ES2769576T3 - Partículas humidificadas que comprenden una sustancia terapéuticamente activa - Google Patents

Partículas humidificadas que comprenden una sustancia terapéuticamente activa Download PDF

Info

Publication number
ES2769576T3
ES2769576T3 ES11748639T ES11748639T ES2769576T3 ES 2769576 T3 ES2769576 T3 ES 2769576T3 ES 11748639 T ES11748639 T ES 11748639T ES 11748639 T ES11748639 T ES 11748639T ES 2769576 T3 ES2769576 T3 ES 2769576T3
Authority
ES
Spain
Prior art keywords
aerosol
particles
spray
temperature
therapeutically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11748639T
Other languages
English (en)
Spanish (es)
Inventor
Daniela Rahmel
Friedemann Taut
Muynck Christian De
Markus Rast
Peter Iwatschenko
Gerhard Pohlmann
Wolfgang Koch
Horst Windt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung eV
Original Assignee
Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung eV filed Critical Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung eV
Application granted granted Critical
Publication of ES2769576T3 publication Critical patent/ES2769576T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/105—Filters
    • A61M16/106—Filters in a path
    • A61M16/1065—Filters in a path in the expiratory path
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/06—Respiratory or anaesthetic masks
    • A61M16/0666—Nasal cannulas or tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • A61M16/142—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase with semi-permeable walls separating the liquid from the respiratory gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • A61M16/16—Devices to humidify the respiration air
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A61M2205/505—Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7518—General characteristics of the apparatus with filters bacterial
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES11748639T 2010-08-23 2011-08-22 Partículas humidificadas que comprenden una sustancia terapéuticamente activa Active ES2769576T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10173759 2010-08-23
PCT/EP2011/064399 WO2012025496A1 (en) 2010-08-23 2011-08-22 Humidified particles comprising a therapeutically active substance

Publications (1)

Publication Number Publication Date
ES2769576T3 true ES2769576T3 (es) 2020-06-26

Family

ID=43501562

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11748639T Active ES2769576T3 (es) 2010-08-23 2011-08-22 Partículas humidificadas que comprenden una sustancia terapéuticamente activa

Country Status (15)

Country Link
US (1) US9693955B2 (enExample)
EP (1) EP2608769B1 (enExample)
JP (1) JP6324069B2 (enExample)
KR (1) KR101957530B1 (enExample)
CN (1) CN103052380B (enExample)
AU (1) AU2011295165B2 (enExample)
BR (1) BR112013003597B1 (enExample)
CA (1) CA2805602A1 (enExample)
EA (1) EA201300255A1 (enExample)
ES (1) ES2769576T3 (enExample)
IL (1) IL224692A (enExample)
MX (1) MX2013001936A (enExample)
NZ (1) NZ607358A (enExample)
WO (1) WO2012025496A1 (enExample)
ZA (1) ZA201300415B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT507187B1 (de) 2008-10-23 2010-03-15 Helmut Dr Buchberger Inhalator
AT510837B1 (de) 2011-07-27 2012-07-15 Helmut Dr Buchberger Inhalatorkomponente
CA2824970C (en) 2011-02-11 2016-05-03 Batmark Limited Inhaler component
MY164560A (en) 2011-09-06 2018-01-15 British American Tobacco Investments Ltd Heating Smokeable Material
KR102671442B1 (ko) 2011-09-06 2024-05-30 니코벤처스 트레이딩 리미티드 가열식 끽연 가능 물질
AT511344B1 (de) 2011-10-21 2012-11-15 Helmut Dr Buchberger Inhalatorkomponente
GB201207039D0 (en) 2012-04-23 2012-06-06 British American Tobacco Co Heating smokeable material
GB2504076A (en) 2012-07-16 2014-01-22 Nicoventures Holdings Ltd Electronic smoking device
GB2504075A (en) 2012-07-16 2014-01-22 Nicoventures Holdings Ltd Electronic smoking device
DE102013001888B4 (de) * 2013-02-02 2017-07-20 Drägerwerk AG & Co. KGaA Vorrichtung und Verfahren zur Bereitstellung eines Atemgasstromes
US9559659B2 (en) 2013-03-15 2017-01-31 Wispry, Inc. Tunable filter systems, devices, and methods
GB2513638A (en) 2013-05-02 2014-11-05 Nicoventures Holdings Ltd Electronic cigarette
GB2513637A (en) 2013-05-02 2014-11-05 Nicoventures Holdings Ltd Electronic cigarette
GB2513639A (en) 2013-05-02 2014-11-05 Nicoventures Holdings Ltd Electronic cigarette
GB2514893B (en) 2013-06-04 2017-12-06 Nicoventures Holdings Ltd Container
AU2015226287B2 (en) * 2014-03-05 2019-01-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Humidifier for humidifying an aerosol
US10737088B2 (en) 2014-03-05 2020-08-11 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Device for providing a constant amount of aerosol
GB201407426D0 (en) 2014-04-28 2014-06-11 Batmark Ltd Aerosol forming component
GB2528673B (en) 2014-07-25 2020-07-01 Nicoventures Holdings Ltd Aerosol provision system
US20160101246A1 (en) * 2014-10-10 2016-04-14 Solaeromed Inc. Apparatus and methods for producing and delivering a vapour medicament
GB2533135B (en) 2014-12-11 2020-11-11 Nicoventures Holdings Ltd Aerosol provision systems
GB201505597D0 (en) 2015-03-31 2015-05-13 British American Tobacco Co Article for use with apparatus for heating smokable material
GB201505595D0 (en) 2015-03-31 2015-05-13 British American Tobacco Co Cartridge for use with apparatus for heating smokeable material
GB201511361D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic vapour provision system
GB201511349D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic aerosol provision systems
US20170055584A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Article for use with apparatus for heating smokable material
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
GB2542838B (en) 2015-10-01 2022-01-12 Nicoventures Trading Ltd Aerosol provision system
US20170119046A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Apparatus for Heating Smokable Material
US11744964B2 (en) 2016-04-27 2023-09-05 Nicoventures Trading Limited Electronic aerosol provision system and vaporizer therefor
DE102016112822A1 (de) * 2016-07-13 2018-01-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Atemgesteuerte Applikation von pulverförmigem Aerosol bei der Beatmung oder Atemunterstützung eines Patienten
AU2017341838A1 (en) * 2016-10-14 2019-05-02 Vapotherm, Inc. Systems and methods for high velocity nasal insufflation
IL266695B (en) 2016-12-08 2022-09-01 Scherer Technologies Llc R P A method of damping stress in capsule shells to reduce the tendency to break
WO2018127591A1 (en) * 2017-01-06 2018-07-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Jet aerosol dispenser
EP3456371B1 (en) * 2017-09-18 2020-04-08 Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. Device for administering a humidified aerosol to a patient interface
CN116115864B (zh) * 2021-11-15 2025-10-21 深圳麦克韦尔科技有限公司 雾化装置
CN115148330B (zh) * 2022-05-24 2023-07-25 中国医学科学院北京协和医院 Pop治疗方案形成方法及系统

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59164724A (ja) 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
US4773410A (en) 1984-10-09 1988-09-27 Transpirator Technologies, Inc. Method and apparatus for the treatment of the respiratory track with vapor-phase water
DE3819988A1 (de) 1988-06-11 1989-12-14 Draegerwerk Ag Atemluftanfeuchter fuer ein atemschutzgeraet
AU638474B2 (en) 1989-07-11 1993-07-01 Genentech Inc. Surfactant compositions and methods
DE69132211T2 (de) 1990-10-17 2000-11-23 The Liposome Co.,Inc. Synthetische oberflächenaktive agentien auf der lunge
GB9120005D0 (en) * 1991-09-19 1991-11-06 Wellcome Found Method of administering phospholipid dispersions
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
DE4418936A1 (de) 1994-05-31 1996-02-08 Byk Gulden Lomberg Chem Fab Polypeptid
SE503771C2 (sv) 1994-12-01 1996-09-02 Gibeck Respiration Ab Anordning vid fukt-värmeväxlare
DE19507410C2 (de) * 1995-03-03 1997-05-22 Gsf Forschungszentrum Umwelt Verfahren und Vorrichtung zur Herstellung von Aerosolen
CZ292186B6 (cs) 1996-01-24 2003-08-13 Altana Pharma Ag Způsob výroby práškového prostředku s obsahem plicní povrchově aktivní látky, práškový prostředek a jeho použití
US6261539B1 (en) * 1998-12-10 2001-07-17 Akwete Adjei Medicinal aerosol formulation
DE19962221A1 (de) 1999-10-01 2001-05-23 Glatt Process Technology Gmbh Dispersionen für Depotapplikationen
ES2251416T3 (es) 1999-12-10 2006-05-01 Vapotherm, Inc. Aparato para terapia del tracto respiratorio.
US6918389B2 (en) 2000-03-21 2005-07-19 Fisher & Paykel Healthcare Limited Breathing assistance apparatus
AU2001291647A1 (en) 2000-10-02 2002-04-15 Novozymes A/S Coated particles containing an active substance
US7708013B2 (en) 2000-12-08 2010-05-04 Vapotherm, Inc. Apparatus and method for delivering water vapor to a gas
US20080038363A1 (en) * 2001-05-24 2008-02-14 Zaffaroni Alejandro C Aerosol delivery system and uses thereof
US6712881B2 (en) * 2002-01-30 2004-03-30 Aerosol Dynamics Inc. Continuous, laminar flow water-based particle condensation device and method
CA2483687A1 (en) * 2002-05-13 2003-11-20 Alexza Pharmaceuticals, Inc. Delivery of drug amines through an inhalation route
GB0326632D0 (en) * 2003-11-14 2003-12-17 Jagotec Ag Dry powder formulations
US7407531B2 (en) * 2004-05-10 2008-08-05 Tsi Incorporated Particle surface treatment for promoting condensation
DE102005016102B3 (de) 2005-04-08 2006-10-26 Altana Pharma Ag Vorrichtung zur Dosierung und Trockenvernebelung
EP1820530B1 (en) 2006-02-20 2014-10-08 Björn Thulin Humidifier and use of the humidifier
DE102006026578B4 (de) 2006-06-08 2009-01-08 Lts Lohmann Therapie-Systeme Ag Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung
KR20090060348A (ko) * 2006-09-19 2009-06-11 디스커버리 래보래토리스, 인크. 폐 계면활성제 제제 및 점액 클리어런스 촉진 방법
US8550075B2 (en) 2007-06-28 2013-10-08 Resmed Limited Removable and/or replaceable humidifier
KR20100060004A (ko) * 2007-09-25 2010-06-04 노파르티스 아게 에어로졸화된 반코마이신과 같은 의약에 의한 폐 질병의 치료
EP2172190A1 (en) 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
BRPI1016186B1 (pt) 2009-04-23 2019-12-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. "dispositivo (1) para dosar e tratar por aerossol material em forma de aerossol e sistema para dosar e nebulizar a seco material nebulizável

Also Published As

Publication number Publication date
KR20130141463A (ko) 2013-12-26
IL224692A (en) 2017-12-31
BR112013003597A8 (pt) 2018-02-06
CN103052380B (zh) 2015-11-25
MX2013001936A (es) 2013-03-08
CA2805602A1 (en) 2012-03-01
WO2012025496A1 (en) 2012-03-01
ZA201300415B (en) 2017-11-29
KR101957530B1 (ko) 2019-03-12
CN103052380A (zh) 2013-04-17
US20130142782A1 (en) 2013-06-06
NZ607358A (en) 2015-04-24
JP2013540704A (ja) 2013-11-07
EP2608769B1 (en) 2019-11-06
US9693955B2 (en) 2017-07-04
EP2608769A1 (en) 2013-07-03
EA201300255A1 (ru) 2013-06-28
BR112013003597B1 (pt) 2021-10-13
JP6324069B2 (ja) 2018-05-16
AU2011295165A1 (en) 2013-04-04
AU2011295165B2 (en) 2015-07-02
BR112013003597A2 (pt) 2016-08-16

Similar Documents

Publication Publication Date Title
US9693955B2 (en) Humidified particles comprising a therapeutically active substance
ES2217309T3 (es) Administracion por via pulmonar de alfa-1 antitripsina pulverulenta.
ES2243094T3 (es) Administracion de un agente activo aerosolizado modulado con resistentcia al flujo.
US9433588B2 (en) Delivery of submicrometer and nanometer aerosols to the lungs using hygroscopic excipients or dual stream nasal delivery
ES2674797T3 (es) Humidificador para humedecer un aerosol
CN101090711A (zh) 治疗肺部感染的颗粒
US20250288516A1 (en) Surfactant Formulations for Inhalation
EP3727418A1 (en) Surfactant formulations for inhalation
de Boer et al. Pulmonary drug delivery: delivery to and through the lung
HK1184061A (en) Humidified particles comprising a therapeutically active substance
Donn et al. Aerosolization and Nebulization
Mazela Aerosolization and nebulization
JP2023553048A (ja) 呼吸器疾患を治療するための組成物、デバイス、及び方法