JP6312591B2 - 多能性幹細胞からの胚体内胚葉の効率的な誘導 - Google Patents

多能性幹細胞からの胚体内胚葉の効率的な誘導 Download PDF

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JP6312591B2
JP6312591B2 JP2014516354A JP2014516354A JP6312591B2 JP 6312591 B2 JP6312591 B2 JP 6312591B2 JP 2014516354 A JP2014516354 A JP 2014516354A JP 2014516354 A JP2014516354 A JP 2014516354A JP 6312591 B2 JP6312591 B2 JP 6312591B2
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stem cells
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JP2014519832A (ja
JP2014519832A5 (https=
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ニナ・フナ
カチャ・ヘス
イェニ・エクベアウ
ヘンリク・セム
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0678—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
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  • Genetics & Genomics (AREA)
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  • Wood Science & Technology (AREA)
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  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
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  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2014516354A 2011-06-21 2012-06-21 多能性幹細胞からの胚体内胚葉の効率的な誘導 Active JP6312591B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11170713 2011-06-21
EP11170713.9 2011-06-21
US201161501351P 2011-06-27 2011-06-27
US61/501,351 2011-06-27
PCT/EP2012/062013 WO2012175633A1 (en) 2011-06-21 2012-06-21 Efficient induction of definitive endoderm from pluripotent stem cells

Publications (3)

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JP2014519832A JP2014519832A (ja) 2014-08-21
JP2014519832A5 JP2014519832A5 (https=) 2015-08-06
JP6312591B2 true JP6312591B2 (ja) 2018-04-18

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US (3) US20140234963A1 (https=)
EP (1) EP2723852B1 (https=)
JP (1) JP6312591B2 (https=)
CN (2) CN108220224A (https=)
ES (1) ES2902650T3 (https=)
WO (1) WO2012175633A1 (https=)

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JP2020532992A (ja) * 2017-09-07 2020-11-19 ステモニックス インコーポレイティド 胚体内胚葉へのヒト幹細胞の効率的な分化
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CN108220224A (zh) 2018-06-29
US20140234963A1 (en) 2014-08-21
JP2014519832A (ja) 2014-08-21
ES2902650T3 (es) 2022-03-29
US20180002668A1 (en) 2018-01-04
EP2723852B1 (en) 2021-11-17
CN103890167A (zh) 2014-06-25
WO2012175633A1 (en) 2012-12-27
US10487313B2 (en) 2019-11-26
US20200190477A1 (en) 2020-06-18
EP2723852A1 (en) 2014-04-30

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