotech, Incorporated | Endoluminal device and method of implanting same |
WO2016011091A1 (en) | 2014-07-14 | 2016-01-21 | C. R. Bard, Inc. | Apparatuses, systems, and methods for inserting split tip catheters having enhanced stiffening and guiding features |
MY193650A (en) * | 2014-08-25 | 2022-10-21 | Celularity Inc | Extracellular matrix compositions |
JP2017529390A (ja) * | 2014-08-27 | 2017-10-05 | パデュー リサーチ ファウンデーション オフィス オブ テクノロジー コマーシャリゼーション | コラーゲンに基づく治療送達系 |
US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
US11919941B2 (en) | 2015-04-21 | 2024-03-05 | Purdue Research Foundation | Cell-collagen-silica composites and methods of making and using the same |
CA3177726A1 (en) | 2015-05-21 | 2016-11-24 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
JP2019513038A (ja) * | 2016-03-14 | 2019-05-23 | リージェンティーズ コーポレイション | 炎症性腸疾患を処置するための方法および組成物 |
US10881555B2 (en) * | 2016-03-30 | 2021-01-05 | Basf Se | Fluid-absorbent article |
US10537417B2 (en) | 2016-07-07 | 2020-01-21 | Collagen Matrix, Inc. | Density gradient biopolymeric matrix implants |
WO2018200750A1 (en) | 2017-04-25 | 2018-11-01 | Purdue Research Foundation | 3-dimensional (3d) tissue-engineered muscle for tissue restoration |
CN109513044B (zh) * | 2019-01-29 | 2022-02-18 | 北京颢美细胞基因生物技术有限公司 | 用于微整形的再生组织基质微粒植入剂、制备方法及应用 |
JP7256395B2 (ja) * | 2019-10-24 | 2023-04-12 | サミー株式会社 | 遊技機 |
US11826490B1 (en) | 2020-12-29 | 2023-11-28 | Acell, Inc. | Extracellular matrix sheet devices with improved mechanical properties and method of making |
Family Cites Families (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT261800B (de) | 1966-08-22 | 1968-05-10 | Braun Internat Gmbh B | Verfahren zur Herstellung von röhrenförmigen, glatten bzw. mit einem Gewinde versehenen Gewebe-Blutgefäß-Prothesen |
US4439521A (en) | 1981-10-21 | 1984-03-27 | Ontario Cancer Institute | Method for producing self-reproducing mammalian pancreatic islet-like structures |
US4801299A (en) | 1983-06-10 | 1989-01-31 | University Patents, Inc. | Body implants of extracellular matrix and means and methods of making and using such implants |
CA1295796C (en) | 1984-03-27 | 1992-02-18 | Conrad Whyne | Biodegradable matrix and methods for producing same |
US4829000A (en) | 1985-08-30 | 1989-05-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Reconstituted basement membrane complex with biological activity |
US4780450A (en) | 1985-12-20 | 1988-10-25 | The University Of Maryland At Baltimore | Physically stable composition and method of use thereof for osseous repair |
GB8618374D0 (en) | 1986-07-28 | 1986-09-03 | Hsc Res Dev Corp | Biological vascular prostheses |
US4902528A (en) * | 1987-08-12 | 1990-02-20 | Nestec S.A. | Preparation of dried precooked rice product |
US4776653A (en) | 1987-10-16 | 1988-10-11 | The Merton Company, Ltd. | Amusement device with kaleidoscope viewer |
US4902508A (en) | 1988-07-11 | 1990-02-20 | Purdue Research Foundation | Tissue graft composition |
US4956178A (en) | 1988-07-11 | 1990-09-11 | Purdue Research Foundation | Tissue graft composition |
JPH02249556A (ja) * | 1988-10-25 | 1990-10-05 | Takao Yamamuro | 骨修復材および人工骨固定化剤 |
US5425769A (en) * | 1990-04-23 | 1995-06-20 | Snyders, Jr.; Robert V. | Composition of material for osseous repair |
US5336616A (en) | 1990-09-12 | 1994-08-09 | Lifecell Corporation | Method for processing and preserving collagen-based tissues for transplantation |
ES2179821T3 (es) | 1991-06-24 | 2003-02-01 | Hcell Technology Inc | Celulas pancreaticas secretoras de hormonas y mantenimiento en cultivo a largo plazo. |
US5281422A (en) | 1991-09-24 | 1994-01-25 | Purdue Research Foundation | Graft for promoting autogenous tissue growth |
US5800537A (en) | 1992-08-07 | 1998-09-01 | Tissue Engineering, Inc. | Method and construct for producing graft tissue from an extracellular matrix |
US5275826A (en) | 1992-11-13 | 1994-01-04 | Purdue Research Foundation | Fluidized intestinal submucosa and its use as an injectable tissue graft |
US5641518A (en) | 1992-11-13 | 1997-06-24 | Purdue Research Foundation | Method of repairing bone tissue |
US5352463A (en) | 1992-11-13 | 1994-10-04 | Badylak Steven F | Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor |
AU1931495A (en) | 1994-03-14 | 1995-10-03 | Cryolife, Inc. | Treated tissue for implantation and preparation methods |
US5891558A (en) | 1994-11-22 | 1999-04-06 | Tissue Engineering, Inc. | Biopolymer foams for use in tissue repair and reconstruction |
US6485723B1 (en) | 1995-02-10 | 2002-11-26 | Purdue Research Foundation | Enhanced submucosal tissue graft constructs |
US5695998A (en) | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
DE69622548T2 (de) | 1995-04-07 | 2003-09-18 | Purdue Research Foundation West Lafayette | Gewebetransplantat zur blasenrekonstruktion |
US5554389A (en) | 1995-04-07 | 1996-09-10 | Purdue Research Foundation | Urinary bladder submucosa derived tissue graft |
US5711969A (en) | 1995-04-07 | 1998-01-27 | Purdue Research Foundation | Large area submucosal tissue graft constructs |
CA2172917A1 (en) * | 1995-06-07 | 1996-12-08 | Hugh R. Mcmullin | Moldable collagen compositions for hard tissue repair and augmentation |
JPH09122227A (ja) | 1995-10-31 | 1997-05-13 | Bio Eng Lab:Kk | 医用材料およびその製造方法 |
JPH09122225A (ja) | 1995-10-31 | 1997-05-13 | Bio Eng Lab:Kk | 医用材料の原料膜材およびその製造方法 |
US5944754A (en) | 1995-11-09 | 1999-08-31 | University Of Massachusetts | Tissue re-surfacing with hydrogel-cell compositions |
US5869041A (en) | 1996-01-12 | 1999-02-09 | The Miriam Hospital | Delivery of bioactive compounds to an organism |
US5755791A (en) | 1996-04-05 | 1998-05-26 | Purdue Research Foundation | Perforated submucosal tissue graft constructs |
US6171344B1 (en) | 1996-08-16 | 2001-01-09 | Children's Medical Center Corporation | Bladder submucosa seeded with cells for tissue reconstruction |
PL331765A1 (en) | 1996-08-23 | 1999-08-02 | Cook Biotech Inc | Trnsplant prosthesis, materials and methods |
WO1998019719A1 (en) | 1996-11-05 | 1998-05-14 | Purdue Research Foundation | Myocardial graft constructs |
EP1671604B1 (en) | 1996-12-10 | 2009-07-22 | Purdue Research Foundation | Synthetic tissue valve |
EP0942739B1 (en) | 1996-12-10 | 2006-04-12 | Purdue Research Foundation | Biomaterial derived from vertebrate liver tissue |
CZ189099A3 (cs) | 1996-12-10 | 1999-08-11 | Purdue Research Foundation | Tubulární konstrukce submukózního štěpu |
JP2001509700A (ja) | 1996-12-10 | 2001-07-24 | クック バイオテック、インク. | ステント移植片含有精製粘膜下組織 |
US5866415A (en) | 1997-03-25 | 1999-02-02 | Villeneuve; Peter E. | Materials for healing cartilage and bone defects |
DE69827001T2 (de) | 1997-04-11 | 2005-09-08 | Cryolife, Inc. | Gewebedezellularization |
DE19828726A1 (de) | 1997-06-27 | 1999-01-07 | Augustinus Dr Bader | Bioartifizielles Transplantat und Verfahren zu seiner Herstellung |
US6485969B1 (en) | 1997-12-23 | 2002-11-26 | Purdue Research Foundation | Biomaterial derived from follicle basement membranes |
WO1999062427A1 (en) | 1998-06-05 | 1999-12-09 | Organogenesis Inc. | Bioengineered vascular graft support prostheses |
JP2002525043A (ja) | 1998-09-11 | 2002-08-13 | パーデュー・リサーチ・ファウンデーション | 改良粘膜下組織グラフト構成物 |
AU769637B2 (en) | 1998-11-19 | 2004-01-29 | Organogenesis Inc. | Bioengineered tissue constructs and methods for producing and using them |
JP2000223701A (ja) * | 1999-01-28 | 2000-08-11 | Mitsubishi Electric Corp | 半導体装置およびその製造方法 |
US6322593B1 (en) | 1999-04-09 | 2001-11-27 | Sulzer Carbomedics Inc. | Method for treating cross-linked biological tissues |
DE60017900T2 (de) | 1999-04-30 | 2006-04-06 | Massachusetts General Hospital, Boston | Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen |
AU782297B2 (en) * | 1999-06-30 | 2005-07-14 | Ethicon Inc. | Porous tissue scaffoldings for the repair or regeneration of tissue |
US6454804B1 (en) | 1999-10-08 | 2002-09-24 | Bret A. Ferree | Engineered tissue annulus fibrosis augmentation methods and apparatus |
US6432712B1 (en) | 1999-11-22 | 2002-08-13 | Bioscience Consultants, Llc | Transplantable recellularized and reendothelialized vascular tissue graft |
US20090053279A1 (en) | 1999-12-22 | 2009-02-26 | Badylak Stephen F | Tissue regenerative composition |
US6576265B1 (en) | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
US6579538B1 (en) | 1999-12-22 | 2003-06-17 | Acell, Inc. | Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof |
DK1749543T3 (da) | 1999-12-22 | 2009-06-15 | Acell Inc | Sammensætning til vævsregeneration |
US20040043006A1 (en) | 2002-08-27 | 2004-03-04 | Badylak Stephen F. | Tissue regenerative composition |
US6479064B1 (en) | 1999-12-29 | 2002-11-12 | Children's Medical Center Corporation | Culturing different cell populations on a decellularized natural biostructure for organ reconstruction |
US6376244B1 (en) | 1999-12-29 | 2002-04-23 | Children's Medical Center Corporation | Methods and compositions for organ decellularization |
US6962814B2 (en) | 2000-08-16 | 2005-11-08 | Duke University | Decellularized tissue engineered constructs and tissues |
US6827966B2 (en) | 2001-05-30 | 2004-12-07 | Novartis Ag | Diffusion-controllable coatings on medical device |
US8877233B2 (en) | 2001-06-29 | 2014-11-04 | Cook Biotech Incorporated | Porous sponge matrix medical devices and methods |
US6613348B1 (en) | 2001-07-31 | 2003-09-02 | Manoj K. Jain | Process of controlling absorbency in collagen flakes |
JP4451658B2 (ja) | 2001-10-18 | 2010-04-14 | ライフセル コーポレーション | 組織および器官のリモデリング |
ATE526047T1 (de) | 2001-11-16 | 2011-10-15 | Childrens Medical Center | Verbesserung der funktion von organen |
US6849339B2 (en) * | 2001-11-27 | 2005-02-01 | Guardian Industries Corporation | Composite laminate structures especially useful for automotive trim components, and methods and tie layers employed to make the same |
WO2003072748A2 (en) | 2002-02-22 | 2003-09-04 | University Of Washington | Bioengineered tissue substitutes |
US6651637B1 (en) * | 2002-10-29 | 2003-11-25 | Transpo Electronics, Inc. | Vehicle ignition system using ignition module with reduced heat generation |
US20040175366A1 (en) | 2003-03-07 | 2004-09-09 | Acell, Inc. | Scaffold for cell growth and differentiation |
US8741352B2 (en) * | 2003-08-25 | 2014-06-03 | Cook Biotech Incorporated | Graft materials containing ECM components, and methods for their manufacture |
US20050283256A1 (en) | 2004-02-09 | 2005-12-22 | Codman & Shurtleff, Inc. | Collagen device and method of preparing the same |
US20050175659A1 (en) | 2004-02-09 | 2005-08-11 | Macomber Laurel R. | Collagen device and method of preparing the same |
CA2560876A1 (en) | 2004-03-29 | 2005-10-13 | Cook Biotech Incorporated | Medical graft products with differing regions and methods and systems for producing the same |
WO2007126411A2 (en) | 2005-07-28 | 2007-11-08 | Carnegie Mellon University | Biocompatible polymers and methods of use |
US8053559B2 (en) | 2005-10-27 | 2011-11-08 | Coloplast A/S | Biodegradable scaffold with ECM material |
US7838022B2 (en) | 2006-05-01 | 2010-11-23 | Warsaw Orthopedic, Inc | Malleable implants containing demineralized bone matrix |
US7771741B2 (en) | 2006-05-01 | 2010-08-10 | Warsaw Orthopedic, Inc | Demineralized bone matrix devices |
US20080005250A1 (en) * | 2006-06-30 | 2008-01-03 | Ragip Dogan Oksum | Messaging System and Related Methods |
WO2008008266A2 (en) | 2006-07-07 | 2008-01-17 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Biohybrid elastomeric scaffolds and methods of use thereof |
US20080026032A1 (en) | 2006-07-27 | 2008-01-31 | Zubery Yuval | Composite implants for promoting bone regeneration and augmentation and methods for their preparation and use |
WO2008109407A2 (en) | 2007-03-02 | 2008-09-12 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Extracellular matrix-derived gels and related methods |
US7799793B2 (en) | 2007-04-27 | 2010-09-21 | Medtronic, Inc. | N-alkylated rifampin |
WO2009076391A2 (en) * | 2007-12-10 | 2009-06-18 | Cook Biotech Incorporated | Medical materials including modified extracellular matrix materials |
AU2008335196B2 (en) * | 2007-12-12 | 2012-04-26 | Mark K. Moser | Light source tracker |
CA2734560C (en) * | 2008-06-20 | 2018-10-23 | Cook Biotech Incorporated | Composite extracellular matrix materials and medical products formed therefrom |
US8652500B2 (en) | 2009-07-22 | 2014-02-18 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
-
2009
- 2009-07-22 US US12/507,311 patent/US8652500B2/en active Active
-
2010
- 2010-07-21 DK DK10737434.0T patent/DK2456476T3/da active
- 2010-07-21 KR KR1020127004389A patent/KR20120069668A/ko active Search and Examination
- 2010-07-21 EP EP10737434.0A patent/EP2456476B1/en active Active
- 2010-07-21 EP EP19194713.4A patent/EP3607975A1/en active Pending
- 2010-07-21 JP JP2012521747A patent/JP6226524B2/ja active Active
- 2010-07-21 AU AU2010276271A patent/AU2010276271B2/en active Active
- 2010-07-21 CN CN201080042075.6A patent/CN102573939B/zh active Active
- 2010-07-21 WO PCT/US2010/042701 patent/WO2011011484A2/en active Application Filing
- 2010-07-21 ES ES10737434T patent/ES2749377T3/es active Active
- 2010-07-21 CA CA2986673A patent/CA2986673C/en active Active
- 2010-07-21 KR KR1020177028050A patent/KR101878236B1/ko active IP Right Grant
- 2010-07-21 KR KR1020187019501A patent/KR101960694B1/ko active IP Right Grant
- 2010-07-21 KR KR1020167036658A patent/KR101794039B1/ko active IP Right Grant
- 2010-07-21 CA CA2768727A patent/CA2768727C/en active Active
-
2012
- 2012-11-20 US US13/681,610 patent/US8968761B2/en active Active
-
2014
- 2014-01-24 US US14/163,046 patent/US9056078B2/en active Active
-
2015
- 2015-05-14 US US14/712,084 patent/US9561307B2/en active Active
- 2015-07-23 JP JP2015145739A patent/JP6340346B2/ja active Active
-
2016
- 2016-11-17 US US15/354,236 patent/US11000628B2/en active Active
-
2017
- 2017-09-28 JP JP2017188962A patent/JP6640808B2/ja active Active
-
2018
- 2018-10-12 US US16/158,805 patent/US10898610B2/en active Active
- 2018-11-20 US US16/196,272 patent/US11013829B2/en active Active
-
2019
- 2019-07-19 JP JP2019134133A patent/JP2019193877A/ja active Pending
-
2020
- 2020-01-21 JP JP2020007232A patent/JP2020058884A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6640808B2 (ja) | 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 | |
US11938246B2 (en) | Tissue-based compositions and methods of use thereof | |
JP2018047245A5 (ja) | ||
AU2013201872B2 (en) | Particulate tissue graft with components of differing density and methods of making and using the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150724 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150724 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160701 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20160927 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20161201 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20170529 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170928 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20171110 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20180116 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180416 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20180426 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20180514 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6340346 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |