ES2902650T3 - Inducción eficiente de endodermo definitivo a partir de células madre pluripotentes - Google Patents
Inducción eficiente de endodermo definitivo a partir de células madre pluripotentes Download PDFInfo
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- ES2902650T3 ES2902650T3 ES12735227T ES12735227T ES2902650T3 ES 2902650 T3 ES2902650 T3 ES 2902650T3 ES 12735227 T ES12735227 T ES 12735227T ES 12735227 T ES12735227 T ES 12735227T ES 2902650 T3 ES2902650 T3 ES 2902650T3
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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| PCT/EP2012/062013 WO2012175633A1 (en) | 2011-06-21 | 2012-06-21 | Efficient induction of definitive endoderm from pluripotent stem cells |
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| EP2723852B1 (en) | 2011-06-21 | 2021-11-17 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
| CN104903440B (zh) | 2012-09-03 | 2018-04-06 | 诺和诺德股份有限公司 | 使用小分子从多能干细胞产生胰内胚层 |
| GB201317869D0 (en) * | 2013-10-09 | 2013-11-20 | Cambridge Entpr Ltd | In vitro production of foregut stem cells |
| CN108699515A (zh) | 2016-02-24 | 2018-10-23 | 诺和诺德股份有限公司 | 由人多能干细胞衍生的内分泌祖细胞生成功能性β细胞 |
| JP2020532992A (ja) * | 2017-09-07 | 2020-11-19 | ステモニックス インコーポレイティド | 胚体内胚葉へのヒト幹細胞の効率的な分化 |
| KR102738995B1 (ko) | 2017-09-11 | 2024-12-06 | 노보 노르디스크 에이/에스 | 시험관 내 줄기 세포로부터 유래된 nkx6.1 및 c-펩티드 공발현 세포의 농축 |
| US12421499B2 (en) | 2018-05-11 | 2025-09-23 | Cornell University | Method of differentiation of human pluripotent stem cells to monohormonal cells |
| WO2020043292A1 (en) | 2018-08-30 | 2020-03-05 | Novo Nordisk A/S | Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors |
| US20220177849A1 (en) | 2019-04-08 | 2022-06-09 | Novo Nordisk A/S | Generation of pancreatic endoderm from stem cell derived definitive endoderm |
| CN114729323B (zh) | 2019-11-22 | 2024-09-17 | 诺和诺德股份有限公司 | 旋转聚集的神经微球及其应用 |
| US20230313145A1 (en) | 2020-08-28 | 2023-10-05 | Novo Nordisk A/S | Method for screening in vitro population of stem cell derived beta like cells and novel markers thereof |
| WO2024008810A1 (en) | 2022-07-06 | 2024-01-11 | Novo Nordisk A/S | Differentiation of stem cells to pancreatic endocrine cells |
| WO2024151541A1 (en) | 2023-01-09 | 2024-07-18 | Sana Biotechnology, Inc. | Type-1 diabetes autoimmune mouse |
| EP4716541A2 (en) | 2023-05-22 | 2026-04-01 | Sana Biotechnology, Inc. | Methods of delivery of islet cells and related methods |
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| US7625753B2 (en) | 2003-12-23 | 2009-12-01 | Cythera, Inc. | Expansion of definitive endoderm cells |
| CN103103158B (zh) | 2004-04-27 | 2016-08-03 | 韦尔赛特公司 | 细胞培养基 |
| GB2445338A (en) | 2005-10-07 | 2008-07-02 | Cellartis Ab | A method for obtaining a xeno-free HBS cell line |
| JP6110048B2 (ja) | 2006-03-02 | 2017-04-05 | ヴィアサイト，インコーポレイテッド | 内分泌前駆細胞、膵臓ホルモン発現細胞及びそれらの製造方法 |
| GB0615327D0 (en) | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
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| AU2007244675A1 (en) | 2006-04-28 | 2007-11-08 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
| US20090298169A1 (en) | 2006-06-02 | 2009-12-03 | The University Of Georgia Research Foundation | Pancreatic and Liver Endoderm Cells and Tissue by Differentiation of Definitive Endoderm Cells Obtained from Human Embryonic Stems |
| CA2676044C (en) * | 2007-01-30 | 2019-10-22 | University Of Georgia Research Foundation, Inc. | Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc) |
| EP2798956A1 (en) | 2007-04-23 | 2014-11-05 | Stowers Institute for Medical Research | Methods and compositions for hematopoeitic stem cell self-renewal |
| US9080145B2 (en) * | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
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| JP2010534065A (ja) | 2007-07-20 | 2010-11-04 | セルアーティス アーベー | ヒト胚盤胞幹細胞に、胚体内胚葉（ＤＥ‐ｈｅｐ）を介して由来する新規な肝細胞の集団 |
| DK2185693T3 (da) | 2007-07-31 | 2019-09-23 | Lifescan Inc | Differentiering af humane embryoniske stamceller |
| EP2584034B8 (en) | 2007-07-31 | 2017-12-06 | Lifescan, Inc. | Pluripotent stem cell differentiation by using human feeder cells |
| EP2195417A1 (en) * | 2007-08-24 | 2010-06-16 | University Court of the University of Edinburgh | Regionalised endoderm cells and uses thereof |
| US8623648B2 (en) * | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| US7939322B2 (en) | 2008-04-24 | 2011-05-10 | Centocor Ortho Biotech Inc. | Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm |
| CA2723820A1 (en) | 2008-05-09 | 2009-11-12 | Vistagen Therapeutics, Inc. | Pancreatic endocrine progenitor cells derived from pluripotent stem cells |
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| AU2009267167A1 (en) | 2008-06-30 | 2010-01-07 | Centocor Ortho Biotech Inc. | Differentiation of pluripotent stem cells |
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| US20100028307A1 (en) | 2008-07-31 | 2010-02-04 | O'neil John J | Pluripotent stem cell differentiation |
| US8278105B2 (en) * | 2008-09-09 | 2012-10-02 | University Of Southern California | Induction, propagation and isolation of liver progenitor cells |
| CN101684454B (zh) * | 2008-09-25 | 2012-08-15 | 中国科学院上海生命科学研究院 | 一种定型内胚层细胞的制备和分离方法 |
| US9234178B2 (en) | 2008-10-31 | 2016-01-12 | Janssen Biotech, Inc. | Differentiation of human pluripotent stem cells |
| EP2350265B1 (en) | 2008-10-31 | 2019-04-17 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells to the pancreatic endocrine lineage |
| JP2012508584A (ja) | 2008-11-14 | 2012-04-12 | ヴィアサイト，インコーポレイテッド | ヒト多能性幹細胞由来膵臓細胞のカプセル化 |
| US8507274B2 (en) | 2009-02-06 | 2013-08-13 | President And Fellows Of Harvard College | Compositions and methods for promoting the generation of definitive endoderm |
| EP2421957B1 (en) | 2009-04-22 | 2020-11-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| WO2010138750A2 (en) | 2009-05-27 | 2010-12-02 | The Salk Institute For Biological Studies | Generation of genetically corrected disease-free induced pluripotent stem cells |
| CN102482643B (zh) | 2009-07-20 | 2016-06-29 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
| US8785184B2 (en) * | 2009-07-20 | 2014-07-22 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| CN102712902B (zh) | 2009-12-23 | 2019-01-08 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
| SG10201408552YA (en) | 2009-12-23 | 2015-02-27 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
| CA2785966C (en) | 2009-12-29 | 2020-10-27 | Takeda Pharmaceutical Company Limited | Method for manufacturing pancreatic-hormone-producing cells |
| PH12012501686A1 (en) | 2010-03-01 | 2020-10-19 | Janssen Biotech Inc | Methods for purifying cells derived from pluripotent stem cells |
| US9719068B2 (en) | 2010-05-06 | 2017-08-01 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| RU2587634C2 (ru) | 2010-05-12 | 2016-06-20 | Янссен Байотек, Инк. | Дифференцирование эмбриональных стволовых клеток человека |
| WO2011160066A1 (en) | 2010-06-17 | 2011-12-22 | Regents Of The University Of Minnesota | Production of insulin producing cells |
| KR20190027969A (ko) | 2010-08-12 | 2019-03-15 | 얀센 바이오테크 인코포레이티드 | 췌장 내분비 전구 세포를 이용한 당뇨병의 치료 |
| EP3372672A1 (en) | 2010-08-31 | 2018-09-12 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
| PL2853589T3 (pl) | 2010-08-31 | 2018-05-30 | Janssen Biotech, Inc | Różnicowanie ludzkich zarodkowych komórek macierzystych |
| US9062292B2 (en) | 2010-09-13 | 2015-06-23 | Enzo Life Sciences Inc. | Mutant T7 polymerases |
| WO2012070014A2 (en) | 2010-11-26 | 2012-05-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells |
| ES2690663T3 (es) | 2010-12-08 | 2018-11-21 | Viacyte, Inc. | Agentes y métodos para inhibir el crecimiento de células madre pluripotentes humanas |
| EP2652125B1 (en) | 2010-12-15 | 2017-04-26 | Kadimastem Ltd. | Insulin producing cells derived from pluripotent stem cells |
| EP2723852B1 (en) | 2011-06-21 | 2021-11-17 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
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| CN108220224A (zh) | 2018-06-29 |
| US20140234963A1 (en) | 2014-08-21 |
| JP2014519832A (ja) | 2014-08-21 |
| US20180002668A1 (en) | 2018-01-04 |
| EP2723852B1 (en) | 2021-11-17 |
| CN103890167A (zh) | 2014-06-25 |
| WO2012175633A1 (en) | 2012-12-27 |
| US10487313B2 (en) | 2019-11-26 |
| JP6312591B2 (ja) | 2018-04-18 |
| US20200190477A1 (en) | 2020-06-18 |
| EP2723852A1 (en) | 2014-04-30 |
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