JP6316846B2 - ポリミキシン含有組成物 - Google Patents
ポリミキシン含有組成物 Download PDFInfo
- Publication number
- JP6316846B2 JP6316846B2 JP2015552046A JP2015552046A JP6316846B2 JP 6316846 B2 JP6316846 B2 JP 6316846B2 JP 2015552046 A JP2015552046 A JP 2015552046A JP 2015552046 A JP2015552046 A JP 2015552046A JP 6316846 B2 JP6316846 B2 JP 6316846B2
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- JP
- Japan
- Prior art keywords
- uhplc
- polymyxin
- salt
- methyloctanoyl
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims description 9
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- YKQOSKADJPQZHB-QNPLFGSASA-N n-[(1s)-3-amino-1-{[(1s,2r)-1-{[(1s)-3-amino-1-{[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl]carbamoyl}-2- Chemical compound CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O YKQOSKADJPQZHB-QNPLFGSASA-N 0.000 description 1
- ZESIAEVDVPWEKB-ORCFLVBFSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound OS(O)(=O)=O.OS(O)(=O)=O.CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O ZESIAEVDVPWEKB-ORCFLVBFSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000002663 nebulization Methods 0.000 description 1
- 210000000885 nephron Anatomy 0.000 description 1
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 1
- 238000000238 one-dimensional nuclear magnetic resonance spectroscopy Methods 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000005588 protonation Effects 0.000 description 1
- 210000000512 proximal kidney tubule Anatomy 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- UOULCEYHQNCFFH-UHFFFAOYSA-M sodium;hydroxymethanesulfonate Chemical compound [Na+].OCS([O-])(=O)=O UOULCEYHQNCFFH-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 238000001551 total correlation spectroscopy Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000004704 ultra performance liquid chromatography Methods 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 238000007738 vacuum evaporation Methods 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
- C07K7/62—Polymyxins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361751341P | 2013-01-11 | 2013-01-11 | |
| US61/751,341 | 2013-01-11 | ||
| US201361904793P | 2013-11-15 | 2013-11-15 | |
| US61/904,793 | 2013-11-15 | ||
| PCT/EP2014/050320 WO2014108469A1 (en) | 2013-01-11 | 2014-01-09 | Polymyxins, compositions, methods of making and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505007A JP2016505007A (ja) | 2016-02-18 |
| JP2016505007A5 JP2016505007A5 (OSRAM) | 2017-01-12 |
| JP6316846B2 true JP6316846B2 (ja) | 2018-04-25 |
Family
ID=50101865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015552046A Active JP6316846B2 (ja) | 2013-01-11 | 2014-01-09 | ポリミキシン含有組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10640536B2 (OSRAM) |
| EP (1) | EP2943503B1 (OSRAM) |
| JP (1) | JP6316846B2 (OSRAM) |
| KR (1) | KR20150107793A (OSRAM) |
| CN (1) | CN104918951B (OSRAM) |
| AU (1) | AU2014204873B2 (OSRAM) |
| BR (1) | BR112015016548A2 (OSRAM) |
| CA (1) | CA2895910C (OSRAM) |
| EA (1) | EA027067B1 (OSRAM) |
| ES (1) | ES2641017T3 (OSRAM) |
| HU (1) | HUE034562T2 (OSRAM) |
| IL (1) | IL239840A (OSRAM) |
| MX (1) | MX360905B (OSRAM) |
| PT (1) | PT2943503T (OSRAM) |
| RU (1) | RU2015132569A (OSRAM) |
| SI (1) | SI2943503T1 (OSRAM) |
| TW (1) | TWI613219B (OSRAM) |
| UA (1) | UA117673C2 (OSRAM) |
| WO (1) | WO2014108469A1 (OSRAM) |
| ZA (1) | ZA201504565B (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA027067B1 (ru) | 2013-01-11 | 2017-06-30 | Кселлия Фармасьютикалз Апс | Полимиксины, композиции, способы получения и способы применения |
| TW201522364A (zh) * | 2013-06-07 | 2015-06-16 | Xellia Pharmaceuticals Aps | 黏菌素甲磺酸鈉（ｃｍｓ）之定性方法 |
| JP2017523953A (ja) | 2014-07-09 | 2017-08-24 | クセリア ファーマシューティカルズ エーピーエスＸｅｌｌｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＡｐＳ | 低置換度ポリミキシン及びその組成物 |
| RS60874B1 (sr) | 2014-10-03 | 2020-11-30 | Xellia Pharmaceuticals Aps | Kompozicije |
| SG11201702666SA (en) | 2014-10-03 | 2017-04-27 | Xellia Pharmaceuticals Aps | Inhalation device |
| WO2016100578A2 (en) | 2014-12-16 | 2016-06-23 | Micurx Pharmaceuticals, Inc. | Antimicrobial polymyxins for treatment of bacterial infections |
| FI126143B (en) * | 2015-01-15 | 2016-07-15 | Northern Antibiotics Oy | Polymyxine derivative and its uses |
| AU2016331658B2 (en) * | 2015-09-29 | 2021-04-01 | Monash University | Antimicrobial polymyxin derivative compounds |
| CN109996806B (zh) * | 2016-12-09 | 2021-11-02 | 正大天晴药业集团股份有限公司 | 高效价的多黏菌素e2甲磺酸钠 |
| CN115298198A (zh) | 2020-01-21 | 2022-11-04 | 上海盟科药业股份有限公司 | 用于肾相关癌症靶向治疗的新型化合物和组合物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1062895A (en) | 1962-12-13 | 1967-03-22 | Wellcome Found | Sulphomethyl derivatives of polymxin |
| FR1586834A (OSRAM) | 1968-02-12 | 1970-03-06 | ||
| DE1906699A1 (de) | 1968-02-12 | 1970-02-05 | Pfizer | Neue Polymyxinderivate und Verfahren zu deren Herstellung |
| EP0362370A1 (en) * | 1988-04-07 | 1990-04-11 | Edward Shanbrom | Non-thrombogenic intravascular time release catheter |
| ATE202481T1 (de) | 1996-11-15 | 2001-07-15 | Pathogenesis Corp | Reines, biologisch aktives colistin, seine bestandteile und eine colistin-zubereitung zur behandlung von entzündungen der atemwege |
| US5767068A (en) | 1997-02-13 | 1998-06-16 | Pathogenesis Corporation | Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections |
| ES2261735T3 (es) | 2001-05-18 | 2006-11-16 | Chiron Corporation | Sistema para la administracion de una formulacion de tobramicina. |
| US20040022740A1 (en) | 2001-07-10 | 2004-02-05 | Baker William R. | Macrolide formulations for inhalation and methods of treatment of endobronchial infections |
| EP1940859A1 (en) * | 2005-10-28 | 2008-07-09 | Arch Pharmalabs Limited | An improved process for preparation of gemcitabine hydrochloride |
| WO2008025560A1 (en) | 2006-09-01 | 2008-03-06 | Pari Pharma Gmbh | Methods for taste masking of nebulised compositions for nasal and pulmonary inhalation therapy |
| US20080066739A1 (en) | 2006-09-20 | 2008-03-20 | Lemahieu Edward | Methods and systems of delivering medication via inhalation |
| WO2012168820A1 (en) | 2011-06-08 | 2012-12-13 | Pfizer Inc. | Polymyxin derivatives useful as antibacterial agents |
| EA027067B1 (ru) | 2013-01-11 | 2017-06-30 | Кселлия Фармасьютикалз Апс | Полимиксины, композиции, способы получения и способы применения |
| TW201522364A (zh) | 2013-06-07 | 2015-06-16 | Xellia Pharmaceuticals Aps | 黏菌素甲磺酸鈉（ｃｍｓ）之定性方法 |
| JP2017523953A (ja) | 2014-07-09 | 2017-08-24 | クセリア ファーマシューティカルズ エーピーエスＸｅｌｌｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ ＡｐＳ | 低置換度ポリミキシン及びその組成物 |
| RS60874B1 (sr) | 2014-10-03 | 2020-11-30 | Xellia Pharmaceuticals Aps | Kompozicije |
-
2014
- 2014-01-09 EA EA201591280A patent/EA027067B1/ru unknown
- 2014-01-09 WO PCT/EP2014/050320 patent/WO2014108469A1/en not_active Ceased
- 2014-01-09 ES ES14704292.3T patent/ES2641017T3/es active Active
- 2014-01-09 JP JP2015552046A patent/JP6316846B2/ja active Active
- 2014-01-09 MX MX2015008878A patent/MX360905B/es active IP Right Grant
- 2014-01-09 RU RU2015132569A patent/RU2015132569A/ru not_active Application Discontinuation
- 2014-01-09 HU HUE14704292A patent/HUE034562T2/en unknown
- 2014-01-09 AU AU2014204873A patent/AU2014204873B2/en active Active
- 2014-01-09 EP EP14704292.3A patent/EP2943503B1/en active Active
- 2014-01-09 CN CN201480004714.8A patent/CN104918951B/zh active Active
- 2014-01-09 UA UAA201507907A patent/UA117673C2/uk unknown
- 2014-01-09 US US14/760,222 patent/US10640536B2/en active Active
- 2014-01-09 SI SI201430386T patent/SI2943503T1/sl unknown
- 2014-01-09 KR KR1020157021592A patent/KR20150107793A/ko not_active Withdrawn
- 2014-01-09 PT PT147042923T patent/PT2943503T/pt unknown
- 2014-01-09 CA CA2895910A patent/CA2895910C/en active Active
- 2014-01-09 BR BR112015016548A patent/BR112015016548A2/pt not_active Application Discontinuation
- 2014-01-10 TW TW103101009A patent/TWI613219B/zh active
-
2015
- 2015-06-24 ZA ZA2015/04565A patent/ZA201504565B/en unknown
- 2015-07-08 IL IL239840A patent/IL239840A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150107793A (ko) | 2015-09-23 |
| EP2943503A1 (en) | 2015-11-18 |
| RU2015132569A (ru) | 2017-02-14 |
| CN104918951A (zh) | 2015-09-16 |
| ES2641017T3 (es) | 2017-11-07 |
| JP2016505007A (ja) | 2016-02-18 |
| SI2943503T1 (sl) | 2017-11-30 |
| CA2895910A1 (en) | 2014-07-17 |
| US10640536B2 (en) | 2020-05-05 |
| MX360905B (es) | 2018-11-21 |
| TW201429995A (zh) | 2014-08-01 |
| US20160002296A1 (en) | 2016-01-07 |
| CA2895910C (en) | 2021-12-21 |
| UA117673C2 (uk) | 2018-09-10 |
| AU2014204873A1 (en) | 2015-07-09 |
| AU2014204873B2 (en) | 2017-07-06 |
| MX2015008878A (es) | 2015-10-30 |
| IL239840A (en) | 2017-09-28 |
| IL239840A0 (en) | 2015-08-31 |
| EA201591280A1 (ru) | 2015-12-30 |
| HUE034562T2 (en) | 2018-03-28 |
| EA027067B1 (ru) | 2017-06-30 |
| EP2943503B1 (en) | 2017-08-23 |
| CN104918951B (zh) | 2018-03-30 |
| TWI613219B (zh) | 2018-02-01 |
| WO2014108469A1 (en) | 2014-07-17 |
| ZA201504565B (en) | 2016-11-30 |
| PT2943503T (pt) | 2017-09-28 |
| BR112015016548A2 (pt) | 2017-07-11 |
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