JP6246227B2 - Ｔａｒｐ−ガンマ８依存性ａｍｐａ受容体アンタゴニストとしての６−（（ｓ）−１−｛１−［５−（２−ヒドロキシ−エトキシ）−ピリジン−２−イル］−１ｈ−ピラゾール−３−イル｝−エチル）−３ｈ−１，３−ベンゾチアゾール−２−オン - Google Patents
Ｔａｒｐ−ガンマ８依存性ａｍｐａ受容体アンタゴニストとしての６−（（ｓ）−１−｛１−［５−（２−ヒドロキシ−エトキシ）−ピリジン−２−イル］−１ｈ−ピラゾール−３−イル｝−エチル）−３ｈ−１，３−ベンゾチアゾール−２−オン Download PDFInfo
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- JP6246227B2 JP6246227B2 JP2015545099A JP2015545099A JP6246227B2 JP 6246227 B2 JP6246227 B2 JP 6246227B2 JP 2015545099 A JP2015545099 A JP 2015545099A JP 2015545099 A JP2015545099 A JP 2015545099A JP 6246227 B2 JP6246227 B2 JP 6246227B2
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- JP
- Japan
- Prior art keywords
- compound
- pyrazol
- ethyl
- seizures
- benzothiazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261730273P | 2012-11-27 | 2012-11-27 | |
| US61/730,273 | 2012-11-27 | ||
| PCT/US2013/070885 WO2014085153A1 (en) | 2012-11-27 | 2013-11-20 | 6-((s)-1-{1-[5-(2-hydroxy-ethoxy)-pyridin-2-yl]-1h-pyrazol-3-yl}- ethyl)-3h-1,3-benzothiazol-2-one as a tarp-gamma 8 dependent ampa receptor antagonist |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016501219A JP2016501219A (ja) | 2016-01-18 |
| JP2016501219A5 JP2016501219A5 (enExample) | 2017-01-12 |
| JP6246227B2 true JP6246227B2 (ja) | 2017-12-13 |
Family
ID=49753484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545099A Active JP6246227B2 (ja) | 2012-11-27 | 2013-11-20 | Ｔａｒｐ−ガンマ８依存性ａｍｐａ受容体アンタゴニストとしての６−（（ｓ）−１−｛１−［５−（２−ヒドロキシ−エトキシ）−ピリジン−２−イル］−１ｈ−ピラゾール−３−イル｝−エチル）−３ｈ−１，３−ベンゾチアゾール−２−オン |
Country Status (35)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201609719A (zh) * | 2014-05-28 | 2016-03-16 | 美國禮來大藥廠 | 作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物 |
| AU2016255434C1 (en) | 2015-04-29 | 2021-09-23 | Rapport Therapeutics, Inc. | Azabenzimidazoles and their use as AMPA receptor modulators |
| BR112017023200A2 (pt) | 2015-04-29 | 2018-08-07 | Janssen Pharmaceutica Nv | compostos de indolona e seu uso como moduladores do receptor de ampa |
| MX373652B (es) | 2015-04-29 | 2020-04-02 | Janssen Pharmaceutica Nv | Imidazopirazinas y pirazolopirimidinas y su uso como moduladores del receptor de ampa. |
| WO2016176449A1 (en) * | 2015-04-29 | 2016-11-03 | Janssen Pharmaceutica Nv | Benzimidazolone and benzothiazolone compounds and their use as ampa receptor modulators |
| EA036903B1 (ru) * | 2016-10-26 | 2021-01-13 | Янссен Фармацевтика Нв | Соединения конденсированных бициклических пиридинов и их применение в качестве модуляторов ampa-рецептора |
| RU2650523C1 (ru) * | 2017-07-24 | 2018-04-16 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Производное пиридоксина для лечения эпилепсии |
| RU2703286C1 (ru) * | 2019-06-18 | 2019-10-16 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Соли (5-гидрокси-3,4-бис(гидроксиметил)-6-метилпиридин-2-ил)метансульфокислоты и способ их получения |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY132385A (en) * | 1995-08-31 | 2007-10-31 | Novartis Ag | 2,3-dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives |
| JP2000281676A (ja) * | 1999-01-25 | 2000-10-10 | Yamanouchi Pharmaceut Co Ltd | Ａｍｐａ拮抗化合物の新規製造法 |
| EP2177520A1 (en) * | 2000-06-12 | 2010-04-21 | Eisai R&D Management Co., Ltd. | 1,5-Di(aryl or heteroaryl)-3-halo-2(1H)-pyridones as intermediates for the preparation of AMPA receptor inhibitors |
| US8995993B2 (en) * | 2000-10-11 | 2015-03-31 | Gogo Llc | System for managing mobile internet protocol addresses in an airborne wireless cellular network |
| ATE404555T1 (de) * | 2004-12-17 | 2008-08-15 | Lilly Co Eli | Neue mch-rezeptorantagonisten |
| WO2007076161A2 (en) | 2005-12-27 | 2007-07-05 | Myriad Genetics, Inc | Compounds with therapeutic activity |
| TW200817385A (en) * | 2006-07-04 | 2008-04-16 | Organon Nv | Heterocyclic derivatives |
| CA2739559A1 (en) * | 2008-10-08 | 2010-04-15 | Pfizer Inc. | Tetrahydrofuranyl sulfonamides and pharmaceutical compositions thereof |
| BRPI1006128A2 (pt) * | 2009-01-12 | 2016-11-01 | Cagen Inc | derivados de sulfonamida |
| CN102985420B (zh) * | 2010-06-01 | 2017-07-04 | 安吉翁生物医药有限公司 | 细胞色素p450抑制剂及其用途 |
| US9527807B2 (en) * | 2011-04-05 | 2016-12-27 | Takeda Pharmaceutical Company Limited | Sulfonamide derivative and use thereof |
| TW201609719A (zh) * | 2014-05-28 | 2016-03-16 | 美國禮來大藥廠 | 作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物 |
-
2013
- 2013-11-17 JO JOP/2013/0331A patent/JO3225B1/ar active
- 2013-11-18 TW TW102141949A patent/TWI618705B/zh not_active IP Right Cessation
- 2013-11-18 TW TW106144388A patent/TW201825484A/zh unknown
- 2013-11-18 AR ARP130104242A patent/AR093527A1/es unknown
- 2013-11-20 CN CN201380061495.2A patent/CN104797578B/zh active Active
- 2013-11-20 ES ES13802786.7T patent/ES2618260T3/es active Active
- 2013-11-20 PT PT138027867T patent/PT2925754T/pt unknown
- 2013-11-20 EA EA201590823A patent/EA026686B1/ru not_active IP Right Cessation
- 2013-11-20 AP AP2015008489A patent/AP2015008489A0/xx unknown
- 2013-11-20 MA MA38126A patent/MA38126B1/fr unknown
- 2013-11-20 DK DK13802786.7T patent/DK2925754T3/en active
- 2013-11-20 MX MX2015006697A patent/MX356478B/es active IP Right Grant
- 2013-11-20 EP EP13802786.7A patent/EP2925754B1/en active Active
- 2013-11-20 JP JP2015545099A patent/JP6246227B2/ja active Active
- 2013-11-20 WO PCT/US2013/070885 patent/WO2014085153A1/en not_active Ceased
- 2013-11-20 SI SI201330464A patent/SI2925754T1/sl unknown
- 2013-11-20 MY MYPI2015701544A patent/MY177721A/en unknown
- 2013-11-20 UA UAA201504865A patent/UA114345C2/uk unknown
- 2013-11-20 HR HRP20170274TT patent/HRP20170274T1/hr unknown
- 2013-11-20 KR KR1020157013470A patent/KR101693133B1/ko active Active
- 2013-11-20 SG SG11201504164VA patent/SG11201504164VA/en unknown
- 2013-11-20 BR BR112015011200A patent/BR112015011200A2/pt not_active IP Right Cessation
- 2013-11-20 CA CA2889243A patent/CA2889243C/en active Active
- 2013-11-20 US US14/084,683 patent/US8765960B2/en active Active
- 2013-11-20 PL PL13802786T patent/PL2925754T3/pl unknown
- 2013-11-20 AU AU2013352594A patent/AU2013352594B2/en active Active
- 2013-11-20 HU HUE13802786A patent/HUE033447T2/en unknown
- 2013-11-20 PE PE2015000694A patent/PE20151728A1/es active IP Right Grant
-
2015
- 2015-05-14 DO DO2015000113A patent/DOP2015000113A/es unknown
- 2015-05-14 IL IL238831A patent/IL238831B/en not_active IP Right Cessation
- 2015-05-20 CR CR20150267A patent/CR20150267A/es unknown
- 2015-05-22 TN TNP2015000200A patent/TN2015000200A1/fr unknown
- 2015-05-25 PH PH12015501154A patent/PH12015501154B1/en unknown
- 2015-05-26 ZA ZA2015/03733A patent/ZA201503733B/en unknown
- 2015-05-26 CL CL2015001419A patent/CL2015001419A1/es unknown
-
2017
- 2017-02-24 CY CY20171100252T patent/CY1118657T1/el unknown
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