DK2794880T3 - METHOD OF MODULATING METASTASE-ASSOCIATED-IN-LONG-ADENOCARCINOM TRANSCRIPT-1- (MALATE-1) EXPRESSION - Google Patents

METHOD OF MODULATING METASTASE-ASSOCIATED-IN-LONG-ADENOCARCINOM TRANSCRIPT-1- (MALATE-1) EXPRESSION Download PDF

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Publication number
DK2794880T3
DK2794880T3 DK12860563.1T DK12860563T DK2794880T3 DK 2794880 T3 DK2794880 T3 DK 2794880T3 DK 12860563 T DK12860563 T DK 12860563T DK 2794880 T3 DK2794880 T3 DK 2794880T3
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antisense
malat
modified
nucleic acid
certain embodiments
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DK12860563.1T
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Danish (da)
English (en)
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C Frank Bennett
Susan M Freier
Eric G Marcusson
Ssucheng J Hsu
Robert A Macleod
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Ionis Pharmaceuticals Inc
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/711Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • C12N2310/113Antisense targeting other non-coding nucleic acids, e.g. antagomirs
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
    • C12N2310/334Modified C
    • C12N2310/33415-Methylcytosine
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    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/341Gapmers, i.e. of the type ===---===
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    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/346Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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DK12860563.1T 2011-12-22 2012-12-21 METHOD OF MODULATING METASTASE-ASSOCIATED-IN-LONG-ADENOCARCINOM TRANSCRIPT-1- (MALATE-1) EXPRESSION DK2794880T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161579343P 2011-12-22 2011-12-22
PCT/US2012/071371 WO2013096837A1 (en) 2011-12-22 2012-12-21 Methods for modulating metastasis-associated-in-lung-adenocarcinoma-transcript-1(malat-1) expression

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DK2794880T3 true DK2794880T3 (en) 2018-07-23

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US (1) US9546368B2 (enExample)
EP (1) EP2794880B1 (enExample)
JP (1) JP6280045B2 (enExample)
AU (1) AU2012358238B2 (enExample)
CA (1) CA2859729C (enExample)
DK (1) DK2794880T3 (enExample)
ES (1) ES2673960T3 (enExample)
WO (1) WO2013096837A1 (enExample)

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US9546368B2 (en) 2017-01-17
JP6280045B2 (ja) 2018-02-14
AU2012358238A1 (en) 2014-06-19
EP2794880A1 (en) 2014-10-29
AU2012358238B2 (en) 2017-12-07
WO2013096837A1 (en) 2013-06-27
EP2794880B1 (en) 2018-05-02
CA2859729A1 (en) 2013-06-27
JP2015507625A (ja) 2015-03-12
EP2794880A4 (en) 2015-10-14
US20140371296A1 (en) 2014-12-18
CA2859729C (en) 2021-03-09
ES2673960T3 (es) 2018-06-26

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