JP6640808B2 - 異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 - Google Patents
異なる密度の成分を有する粒子状組織グラフトならびにそれを作成および使用する方法 Download PDFInfo
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- JP6640808B2 JP6640808B2 JP2017188962A JP2017188962A JP6640808B2 JP 6640808 B2 JP6640808 B2 JP 6640808B2 JP 2017188962 A JP2017188962 A JP 2017188962A JP 2017188962 A JP2017188962 A JP 2017188962A JP 6640808 B2 JP6640808 B2 JP 6640808B2
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- A61L2430/00—Materials or treatment for tissue regeneration
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- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
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Description
porcine bone)、脱塩同種移植骨、または石灰化した同種移植骨などの、骨代替材料と組み合わせ可能である。別の実施形態では、骨粒子および本発明の異なる密度のECM粒子は、接着剤、結合剤、またはあらゆるその他の添加剤を用いずに混合可能である。粒子は骨代替材料に被覆および/または注入される。骨代替材料が患者の組織部位に移植されると、骨代替材料は欠損を安定化するために強固な構造をもたらし、一方で、低密度な粒子は部位における急速な組織修復を促進する。高密度な粒子が低密度な粒子よりも低速で生体吸収されるため、長期間の間、高密度な粒子は移植部位における組織修復を維持する。高密度粒子は組織部位が修復するまで、通常は完全に生体吸収されない。
ECM粒子の混合物を、50〜1000μmの大きさで約0.05g/cm3の密度を有する60mgのUBM粒子、および50〜500μmの大きさで約0.25g/cm3の密度を有する20mgのUBM粒子を、重量に基づき3:1の粒子割合で用いて作成する。混合物を慢性皮膚潰瘍に局所的に投与する。10日以内に、0.05g/cm3の粒子が吸収され、組織再生が創傷部位において観察される。30日以内に、0.25g/cm3の粒子が吸収され、創傷部位の組織が完全に再生する。
ECM粒子の混合物を、腫瘍が切除された腎臓部位へ移植するために調製する。ECM粒子の混合物を、500〜1000μmの大きさで約0.10g/cm3の密度を有する200mgのUBM粒子、および50〜500μmの大きさで約0.35g/cm3の密度を有する1000mgのUBM粒子を、重量に基づき1:5の粒子割合で用いて作成する。混合物を患者に注射器を用いて外科的に移植する。20日以内に、0.10g/cm3の粒子が吸収され、磁気共鳴画像法によって組織再生が創傷部位において観察される。60日以内に、0.35g/cm3の粒子が吸収され、磁気共鳴画像法で観察されるよう
に、創傷部位の組織は完全に再生する。
Claims (20)
- 哺乳動物患者の解剖学的組織部位に移植する移植片であって、
複数の生体吸収性複合粒子を含み、
各複合粒子が、異なる二つの細胞外マトリックスの各々に由来する部位を含み、
前記二つの細胞外マトリックスの一方が、前記二つの細胞外マトリックスの他方の密度の少なくとも150%の密度を有する、
移植片。 - 前記二つの細胞外マトリックスの一方が、上皮基底膜を含む請求項1に記載の移植片。
- 前記二つの細胞外マトリックスの一方が、水和された細胞外マトリックスを含む請求項1に記載の移植片。
- さらに、非複合粒子を含む請求項1に記載の移植片。
- 前記二つの細胞外マトリックスの一方の密度が、前記二つの細胞外マトリックスの他方の密度の150〜500%である請求項1に記載の移植片。
- 前記二つの細胞外マトリックスの一方が、圧縮された細胞外マトリックスを含む請求項1に記載の移植片。
- 前記二つの細胞外マトリックスの一方が、凍結乾燥された細胞外マトリックスを含む請求項1に記載の移植片。
- さらに、細胞外マトリックスの第1シートと細胞外マトリックスの第2シートとを含む薄層を含み、前記複合粒子が第1シートと第2シートとの間に含まれる請求項1に記載の移植片。
- 身体部位形状に形成された請求項1に記載の移植片。
- 前記身体部位が、腎臓、鼻、脾臓、耳、肝臓、骨、椎間板、心臓及び心臓内構造からなる群から選ばれる請求項9に記載の移植片。
- さらに、外科用医療機器を含む請求項1に記載の移植片。
- 前記外科用医療機器が、ステント、心臓用オクルーダ、縫合材料及びメッシュからなる群から選ばれる請求項11に記載の移植片。
- さらに、化学結合、ペプチドリンカー及び化学的接着から選ばれ、前記複合粒子と前記外科用医療機器とを結合させる、化学材料を含む、請求項12に記載の移植片。
- 前記複数の生体吸収性複合粒子が、さらに、1以上の生理活性因子、薬剤、またはDNAベクターを含む請求項1に記載の移植片。
- 前記身体部位形状が、前記複数の生体吸収性複合粒子を含んで形成される請求項9に記載の移植片。
- 前記身体部位形状が、中心部と周辺層とを含み、前記中心部が前記複数の生体吸収性複合粒子を含み、前記周辺層が前記中心部の密度よりも小さい密度を有する粒子を含む請求項15に記載の移植片。
- 前記複数の生体吸収性複合粒子のシートを含む請求項1に記載の移植片。
- 前記シートが、患者の解剖学的部位に適合するように切断された請求項17に記載の移植片。
- 前記解剖学的部位が、前記患者の皮膚、腸、血管、心臓及びヘルニアからなる群から選ばれる請求項18に記載の移植片。
- 前記複数の生体吸収性複合粒子が、液体、ゲル及びペーストからなる群から選ばれる形態で維持される請求項1に記載の移植片。
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