CN108220224A - 自多潜能干细胞有效诱导定形内胚层 - Google Patents

自多潜能干细胞有效诱导定形内胚层 Download PDF

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Publication number
CN108220224A
CN108220224A CN201810066827.0A CN201810066827A CN108220224A CN 108220224 A CN108220224 A CN 108220224A CN 201810066827 A CN201810066827 A CN 201810066827A CN 108220224 A CN108220224 A CN 108220224A
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cells
chir
stem cells
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activin
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N.富纳
K.赫斯
J.伊克伯格
H.塞姆布
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Novo Nordisk AS
Cellectis SA
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • C12N5/0678Stem cells; Progenitor cells; Precursor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0696Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/115Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/16Activin; Inhibin; Mullerian inhibiting substance
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40Regulators of development
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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CN201810066827.0A 2011-06-21 2012-06-21 自多潜能干细胞有效诱导定形内胚层 Pending CN108220224A (zh)

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EP11170713 2011-06-21
EP11170713.9 2011-06-21
US201161501351P 2011-06-27 2011-06-27
US61/501351 2011-06-27
CN201280040881.9A CN103890167A (zh) 2011-06-21 2012-06-21 自多潜能干细胞有效诱导定形内胚层

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US (3) US20140234963A1 (https=)
EP (1) EP2723852B1 (https=)
JP (1) JP6312591B2 (https=)
CN (2) CN108220224A (https=)
ES (1) ES2902650T3 (https=)
WO (1) WO2012175633A1 (https=)

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CN104903440B (zh) 2012-09-03 2018-04-06 诺和诺德股份有限公司 使用小分子从多能干细胞产生胰内胚层
GB201317869D0 (en) * 2013-10-09 2013-11-20 Cambridge Entpr Ltd In vitro production of foregut stem cells
CN108699515A (zh) 2016-02-24 2018-10-23 诺和诺德股份有限公司 由人多能干细胞衍生的内分泌祖细胞生成功能性β细胞
JP2020532992A (ja) * 2017-09-07 2020-11-19 ステモニックス インコーポレイティド 胚体内胚葉へのヒト幹細胞の効率的な分化
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WO2020043292A1 (en) 2018-08-30 2020-03-05 Novo Nordisk A/S Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors
US20220177849A1 (en) 2019-04-08 2022-06-09 Novo Nordisk A/S Generation of pancreatic endoderm from stem cell derived definitive endoderm
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WO2024008810A1 (en) 2022-07-06 2024-01-11 Novo Nordisk A/S Differentiation of stem cells to pancreatic endocrine cells
WO2024151541A1 (en) 2023-01-09 2024-07-18 Sana Biotechnology, Inc. Type-1 diabetes autoimmune mouse
EP4716541A2 (en) 2023-05-22 2026-04-01 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods
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US20140234963A1 (en) 2014-08-21
JP2014519832A (ja) 2014-08-21
ES2902650T3 (es) 2022-03-29
US20180002668A1 (en) 2018-01-04
EP2723852B1 (en) 2021-11-17
CN103890167A (zh) 2014-06-25
WO2012175633A1 (en) 2012-12-27
US10487313B2 (en) 2019-11-26
JP6312591B2 (ja) 2018-04-18
US20200190477A1 (en) 2020-06-18
EP2723852A1 (en) 2014-04-30

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