JP6298998B2 - ウイルス感染を治療するための１，２，４−トリアジン誘導体 - Google Patents
ウイルス感染を治療するための１，２，４−トリアジン誘導体 Download PDFInfo
- Publication number
- JP6298998B2 JP6298998B2 JP2015533635A JP2015533635A JP6298998B2 JP 6298998 B2 JP6298998 B2 JP 6298998B2 JP 2015533635 A JP2015533635 A JP 2015533635A JP 2015533635 A JP2015533635 A JP 2015533635A JP 6298998 B2 JP6298998 B2 JP 6298998B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- carboxylic acid
- compound
- heteroarylalkyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- ZWZUFQPXYVYAFO-UHFFFAOYSA-N CC(C)(C)OC(C=P(c1ccccc1)(c1ccccc1)c1ccccc1)=O Chemical compound CC(C)(C)OC(C=P(c1ccccc1)(c1ccccc1)c1ccccc1)=O ZWZUFQPXYVYAFO-UHFFFAOYSA-N 0.000 description 1
- UUJMTRBDHSMCOA-ZETCQYMHSA-N CCCC[C@@H](CCO)N Chemical compound CCCC[C@@H](CCO)N UUJMTRBDHSMCOA-ZETCQYMHSA-N 0.000 description 1
- HSMNWJOMCZNJEO-LGGPFLRQSA-N CCCC[Si@@H](CC(OC(C)(C)C)=O)N(Cc1ccccc1)[C@@H](C)c1ccccc1 Chemical compound CCCC[Si@@H](CC(OC(C)(C)C)=O)N(Cc1ccccc1)[C@@H](C)c1ccccc1 HSMNWJOMCZNJEO-LGGPFLRQSA-N 0.000 description 1
- VNTFEWXYAOATFA-UHFFFAOYSA-N O=C(C(Br)=NN1)NC1=O Chemical compound O=C(C(Br)=NN1)NC1=O VNTFEWXYAOATFA-UHFFFAOYSA-N 0.000 description 1
- SSPYSWLZOPCOLO-UHFFFAOYSA-N O=C(C=NN1)NC1=O Chemical compound O=C(C=NN1)NC1=O SSPYSWLZOPCOLO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306196.2A EP2712866A1 (en) | 2012-10-01 | 2012-10-01 | 1,2,4-triazine derivatives for the treatment of viral infections |
| EP12306196.2 | 2012-10-01 | ||
| PCT/EP2013/070488 WO2014053516A1 (en) | 2012-10-01 | 2013-10-01 | 1,2,4-triazine derivatives for the treatment of viral infections. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015535839A JP2015535839A (ja) | 2015-12-17 |
| JP2015535839A5 JP2015535839A5 (OSRAM) | 2016-11-10 |
| JP6298998B2 true JP6298998B2 (ja) | 2018-03-28 |
Family
ID=46982496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015533635A Expired - Fee Related JP6298998B2 (ja) | 2012-10-01 | 2013-10-01 | ウイルス感染を治療するための１，２，４−トリアジン誘導体 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9416114B2 (OSRAM) |
| EP (2) | EP2712866A1 (OSRAM) |
| JP (1) | JP6298998B2 (OSRAM) |
| KR (1) | KR102138393B1 (OSRAM) |
| CN (1) | CN104812747B (OSRAM) |
| AU (1) | AU2013326579B2 (OSRAM) |
| BR (1) | BR112015007310B1 (OSRAM) |
| CA (1) | CA2886630C (OSRAM) |
| CL (1) | CL2015000787A1 (OSRAM) |
| EA (1) | EA026236B1 (OSRAM) |
| ES (1) | ES2616496T3 (OSRAM) |
| IL (1) | IL237871A (OSRAM) |
| IN (1) | IN2015DN03327A (OSRAM) |
| MX (1) | MX348229B (OSRAM) |
| MY (1) | MY182558A (OSRAM) |
| NZ (1) | NZ706354A (OSRAM) |
| PH (1) | PH12015500724B1 (OSRAM) |
| SG (1) | SG11201502522WA (OSRAM) |
| UA (1) | UA114644C2 (OSRAM) |
| WO (1) | WO2014053516A1 (OSRAM) |
| ZA (1) | ZA201502240B (OSRAM) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3590928T (lt) | 2011-04-08 | 2021-08-25 | Janssen Sciences Ireland Unlimited Company | Pirimidino dariniai, skirti virusinės infekcijos gydymui |
| EA036645B1 (ru) | 2011-11-09 | 2020-12-03 | Янссен Сайенсиз Айрлэнд Юси | Производные пурина для лечения вирусных инфекций |
| PL2872515T3 (pl) | 2012-07-13 | 2017-05-31 | Janssen Sciences Ireland Uc | Puryny makrocykliczne do leczenia infekcji wirusowych |
| SI2906563T1 (en) | 2012-10-10 | 2018-06-29 | Janssen Sciences Ireland Uc | Derivatives of pyrrolo (3,2-d) pyrimidine for the treatment of viral infections and other diseases |
| MY171115A (en) | 2012-11-16 | 2019-09-26 | Janssen Sciences Ireland Uc | Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections |
| UA118751C2 (uk) | 2013-02-21 | 2019-03-11 | ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі | Похідні 2-амінопіримідину для лікування вірусних інфекцій |
| PL2978429T3 (pl) | 2013-03-29 | 2017-08-31 | Janssen Sciences Ireland Uc | Deazapurynony makrocykliczne do leczenia infekcji wirusowych |
| CN105377833B (zh) | 2013-05-24 | 2018-11-06 | 爱尔兰詹森科学公司 | 用于治疗病毒感染和另外的疾病的吡啶酮衍生物 |
| WO2014207082A1 (en) | 2013-06-27 | 2014-12-31 | Janssen R&D Ireland | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases |
| ES2836881T3 (es) | 2013-07-30 | 2021-06-28 | Janssen Sciences Ireland Unlimited Co | Derivados de tieno[3,2-d]pirimidinas para el tratamiento de infecciones virales |
| CA3027471A1 (en) | 2016-07-01 | 2018-01-04 | Janssen Sciences Ireland Unlimited Company | Dihydropyranopyrimidines for the treatment of viral infections |
| KR102450287B1 (ko) * | 2016-09-29 | 2022-09-30 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 바이러스 감염 및 추가적인 질환의 치료를 위한 피리미딘 프로드러그 |
| TW202415645A (zh) | 2018-03-01 | 2024-04-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | ２，４－二胺基喹唑啉衍生物及其醫學用途 |
| JP7287708B2 (ja) | 2019-02-08 | 2023-06-06 | プロジェニア インコーポレイテッド | Ｔｏｌｌ－ｌｉｋｅ受容体７または８アゴニストとコレステロールの結合体およびその用途 |
| JP2023516372A (ja) | 2020-03-02 | 2023-04-19 | プロジェニア インコーポレイテッド | 病原菌外壁成分基盤の生病原体模倣ナノ粒子及びその製造方法 |
| US20230355750A1 (en) | 2020-08-04 | 2023-11-09 | Progeneer Inc. | Kinetically acting adjuvant ensemble |
| WO2022031057A1 (ko) | 2020-08-04 | 2022-02-10 | 성균관대학교산학협력단 | 활성화 부위가 일시적으로 비활성화된 톨-유사 수용체 7 또는 8 작용자와 기능성 약물의 결합체 및 그 용도 |
| EP4194006A4 (en) | 2020-08-04 | 2024-12-04 | Progeneer Inc. | mRNA VACCINE WITH AN ADJUVANT CAPABLE OF KINETIC CONTROL |
| WO2024151953A1 (en) * | 2023-01-15 | 2024-07-18 | Viradem Inc. | Compounds and methods for treating diseases caused by sars-cov-2 and other coronaviruses |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2485531A1 (fr) * | 1980-06-25 | 1981-12-31 | Fabre Sa Pierre | Nouveaux n-oxydes de diaryl-5,6 as triazines 1-2-4, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
| ATE283855T1 (de) | 1996-07-03 | 2004-12-15 | Sumitomo Pharma | Neue purinderivate |
| US6329381B1 (en) | 1997-11-28 | 2001-12-11 | Sumitomo Pharmaceuticals Company, Limited | Heterocyclic compounds |
| ES2442857T3 (es) * | 2004-08-10 | 2014-02-13 | Janssen Pharmaceutica Nv | Derivados de 1,2,4-triazin-6-ona inhibidores de VIH |
| AU2006242920A1 (en) | 2005-05-04 | 2006-11-09 | Pfizer Limited | 2-amido-6-amino-8-oxopurine derivatives as Toll-Like receptor modulators for the treatment of cancer and viral infections, such as hepatitis C |
| JP4850911B2 (ja) * | 2005-09-01 | 2012-01-11 | エフ．ホフマン−ラ ロシュ アーゲー | Ｐ２ｘ３およびｐ２ｘ２／３モジュレーターとしてのジアミノピリミジン |
| RU2352565C1 (ru) * | 2007-10-08 | 2009-04-20 | Государственное образовательное учреждение высшего профессионального образования "Пермский государственный университет" | 3-амино-6-ароилметил-5-гидрокси-1,2,4-триазины и способ их получения |
| PE20091236A1 (es) * | 2007-11-22 | 2009-09-16 | Astrazeneca Ab | Derivados de pirimidina como immunomoduladores de tlr7 |
| WO2012067269A1 (en) * | 2010-11-19 | 2012-05-24 | Dainippon Sumitomo Pharma Co., Ltd. | Aminoalkoxyphenyl compounds and their use in the treatment of disease |
-
2012
- 2012-10-01 EP EP12306196.2A patent/EP2712866A1/en not_active Withdrawn
-
2013
- 2013-10-01 KR KR1020157009515A patent/KR102138393B1/ko not_active Expired - Fee Related
- 2013-10-01 MX MX2015004160A patent/MX348229B/es active IP Right Grant
- 2013-10-01 BR BR112015007310-7A patent/BR112015007310B1/pt not_active IP Right Cessation
- 2013-10-01 CA CA2886630A patent/CA2886630C/en active Active
- 2013-10-01 AU AU2013326579A patent/AU2013326579B2/en not_active Ceased
- 2013-10-01 EA EA201500383A patent/EA026236B1/ru not_active IP Right Cessation
- 2013-10-01 MY MYPI2015000804A patent/MY182558A/en unknown
- 2013-10-01 WO PCT/EP2013/070488 patent/WO2014053516A1/en not_active Ceased
- 2013-10-01 IN IN3327DEN2015 patent/IN2015DN03327A/en unknown
- 2013-10-01 NZ NZ706354A patent/NZ706354A/en not_active IP Right Cessation
- 2013-10-01 UA UAA201504222A patent/UA114644C2/uk unknown
- 2013-10-01 EP EP13773690.6A patent/EP2903976B1/en active Active
- 2013-10-01 JP JP2015533635A patent/JP6298998B2/ja not_active Expired - Fee Related
- 2013-10-01 SG SG11201502522WA patent/SG11201502522WA/en unknown
- 2013-10-01 US US14/432,269 patent/US9416114B2/en active Active
- 2013-10-01 CN CN201380050972.5A patent/CN104812747B/zh not_active Expired - Fee Related
- 2013-10-01 ES ES13773690.6T patent/ES2616496T3/es active Active
-
2015
- 2015-03-22 IL IL237871A patent/IL237871A/en active IP Right Grant
- 2015-03-30 CL CL2015000787A patent/CL2015000787A1/es unknown
- 2015-03-31 PH PH12015500724A patent/PH12015500724B1/en unknown
- 2015-03-31 ZA ZA2015/02240A patent/ZA201502240B/en unknown
Also Published As
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