HRP20170274T1 - 6-((s)-1-{1-[5-(2-hidroksietoksi)piridin-2-il]-1h-pirazol-3-il}-etil)-3h-1,3-benzotiazol-2-on kao tarp-gama 8-ovisni antagonist ampa receptora - Google Patents
6-((s)-1-{1-[5-(2-hidroksietoksi)piridin-2-il]-1h-pirazol-3-il}-etil)-3h-1,3-benzotiazol-2-on kao tarp-gama 8-ovisni antagonist ampa receptoraInfo
- Publication number
- HRP20170274T1 HRP20170274T1 HRP20170274TT HRP20170274T HRP20170274T1 HR P20170274 T1 HRP20170274 T1 HR P20170274T1 HR P20170274T T HRP20170274T T HR P20170274TT HR P20170274 T HRP20170274 T HR P20170274T HR P20170274 T1 HRP20170274 T1 HR P20170274T1
- Authority
- HR
- Croatia
- Prior art keywords
- tarp
- gama
- benzothiazol
- hydroxyethoxy
- pyrazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261730273P | 2012-11-27 | 2012-11-27 | |
| PCT/US2013/070885 WO2014085153A1 (en) | 2012-11-27 | 2013-11-20 | 6-((s)-1-{1-[5-(2-hydroxy-ethoxy)-pyridin-2-yl]-1h-pyrazol-3-yl}- ethyl)-3h-1,3-benzothiazol-2-one as a tarp-gamma 8 dependent ampa receptor antagonist |
| EP13802786.7A EP2925754B1 (en) | 2012-11-27 | 2013-11-20 | 6-((s)-1-{1-[5-(2-hydroxy-ethoxy)-pyridin-2-yl]-1h-pyrazol-3-yl}-ethyl)-3h-1,3-benzothiazol-2-one as a tarp-gamma 8 dependent ampa receptor antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170274T1 true HRP20170274T1 (hr) | 2017-04-07 |
Family
ID=49753484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170274TT HRP20170274T1 (hr) | 2012-11-27 | 2013-11-20 | 6-((s)-1-{1-[5-(2-hidroksietoksi)piridin-2-il]-1h-pirazol-3-il}-etil)-3h-1,3-benzotiazol-2-on kao tarp-gama 8-ovisni antagonist ampa receptora |
Country Status (35)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201609719A (zh) * | 2014-05-28 | 2016-03-16 | 美國禮來大藥廠 | 作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物 |
| CA2984290C (en) * | 2015-04-29 | 2022-03-01 | Janssen Pharmaceutica Nv | Benzimidazolone and benzothiazolone compounds and their use as ampa receptor modulators |
| ES2865330T3 (es) * | 2015-04-29 | 2021-10-15 | Janssen Pharmaceutica Nv | Azabenzimidazoles y su uso como moduladores del receptor AMPA |
| US10604484B2 (en) | 2015-04-29 | 2020-03-31 | Janssen Pharmaceutica Nv | Indolone compounds and their use as AMPA receptor modulators |
| JP6800885B2 (ja) | 2015-04-29 | 2020-12-16 | ヤンセン ファーマシューティカ エヌ．ベー． | イミダゾピラジン及びピラゾロピリミジン、並びにａｍｐａ受容体調節物質としてのこれらの使用 |
| JP6953527B2 (ja) * | 2016-10-26 | 2021-10-27 | ヤンセン ファーマシューティカ エヌ．ベー． | 縮合二環ピリジン化合物、及びａｍｐａ受容体調節因子としてのそれらの使用 |
| RU2650523C1 (ru) * | 2017-07-24 | 2018-04-16 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Производное пиридоксина для лечения эпилепсии |
| RU2703286C1 (ru) * | 2019-06-18 | 2019-10-16 | федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) | Соли (5-гидрокси-3,4-бис(гидроксиметил)-6-метилпиридин-2-ил)метансульфокислоты и способ их получения |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY132385A (en) * | 1995-08-31 | 2007-10-31 | Novartis Ag | 2,3-dioxo-1,2,3,4-tetrahydro-quinoxalinyl derivatives |
| JP2000281676A (ja) * | 1999-01-25 | 2000-10-10 | Yamanouchi Pharmaceut Co Ltd | Ａｍｐａ拮抗化合物の新規製造法 |
| CN1245386C (zh) | 2000-06-12 | 2006-03-15 | 卫材株式会社 | 1,2－二氢吡啶化合物及其制备方法和用途 |
| US8995993B2 (en) * | 2000-10-11 | 2015-03-31 | Gogo Llc | System for managing mobile internet protocol addresses in an airborne wireless cellular network |
| ATE404555T1 (de) * | 2004-12-17 | 2008-08-15 | Lilly Co Eli | Neue mch-rezeptorantagonisten |
| WO2007076161A2 (en) | 2005-12-27 | 2007-07-05 | Myriad Genetics, Inc | Compounds with therapeutic activity |
| TW200817385A (en) * | 2006-07-04 | 2008-04-16 | Organon Nv | Heterocyclic derivatives |
| JP2012505198A (ja) * | 2008-10-08 | 2012-03-01 | ファイザー・インク | Ｃｎｓ障害を治療する際にａｍｐａ調節剤として使用するためのテトラヒドロフラニルスルホンアミド |
| HRP20150355T1 (hr) * | 2009-01-12 | 2015-06-19 | Pfizer Limited | Sulfonamidni derivati |
| JP6088425B2 (ja) * | 2010-06-01 | 2017-03-01 | アンジオン バイオメディカ コーポレーション | チトクロームｐ４５０阻害剤およびその使用 |
| JP5976011B2 (ja) * | 2011-04-05 | 2016-08-23 | 武田薬品工業株式会社 | スルホンアミド誘導体およびその用途 |
| TW201609719A (zh) * | 2014-05-28 | 2016-03-16 | 美國禮來大藥廠 | 作為ＴＡＲＰ－γ８依賴性ＡＭＰＡ受體拮抗劑之６－經取代－３Ｈ－１，３－苯并噻唑－２－酮化合物 |
-
2013
- 2013-11-17 JO JOP/2013/0331A patent/JO3225B1/ar active
- 2013-11-18 TW TW106144388A patent/TW201825484A/zh unknown
- 2013-11-18 TW TW102141949A patent/TWI618705B/zh not_active IP Right Cessation
- 2013-11-18 AR ARP130104242A patent/AR093527A1/es unknown
- 2013-11-20 HR HRP20170274TT patent/HRP20170274T1/hr unknown
- 2013-11-20 EA EA201590823A patent/EA026686B1/ru not_active IP Right Cessation
- 2013-11-20 MA MA38126A patent/MA38126B1/fr unknown
- 2013-11-20 KR KR1020157013470A patent/KR101693133B1/ko active Active
- 2013-11-20 MX MX2015006697A patent/MX356478B/es active IP Right Grant
- 2013-11-20 MY MYPI2015701544A patent/MY177721A/en unknown
- 2013-11-20 EP EP13802786.7A patent/EP2925754B1/en active Active
- 2013-11-20 CN CN201380061495.2A patent/CN104797578B/zh active Active
- 2013-11-20 BR BR112015011200A patent/BR112015011200A2/pt not_active IP Right Cessation
- 2013-11-20 AP AP2015008489A patent/AP2015008489A0/xx unknown
- 2013-11-20 US US14/084,683 patent/US8765960B2/en active Active
- 2013-11-20 AU AU2013352594A patent/AU2013352594B2/en active Active
- 2013-11-20 HU HUE13802786A patent/HUE033447T2/en unknown
- 2013-11-20 UA UAA201504865A patent/UA114345C2/uk unknown
- 2013-11-20 PT PT138027867T patent/PT2925754T/pt unknown
- 2013-11-20 ES ES13802786.7T patent/ES2618260T3/es active Active
- 2013-11-20 PL PL13802786T patent/PL2925754T3/pl unknown
- 2013-11-20 DK DK13802786.7T patent/DK2925754T3/en active
- 2013-11-20 SG SG11201504164VA patent/SG11201504164VA/en unknown
- 2013-11-20 PE PE2015000694A patent/PE20151728A1/es active IP Right Grant
- 2013-11-20 SI SI201330464A patent/SI2925754T1/sl unknown
- 2013-11-20 JP JP2015545099A patent/JP6246227B2/ja active Active
- 2013-11-20 WO PCT/US2013/070885 patent/WO2014085153A1/en not_active Ceased
- 2013-11-20 CA CA2889243A patent/CA2889243C/en active Active
-
2015
- 2015-05-14 IL IL238831A patent/IL238831B/en not_active IP Right Cessation
- 2015-05-14 DO DO2015000113A patent/DOP2015000113A/es unknown
- 2015-05-20 CR CR20150267A patent/CR20150267A/es unknown
- 2015-05-22 TN TNP2015000200A patent/TN2015000200A1/fr unknown
- 2015-05-25 PH PH12015501154A patent/PH12015501154B1/en unknown
- 2015-05-26 ZA ZA2015/03733A patent/ZA201503733B/en unknown
- 2015-05-26 CL CL2015001419A patent/CL2015001419A1/es unknown
-
2017
- 2017-02-24 CY CY20171100252T patent/CY1118657T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20170274T1 (hr) | 6-((s)-1-{1-[5-(2-hidroksietoksi)piridin-2-il]-1h-pirazol-3-il}-etil)-3h-1,3-benzotiazol-2-on kao tarp-gama 8-ovisni antagonist ampa receptora | |
| BRPI1012108A2 (pt) | 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octano- ou heptano-nitrila como inibidores de jak | |
| HUS1700040I1 (hu) | Antivirális 1-fenil-2,5-dibenzimidazol-5-il-pirrolidin-származék | |
| CY2017031I1 (el) | Αντι-ιικο παραγωγο 1-φαινυλ-2,5-διβενζιμιδαζολ-5-υλ-πυρρολιδινης | |
| LT3483163T (lt) | Triazol[4,5-d]pirimidino dariniai kaip cb2 receptorių antagonistai | |
| EP2681216A4 (en) | SUBSTITUTED 6.5-CONDENSED BICYCLIC HETEROARYL COMPOUNDS | |
| FI20165907A7 (fi) | Konemaisen viestinnän käyttäjävälineiden | |
| CL2014000534A1 (es) | Procesos para preparar {1-{1-[3-fluoro-2-(trifluorometil)isonicotinoil]piperidin-4-il}-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]azetidin-3-il}acetonitrilo y compuestos intermediarios, inhibidores de jak; y compuesto intermediario (3-fluoro-2-(trifluorometil)piridin-4-il)(1,4-dioxa-8-azaspiro[4,5]decan-8-il)metanona. | |
| EP2673745A4 (en) | USER INTERFACES FOR PERSONALIZED RECOMMENDATIONS | |
| BR112013025792A2 (pt) | Inibidores de quinase relacionada à pirrolo[2,3-d] pirimidina tropomisina | |
| LT2768859T (lt) | Il17c antagonistai, skirti uždegiminių ligų gydymui | |
| IL239562A0 (en) | Derivatives of 1-(converted-benzoyl)-5-fluoro-4-imino-3-methyl-4,3-dihydropyrimidine-2(1h)-one | |
| DK3524230T3 (da) | Farmakologiske formuleringer, der omfatter ccr3-antagonister | |
| IL232917A (en) | Annals of 5 - (3-aminophenyl) -5-alkyl-6,5-dihydro-2h [4,1] oxazin-3-amine | |
| DK3312169T3 (da) | 5-ht3 receptorantagonister | |
| PL3077390T3 (pl) | Krystaliczna postać soli (s)-(2-(6-chloro-7-metylo-1h-benzo[d]imidazol-2-ilo)-2-metylopirolidyn-1-ylo)(5-metoksy-2-(2h-1,2,3-triazol-2-ilo)fenylo)metanonu jako antagonista receptora oreksyny | |
| IL241743A0 (en) | Non-competitive nicotinic receptor antagonists | |
| BR112015005750A2 (pt) | antagonistas peptídicos do receptor de vasopressina-2 | |
| SG11201406273XA (en) | Tools for making retroreflective articles | |
| EP2846800A4 (en) | HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | |
| CO6821933A2 (es) | Antagonistas no competitivos de receptores nicotínicos | |
| PL395738A1 (pl) | Nowe zastosowanie medyczne substancji 4-(n-butylo)-5-(3-chlorofenylo)-2,4-dihydro-3H-1,2,4-triazolo-3-tionu |