ES2769576T3 - Partículas humidificadas que comprenden una sustancia terapéuticamente activa - Google Patents

Partículas humidificadas que comprenden una sustancia terapéuticamente activa Download PDF

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Publication number
ES2769576T3
ES2769576T3 ES11748639T ES11748639T ES2769576T3 ES 2769576 T3 ES2769576 T3 ES 2769576T3 ES 11748639 T ES11748639 T ES 11748639T ES 11748639 T ES11748639 T ES 11748639T ES 2769576 T3 ES2769576 T3 ES 2769576T3
Authority
ES
Spain
Prior art keywords
aerosol
particles
spray
temperature
therapeutically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11748639T
Other languages
English (en)
Spanish (es)
Inventor
Daniela Rahmel
Friedemann Taut
Muynck Christian De
Markus Rast
Peter Iwatschenko
Gerhard Pohlmann
Wolfgang Koch
Horst Windt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A61K9/122—Foams; Dry foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0082—Lung surfactant, artificial mucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/003—Particle size control by passing the aerosol trough sieves or filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/105—Filters
    • A61M16/106—Filters in a path
    • A61M16/1065—Filters in a path in the expiratory path
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/06—Respiratory or anaesthetic masks
    • A61M16/0666—Nasal cannulas or tubing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • A61M16/142—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase with semi-permeable walls separating the liquid from the respiratory gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/14—Preparation of respiratory gases or vapours by mixing different fluids, one of them being in a liquid phase
    • A61M16/16—Devices to humidify the respiration air
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502—User interfaces, e.g. screens or keyboards
    • A61M2205/505—Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7518—General characteristics of the apparatus with filters bacterial
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/0318—Processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES11748639T 2010-08-23 2011-08-22 Partículas humidificadas que comprenden una sustancia terapéuticamente activa Active ES2769576T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10173759 2010-08-23
PCT/EP2011/064399 WO2012025496A1 (en) 2010-08-23 2011-08-22 Humidified particles comprising a therapeutically active substance

Publications (1)

Publication Number Publication Date
ES2769576T3 true ES2769576T3 (es) 2020-06-26

Family

ID=43501562

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11748639T Active ES2769576T3 (es) 2010-08-23 2011-08-22 Partículas humidificadas que comprenden una sustancia terapéuticamente activa

Country Status (15)

Country Link
US (1) US9693955B2 (enExample)
EP (1) EP2608769B1 (enExample)
JP (1) JP6324069B2 (enExample)
KR (1) KR101957530B1 (enExample)
CN (1) CN103052380B (enExample)
AU (1) AU2011295165B2 (enExample)
BR (1) BR112013003597B1 (enExample)
CA (1) CA2805602A1 (enExample)
EA (1) EA201300255A1 (enExample)
ES (1) ES2769576T3 (enExample)
IL (1) IL224692A (enExample)
MX (1) MX2013001936A (enExample)
NZ (1) NZ607358A (enExample)
WO (1) WO2012025496A1 (enExample)
ZA (1) ZA201300415B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT507187B1 (de) 2008-10-23 2010-03-15 Helmut Dr Buchberger Inhalator
US8752545B2 (en) 2011-02-11 2014-06-17 Batmark Limited Inhaler component
AT510837B1 (de) 2011-07-27 2012-07-15 Helmut Dr Buchberger Inhalatorkomponente
WO2013034459A1 (en) 2011-09-06 2013-03-14 British American Tobacco (Investments) Limited Heating smokeable material
CN107252136A (zh) 2011-09-06 2017-10-17 英美烟草(投资)有限公司 加热可点燃抽吸材料
AT511344B1 (de) 2011-10-21 2012-11-15 Helmut Dr Buchberger Inhalatorkomponente
GB201207039D0 (en) 2012-04-23 2012-06-06 British American Tobacco Co Heating smokeable material
GB2504075A (en) 2012-07-16 2014-01-22 Nicoventures Holdings Ltd Electronic smoking device
GB2504076A (en) 2012-07-16 2014-01-22 Nicoventures Holdings Ltd Electronic smoking device
DE102013001888B4 (de) * 2013-02-02 2017-07-20 Drägerwerk AG & Co. KGaA Vorrichtung und Verfahren zur Bereitstellung eines Atemgasstromes
CN105210291B (zh) 2013-03-15 2018-10-02 维斯普瑞公司 可调滤波器系统、装置以及方法
GB2513639A (en) 2013-05-02 2014-11-05 Nicoventures Holdings Ltd Electronic cigarette
GB2513638A (en) 2013-05-02 2014-11-05 Nicoventures Holdings Ltd Electronic cigarette
GB2513637A (en) 2013-05-02 2014-11-05 Nicoventures Holdings Ltd Electronic cigarette
GB2514893B (en) 2013-06-04 2017-12-06 Nicoventures Holdings Ltd Container
JP6803002B2 (ja) * 2014-03-05 2020-12-23 フラウンホファー ゲセルシャフト ツール フェールデルンク ダー アンゲヴァンテン フォルシュンク エー．ファオ． エーロゾルを加湿する加湿機
EP3113816B8 (en) 2014-03-05 2020-04-08 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Device for providing a constant amount of aerosol and control system
GB201407426D0 (en) * 2014-04-28 2014-06-11 Batmark Ltd Aerosol forming component
GB2528673B (en) 2014-07-25 2020-07-01 Nicoventures Holdings Ltd Aerosol provision system
US20160101246A1 (en) * 2014-10-10 2016-04-14 Solaeromed Inc. Apparatus and methods for producing and delivering a vapour medicament
GB2533135B (en) 2014-12-11 2020-11-11 Nicoventures Holdings Ltd Aerosol provision systems
GB201505595D0 (en) 2015-03-31 2015-05-13 British American Tobacco Co Cartridge for use with apparatus for heating smokeable material
GB201505597D0 (en) 2015-03-31 2015-05-13 British American Tobacco Co Article for use with apparatus for heating smokable material
GB201511349D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic aerosol provision systems
GB201511361D0 (en) 2015-06-29 2015-08-12 Nicoventures Holdings Ltd Electronic vapour provision system
US20170055584A1 (en) 2015-08-31 2017-03-02 British American Tobacco (Investments) Limited Article for use with apparatus for heating smokable material
US11924930B2 (en) 2015-08-31 2024-03-05 Nicoventures Trading Limited Article for use with apparatus for heating smokable material
GB2542838B (en) 2015-10-01 2022-01-12 Nicoventures Trading Ltd Aerosol provision system
US20170119046A1 (en) 2015-10-30 2017-05-04 British American Tobacco (Investments) Limited Apparatus for Heating Smokable Material
CA3022340C (en) 2016-04-27 2021-09-21 Nicoventures Holdings Limited Electronic aerosol provision system and vaporizer therefor
DE102016112822A1 (de) * 2016-07-13 2018-01-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Atemgesteuerte Applikation von pulverförmigem Aerosol bei der Beatmung oder Atemunterstützung eines Patienten
EP3525861B1 (en) * 2016-10-14 2022-03-30 Vapotherm, Inc. System for high velocity nasal insufflation
IL266695B (en) 2016-12-08 2022-09-01 Scherer Technologies Llc R P A method of damping stress in capsule shells to reduce the tendency to break
WO2018127591A1 (en) * 2017-01-06 2018-07-12 INSERM (Institut National de la Santé et de la Recherche Médicale) Jet aerosol dispenser
ES2798399T3 (es) * 2017-09-18 2020-12-11 Fraunhofer Ges Forschung Dispositivo para administrar un aerosol humidificado a una interconexión de paciente
CN116115864B (zh) * 2021-11-15 2025-10-21 深圳麦克韦尔科技有限公司 雾化装置
CN115148330B (zh) * 2022-05-24 2023-07-25 中国医学科学院北京协和医院 Pop治疗方案形成方法及系统

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59164724A (ja) 1983-03-10 1984-09-17 Tokyo Tanabe Co Ltd サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤
US4773410A (en) 1984-10-09 1988-09-27 Transpirator Technologies, Inc. Method and apparatus for the treatment of the respiratory track with vapor-phase water
DE3819988A1 (de) 1988-06-11 1989-12-14 Draegerwerk Ag Atemluftanfeuchter fuer ein atemschutzgeraet
WO1991000871A1 (en) 1989-07-11 1991-01-24 Genentech, Inc. Surfactant compositions and methods
KR0181309B1 (ko) 1990-10-17 1999-03-20 알렌 불룸 합성 폐 계면활성제
GB9120005D0 (en) * 1991-09-19 1991-11-06 Wellcome Found Method of administering phospholipid dispersions
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
DE4418936A1 (de) 1994-05-31 1996-02-08 Byk Gulden Lomberg Chem Fab Polypeptid
SE503771C2 (sv) * 1994-12-01 1996-09-02 Gibeck Respiration Ab Anordning vid fukt-värmeväxlare
DE19507410C2 (de) 1995-03-03 1997-05-22 Gsf Forschungszentrum Umwelt Verfahren und Vorrichtung zur Herstellung von Aerosolen
ES2171883T3 (es) 1996-01-24 2002-09-16 Byk Gulden Lomberg Chem Fab Procedimiento para la preparacion de formulaciones de agentes tensioactivos pulmonares en forma de polvos.
US6261539B1 (en) 1998-12-10 2001-07-17 Akwete Adjei Medicinal aerosol formulation
DE19962221A1 (de) 1999-10-01 2001-05-23 Glatt Process Technology Gmbh Dispersionen für Depotapplikationen
CA2393743C (en) 1999-12-10 2012-01-03 Vapotherm, Inc. Apparatus and method for respiratory tract therapy
US6918389B2 (en) 2000-03-21 2005-07-19 Fisher & Paykel Healthcare Limited Breathing assistance apparatus
CN1292734C (zh) 2000-10-02 2007-01-03 诺和酶股份有限公司 含有活性物质的包衣微粒
US7708013B2 (en) 2000-12-08 2010-05-04 Vapotherm, Inc. Apparatus and method for delivering water vapor to a gas
US20080038363A1 (en) * 2001-05-24 2008-02-14 Zaffaroni Alejandro C Aerosol delivery system and uses thereof
DE10392241B4 (de) 2002-01-30 2009-03-05 Aerosol Dynamics Inc., Berkeley Kontinuierliche wasserbasierte Laminarstrom-Partikelkondensationsvorrichtung und -verfahren
CA2483687A1 (en) * 2002-05-13 2003-11-20 Alexza Molecular Delivery Corporation Delivery of drug amines through an inhalation route
GB0326632D0 (en) * 2003-11-14 2003-12-17 Jagotec Ag Dry powder formulations
US7407531B2 (en) * 2004-05-10 2008-08-05 Tsi Incorporated Particle surface treatment for promoting condensation
DE102005016102B3 (de) 2005-04-08 2006-10-26 Altana Pharma Ag Vorrichtung zur Dosierung und Trockenvernebelung
EP1820530B1 (en) 2006-02-20 2014-10-08 Björn Thulin Humidifier and use of the humidifier
DE102006026578B4 (de) 2006-06-08 2009-01-08 Lts Lohmann Therapie-Systeme Ag Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung
BRPI0717177A2 (pt) 2006-09-19 2013-10-08 Discovery Lab Inc Formulações de tensoativo pulmonar e métodos para promoção de eliminação de muco
US8550075B2 (en) 2007-06-28 2013-10-08 Resmed Limited Removable and/or replaceable humidifier
US20100282247A1 (en) * 2007-09-25 2010-11-11 Novartis Ag Treatment of pulmonary disorders with aerosolized medicaments such as vancomycin
EP2172190A1 (en) 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
JP5656974B2 (ja) 2009-04-23 2015-01-21 タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツングＴａｋｅｄａ ＧｍｂＨ 大量のドライパウダーをエアロゾル化する改良された装置

Also Published As

Publication number Publication date
JP6324069B2 (ja) 2018-05-16
BR112013003597A2 (pt) 2016-08-16
EP2608769A1 (en) 2013-07-03
US20130142782A1 (en) 2013-06-06
CA2805602A1 (en) 2012-03-01
CN103052380B (zh) 2015-11-25
KR101957530B1 (ko) 2019-03-12
EP2608769B1 (en) 2019-11-06
KR20130141463A (ko) 2013-12-26
BR112013003597A8 (pt) 2018-02-06
CN103052380A (zh) 2013-04-17
JP2013540704A (ja) 2013-11-07
ZA201300415B (en) 2017-11-29
IL224692A (en) 2017-12-31
MX2013001936A (es) 2013-03-08
US9693955B2 (en) 2017-07-04
EA201300255A1 (ru) 2013-06-28
AU2011295165A1 (en) 2013-04-04
WO2012025496A1 (en) 2012-03-01
BR112013003597B1 (pt) 2021-10-13
AU2011295165B2 (en) 2015-07-02
NZ607358A (en) 2015-04-24

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