JP6275120B2 - 大きい標的化ベクターによるヌクレアーゼ媒介標的化 - Google Patents

大きい標的化ベクターによるヌクレアーゼ媒介標的化 Download PDF

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JP6275120B2
JP6275120B2 JP2015509128A JP2015509128A JP6275120B2 JP 6275120 B2 JP6275120 B2 JP 6275120B2 JP 2015509128 A JP2015509128 A JP 2015509128A JP 2015509128 A JP2015509128 A JP 2015509128A JP 6275120 B2 JP6275120 B2 JP 6275120B2
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nucleic acid
acid sequence
sequence
human
insert
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JP2015514439A5 (enExample
JP2015514439A (ja
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デイビッド フレンデウェイ，
デイビッド フレンデウェイ，
ウォジテック アウアーバッハ，
ウォジテック アウアーバッハ，
デイビッド エム． ヴァレンズエラ，
デイビッド エム． ヴァレンズエラ，
ジョージ ディー． ヤンコポーロス，
ジョージ ディー． ヤンコポーロス，
カ−マン ビーナス ライ，
カ−マン ビーナス ライ，
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Regeneron Pharmaceuticals Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells

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JP2015509128A 2012-04-25 2013-04-25 大きい標的化ベクターによるヌクレアーゼ媒介標的化 Active JP6275120B2 (ja)

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US201261638267P 2012-04-25 2012-04-25
US61/638,267 2012-04-25
PCT/US2013/038165 WO2013163394A1 (en) 2012-04-25 2013-04-25 Nuclease-mediated targeting with large targeting vectors

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JP2015514439A JP2015514439A (ja) 2015-05-21
JP2015514439A5 JP2015514439A5 (enExample) 2016-06-02
JP6275120B2 true JP6275120B2 (ja) 2018-02-07

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CN (2) CN104364380B (enExample)
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