AU2013310839B2 - Highly diverse combinatorial antibody libraries - Google Patents

Highly diverse combinatorial antibody libraries Download PDF

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Publication number
AU2013310839B2
AU2013310839B2 AU2013310839A AU2013310839A AU2013310839B2 AU 2013310839 B2 AU2013310839 B2 AU 2013310839B2 AU 2013310839 A AU2013310839 A AU 2013310839A AU 2013310839 A AU2013310839 A AU 2013310839A AU 2013310839 B2 AU2013310839 B2 AU 2013310839B2
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Australia
Prior art keywords
antibody
library
human
families
antibodies
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AU2013310839A
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AU2013310839A1 (en
Inventor
Ikbel ACHOUR
Christophe Frederic Jerome Blanchetot
Johannes Joseph Wilhelmus De Haard
Jurgen DEL FAVERO
Khalil EL MAZOUARI
Alex KLARENBEEK
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ArgenX BVBA
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ArgenX BVBA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
AU2013310839A 2012-08-31 2013-09-02 Highly diverse combinatorial antibody libraries Active AU2013310839B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261695819P 2012-08-31 2012-08-31
US61/695,819 2012-08-31
PCT/EP2013/068110 WO2014033304A2 (en) 2012-08-31 2013-09-02 Highly diverse combinatorial antibody libraries

Publications (2)

Publication Number Publication Date
AU2013310839A1 AU2013310839A1 (en) 2015-01-29
AU2013310839B2 true AU2013310839B2 (en) 2017-06-01

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Family Applications (1)

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AU2013310839A Active AU2013310839B2 (en) 2012-08-31 2013-09-02 Highly diverse combinatorial antibody libraries

Country Status (9)

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US (1) US10040870B2 (enExample)
EP (1) EP2890709A2 (enExample)
JP (1) JP6283030B2 (enExample)
CN (1) CN104583236A (enExample)
AU (1) AU2013310839B2 (enExample)
CA (1) CA2879834A1 (enExample)
IL (1) IL236524B (enExample)
IN (1) IN2015DN00138A (enExample)
WO (1) WO2014033304A2 (enExample)

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CN111234027A (zh) 2015-05-21 2020-06-05 哈普恩治疗公司 三特异性结合蛋白质及使用方法
CN109641046B (zh) 2016-05-20 2023-11-07 哈普恩治疗公司 单链可变片段cd3结合蛋白质
BR112018073739A2 (pt) 2016-05-20 2019-02-26 Harpoon Therapeutics, Inc. proteína de ligação de albumina sérica de domínio único
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
CA3030099A1 (en) 2016-07-08 2018-01-11 Staten Biotechnology B.V. Anti-apoc3 antibodies and methods of use thereof
JP7215997B2 (ja) * 2016-11-23 2023-01-31 ハープーン セラピューティクス，インク． 前立腺特異的膜抗原（ｐｓｍａ）を標的とする三重特異性タンパク質と使用方法
JP6812551B2 (ja) 2016-11-23 2021-01-13 ハープーン セラピューティクス，インク． 前立腺特異的膜抗原結合タンパク質
CN110139952B (zh) * 2016-12-09 2022-11-25 深圳华大生命科学研究院 骆驼科抗体可变区免疫组库构建的引物组合及应用
US11535668B2 (en) 2017-02-28 2022-12-27 Harpoon Therapeutics, Inc. Inducible monovalent antigen binding protein
JP2020517242A (ja) 2017-04-21 2020-06-18 スターテン・バイオテクノロジー・ベー・フェー 抗ＡｐｏＣ３抗体およびその使用方法
CA3063362A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Msln targeting trispecific proteins and methods of use
CA3063359A1 (en) 2017-05-12 2018-11-15 Harpoon Therapeutics, Inc. Mesothelin binding proteins
UA129446C2 (uk) 2017-10-13 2025-04-30 Гарпун Терап'Ютікс, Інк. Триспецифічні білки і способи їх застосування
IL315737A (en) 2017-10-13 2024-11-01 Harpoon Therapeutics Inc B-cell maturation antigen-binding proteins
BR112020008514A2 (pt) 2017-10-31 2020-10-20 Staten Biotechnology B.V. anticorpos anti-apoc3 e métodos de uso dos mesmos
US10538583B2 (en) 2017-10-31 2020-01-21 Staten Biotechnology B.V. Anti-APOC3 antibodies and compositions thereof
WO2019222283A1 (en) 2018-05-14 2019-11-21 Harpoon Therapeutics, Inc. Binding moiety for conditional activation of immunoglobulin molecules
US12195544B2 (en) 2018-09-21 2025-01-14 Harpoon Therapeutics, Inc. EGFR binding proteins and methods of use
EP3856771A4 (en) 2018-09-25 2022-06-29 Harpoon Therapeutics, Inc. Dll3 binding proteins and methods of use
IL295448A (en) 2020-02-21 2022-10-01 Harpoon Therapeutics Inc flt3 binding proteins and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110165621A1 (en) * 2010-01-04 2011-07-07 arGEN-X BV Humanized antibodies
US20110300140A1 (en) * 2008-07-02 2011-12-08 Argen-X B.V. Antigen binding polypeptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
GB2461546B (en) * 2008-07-02 2010-07-07 Argen X Bv Antigen binding polypeptides
CN102459591B (zh) * 2009-05-20 2015-05-13 诺维莫尼公司 合成性的多肽文库以及用于建立具有天然多样性的多肽变体的方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110300140A1 (en) * 2008-07-02 2011-12-08 Argen-X B.V. Antigen binding polypeptides
US20110165621A1 (en) * 2010-01-04 2011-07-07 arGEN-X BV Humanized antibodies

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SCHOFIELD DARREN J ET AL, "Application of phage display to high throughput antibody generation and characterization", GENOME BIOLOGY, BIOMED CENTRAL LTD., LONDON, GB, (20071129), vol. 8, no. 11, ISSN 1465-6906, page R254 *

Also Published As

Publication number Publication date
JP6283030B2 (ja) 2018-02-21
US10040870B2 (en) 2018-08-07
EP2890709A2 (en) 2015-07-08
JP2015526495A (ja) 2015-09-10
WO2014033304A2 (en) 2014-03-06
US20150166680A1 (en) 2015-06-18
IN2015DN00138A (enExample) 2015-06-12
AU2013310839A1 (en) 2015-01-29
CA2879834A1 (en) 2014-03-06
CN104583236A (zh) 2015-04-29
WO2014033304A3 (en) 2014-05-01
IL236524B (en) 2019-01-31
IL236524A0 (en) 2015-02-26

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Owner name: ARGENX BVBA

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