JP6324069B2 - 治療学的に有効な物質を含む加湿された粒子 - Google Patents

治療学的に有効な物質を含む加湿された粒子 Download PDF

Info

Publication number
JP6324069B2
JP6324069B2 JP2013525275A JP2013525275A JP6324069B2 JP 6324069 B2 JP6324069 B2 JP 6324069B2 JP 2013525275 A JP2013525275 A JP 2013525275A JP 2013525275 A JP2013525275 A JP 2013525275A JP 6324069 B2 JP6324069 B2 JP 6324069B2
Authority
JP
Japan
Prior art keywords
aerosol
particles
temperature
water vapor
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2013525275A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013540704A5 (enExample
JP2013540704A (ja
Inventor
ラーメル ダニエラ
ラーメル ダニエラ
タウト フリーデマン
タウト フリーデマン
デ マインク クリスティアン
デ マインク クリスティアン
ラスト マークス
ラスト マークス
イヴァチェンコ ペーター
イヴァチェンコ ペーター
ポールマン ゲアハート
ポールマン ゲアハート
コッホ ヴォルフガング
コッホ ヴォルフガング
ヴィント ホアスト
ヴィント ホアスト
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV filed Critical Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Publication of JP2013540704A publication Critical patent/JP2013540704A/ja
Publication of JP2013540704A5 publication Critical patent/JP2013540704A5/ja
Application granted granted Critical
Publication of JP6324069B2 publication Critical patent/JP6324069B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/105—Filters
    • A61M16/106—Filters in a path
    • A61M16/1065—Filters in a path in the expiratory path
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/06—Respiratory or anaesthetic masks
    • A61M16/0666—Nasal cannulas or tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • A61M16/142—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase with semi-permeable walls separating the liquid from the respiratory gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • A61M16/16—Devices to humidify the respiration air
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A61M2205/505—Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7518—General characteristics of the apparatus with filters bacterial
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2013525275A 2010-08-23 2011-08-22 治療学的に有効な物質を含む加湿された粒子 Active JP6324069B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10173759.1 2010-08-23
EP10173759 2010-08-23
PCT/EP2011/064399 WO2012025496A1 (en) 2010-08-23 2011-08-22 Humidified particles comprising a therapeutically active substance

Publications (3)

Publication Number Publication Date
JP2013540704A JP2013540704A (ja) 2013-11-07
JP2013540704A5 JP2013540704A5 (enExample) 2014-10-09
JP6324069B2 true JP6324069B2 (ja) 2018-05-16

Family

ID=43501562

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013525275A Active JP6324069B2 (ja) 2010-08-23 2011-08-22 治療学的に有効な物質を含む加湿された粒子

Country Status (15)

Country Link
US (1) US9693955B2 (enExample)
EP (1) EP2608769B1 (enExample)
JP (1) JP6324069B2 (enExample)
KR (1) KR101957530B1 (enExample)
CN (1) CN103052380B (enExample)
AU (1) AU2011295165B2 (enExample)
BR (1) BR112013003597B1 (enExample)
CA (1) CA2805602A1 (enExample)
EA (1) EA201300255A1 (enExample)
ES (1) ES2769576T3 (enExample)
IL (1) IL224692A (enExample)
MX (1) MX2013001936A (enExample)
NZ (1) NZ607358A (enExample)
WO (1) WO2012025496A1 (enExample)
ZA (1) ZA201300415B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT507187B1 (de) 2008-10-23 2010-03-15 Helmut Dr Buchberger Inhalator
AT510837B1 (de) 2011-07-27 2012-07-15 Helmut Dr Buchberger Inhalatorkomponente
HUE026804T2 (en) 2011-02-11 2016-07-28 Batmark Ltd Inhaler component
JP6017562B2 (ja) 2011-09-06 2016-11-02 ブリティッシュ アメリカン タバコ （インヴェストメンツ） リミテッドＢｒｉｔｉｓｈ Ａｍｅｒｉｃａｎ Ｔｏｂａｃｃｏ （Ｉｎｖｅｓｔｍｅｎｔｓ） Ｌｉｍｉｔｅｄ 喫煙材の加熱
UA110646C2 (uk) 2011-09-06 2016-01-25 Брітіш Амерікан Тобакко (Інвестментс) Лімітед Пристрій для нагрівання курильного матеріалу
AT511344B1 (de) 2011-10-21 2012-11-15 Helmut Dr Buchberger Inhalatorkomponente
GB201207039D0 (en) 2012-04-23 2012-06-06 British American Tobacco Co Heating smokeable material
GB2504075A (en) 2012-07-16 2014-01-22 Nicoventures Holdings Ltd Electronic smoking device
GB2504076A (en) 2012-07-16 2014-01-22 Nicoventures Holdings Ltd Electronic smoking device
DE102013001888B4 (de) 2013-02-02 2017-07-20 Drägerwerk AG & Co. KGaA Vorrichtung und Verfahren zur Bereitstellung eines Atemgasstromes
CN105210291B (zh) 2013-03-15 2018-10-02 维斯普瑞公司 可调滤波器系统、装置以及方法
GB2513637A (en) 2013-05-02 2014-11-05 Nicoventures Holdings Ltd Electronic cigarette
GB2513639A (en) 2013-05-02 2014-11-05 Nicoventures Holdings Ltd Electronic cigarette
GB2513638A (en) 2013-05-02 2014-11-05 Nicoventures Holdings Ltd Electronic cigarette
GB2514893B (en) 2013-06-04 2017-12-06 Nicoventures Holdings Ltd Container
AU2015226289B8 (en) 2014-03-05 2019-10-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device for providing a constant amount of aerosol
WO2015132172A1 (en) * 2014-03-05 2015-09-11 Takeda Gmbh Humidifier for humidifying an aerosol
GB201407426D0 (en) 2014-04-28 2014-06-11 Batmark Ltd Aerosol forming component
GB2528673B (en) 2014-07-25 2020-07-01 Nicoventures Holdings Ltd Aerosol provision system
US20160101246A1 (en) * 2014-10-10 2016-04-14 Solaeromed Inc. Apparatus and methods for producing and delivering a vapour medicament
GB2533135B (en) 2014-12-11 2020-11-11 Nicoventures Holdings Ltd Aerosol provision systems
GB201505595D0 (en) 2015-03-31 2015-05-13 British American Tobacco Co Cartridge for use with apparatus for heating smokeable material
GB201505597D0 (en) 2015-03-31 2015-05-13 British American Tobacco Co Article for use with apparatus for heating smokable material
GB201511349D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic aerosol provision systems
GB201511361D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic vapour provision system
US20170055584A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Article for use with apparatus for heating smokable material
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
GB2542838B (en) 2015-10-01 2022-01-12 Nicoventures Trading Ltd Aerosol provision system
US20170119046A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Apparatus for Heating Smokable Material
WO2017187148A1 (en) 2016-04-27 2017-11-02 Nicoventures Holdings Limited Electronic aerosol provision system and vaporizer therefor
DE102016112822A1 (de) * 2016-07-13 2018-01-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Atemgesteuerte Applikation von pulverförmigem Aerosol bei der Beatmung oder Atemunterstützung eines Patienten
WO2018071812A1 (en) * 2016-10-14 2018-04-19 Vapotherm, Inc. Systems and methods for high velocity nasal insufflation
CN110167510B (zh) 2016-12-08 2021-12-14 R·P·谢勒技术有限公司 减轻胶囊壳中的应力以降低破裂倾向的方法
WO2018127591A1 (en) * 2017-01-06 2018-07-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Jet aerosol dispenser
EP3456371B1 (en) * 2017-09-18 2020-04-08 Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. Device for administering a humidified aerosol to a patient interface
CN116115864B (zh) * 2021-11-15 2025-10-21 深圳麦克韦尔科技有限公司 雾化装置
CN115148330B (zh) * 2022-05-24 2023-07-25 中国医学科学院北京协和医院 Pop治疗方案形成方法及系统

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59164724A (ja) 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
US4773410A (en) 1984-10-09 1988-09-27 Transpirator Technologies, Inc. Method and apparatus for the treatment of the respiratory track with vapor-phase water
DE3819988A1 (de) 1988-06-11 1989-12-14 Draegerwerk Ag Atemluftanfeuchter fuer ein atemschutzgeraet
EP0482097B1 (en) 1989-07-11 2001-06-06 Genentech, Inc. Surfactant compositions and methods
DE69132211T2 (de) 1990-10-17 2000-11-23 The Liposome Co.,Inc. Synthetische oberflächenaktive agentien auf der lunge
GB9120005D0 (en) * 1991-09-19 1991-11-06 Wellcome Found Method of administering phospholipid dispersions
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
DE4418936A1 (de) 1994-05-31 1996-02-08 Byk Gulden Lomberg Chem Fab Polypeptid
SE503771C2 (sv) 1994-12-01 1996-09-02 Gibeck Respiration Ab Anordning vid fukt-värmeväxlare
DE19507410C2 (de) * 1995-03-03 1997-05-22 Gsf Forschungszentrum Umwelt Verfahren und Vorrichtung zur Herstellung von Aerosolen
DK0877602T3 (da) 1996-01-24 2002-05-06 Byk Gulden Lomberg Chem Fab Fremgangsmåde til fremstilling af pulverformede lungesurfactant-præparater
US6261539B1 (en) * 1998-12-10 2001-07-17 Akwete Adjei Medicinal aerosol formulation
DE19962221A1 (de) 1999-10-01 2001-05-23 Glatt Process Technology Gmbh Dispersionen für Depotapplikationen
ES2251416T3 (es) 1999-12-10 2006-05-01 Vapotherm, Inc. Aparato para terapia del tracto respiratorio.
US6918389B2 (en) 2000-03-21 2005-07-19 Fisher & Paykel Healthcare Limited Breathing assistance apparatus
ATE326952T1 (de) 2000-10-02 2006-06-15 Novozymes As Einen wirkstoff enthaltende, beschichtete teilchen
US7708013B2 (en) 2000-12-08 2010-05-04 Vapotherm, Inc. Apparatus and method for delivering water vapor to a gas
US20080038363A1 (en) * 2001-05-24 2008-02-14 Zaffaroni Alejandro C Aerosol delivery system and uses thereof
US6712881B2 (en) * 2002-01-30 2004-03-30 Aerosol Dynamics Inc. Continuous, laminar flow water-based particle condensation device and method
CA2483687A1 (en) * 2002-05-13 2003-11-20 Alexza Molecular Delivery Corporation Delivery of drug amines through an inhalation route
GB0326632D0 (en) * 2003-11-14 2003-12-17 Jagotec Ag Dry powder formulations
US7407531B2 (en) * 2004-05-10 2008-08-05 Tsi Incorporated Particle surface treatment for promoting condensation
DE102005016100B3 (de) 2005-04-08 2006-10-26 Altana Pharma Ag Vorrichtung zur Dosierung und Trockenvernebelung
EP1820530B1 (en) 2006-02-20 2014-10-08 Björn Thulin Humidifier and use of the humidifier
DE102006026578B4 (de) 2006-06-08 2009-01-08 Lts Lohmann Therapie-Systeme Ag Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung
CA2663795A1 (en) * 2006-09-19 2008-03-27 Discovery Laboratories, Inc. Pulmonary surfactant formulations and methods for promoting mucus clearance
US8550075B2 (en) 2007-06-28 2013-10-08 Resmed Limited Removable and/or replaceable humidifier
CA2700534A1 (en) 2007-09-25 2009-04-02 Novartis Ag Treatment of pulmonary disorders with aerosolized medicaments such as vancomycin
EP2172190A1 (en) 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
CN102421473B (zh) 2009-04-23 2014-11-05 塔科达有限责任公司 用于大体积干粉烟雾化的改进型设备

Also Published As

Publication number Publication date
US20130142782A1 (en) 2013-06-06
MX2013001936A (es) 2013-03-08
AU2011295165B2 (en) 2015-07-02
CN103052380A (zh) 2013-04-17
CN103052380B (zh) 2015-11-25
ZA201300415B (en) 2017-11-29
EA201300255A1 (ru) 2013-06-28
IL224692A (en) 2017-12-31
WO2012025496A1 (en) 2012-03-01
ES2769576T3 (es) 2020-06-26
AU2011295165A1 (en) 2013-04-04
EP2608769A1 (en) 2013-07-03
US9693955B2 (en) 2017-07-04
KR20130141463A (ko) 2013-12-26
KR101957530B1 (ko) 2019-03-12
NZ607358A (en) 2015-04-24
JP2013540704A (ja) 2013-11-07
CA2805602A1 (en) 2012-03-01
BR112013003597A2 (pt) 2016-08-16
BR112013003597B1 (pt) 2021-10-13
BR112013003597A8 (pt) 2018-02-06
EP2608769B1 (en) 2019-11-06

Similar Documents

Publication Publication Date Title
JP6324069B2 (ja) 治療学的に有効な物質を含む加湿された粒子
AU2025200588A1 (en) Surfactant Formulations for Inhalation
US11123513B2 (en) Humidifier for humidifying an aerosol
WO2019126283A1 (en) Surfactant formulations for inhalation
HK1184061A (en) Humidified particles comprising a therapeutically active substance
Donn et al. Aerosolization and Nebulization
Mazela Aerosolization and nebulization
JP2023553048A (ja) 呼吸器疾患を治療するための組成物、デバイス、及び方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140819

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20140819

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A712

Effective date: 20150414

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20150417

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150511

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150810

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20150910

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20151013

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20160314

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20160502

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160714

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20160726

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20160930

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180126

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20180410

R150 Certificate of patent or registration of utility model

Ref document number: 6324069

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250