JP6283030B2 - 高度に多様なコンビナトリアル抗体ライブラリ - Google Patents

高度に多様なコンビナトリアル抗体ライブラリ Download PDF

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JP6283030B2
JP6283030B2 JP2015529046A JP2015529046A JP6283030B2 JP 6283030 B2 JP6283030 B2 JP 6283030B2 JP 2015529046 A JP2015529046 A JP 2015529046A JP 2015529046 A JP2015529046 A JP 2015529046A JP 6283030 B2 JP6283030 B2 JP 6283030B2
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antibody
library
human
camel
families
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JP2015526495A (ja
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ジョセプフ ウイルヘルムス デ ハアルド ジョハンネス
ジョセプフ ウイルヘルムス デ ハアルド ジョハンネス
フレデリク ジェロメ ブランチェトト クリストプヘ
フレデリク ジェロメ ブランチェトト クリストプヘ
クラレンベエク アレク
クラレンベエク アレク
アチョウル イクベル
アチョウル イクベル
エル マゾウアリ クハリル
エル マゾウアリ クハリル
デル ファベロ ジュルゲン
デル ファベロ ジュルゲン
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アルゲン−エックス ビーブイビーエー
アルゲン−エックス ビーブイビーエー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
JP2015529046A 2012-08-31 2013-09-02 高度に多様なコンビナトリアル抗体ライブラリ Active JP6283030B2 (ja)

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US201261695819P 2012-08-31 2012-08-31
US61/695,819 2012-08-31
PCT/EP2013/068110 WO2014033304A2 (en) 2012-08-31 2013-09-02 Highly diverse combinatorial antibody libraries

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JP2015526495A JP2015526495A (ja) 2015-09-10
JP6283030B2 true JP6283030B2 (ja) 2018-02-21

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US (1) US10040870B2 (enExample)
EP (1) EP2890709A2 (enExample)
JP (1) JP6283030B2 (enExample)
CN (1) CN104583236A (enExample)
AU (1) AU2013310839B2 (enExample)
CA (1) CA2879834A1 (enExample)
IL (1) IL236524B (enExample)
IN (1) IN2015DN00138A (enExample)
WO (1) WO2014033304A2 (enExample)

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US9708412B2 (en) 2015-05-21 2017-07-18 Harpoon Therapeutics, Inc. Trispecific binding proteins and methods of use
WO2017201493A1 (en) 2016-05-20 2017-11-23 Harpoon Therapeutics, Inc. Single chain variable fragment cd3 binding proteins
EP3493844A4 (en) 2016-05-20 2021-03-24 Harpoon Therapeutics Inc. SINGLE DOMAIN SERUM ALBUMIN BINDING PROTEIN
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
WO2018007999A1 (en) 2016-07-08 2018-01-11 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
AU2017363300A1 (en) 2016-11-23 2019-06-20 Harpoon Therapeutics, Inc. Prostate specific membrane antigen binding protein
WO2018098356A1 (en) * 2016-11-23 2018-05-31 Harpoon Therapeutics, Inc. Psma targeting trispecific proteins and methods of use
WO2018103093A1 (zh) * 2016-12-09 2018-06-14 深圳华大基因研究院 骆驼科抗体可变区免疫组库构建的引物组合及应用
US11535668B2 (en) 2017-02-28 2022-12-27 Harpoon Therapeutics, Inc. Inducible monovalent antigen binding protein
CN110506056A (zh) 2017-04-21 2019-11-26 斯塔滕生物技术有限公司 抗apoc3抗体和其使用方法
WO2018209304A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Msln targeting trispecific proteins and methods of use
EP3621994A4 (en) 2017-05-12 2020-12-30 Harpoon Therapeutics, Inc. MESOTHELIN BINDING PROTEINS
MX2020003915A (es) 2017-10-13 2020-10-08 Harpoon Therapeutics Inc Proteinas trispecificas y metodos de uso.
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
PE20210119A1 (es) 2017-10-31 2021-01-19 Staten Biotechnology B V Anticuerpos anti-apoc3 y metodos de uso de estos
BR112020023330A2 (pt) 2018-05-14 2021-04-20 Harpoon Therapeutics, Inc. porção de ligação para ativação condicional de moléculas de imunoglobulina
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
US10815311B2 (en) 2018-09-25 2020-10-27 Harpoon Therapeutics, Inc. DLL3 binding proteins and methods of use
AU2020275002A1 (en) 2019-05-14 2021-12-23 Harpoon Therapeutics, Inc. EpCAM binding proteins and methods of use
CN115768463A (zh) 2020-02-21 2023-03-07 哈普恩治疗公司 Flt3结合蛋白及使用方法

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GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
US8444976B2 (en) * 2008-07-02 2013-05-21 Argen-X B.V. Antigen binding polypeptides
GB2461546B (en) * 2008-07-02 2010-07-07 Argen X Bv Antigen binding polypeptides
CN102459591B (zh) * 2009-05-20 2015-05-13 诺维莫尼公司 合成性的多肽文库以及用于建立具有天然多样性的多肽变体的方法
GB2476681B (en) 2010-01-04 2012-04-04 Argen X Bv Humanized camelid VH, VK and VL immunoglobulin domains

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CN104583236A (zh) 2015-04-29
AU2013310839B2 (en) 2017-06-01
IN2015DN00138A (enExample) 2015-06-12
WO2014033304A2 (en) 2014-03-06
IL236524A0 (en) 2015-02-26
JP2015526495A (ja) 2015-09-10
WO2014033304A3 (en) 2014-05-01
IL236524B (en) 2019-01-31
AU2013310839A1 (en) 2015-01-29
CA2879834A1 (en) 2014-03-06
US20150166680A1 (en) 2015-06-18
EP2890709A2 (en) 2015-07-08
US10040870B2 (en) 2018-08-07

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