JP6280045B2 - 肺腺癌内転移関連性転写物1(metastasis−associated−in−lung−adenocarcinoma−transcript−1:malat−1)の発現調節法 - Google Patents

肺腺癌内転移関連性転写物1(metastasis−associated−in−lung−adenocarcinoma−transcript−1:malat−1)の発現調節法 Download PDF

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JP6280045B2
JP6280045B2 JP2014548964A JP2014548964A JP6280045B2 JP 6280045 B2 JP6280045 B2 JP 6280045B2 JP 2014548964 A JP2014548964 A JP 2014548964A JP 2014548964 A JP2014548964 A JP 2014548964A JP 6280045 B2 JP6280045 B2 JP 6280045B2
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malat
modified
nucleic acid
antisense
certain embodiments
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JP2015507625A5 (enExample
JP2015507625A (ja
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ベネット,シー・フランク
フレアー,スーザン・エム
マークソン,エリック・ジー
シュー,シューチェン・ジェイ
マクラウド,ロバート・エイ
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Ionis Pharmaceuticals Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
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    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2014548964A 2011-12-22 2012-12-21 肺腺癌内転移関連性転写物1(metastasis−associated−in−lung−adenocarcinoma−transcript−1:malat−1)の発現調節法 Active JP6280045B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161579343P 2011-12-22 2011-12-22
US61/579,343 2011-12-22
PCT/US2012/071371 WO2013096837A1 (en) 2011-12-22 2012-12-21 Methods for modulating metastasis-associated-in-lung-adenocarcinoma-transcript-1(malat-1) expression

Publications (3)

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JP2015507625A JP2015507625A (ja) 2015-03-12
JP2015507625A5 JP2015507625A5 (enExample) 2016-02-18
JP6280045B2 true JP6280045B2 (ja) 2018-02-14

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US (1) US9546368B2 (enExample)
EP (1) EP2794880B1 (enExample)
JP (1) JP6280045B2 (enExample)
AU (1) AU2012358238B2 (enExample)
CA (1) CA2859729C (enExample)
DK (1) DK2794880T3 (enExample)
ES (1) ES2673960T3 (enExample)
WO (1) WO2013096837A1 (enExample)

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ES2673960T3 (es) 2018-06-26
US20140371296A1 (en) 2014-12-18
AU2012358238B2 (en) 2017-12-07
EP2794880A1 (en) 2014-10-29
AU2012358238A1 (en) 2014-06-19
US9546368B2 (en) 2017-01-17
EP2794880A4 (en) 2015-10-14
DK2794880T3 (en) 2018-07-23
WO2013096837A1 (en) 2013-06-27
CA2859729A1 (en) 2013-06-27
JP2015507625A (ja) 2015-03-12
EP2794880B1 (en) 2018-05-02
CA2859729C (en) 2021-03-09

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