JP6301024B2 - フィーカリバクテリウム属細菌増殖剤 - Google Patents
フィーカリバクテリウム属細菌増殖剤 Download PDFInfo
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- JP6301024B2 JP6301024B2 JP2017549363A JP2017549363A JP6301024B2 JP 6301024 B2 JP6301024 B2 JP 6301024B2 JP 2017549363 A JP2017549363 A JP 2017549363A JP 2017549363 A JP2017549363 A JP 2017549363A JP 6301024 B2 JP6301024 B2 JP 6301024B2
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/32—Foods, ingredients or supplements having a functional effect on health having an effect on the health of the digestive tract
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Description
下記の組成の液体培地を無菌的に調製した。各種オリゴ糖としては、1−ケストース(純度99質量%;物産フードサイエンス社)、ニストース(純度98質量%;和光純薬社)、キシロオリゴ糖(純度98質量%;物産フードサイエンス社)、ラフィノース(純度98質量%;明治フードマテリア社)またはラクトスクロース(純度89質量%;塩水港精糖社)を用いた。また、コントロールとして、下記の組成のうちオリゴ糖を含まない液体培地を同様に調製した。
《液体培地の組成/1Lあたり》(最終pH:pH7.0)
カゼイン分解物15.0g、酵母抽出物5.0g、L−シスチン0.5g、塩化ナトリウム2.5g、チオグリコール酸0.5g、トリプトファン25mg、ヘミン(Hemin)適量、ビタミンK1適量、各種オリゴ糖5.0g。
すなわち、1−ケストースを添加した液体培地では、オリゴ糖を添加していない液体培地(コントロールの液体培地)ならびに他のオリゴ糖(ニストース、キシロオリゴ糖、ラフィノースおよびラクトスクロース)を添加した液体培地と比較して、24時間、48時間および72時間のいずれの培養時間においてもOD値が顕著に大きかった。
6か月〜6歳の乳幼児58名を29名ずつ2つの群に分け、1−ケストース群およびマルトース群とした。1−ケストース群には1−ケストース(純度98質量%以上;物産フードサイエンス社)を、マルトース群にはマルトース(純度92質量%以上;「サンマルト−S」粉末品;三和澱粉工業社)を、試験期間中、毎日経口摂取させた。試験期間は12週間とした。1−ケストースまたはマルトースの1日の摂取量は、1歳未満が1g(目安摂取量;0.121g/kg体重/日)、1?3歳が2g(目安摂取量;0.169g/kg体重/日)、4?6歳が3g(目安摂取量;0.170g/kg体重/日)とした。試験期間の開始時(0週)、6週間経過時(6週)および12週間経過時(12週)に糞便を回収した。
《フィーカリバクテリウム属細菌に特異的なプライマーの配列》
フォワードプライマー;CCATGAATTGCCTTCAAAACTGTT(配列番号1)
リバースプライマー;GAGCCTCAGCGTCAGTTGGT(配列番号2)
一方、マルトース群の菌数は、0週で7.6×106個/糞便1gであったのに対して、6週では5.8×106個/糞便1g、12週では1.3×107個/糞便1gであった。すなわち、0週と比較した菌数は、6週ではわずかに減少し、12週ではやや増加したものの、有意差は無かった。
Claims (6)
- 1−ケストースを有効成分とするフィーカリバクテリウム(Faecalibacterium)属細菌増殖剤。
- 腸内炎症の予防または治療に用いられることを特徴とする、請求項1に記載のフィーカリバクテリウム(Faecalibacterium)属細菌増殖剤。
- 腸内炎症が炎症性腸疾患である、請求項2に記載のフィーカリバクテリウム(Faecalibacterium)属細菌増殖剤。
- 炎症性腸疾患がクローン病または潰瘍性大腸炎である、請求項3に記載のフィーカリバクテリウム(Faecalibacterium)属細菌増殖剤。
- 1−ケストースを有効成分とするフィーカリバクテリウム(Faecalibacterium)属細菌増殖用食品組成物。
- フィーカリバクテリウム(Faecalibacterium)属細菌を含む培地に1−ケストースを添加して培養する工程を有する、フィーカリバクテリウム(Faecalibacterium)属細菌の増殖方法。
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JP2016049586 | 2016-03-14 | ||
JP2016049586 | 2016-03-14 | ||
PCT/JP2017/010070 WO2017159647A1 (ja) | 2016-03-14 | 2017-03-14 | フィーカリバクテリウム属細菌増殖剤 |
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US (1) | US20190070204A1 (ja) |
EP (1) | EP3431090A4 (ja) |
JP (1) | JP6301024B2 (ja) |
KR (1) | KR20180122380A (ja) |
CN (1) | CN109069521A (ja) |
PH (1) | PH12018501989A1 (ja) |
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US10874680B2 (en) | 2017-09-25 | 2020-12-29 | Tata Chemicals Limited | Method of increasing relative abundance of oscillospira |
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PT820292E (pt) * | 1995-04-05 | 2003-06-30 | Abbott Lab | Inibicao de infeccoes por c. difficile com oligossacaridos nao digeriveis |
JP2004049093A (ja) * | 2002-07-18 | 2004-02-19 | Meiji Milk Prod Co Ltd | 腸内酪酸上昇食品組成物および医薬品 |
US20050119222A1 (en) * | 2003-12-01 | 2005-06-02 | The Iams Company | Compositions comprising fermentable fiber which are adapted for use by a companion animal and kits and methods of their use |
US20050118299A1 (en) * | 2003-12-01 | 2005-06-02 | The Iams Company | Companion animal compositions comprising short chain oligofructose |
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US20090142304A1 (en) * | 2005-10-13 | 2009-06-04 | Koichiro Murashima | Composition for Improving Intestinal Flora |
JP2012176907A (ja) * | 2011-02-25 | 2012-09-13 | Glico Dairy Products Co Ltd | フラクトオリゴ糖を有効成分とするミオシン軽鎖脱リン酸化促進剤、疾患の予防又は治療剤、及び飲食品 |
MX2014005433A (es) * | 2011-11-04 | 2014-08-22 | Gen Mills Inc | Métodos y composiciones para modular bacterias gastrointestinales para promover la salud. |
JP5921894B2 (ja) * | 2012-01-20 | 2016-05-24 | アサヒカルピスウェルネス株式会社 | 腸内酪酸産生菌増加剤 |
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CN109069521A (zh) | 2018-12-21 |
PH12018501989A1 (en) | 2019-06-24 |
KR20180122380A (ko) | 2018-11-12 |
EP3431090A1 (en) | 2019-01-23 |
JPWO2017159647A1 (ja) | 2018-03-22 |
EP3431090A4 (en) | 2020-04-15 |
WO2017159647A1 (ja) | 2017-09-21 |
SG11201807616RA (en) | 2018-10-30 |
US20190070204A1 (en) | 2019-03-07 |
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