IL236524B - Camel antibody libraries - Google Patents

Camel antibody libraries

Info

Publication number
IL236524B
IL236524B IL236524A IL23652414A IL236524B IL 236524 B IL236524 B IL 236524B IL 236524 A IL236524 A IL 236524A IL 23652414 A IL23652414 A IL 23652414A IL 236524 B IL236524 B IL 236524B
Authority
IL
Israel
Prior art keywords
antibody libraries
camelid antibody
camelid
libraries
antibody
Prior art date
Application number
IL236524A
Other languages
English (en)
Hebrew (he)
Other versions
IL236524A0 (en
Inventor
Christophe Frederic Jerome Blanchetot
Haard Johannes Joseph Wilhelmus De
Alex Klarenbeek
Ikbel Achour
Mazouari Khalil El
Favero Jurgen Del
Original Assignee
Christophe Frederic Jerome Blanchetot
Haard Johannes Joseph Wilhelmus De
Alex Klarenbeek
Ikbel Achour
Mazouari Khalil El
Favero Jurgen Del
Argenx Bvba
Argenx Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Christophe Frederic Jerome Blanchetot, Haard Johannes Joseph Wilhelmus De, Alex Klarenbeek, Ikbel Achour, Mazouari Khalil El, Favero Jurgen Del, Argenx Bvba, Argenx Se filed Critical Christophe Frederic Jerome Blanchetot
Publication of IL236524A0 publication Critical patent/IL236524A0/en
Publication of IL236524B publication Critical patent/IL236524B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
IL236524A 2012-08-31 2014-12-31 Camel antibody libraries IL236524B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261695819P 2012-08-31 2012-08-31
PCT/EP2013/068110 WO2014033304A2 (en) 2012-08-31 2013-09-02 Highly diverse combinatorial antibody libraries

Publications (2)

Publication Number Publication Date
IL236524A0 IL236524A0 (en) 2015-02-26
IL236524B true IL236524B (en) 2019-01-31

Family

ID=49117845

Family Applications (1)

Application Number Title Priority Date Filing Date
IL236524A IL236524B (en) 2012-08-31 2014-12-31 Camel antibody libraries

Country Status (9)

Country Link
US (1) US10040870B2 (enExample)
EP (1) EP2890709A2 (enExample)
JP (1) JP6283030B2 (enExample)
CN (1) CN104583236A (enExample)
AU (1) AU2013310839B2 (enExample)
CA (1) CA2879834A1 (enExample)
IL (1) IL236524B (enExample)
IN (1) IN2015DN00138A (enExample)
WO (1) WO2014033304A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111234027A (zh) 2015-05-21 2020-06-05 哈普恩治疗公司 三特异性结合蛋白质及使用方法
CN109641046B (zh) 2016-05-20 2023-11-07 哈普恩治疗公司 单链可变片段cd3结合蛋白质
BR112018073739A2 (pt) 2016-05-20 2019-02-26 Harpoon Therapeutics, Inc. proteína de ligação de albumina sérica de domínio único
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
CA3030099A1 (en) 2016-07-08 2018-01-11 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
JP7215997B2 (ja) * 2016-11-23 2023-01-31 ハープーン セラピューティクス，インク． 前立腺特異的膜抗原（ｐｓｍａ）を標的とする三重特異性タンパク質と使用方法
JP6812551B2 (ja) 2016-11-23 2021-01-13 ハープーン セラピューティクス，インク． 前立腺特異的膜抗原結合タンパク質
CN110139952B (zh) * 2016-12-09 2022-11-25 深圳华大生命科学研究院 骆驼科抗体可变区免疫组库构建的引物组合及应用
US11535668B2 (en) 2017-02-28 2022-12-27 Harpoon Therapeutics, Inc. Inducible monovalent antigen binding protein
JP2020517242A (ja) 2017-04-21 2020-06-18 スターテン・バイオテクノロジー・ベー・フェー 抗ＡｐｏＣ３抗体およびその使用方法
CA3063362A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Msln targeting trispecific proteins and methods of use
CA3063359A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Mesothelin binding proteins
UA129446C2 (uk) 2017-10-13 2025-04-30 Гарпун Терап'Ютікс, Інк. Триспецифічні білки і способи їх застосування
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
BR112020008514A2 (pt) 2017-10-31 2020-10-20 Staten Biotechnology B.V. anticorpos anti-apoc3 e métodos de uso dos mesmos
US10538583B2 (en) 2017-10-31 2020-01-21 Staten Biotechnology B.V. Anti-APOC3 antibodies and compositions thereof
WO2019222283A1 (en) 2018-05-14 2019-11-21 Harpoon Therapeutics, Inc. Binding moiety for conditional activation of immunoglobulin molecules
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
EP3856771A4 (en) 2018-09-25 2022-06-29 Harpoon Therapeutics, Inc. Dll3 binding proteins and methods of use
IL295448A (en) 2020-02-21 2022-10-01 Harpoon Therapeutics Inc flt3 binding proteins and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
GB2461546B (en) * 2008-07-02 2010-07-07 Argen X Bv Antigen binding polypeptides
US8444976B2 (en) * 2008-07-02 2013-05-21 Argen-X B.V. Antigen binding polypeptides
CN102459591B (zh) * 2009-05-20 2015-05-13 诺维莫尼公司 合成性的多肽文库以及用于建立具有天然多样性的多肽变体的方法
GB2476681B (en) 2010-01-04 2012-04-04 Argen X Bv Humanized camelid VH, VK and VL immunoglobulin domains

Also Published As

Publication number Publication date
JP6283030B2 (ja) 2018-02-21
US10040870B2 (en) 2018-08-07
EP2890709A2 (en) 2015-07-08
JP2015526495A (ja) 2015-09-10
WO2014033304A2 (en) 2014-03-06
US20150166680A1 (en) 2015-06-18
IN2015DN00138A (enExample) 2015-06-12
AU2013310839A1 (en) 2015-01-29
CA2879834A1 (en) 2014-03-06
CN104583236A (zh) 2015-04-29
WO2014033304A3 (en) 2014-05-01
AU2013310839B2 (en) 2017-06-01
IL236524A0 (en) 2015-02-26

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